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The map label for this gene is purM

Identifier: 148267564

GI number: 148267564

Start: 1173121

End: 1174149

Strand: Direct

Name: purM

Synonym: SaurJH9_1131

Alternate gene names: 148267564

Gene position: 1173121-1174149 (Clockwise)

Preceding gene: 148267563

Following gene: 148267565

Centisome position: 40.36

GC content: 35.67

Gene sequence:

>1029_bases
ATGTCTAAAGCATATGAACAATCTGGTGTAAATATTCATGCTGGTTATGAAGCTGTAGAAAGAATGTCTAGTCATGTTAA
ACGTACGATGCGTAAAGAAGTTATCGGTGGTTTAGGTGGATTCGGTGCTACATTTGATTTATCACAATTAAATATGACAG
CGCCAGTTTTAGTTTCTGGAACAGACGGAGTAGGTACGAAATTAAAACTAGCTATCGACTATGGGAAACATGATTCGATA
GGTATCGATGCAGTTGCAATGTGTGTTAATGATATTTTAACGACAGGTGCAGAACCATTGTATTTTTTAGATTACATCGC
TACAAATAAAGTTGTTCCTGAAGTTATTGAACAAATTGTTAAAGGTATTAGTGATGCATGCGTTGAAACGAATACTGCAC
TTATCGGTGGAGAGACTGCTGAAATGGGTGAAATGTATCACGAAGGTGAATATGATGTAGCCGGATTTGCTGTTGGAGCA
GTTGAAAAGGATGACTATGTAGATGGTTCAGAAGTGAAAGAGGGACAAGTTGTTATAGGACTTGCGTCAAGTGGCATTCA
TTCAAATGGATACAGTTTAGTGCGCAAATTAATTAATGAATCAGGCATTGATTTGGCATCAAACTTCGATAATCGTCCAT
TTATAGATGTCTTTTTAGAACCAACTAAATTATATGTCAAACCTGTACTTGCTTTAAAAAAAGAAGTTTCTATTAAGGCA
ATGAATCATATTACTGGTGGAGGTTTTTATGAAAATATTCCACGTGCATTGCCAGCCGGATATGCTGCTAGAATTGATAC
TACATCATTTCCAACGCCAAAAATATTTGATTGGTTACAACAACAAGGCAATATAGACACAAATGAAATGTATAACATTT
TTAACATGGGTATTGGCTATACGGTTATCGTTGATGAAAAAGATGCATCACGCGCTTTGAAGATTTTAGCAGAACAAAAT
GTGGAAGCTTATCAAATTGGTCATATTGTGAAAAATGAGTCAACTGCAATTGAATTGTTGGGGGTATAA

Upstream 100 bases:

>100_bases
TTATATGATTATGAAGCAAATTATAAAGCACATTTAAGTCATCGACAAAAGCAATATATTTCTAAAAACAAACACTTTTT
TGATAGCGAGGGAAATTTAA

Downstream 100 bases:

>100_bases
CAATGGTTAAAATTGCGATTTTTGCATCAGGTTCAGGAAGTAACTTTGAAAATATAGTTGAGCATGTTGAATCAGGAAAA
CTTGAAAATATTGAAGTTAC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSI
GIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGA
VEKDDYVDGSEVKEGQVVIGLASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKA
MNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDASRALKILAEQN
VEAYQIGHIVKNESTAIELLGV

Sequences:

>Translated_342_residues
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSI
GIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGA
VEKDDYVDGSEVKEGQVVIGLASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKA
MNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDASRALKILAEQN
VEAYQIGHIVKNESTAIELLGV
>Mature_341_residues
SKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSIG
IDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAV
EKDDYVDGSEVKEGQVVIGLASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKAM
NHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDASRALKILAEQNV
EAYQIGHIVKNESTAIELLGV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=45.5089820359281, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=45.5089820359281, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=45.5089820359281, Blast_Score=300, Evalue=1e-81,
Organism=Escherichia coli, GI1788845, Length=334, Percent_Identity=50.5988023952096, Blast_Score=342, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=40.1785714285714, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=40.4129793510324, Blast_Score=259, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24582400, Length=270, Percent_Identity=40.7407407407407, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_STAA1 (A7X0W4)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441653.1
- ProteinModelPortal:   A7X0W4
- SMR:   A7X0W4
- STRING:   A7X0W4
- EnsemblBacteria:   EBSTAT00000004807
- GeneID:   5561044
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1063
- eggNOG:   COG0150
- GeneTree:   EBGT00050000024063
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   SAUR418127:SAHV_1063-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36989; Mature: 36858

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSG
CCCCHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCEEEEC
TDGVGTKLKLAIDYGKHDSIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHH
KGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAVEKDDYVDGSEVKEGQVVIG
HHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEE
LASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKA
EECCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
MNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGY
HHHCCCCCHHHHCHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCE
TVIVDEKDASRALKILAEQNVEAYQIGHIVKNESTAIELLGV
EEEEECCCHHHHHHHHHHCCCCCEEHHHEECCCCCEEEEECC
>Mature Secondary Structure 
SKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSG
CCCHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCEEEEC
TDGVGTKLKLAIDYGKHDSIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHH
KGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAVEKDDYVDGSEVKEGQVVIG
HHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEE
LASSGIHSNGYSLVRKLINESGIDLASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKA
EECCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
MNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGY
HHHCCCCCHHHHCHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCE
TVIVDEKDASRALKILAEQNVEAYQIGHIVKNESTAIELLGV
EEEEECCCHHHHHHHHHHCCCCCEEHHHEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA