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The map label for this gene is umuD [H]

Identifier: 148359239

GI number: 148359239

Start: 1970200

End: 1970724

Strand: Reverse

Name: umuD [H]

Synonym: LPC_1133

Alternate gene names: 148359239

Gene position: 1970724-1970200 (Counterclockwise)

Preceding gene: 148359245

Following gene: 148359238

Centisome position: 55.1

GC content: 43.24

Gene sequence:

>525_bases
ATGTCTCATGGTGGTGCACGAGCAGGCGCTGGGCGCCCTCGTGGGCAAGGTAAATATGGAGAATCAACCAAATCAGTCCG
TATACCTGAATCTCGTATACAGGATGTGATGAAATATCTTCAAGGAGAAAAGGAGTTCCCAGCGATTCCTTTATATACCA
GTTCTGTAAGAGCTGGTTTTCCTTCTCCGGGTGATGACTATATTGAATCCATGCTGGATTTGAATGAGTACCTGATCAAG
CATCCTGCATCCACATTTTTTGTACGAGCTTCTGGAGAATCCATGATAAATGCCGGTATTTACTCCGGTGATATTTTAAT
CGTTGATCGTGGCATAGAGGCTACTCATGGAAAAATTGTAATCGTTGCCCTGAATGGCGAATTGACAGTAAAACGTTTAT
CCCGTCAACATGGGCAAGTTAAGTTGCTGGCTGAAAACCCTGATTTTCCTCCCATAGATATTACAGAGGAATACGATATG
GTGATTTGGGGAGTCGTCACTCATGTTATTCATACGGTATTGTGA

Upstream 100 bases:

>100_bases
TAGTCGTCATATGAAACTCTCATTATTGTCGGAACTTTACAATGGGCTACTTTAAAATTAAACTTGAATTTTGATTCTAA
ATTCAAGTTTAGGGGAGTAT

Downstream 100 bases:

>100_bases
TGTTTGCGCTGGTCGATTGTAATAATTTTTATGTCTCGTGTGAGCGTTTATTTAAACCAGCCTTAGCGAATAAACCCATT
TTGGTCTTGTCTAATAATGA

Product: SOS (error prone) mutagenesis protein UmuD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MSHGGARAGAGRPRGQGKYGESTKSVRIPESRIQDVMKYLQGEKEFPAIPLYTSSVRAGFPSPGDDYIESMLDLNEYLIK
HPASTFFVRASGESMINAGIYSGDILIVDRGIEATHGKIVIVALNGELTVKRLSRQHGQVKLLAENPDFPPIDITEEYDM
VIWGVVTHVIHTVL

Sequences:

>Translated_174_residues
MSHGGARAGAGRPRGQGKYGESTKSVRIPESRIQDVMKYLQGEKEFPAIPLYTSSVRAGFPSPGDDYIESMLDLNEYLIK
HPASTFFVRASGESMINAGIYSGDILIVDRGIEATHGKIVIVALNGELTVKRLSRQHGQVKLLAENPDFPPIDITEEYDM
VIWGVVTHVIHTVL
>Mature_173_residues
SHGGARAGAGRPRGQGKYGESTKSVRIPESRIQDVMKYLQGEKEFPAIPLYTSSVRAGFPSPGDDYIESMLDLNEYLIKH
PASTFFVRASGESMINAGIYSGDILIVDRGIEATHGKIVIVALNGELTVKRLSRQHGQVKLLAENPDFPPIDITEEYDMV
IWGVVTHVIHTVL

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=127, Percent_Identity=48.8188976377953, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1790476, Length=137, Percent_Identity=35.036496350365, Blast_Score=74, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 19108; Mature: 18977

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHGGARAGAGRPRGQGKYGESTKSVRIPESRIQDVMKYLQGEKEFPAIPLYTSSVRAGF
CCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEECCCCCCCC
PSPGDDYIESMLDLNEYLIKHPASTFFVRASGESMINAGIYSGDILIVDRGIEATHGKIV
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCEECCCEEEEECCCCCCCCEEE
IVALNGELTVKRLSRQHGQVKLLAENPDFPPIDITEEYDMVIWGVVTHVIHTVL
EEEECCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SHGGARAGAGRPRGQGKYGESTKSVRIPESRIQDVMKYLQGEKEFPAIPLYTSSVRAGF
CCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEECCCCCCCC
PSPGDDYIESMLDLNEYLIKHPASTFFVRASGESMINAGIYSGDILIVDRGIEATHGKIV
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCEECCCEEEEECCCCCCCCEEE
IVALNGELTVKRLSRQHGQVKLLAENPDFPPIDITEEYDMVIWGVVTHVIHTVL
EEEECCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]