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The map label for this gene is fadN [H]

Identifier: 148266656

GI number: 148266656

Start: 262235

End: 264496

Strand: Reverse

Name: fadN [H]

Synonym: SaurJH9_0216

Alternate gene names: 148266656

Gene position: 264496-262235 (Counterclockwise)

Preceding gene: 148266657

Following gene: 148266655

Centisome position: 9.1

GC content: 37.53

Gene sequence:

>2262_bases
ATGACAATTAATAAAGTAACCGTTCTTGGCGCAGGCACGATGGGCGCTCAACTGGCAGCACTCTTTGTGAATGCTGGACT
TAAAGTAAAACTATTAGATATTGTAGTGGACAAAAACGATCCAAATCTCATTGCGAAAAAATCTTACGATAAAATTACAG
ATAAGAAACGGCCGCTACTATTCGACTTAAATCTAGTGAGTCATTTAACATATGGTAATTTTGATGATGACTTGGTAAAT
GATGATGCTGATTTATATATCGAAGCAGTCAAAGAAGATATTGAAATTAAGCATGCTGTTTGGCAACAAGTTCTACAACA
TGCTAAAGAAGATGCTTTATTTGCTACAAATACATCAGGTATTCCAATTAATGCGATTGCTCAAGCATTTAACGAGAAGG
ATCAAGAACGATTCTTTGGTCTACATTTCTTTAACCCACCACGTATTATGAAATTAGTGGAGTTAATACCTACGTCACAC
ACGAAGGAATCTATCATATTAGATGTAAAAAATTTCGCGCAAAATGTATTAGGTAAAGGTGTCATTGTCGTCAATGATGT
GCCTGGCTTTGTCGCAAATAGAGTCGGCACGCAAACAATGAATGATATTATGTATCGCGCCGAGCAACACAAGTTAAGCA
TTGTAGATGTGGATGCTTTAACTGGGCAAGCGATTGGTCGTCCTAAAACAGGTACATATGCCCTATCCGACCTAGTCGGT
TTAGATATTGCAGTGTCTGTAATTAAAGGCATGCAACAAGTACCTGAAGAAACGCCTTATTTTCATGATGTCAAAATTGT
AAATACGTTGTTTGACAATGGCGCACTCGGACGTAAAACGAAACAAGGATTTTACAAAAAGGATAAAGAAACTAAAGCTC
GACTTGTTTACGATGTTGAAAAACAAGATTATGTACCTGTATCGCAACCACAATTACCAATTTTAAATGAATTTAATAAA
GACTTAGTGCATAACCTTGATGTCATATTCAATGCGCAAGACGAAGCGGGACTATTTTTATGGGAGACATTACGTAATAA
TTTCTATTACTCTGCTATCAATGTACCTAAAGCTACCGATGATTTCCGAGACATAGACCGTGCGCTTGTCTGGGGGTTCA
ACTGGAAACTTGGTCCATTCCAATTATGGGATGCAATGGGATACGAACGTGTTAAAACACGTATGGAAGACGAACTTGGA
GACTTACCACAATGGATTAGTGATTTAGATGGTGGCTTTTATAAACAAGATGAGACCATTGAATATGCAACACCTGTTTC
TCACTTCGTAAAAGATGAACTTTGGGATAAAGGTGATGCCAAACTTTCCGTAACTCATGATGATCAACTGTTACTGAAAT
TACAAAGTAAAAATAATGTCATTACCGATGAATTCAACGATGCGTTAGTTGATGCCATTGATTTACTGGAAAATGACCAT
TACACAAGTATGGTCATTTATGCAGATGGTAATAATTTCAGTGTGGGTGCTAACCTTTTCTTAATGAAAAAGGCGCATGA
AGACGGTCTTGTAGATGATGTCGTTGCACAATCAATTGATAAATTACATTATAGCTTTAATCGTTTGAAGTATAGTTTGA
AACCAGTAGTCACAGCTGTTCAAGGTCGTGCCTTAGGCGGTGGCTGTGAGCTTGTACTTTACTCACCTATTGTTGTCGCT
GCAAGTGAAACATATATAGGTCTTGTTGAAGCAGGCGTTGGCTTATTACCGAGTGGCGGTGGCCTTGCAGAAATGGCTGA
TCGCATATTACGCACATCGCATAAGTTTGATGACAAACAAGCTTCCATGACAAAAGTACTGACGAATATCGCATTTGCGA
AAGTCTCTACAAATGCCTTTGAGGCACGTCGTTATGGTTATTTACGTGATACAGATACGATTATTTTCAATACAGCACAA
CGTGTCGAAGTTGCGCTCAAACGTGCGAAATATGAAGCAGAAACAAACTATATTCCGAATCCTAGACATCAATATATCGC
TTTAGGTGAAGACTTCAAAGCATTGATCCAAGGACAATTAGATGCGCAAAGACGGGGGCATTTTATTAGCGACCATGATT
ATCATATCGCCTTAAATATCGCCACAATTTTAGCGGGTGGTGATTTACCAAGAAATACATTTATAAATCAACGTTACATT
CAATCGTTGGAGAAAATTGGCTTTATTGACTTACTAAAATCTAAAAAATCATATGAAAGAATTGCACATATGTTAAAAAC
TGGTAAGCCATTACGTAATTAA

Upstream 100 bases:

>100_bases
AGATGACTGTCAAAGATACTTAATTAATTTTATAAAATAGCAACGTTATTCCAATTATCTTAATGGTTATCTTATCCTCA
ACTAAATTGGAGGAATCACT

Downstream 100 bases:

>100_bases
AAGATAGTCATTAAGAGAGGATGATAACCATGCAAGAAGCATACATTGTAGCTTATGGGCGTTCAGCCGCAGCGAAAGCA
AAGCAAGGCGCATTATTCCA

Product: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 753; Mature: 752

Protein sequence:

>753_residues
MTINKVTVLGAGTMGAQLAALFVNAGLKVKLLDIVVDKNDPNLIAKKSYDKITDKKRPLLFDLNLVSHLTYGNFDDDLVN
DDADLYIEAVKEDIEIKHAVWQQVLQHAKEDALFATNTSGIPINAIAQAFNEKDQERFFGLHFFNPPRIMKLVELIPTSH
TKESIILDVKNFAQNVLGKGVIVVNDVPGFVANRVGTQTMNDIMYRAEQHKLSIVDVDALTGQAIGRPKTGTYALSDLVG
LDIAVSVIKGMQQVPEETPYFHDVKIVNTLFDNGALGRKTKQGFYKKDKETKARLVYDVEKQDYVPVSQPQLPILNEFNK
DLVHNLDVIFNAQDEAGLFLWETLRNNFYYSAINVPKATDDFRDIDRALVWGFNWKLGPFQLWDAMGYERVKTRMEDELG
DLPQWISDLDGGFYKQDETIEYATPVSHFVKDELWDKGDAKLSVTHDDQLLLKLQSKNNVITDEFNDALVDAIDLLENDH
YTSMVIYADGNNFSVGANLFLMKKAHEDGLVDDVVAQSIDKLHYSFNRLKYSLKPVVTAVQGRALGGGCELVLYSPIVVA
ASETYIGLVEAGVGLLPSGGGLAEMADRILRTSHKFDDKQASMTKVLTNIAFAKVSTNAFEARRYGYLRDTDTIIFNTAQ
RVEVALKRAKYEAETNYIPNPRHQYIALGEDFKALIQGQLDAQRRGHFISDHDYHIALNIATILAGGDLPRNTFINQRYI
QSLEKIGFIDLLKSKKSYERIAHMLKTGKPLRN

Sequences:

>Translated_753_residues
MTINKVTVLGAGTMGAQLAALFVNAGLKVKLLDIVVDKNDPNLIAKKSYDKITDKKRPLLFDLNLVSHLTYGNFDDDLVN
DDADLYIEAVKEDIEIKHAVWQQVLQHAKEDALFATNTSGIPINAIAQAFNEKDQERFFGLHFFNPPRIMKLVELIPTSH
TKESIILDVKNFAQNVLGKGVIVVNDVPGFVANRVGTQTMNDIMYRAEQHKLSIVDVDALTGQAIGRPKTGTYALSDLVG
LDIAVSVIKGMQQVPEETPYFHDVKIVNTLFDNGALGRKTKQGFYKKDKETKARLVYDVEKQDYVPVSQPQLPILNEFNK
DLVHNLDVIFNAQDEAGLFLWETLRNNFYYSAINVPKATDDFRDIDRALVWGFNWKLGPFQLWDAMGYERVKTRMEDELG
DLPQWISDLDGGFYKQDETIEYATPVSHFVKDELWDKGDAKLSVTHDDQLLLKLQSKNNVITDEFNDALVDAIDLLENDH
YTSMVIYADGNNFSVGANLFLMKKAHEDGLVDDVVAQSIDKLHYSFNRLKYSLKPVVTAVQGRALGGGCELVLYSPIVVA
ASETYIGLVEAGVGLLPSGGGLAEMADRILRTSHKFDDKQASMTKVLTNIAFAKVSTNAFEARRYGYLRDTDTIIFNTAQ
RVEVALKRAKYEAETNYIPNPRHQYIALGEDFKALIQGQLDAQRRGHFISDHDYHIALNIATILAGGDLPRNTFINQRYI
QSLEKIGFIDLLKSKKSYERIAHMLKTGKPLRN
>Mature_752_residues
TINKVTVLGAGTMGAQLAALFVNAGLKVKLLDIVVDKNDPNLIAKKSYDKITDKKRPLLFDLNLVSHLTYGNFDDDLVND
DADLYIEAVKEDIEIKHAVWQQVLQHAKEDALFATNTSGIPINAIAQAFNEKDQERFFGLHFFNPPRIMKLVELIPTSHT
KESIILDVKNFAQNVLGKGVIVVNDVPGFVANRVGTQTMNDIMYRAEQHKLSIVDVDALTGQAIGRPKTGTYALSDLVGL
DIAVSVIKGMQQVPEETPYFHDVKIVNTLFDNGALGRKTKQGFYKKDKETKARLVYDVEKQDYVPVSQPQLPILNEFNKD
LVHNLDVIFNAQDEAGLFLWETLRNNFYYSAINVPKATDDFRDIDRALVWGFNWKLGPFQLWDAMGYERVKTRMEDELGD
LPQWISDLDGGFYKQDETIEYATPVSHFVKDELWDKGDAKLSVTHDDQLLLKLQSKNNVITDEFNDALVDAIDLLENDHY
TSMVIYADGNNFSVGANLFLMKKAHEDGLVDDVVAQSIDKLHYSFNRLKYSLKPVVTAVQGRALGGGCELVLYSPIVVAA
SETYIGLVEAGVGLLPSGGGLAEMADRILRTSHKFDDKQASMTKVLTNIAFAKVSTNAFEARRYGYLRDTDTIIFNTAQR
VEVALKRAKYEAETNYIPNPRHQYIALGEDFKALIQGQLDAQRRGHFISDHDYHIALNIATILAGGDLPRNTFINQRYIQ
SLEKIGFIDLLKSKKSYERIAHMLKTGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=297, Percent_Identity=31.986531986532, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI20127408, Length=407, Percent_Identity=29.2383292383292, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI296179427, Length=312, Percent_Identity=30.4487179487179, Blast_Score=120, Evalue=7e-27,
Organism=Homo sapiens, GI261878539, Length=302, Percent_Identity=28.8079470198675, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI68989263, Length=302, Percent_Identity=28.8079470198675, Blast_Score=93, Evalue=1e-18,
Organism=Escherichia coli, GI1787661, Length=319, Percent_Identity=28.8401253918495, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790281, Length=245, Percent_Identity=33.8775510204082, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788682, Length=392, Percent_Identity=27.5510204081633, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1787659, Length=233, Percent_Identity=28.3261802575107, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17549919, Length=299, Percent_Identity=35.1170568561873, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17553560, Length=297, Percent_Identity=31.3131313131313, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17558304, Length=412, Percent_Identity=27.6699029126214, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=29.3103448275862, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17508953, Length=405, Percent_Identity=27.6543209876543, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508951, Length=401, Percent_Identity=27.6807980049875, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144276, Length=288, Percent_Identity=30.5555555555556, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71985930, Length=406, Percent_Identity=25.615763546798, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71985923, Length=415, Percent_Identity=24.0963855421687, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921000, Length=444, Percent_Identity=28.1531531531532, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583077, Length=444, Percent_Identity=28.1531531531532, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583079, Length=444, Percent_Identity=28.1531531531532, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 84621; Mature: 84490

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTINKVTVLGAGTMGAQLAALFVNAGLKVKLLDIVVDKNDPNLIAKKSYDKITDKKRPLL
CCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEECCCHHHHCCCCCCEE
FDLNLVSHLTYGNFDDDLVNDDADLYIEAVKEDIEIKHAVWQQVLQHAKEDALFATNTSG
EEEHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
IPINAIAQAFNEKDQERFFGLHFFNPPRIMKLVELIPTSHTKESIILDVKNFAQNVLGKG
CCHHHHHHHHCCCCHHHEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCCC
VIVVNDVPGFVANRVGTQTMNDIMYRAEQHKLSIVDVDALTGQAIGRPKTGTYALSDLVG
EEEEECCCCHHHHHHCHHHHHHHHHHHHHCEEEEEEECHHCCCCCCCCCCCCHHHHHHHH
LDIAVSVIKGMQQVPEETPYFHDVKIVNTLFDNGALGRKTKQGFYKKDKETKARLVYDVE
HHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCHHHHCCHHCCCCCCEEEEEEEC
KQDYVPVSQPQLPILNEFNKDLVHNLDVIFNAQDEAGLFLWETLRNNFYYSAINVPKATD
CCCCCCCCCCCCCHHHHHCHHHHHCCEEEEECCCCCCCHHHHHHHCCEEEEEECCCCCCH
DFRDIDRALVWGFNWKLGPFQLWDAMGYERVKTRMEDELGDLPQWISDLDGGFYKQDETI
HHHHHHHHHEECCCCCCCHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCE
EYATPVSHFVKDELWDKGDAKLSVTHDDQLLLKLQSKNNVITDEFNDALVDAIDLLENDH
EECCHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCEECCCHHHHHHHHHHHHCCCC
YTSMVIYADGNNFSVGANLFLMKKAHEDGLVDDVVAQSIDKLHYSFNRLKYSLKPVVTAV
CEEEEEEECCCCEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGRALGGGCELVLYSPIVVAASETYIGLVEAGVGLLPSGGGLAEMADRILRTSHKFDDKQ
CCCCCCCCEEEEEECCEEEEECCHHEEHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
ASMTKVLTNIAFAKVSTNAFEARRYGYLRDTDTIIFNTAQRVEVALKRAKYEAETNYIPN
HHHHHHHHHHHHHEECCCHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCC
PRHQYIALGEDFKALIQGQLDAQRRGHFISDHDYHIALNIATILAGGDLPRNTFINQRYI
CCCCEEEECHHHHHHHHCCCCHHHCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHH
QSLEKIGFIDLLKSKKSYERIAHMLKTGKPLRN
HHHHHCCHHHHHHCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TINKVTVLGAGTMGAQLAALFVNAGLKVKLLDIVVDKNDPNLIAKKSYDKITDKKRPLL
CCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEECCCHHHHCCCCCCEE
FDLNLVSHLTYGNFDDDLVNDDADLYIEAVKEDIEIKHAVWQQVLQHAKEDALFATNTSG
EEEHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
IPINAIAQAFNEKDQERFFGLHFFNPPRIMKLVELIPTSHTKESIILDVKNFAQNVLGKG
CCHHHHHHHHCCCCHHHEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCCC
VIVVNDVPGFVANRVGTQTMNDIMYRAEQHKLSIVDVDALTGQAIGRPKTGTYALSDLVG
EEEEECCCCHHHHHHCHHHHHHHHHHHHHCEEEEEEECHHCCCCCCCCCCCCHHHHHHHH
LDIAVSVIKGMQQVPEETPYFHDVKIVNTLFDNGALGRKTKQGFYKKDKETKARLVYDVE
HHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCHHHHCCHHCCCCCCEEEEEEEC
KQDYVPVSQPQLPILNEFNKDLVHNLDVIFNAQDEAGLFLWETLRNNFYYSAINVPKATD
CCCCCCCCCCCCCHHHHHCHHHHHCCEEEEECCCCCCCHHHHHHHCCEEEEEECCCCCCH
DFRDIDRALVWGFNWKLGPFQLWDAMGYERVKTRMEDELGDLPQWISDLDGGFYKQDETI
HHHHHHHHHEECCCCCCCHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCE
EYATPVSHFVKDELWDKGDAKLSVTHDDQLLLKLQSKNNVITDEFNDALVDAIDLLENDH
EECCHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCEECCCHHHHHHHHHHHHCCCC
YTSMVIYADGNNFSVGANLFLMKKAHEDGLVDDVVAQSIDKLHYSFNRLKYSLKPVVTAV
CEEEEEEECCCCEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGRALGGGCELVLYSPIVVAASETYIGLVEAGVGLLPSGGGLAEMADRILRTSHKFDDKQ
CCCCCCCCEEEEEECCEEEEECCHHEEHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
ASMTKVLTNIAFAKVSTNAFEARRYGYLRDTDTIIFNTAQRVEVALKRAKYEAETNYIPN
HHHHHHHHHHHHHEECCCHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCC
PRHQYIALGEDFKALIQGQLDAQRRGHFISDHDYHIALNIATILAGGDLPRNTFINQRYI
CCCCEEEECHHHHHHHHCCCCHHHCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHH
QSLEKIGFIDLLKSKKSYERIAHMLKTGKPLRN
HHHHHCCHHHHHHCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]