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The map label for this gene is clpP

Identifier: 148267228

GI number: 148267228

Start: 869622

End: 870209

Strand: Direct

Name: clpP

Synonym: SaurJH9_0793

Alternate gene names: 148267228

Gene position: 869622-870209 (Clockwise)

Preceding gene: 148267227

Following gene: 148267230

Centisome position: 29.92

GC content: 34.35

Gene sequence:

>588_bases
ATGAATTTAATTCCTACAGTTATTGAAACAACAAACCGCGGTGAACGTGCATATGATATATACTCACGTTTATTAAAAGA
CCGTATTATTATGTTAGGTTCACAAATTGATGACAACGTAGCAAATTCAATCGTATCACAGTTATTATTCTTACAAGCGC
AAGACTCAGAGAAAGATATTTATTTATACATTAATTCACCAGGTGGAAGTGTAACAGCTGGTTTTGCGATTTATGATACA
ATTCAACACATTAAACCTGATGTTCAAACAATTTGTATCGGTATGGCTGCATCAATGGGATCATTCTTATTAGCAGCTGG
TGCAAAAGGTAAACGTTTCGCGTTACCAAATGCAGAAGTAATGATTCACCAACCATTAGGTGGTGCTCAAGGACAAGCAA
CTGAAATCGAAATTGCTGCAAATCACATTTTAAAAACACGTGAAAAATTAAACCGCATTTTATCAGAGCGTACTGGTCAA
AGTATTGAAAAAATACAAAAAGACACAGATCGTGATAACTTCTTAACTGCAGAAGAAGCTAAAGAATATGGCTTAATTGA
TGAAGTGATGGTACCTGAAACAAAATAA

Upstream 100 bases:

>100_bases
AAGCGTCAAACAATGTAACTATTTAAAGTCAAAGTGTTTGACCAAATTTGACTTAATATGTAAAATAATGAGTAACAGTT
ATTACAAGGAGGAAATATAG

Downstream 100 bases:

>100_bases
TTCAAAGTAAAGAGTAGACTAAGCAGTCTGCTCTTTTTGTATGAGTAAACCGAGGTGTCAATAAATTGTTTACTATACTT
TGAGCGGAAATATGATTGAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDT
IQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQ
SIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK

Sequences:

>Translated_195_residues
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDT
IQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQ
SIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>Mature_195_residues
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDT
IQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQ
SIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=53.9267015706806, Blast_Score=226, Evalue=1e-59,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=65.2631578947368, Blast_Score=275, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.3010752688172, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=56.6326530612245, Blast_Score=234, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_STAA1 (A7WZR9)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441355.1
- ProteinModelPortal:   A7WZR9
- SMR:   A7WZR9
- STRING:   A7WZR9
- EnsemblBacteria:   EBSTAT00000005056
- GeneID:   5560982
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0765
- eggNOG:   COG0740
- GeneTree:   EBGT00050000023653
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   SAUR418127:SAHV_0765-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21514; Mature: 21514

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDI
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEE
YLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEV
EEEEECCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEA
EEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHH
KEYGLIDEVMVPETK
HHCCCHHHCCCCCCC
>Mature Secondary Structure
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDI
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEE
YLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEV
EEEEECCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEA
EEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHH
KEYGLIDEVMVPETK
HHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA