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The map label for this gene is fadA [H]

Identifier: 148266655

GI number: 148266655

Start: 261021

End: 262205

Strand: Reverse

Name: fadA [H]

Synonym: SaurJH9_0215

Alternate gene names: 148266655

Gene position: 262205-261021 (Counterclockwise)

Preceding gene: 148266656

Following gene: 148266653

Centisome position: 9.02

GC content: 43.63

Gene sequence:

>1185_bases
ATGCAAGAAGCATACATTGTAGCTTATGGGCGTTCAGCCGCAGCGAAAGCAAAGCAAGGCGCATTATTCCACGAAAGACC
TGATGATGTCGCAGCCAAAGCATTACAAGGCGTATTGAAACGTATTGACGGAAAATTCAATAAGAATATGATTGAAGATG
TCATTGTTGGTACGGCTTTTCCAGAAGGATTACAAGGACAAAACATTGCACGAACGATTGCATTGCGTGCGGGATTATCT
GACACGGTACCGGGTCAAACAGTGAATCGCTACTGCTCATCAGGATTACAAACCATCGCGATTGCAGCCAATCAAATTAT
GGCTGGTCAAGGAGATATACTTGTAGCTGGTGGCGTTGAATTGATGAGTGCCGTACCAATGGGTGGCAACGAGCCCACAA
ACAATCCAACCTTACAATATGATGATATAGGTGCGTCATATCCTATGGGTTTAACTGCTGAAAATGTAGCATCCCAATTT
GACGTATCACGCGAAGATCAAGATGCTTATGCTGTCAGAAGTCATCAACGTGCCTATGACGCACAACGTGATGGTCGGTT
CAAAGATGAAATTATTCCAATACGGGTAAACTCAGTTGAATATACAAACGCAGGACCAAAAGTACACACAAATATCTTTG
ACCAAGATGAATTTATACGCCCTGACACCACGATGGAGGCATTAGCCAAATTACGTACAGTATTTAAAGCTGACGGCACT
GTGACTGCGGGAACATCTGCCCCACTTTCTGATGGTGCAGGATTTGTAGTTTTAATGTCTGGAGATAAAGTGAAAGAACT
AGGCGTGACACCTATTGCACGATTCGTTGGTTATAAGGCAGTAGGCGTTGACCCGAAAATTATGGGTATTGGGCCTGCAT
ATGCGATTCCTGAAGTATTGTCACTCAGCAATCTATCTGTTGAAGACATTGATTTGATCGAATTGAACGAAGCATTTGCT
TCTCAAACGATTGCATCTATTAAAGAAGTAGGTCTAGATATATCACGTACGAATGTGAATGGTGGCGCTATTGCTTTAGG
TCATCCATTAGGTGCTACAGGGGCAATGTTAACCGCGCGTTTACTTAATGAAATGGGTAGACGTCCCGATAGCCGTTACG
GCATGGTTACGATGTGTATTGGTGTCGGCATGGGTGCAGCTGCTATATTTGAGTATGTGCGTTAG

Upstream 100 bases:

>100_bases
TACTAAAATCTAAAAAATCATATGAAAGAATTGCACATATGTTAAAAACTGGTAAGCCATTACGTAATTAAAAGATAGTC
ATTAAGAGAGGATGATAACC

Downstream 100 bases:

>100_bases
AATGGTTGATTTTGGATGAAGCGGATTCGTTAGGTTATTGAATGAAGTAGGCTGAAGTTGAAGCGGGTTGAAGCAATTTC
GTTTTATTAATGAAGCTGTG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKALQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Sequences:

>Translated_394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKALQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
>Mature_394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKALQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=43.9897698209719, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI167614485, Length=360, Percent_Identity=41.1111111111111, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI148539872, Length=386, Percent_Identity=39.3782383419689, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4557237, Length=368, Percent_Identity=35.8695652173913, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4504327, Length=412, Percent_Identity=33.9805825242718, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI194353979, Length=240, Percent_Identity=35.4166666666667, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=41.8491484184915, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=42.3173803526448, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=40.0990099009901, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI87082165, Length=355, Percent_Identity=40, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=32.360097323601, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI133906874, Length=377, Percent_Identity=39.7877984084881, Blast_Score=250, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=31.7380352644836, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17535921, Length=354, Percent_Identity=34.4632768361582, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=410, Percent_Identity=28.5365853658537, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=321, Percent_Identity=27.7258566978193, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=40, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=31.5533980582524, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=39.6039603960396, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI17648125, Length=356, Percent_Identity=41.2921348314607, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24640423, Length=356, Percent_Identity=35.3932584269663, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17137578, Length=412, Percent_Identity=33.495145631068, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41821; Mature: 41821

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKALQGVLKRIDGKFNKNMIEDVIVGTAF
CCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEECCHH
LMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYD
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
HHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVL
EECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHHHHH
SLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTAR
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCHHHHHHHH
LLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHCCCCCCCCCHHHEEHHCCCCHHHHHHHHC
>Mature Secondary Structure
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKALQGVLKRIDGKFNKNMIEDVIVGTAF
CCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEECCHH
LMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYD
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
HHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVL
EECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHHHHH
SLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTAR
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCHHHHHHHH
LLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHCCCCCCCCCHHHEEHHCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]