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The map label for this gene is umuC [H]

Identifier: 148359238

GI number: 148359238

Start: 1968944

End: 1970200

Strand: Reverse

Name: umuC [H]

Synonym: LPC_1132

Alternate gene names: 148359238

Gene position: 1970200-1968944 (Counterclockwise)

Preceding gene: 148359239

Following gene: 148359235

Centisome position: 55.09

GC content: 39.7

Gene sequence:

>1257_bases
ATGTTTGCGCTGGTCGATTGTAATAATTTTTATGTCTCGTGTGAGCGTTTATTTAAACCAGCCTTAGCGAATAAACCCAT
TTTGGTCTTGTCTAATAATGATGGTTGTGTGATTGCGCGATCTAATGAAGTAAAAGCTTTGGGTGTTCAAATGGGAGTGC
CTTATTTTGCAGTCAAAGCATTATGTAAGCAGCATAAAGTGCATGTGTTTTCATCCAATTACACATTGTATGCTGATATG
TCACGCCGGGTTATGTCAGTTCTTGAAGACAATTGGCCAGCAATAGAGATTTACTCCATTGATGAAGCTTTTCTTGATTT
GAATACTTTGCCCCAATCTGAACATGATGAGTTTTGCCGCAAGTTACAAAAAATTGTTTTGCGCCATACCGGTATTCCCG
TATCCATAGGCATAGGGGCAACCAAAACCCTGGCTAAACTCGCAAACCATATTGCGAAAAAGGAATTAAGAACCCCTGTA
TTTAACATTGAAAATCAATATCATTGGCTAGCTAAAATAGTTGTTGGCGAGGTATGGGGGATAGGACGGCAATGGGGTAA
AAAGTTAGTACAACAGGGGATTTATACAGCTCATGACTTGGCTGGTATGGATTTGCAATTAATTAAAAAATTATTTAGTG
TTGTATTGCAACGAACAGTGCTTGAGTTGCGTGGGGTTTCATGTGGCAGTTTACAGGATTTTGAGTCAAGAAAAAGCATA
ATATCTTCCAAATCCTTTGGTTCTATGCAAACAGAGTATTCTGCTCTTGCTCAGGCCATCAGCAGCCATTGTGCCAGAGC
TTGGGAAAAGTTACGTCATCAAAAATTGATGGCATGCCATCTTTCCATATTTATCAAAACCAATCAATTTCGTTTGGATT
TGCCACAATATCAGCAAACTATAGGGTTTAAGCTGATTAATCCAACTGATGATCTGCGACATTTGATTCGTTGTGCCAAA
TTGTGCCTGCGTAAAATATTTCGCTCTGGATTCCATTACCAAAAGGTAGGCGTTTATTTAGGAGATTTAATTGAAAAAAA
CTGTTTGCAGTTAGATTTGTTTAACCAGGTTTCAGAGAAAGAATTGAATCAGACAGAGCGATTGATGTCGGTATTAGATG
AAATCAACACGAAATATGGCCGCCATACCTTGCGTTTGGCAGCAGAAGGGCATGTGAAGCCATGGGCTATGCGGGCGCAG
TCCCGTTCTCCTCGCTATACAACTTCCTGGTCTGAATTGCCTGTGGTAATTATTTAA

Upstream 100 bases:

>100_bases
TGCTGGCTGAAAACCCTGATTTTCCTCCCATAGATATTACAGAGGAATACGATATGGTGATTTGGGGAGTCGTCACTCAT
GTTATTCATACGGTATTGTG

Downstream 100 bases:

>100_bases
AGAGAAACTGATAGCTATAATGTCATCCGGGAAATCAACTTAAGTCATCCCGGATGATAGCCTGTGTTAATAACCCAGGC
TGGAAATTAATGCCGGACGG

Product: SOS mutagenesis and repair UmuC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKALGVQMGVPYFAVKALCKQHKVHVFSSNYTLYADM
SRRVMSVLEDNWPAIEIYSIDEAFLDLNTLPQSEHDEFCRKLQKIVLRHTGIPVSIGIGATKTLAKLANHIAKKELRTPV
FNIENQYHWLAKIVVGEVWGIGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVSCGSLQDFESRKSI
ISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKTNQFRLDLPQYQQTIGFKLINPTDDLRHLIRCAK
LCLRKIFRSGFHYQKVGVYLGDLIEKNCLQLDLFNQVSEKELNQTERLMSVLDEINTKYGRHTLRLAAEGHVKPWAMRAQ
SRSPRYTTSWSELPVVII

Sequences:

>Translated_418_residues
MFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKALGVQMGVPYFAVKALCKQHKVHVFSSNYTLYADM
SRRVMSVLEDNWPAIEIYSIDEAFLDLNTLPQSEHDEFCRKLQKIVLRHTGIPVSIGIGATKTLAKLANHIAKKELRTPV
FNIENQYHWLAKIVVGEVWGIGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVSCGSLQDFESRKSI
ISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKTNQFRLDLPQYQQTIGFKLINPTDDLRHLIRCAK
LCLRKIFRSGFHYQKVGVYLGDLIEKNCLQLDLFNQVSEKELNQTERLMSVLDEINTKYGRHTLRLAAEGHVKPWAMRAQ
SRSPRYTTSWSELPVVII
>Mature_418_residues
MFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKALGVQMGVPYFAVKALCKQHKVHVFSSNYTLYADM
SRRVMSVLEDNWPAIEIYSIDEAFLDLNTLPQSEHDEFCRKLQKIVLRHTGIPVSIGIGATKTLAKLANHIAKKELRTPV
FNIENQYHWLAKIVVGEVWGIGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVSCGSLQDFESRKSI
ISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKTNQFRLDLPQYQQTIGFKLINPTDDLRHLIRCAK
LCLRKIFRSGFHYQKVGVYLGDLIEKNCLQLDLFNQVSEKELNQTERLMSVLDEINTKYGRHTLRLAAEGHVKPWAMRAQ
SRSPRYTTSWSELPVVII

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=420, Percent_Identity=48.0952380952381, Blast_Score=367, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47700; Mature: 47700

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKALGVQMGVPYFAVKA
CEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCEEEHHHHCCHHHHHHH
LCKQHKVHVFSSNYTLYADMSRRVMSVLEDNWPAIEIYSIDEAFLDLNTLPQSEHDEFCR
HHHHCCEEEEECCEEEEEHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCCCCHHHHHHH
KLQKIVLRHTGIPVSIGIGATKTLAKLANHIAKKELRTPVFNIENQYHWLAKIVVGEVWG
HHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
IGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVSCGSLQDFESRKSI
CHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
ISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKTNQFRLDLPQYQQT
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEECCHHHHHH
IGFKLINPTDDLRHLIRCAKLCLRKIFRSGFHYQKVGVYLGDLIEKNCLQLDLFNQVSEK
HCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELNQTERLMSVLDEINTKYGRHTLRLAAEGHVKPWAMRAQSRSPRYTTSWSELPVVII
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCEEEC
>Mature Secondary Structure
MFALVDCNNFYVSCERLFKPALANKPILVLSNNDGCVIARSNEVKALGVQMGVPYFAVKA
CEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCEEEHHHHCCHHHHHHH
LCKQHKVHVFSSNYTLYADMSRRVMSVLEDNWPAIEIYSIDEAFLDLNTLPQSEHDEFCR
HHHHCCEEEEECCEEEEEHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCCCCHHHHHHH
KLQKIVLRHTGIPVSIGIGATKTLAKLANHIAKKELRTPVFNIENQYHWLAKIVVGEVWG
HHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
IGRQWGKKLVQQGIYTAHDLAGMDLQLIKKLFSVVLQRTVLELRGVSCGSLQDFESRKSI
CHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
ISSKSFGSMQTEYSALAQAISSHCARAWEKLRHQKLMACHLSIFIKTNQFRLDLPQYQQT
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEECCHHHHHH
IGFKLINPTDDLRHLIRCAKLCLRKIFRSGFHYQKVGVYLGDLIEKNCLQLDLFNQVSEK
HCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELNQTERLMSVLDEINTKYGRHTLRLAAEGHVKPWAMRAQSRSPRYTTSWSELPVVII
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]