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The map label for this gene is deoA [C]

Identifier: 148360320

GI number: 148360320

Start: 1227433

End: 1228947

Strand: Direct

Name: deoA [C]

Synonym: LPC_2257

Alternate gene names: 148360320

Gene position: 1227433-1228947 (Clockwise)

Preceding gene: 148360321

Following gene: 148360319

Centisome position: 34.32

GC content: 46.34

Gene sequence:

>1515_bases
ATGAGTAAGAAAACCGCTCATGGGCTTCGTTTAAAGCATTTAGGGATTAAAACCTACCATGAGGCCATTATTTACATGCG
CGAGGATTGTCATGTTTGTCATTCGGAAGGATTCGAAGTACAGACCCGTATCCAAGTGACTTTAGGTCAGCACTCTATTA
TAGCCACCCTTAATGTGGTGACCTCAGAGCTTCTAGCTCCAGGGGAAGCTGGTTTGTCAGATTATGCCTGGGATGCTTTA
CATGCCAAAGAAGGCGATGAAATTCAAGTTTCCCATCCAAAACCCTTGGAATCCCTAAGCTATGTGCATACCAAGATTTA
TGGCAATGAACTGTCTTATGAACAAATGAAGGTCATCATTGATGATGTGTTAAGCGGTCGTCTTTCTGATGTACAAATCT
CCGCTTTTTTAGCGGCAAGTAGTGCAGGACGTCTAACCCGTACGGAAATCATGAAACTCACCAAAGCCATGATAGACAGT
GGTGATCGCTTATCCTGGTCTTCACCTCTGGTCGTCGATAAACATTGCGTGGGAGGATTGCCGGGAAATCGCACAACTCT
GATTGTAGTTCCCATTGTGGCCGCTTTTGGATTGATGATTCCAAAAACATCATCACGTGCCATTACATCACCCGCGGGGA
CTGCGGATACCATGGAGACTTTAGCTCCAGTCCACTTAAGTCCCCAAAAGATGCGCCAAGTGGTTGAACAAGAAAACGGC
TGTATCGTCTGGGGTGGGGCTGTGAGTTTAAGTCCTGCTGATGACGTGCTCATCCGTGTGGAACGAGCCATTGATTTAGA
TAGTGAAGGGCAATTAGTGGCGTCCATTCTTTCTAAAAAAATTGCAACAGGTGCTACGCATGCAGTCATTGATATCCCCG
TAGGACCTACTGCCAAAGTCAGGAATCAGTCTATGGCGCTCCTTCTGAAACAATCGCTTGAGGAGGTAGGTAACGAGTTA
GGATTGGTTGTCCATACGATATTGACCGATGGGTCGCAGCCGGTAGGACATGGCATTGGCCCGTCGTTAGAAGCTCGCGA
TGTAATGTCAGTATTACAAGGGTTGCCTGATGCCCCCAATGATTTGCGTGAACGAGCGTTGACGCTTGCAGGTGCTGCAT
TAGAGTGTTCTTCGAAAGTTCAACCGGGTTTAGGGAAATCCATTGCGAAACAAATATTGGAGAGTGGGAAAGCGTTTAAA
AAATTTCAGGCCATTTGTGAGGCCCAGGGTGGGATGAGGGAATTGACCAAGGCACGTTTTACTCATCCTGTTGTGGCTGC
AAAGGAAGGAAAAGTCTCCCTCATTGACAATCGAAAGCTTGCAAAAATAGCTAAGCTTGCTGGTGCGCCAAAATCGAAAT
CGGCGGGTATTGACCTCCATGCCCATGTCGGCGAATCCGTTGAACAAGGCGAACCTTTGTTTACAATTCATTCGGAGTCC
TCAGGGGAGCTCAATTACGCTTGTGATTTACTTCGCGATAAACAAGACATCATTATTTTAGGAGAAAATTCTTGA

Upstream 100 bases:

>100_bases
ATGGGGAGCCTCACAGTGCTCAAACTCTAAAAGAGAGGATTGAAAAGCAATTAGGTTTTTCTTGCACCATTCCTTCTTAT
CTGCAAATGGAGGAGTTGTT

Downstream 100 bases:

>100_bases
AGCCTCTGTTATTTTCATTATTTGATTCTTCAGAAATCGCCGGACAATTACAAAAGACACTTCAAGTGGAGGTGGGTAGG
GTCACTTTTCATCGTTTCCC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSKKTAHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVTLGQHSIIATLNVVTSELLAPGEAGLSDYAWDAL
HAKEGDEIQVSHPKPLESLSYVHTKIYGNELSYEQMKVIIDDVLSGRLSDVQISAFLAASSAGRLTRTEIMKLTKAMIDS
GDRLSWSSPLVVDKHCVGGLPGNRTTLIVVPIVAAFGLMIPKTSSRAITSPAGTADTMETLAPVHLSPQKMRQVVEQENG
CIVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATHAVIDIPVGPTAKVRNQSMALLLKQSLEEVGNEL
GLVVHTILTDGSQPVGHGIGPSLEARDVMSVLQGLPDAPNDLRERALTLAGAALECSSKVQPGLGKSIAKQILESGKAFK
KFQAICEAQGGMRELTKARFTHPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESVEQGEPLFTIHSES
SGELNYACDLLRDKQDIIILGENS

Sequences:

>Translated_504_residues
MSKKTAHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVTLGQHSIIATLNVVTSELLAPGEAGLSDYAWDAL
HAKEGDEIQVSHPKPLESLSYVHTKIYGNELSYEQMKVIIDDVLSGRLSDVQISAFLAASSAGRLTRTEIMKLTKAMIDS
GDRLSWSSPLVVDKHCVGGLPGNRTTLIVVPIVAAFGLMIPKTSSRAITSPAGTADTMETLAPVHLSPQKMRQVVEQENG
CIVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATHAVIDIPVGPTAKVRNQSMALLLKQSLEEVGNEL
GLVVHTILTDGSQPVGHGIGPSLEARDVMSVLQGLPDAPNDLRERALTLAGAALECSSKVQPGLGKSIAKQILESGKAFK
KFQAICEAQGGMRELTKARFTHPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESVEQGEPLFTIHSES
SGELNYACDLLRDKQDIIILGENS
>Mature_503_residues
SKKTAHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVTLGQHSIIATLNVVTSELLAPGEAGLSDYAWDALH
AKEGDEIQVSHPKPLESLSYVHTKIYGNELSYEQMKVIIDDVLSGRLSDVQISAFLAASSAGRLTRTEIMKLTKAMIDSG
DRLSWSSPLVVDKHCVGGLPGNRTTLIVVPIVAAFGLMIPKTSSRAITSPAGTADTMETLAPVHLSPQKMRQVVEQENGC
IVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATHAVIDIPVGPTAKVRNQSMALLLKQSLEEVGNELG
LVVHTILTDGSQPVGHGIGPSLEARDVMSVLQGLPDAPNDLRERALTLAGAALECSSKVQPGLGKSIAKQILESGKAFKK
FQAICEAQGGMRELTKARFTHPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESVEQGEPLFTIHSESS
GELNYACDLLRDKQDIIILGENS

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=417, Percent_Identity=29.7362110311751, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4503445, Length=417, Percent_Identity=29.7362110311751, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI166158922, Length=417, Percent_Identity=29.7362110311751, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1790842, Length=403, Percent_Identity=30.0248138957816, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 53922; Mature: 53790

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKTAHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVTLGQHSIIATLNVV
CCCCCCCCEEEECCCHHHHHHHHHEECCCHHHHHCCCCEEEEEEEEEECCCHHHHHHHHH
TSELLAPGEAGLSDYAWDALHAKEGDEIQVSHPKPLESLSYVHTKIYGNELSYEQMKVII
HHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
DDVLSGRLSDVQISAFLAASSAGRLTRTEIMKLTKAMIDSGDRLSWSSPLVVDKHCVGGL
HHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHCCCC
PGNRTTLIVVPIVAAFGLMIPKTSSRAITSPAGTADTMETLAPVHLSPQKMRQVVEQENG
CCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCC
CIVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATHAVIDIPVGPTAKV
EEEECCCEECCCCHHHHEEEHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
RNQSMALLLKQSLEEVGNELGLVVHTILTDGSQPVGHGIGPSLEARDVMSVLQGLPDAPN
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCH
DLRERALTLAGAALECSSKVQPGLGKSIAKQILESGKAFKKFQAICEAQGGMRELTKARF
HHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHH
THPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESVEQGEPLFTIHSES
CCCEEEECCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEEHHCCCHHHCCCCEEEEECCC
SGELNYACDLLRDKQDIIILGENS
CCCHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
SKKTAHGLRLKHLGIKTYHEAIIYMREDCHVCHSEGFEVQTRIQVTLGQHSIIATLNVV
CCCCCCCEEEECCCHHHHHHHHHEECCCHHHHHCCCCEEEEEEEEEECCCHHHHHHHHH
TSELLAPGEAGLSDYAWDALHAKEGDEIQVSHPKPLESLSYVHTKIYGNELSYEQMKVII
HHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
DDVLSGRLSDVQISAFLAASSAGRLTRTEIMKLTKAMIDSGDRLSWSSPLVVDKHCVGGL
HHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHCCCC
PGNRTTLIVVPIVAAFGLMIPKTSSRAITSPAGTADTMETLAPVHLSPQKMRQVVEQENG
CCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCC
CIVWGGAVSLSPADDVLIRVERAIDLDSEGQLVASILSKKIATGATHAVIDIPVGPTAKV
EEEECCCEECCCCHHHHEEEHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
RNQSMALLLKQSLEEVGNELGLVVHTILTDGSQPVGHGIGPSLEARDVMSVLQGLPDAPN
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCH
DLRERALTLAGAALECSSKVQPGLGKSIAKQILESGKAFKKFQAICEAQGGMRELTKARF
HHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHH
THPVVAAKEGKVSLIDNRKLAKIAKLAGAPKSKSAGIDLHAHVGESVEQGEPLFTIHSES
CCCEEEECCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEEHHCCCHHHCCCCEEEEECCC
SGELNYACDLLRDKQDIIILGENS
CCCHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA