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The map label for this gene is zntA [H]

Identifier: 148243758

GI number: 148243758

Start: 151500

End: 152534

Strand: Reverse

Name: zntA [H]

Synonym: Acry_3236

Alternate gene names: 148243758

Gene position: 152534-151500 (Counterclockwise)

Preceding gene: 148243760

Following gene: 148243757

Centisome position: 74.92

GC content: 65.12

Gene sequence:

>1035_bases
ATGGCTGCCGCGATTAGTGTCAAGCTGAAGATCGAAGGCATGGATTGCGGCGGCTGCGCCGTGAAGATCGAGAATGCCAT
GAAGCGGTTGCCTGGCGTCACGGATGTCTCTGTCAGTTTCAGCACCGCCTCCCTGTCGCTCATGCTGGACGAAGACCGCA
CCGCGAGAACCATGATCGAGGCGAGGATCAGAGCGCTCGGCTTCACGCCTCTCGGAGGCACCAGGCAGGCGGATGCGGAT
AAGGTCCGGACGGAATCAGCCAGCGGAAACGTCTGGTGGAAGACCCGCAAGGTCCGACTGGTCGGCGTCACGGGGTTGCT
CCTCGCGCTTGGATTTGTCGTGACGCAGGCAGAGCCGGCCTGGTCGCCCTGGCCCTATGTCGCAGCCGCGCTGGTCGGCC
TGCTGCCGATTGTCCGCCGGGCGCTGGCGGGCATGCGGACTGGCACGCCCTTCACAATGGAAACCCTGATGTCGATTGCA
TCGATCGGCGCCCTTGCGATCGGCGAGGGTGCTGACGCCGCAATCGTCGTGTTCCTGTTCGCGCTGGGTGAACTGCTAGA
GGGCGTCGCCGCTGGCCGGGCGCGGGCCGGTATCGAGGGGCTGATCGGCCTCGTGCCGCGCACCGCACGCCGAGTGCGCG
GCGACGCGATTGAAACGGTGCCGGTCGAGACCCTCGCCATCGGCGACGTTGTGACGGTTCGCGCCGGCGATCGGGTACCG
TCCGATGGAACGGTGGTCGGGGGCACGTCCCAGGTCAATGAAGCACCGGTGACCGGGGAATCCGCGCCCGTCGTCAAAGC
CGAGGGGGCGCCGGTTTATGCCGGCAGCATTGCCGGACATGGCGAGCTTCGCATCGAGATCACCCGCACCTCTGCCGACA
ACACGATAGCTCGCATCATCCACATGGTCGAGGAAGCTCAGGCTACGAAAGCCCCGACGGCACGGTTCATTGACCGGTTC
AGCCGTTGGTATACGCCTGCCGCCATGGCGTTCTCAGCCCTCGTGATGCTGGGTCCGCCTGTTGATTTCCACTGA

Upstream 100 bases:

>100_bases
CCGAGTTCGCCGATTGCCAAAAATCCACCTGACATCGCTTGACCCTATAGTGACTACAGGGATCATATCGGATTCATGTC
GTGATTGTCGAGGAAAAGCC

Downstream 100 bases:

>100_bases
GAAGTGACCCGGGAAGGCCGGATTTTTCCACTGAGATTTGACCCATGTTTGACTGTTTCCCCGTCTGGAAGAGGCGGGGG
CGAACGGAGTGTTGGACATG

Product: E1-E2 ATPase-associated domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MAAAISVKLKIEGMDCGGCAVKIENAMKRLPGVTDVSVSFSTASLSLMLDEDRTARTMIEARIRALGFTPLGGTRQADAD
KVRTESASGNVWWKTRKVRLVGVTGLLLALGFVVTQAEPAWSPWPYVAAALVGLLPIVRRALAGMRTGTPFTMETLMSIA
SIGALAIGEGADAAIVVFLFALGELLEGVAAGRARAGIEGLIGLVPRTARRVRGDAIETVPVETLAIGDVVTVRAGDRVP
SDGTVVGGTSQVNEAPVTGESAPVVKAEGAPVYAGSIAGHGELRIEITRTSADNTIARIIHMVEEAQATKAPTARFIDRF
SRWYTPAAMAFSALVMLGPPVDFH

Sequences:

>Translated_344_residues
MAAAISVKLKIEGMDCGGCAVKIENAMKRLPGVTDVSVSFSTASLSLMLDEDRTARTMIEARIRALGFTPLGGTRQADAD
KVRTESASGNVWWKTRKVRLVGVTGLLLALGFVVTQAEPAWSPWPYVAAALVGLLPIVRRALAGMRTGTPFTMETLMSIA
SIGALAIGEGADAAIVVFLFALGELLEGVAAGRARAGIEGLIGLVPRTARRVRGDAIETVPVETLAIGDVVTVRAGDRVP
SDGTVVGGTSQVNEAPVTGESAPVVKAEGAPVYAGSIAGHGELRIEITRTSADNTIARIIHMVEEAQATKAPTARFIDRF
SRWYTPAAMAFSALVMLGPPVDFH
>Mature_343_residues
AAAISVKLKIEGMDCGGCAVKIENAMKRLPGVTDVSVSFSTASLSLMLDEDRTARTMIEARIRALGFTPLGGTRQADADK
VRTESASGNVWWKTRKVRLVGVTGLLLALGFVVTQAEPAWSPWPYVAAALVGLLPIVRRALAGMRTGTPFTMETLMSIAS
IGALAIGEGADAAIVVFLFALGELLEGVAAGRARAGIEGLIGLVPRTARRVRGDAIETVPVETLAIGDVVTVRAGDRVPS
DGTVVGGTSQVNEAPVTGESAPVVKAEGAPVYAGSIAGHGELRIEITRTSADNTIARIIHMVEEAQATKAPTARFIDRFS
RWYTPAAMAFSALVMLGPPVDFH

Specific function: Involved in export of lead, cadmium, zinc and mercury [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=375, Percent_Identity=28.8, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI115529486, Length=173, Percent_Identity=38.150289017341, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI55743073, Length=126, Percent_Identity=37.3015873015873, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1789879, Length=324, Percent_Identity=39.5061728395062, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1786691, Length=149, Percent_Identity=34.2281879194631, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786914, Length=147, Percent_Identity=38.7755102040816, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17556548, Length=168, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320475, Length=174, Percent_Identity=29.8850574712644, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319772, Length=187, Percent_Identity=31.0160427807487, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221329854, Length=359, Percent_Identity=27.2980501392758, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006404
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 36032; Mature: 35901

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAISVKLKIEGMDCGGCAVKIENAMKRLPGVTDVSVSFSTASLSLMLDEDRTARTMIE
CCCEEEEEEEEECCCCCCCEEEHHHHHHHCCCCCEEEEEEEEEEEEEEECCCHHHHHHHH
ARIRALGFTPLGGTRQADADKVRTESASGNVWWKTRKVRLVGVTGLLLALGFVVTQAEPA
HHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHCCCCCC
WSPWPYVAAALVGLLPIVRRALAGMRTGTPFTMETLMSIASIGALAIGEGADAAIVVFLF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHH
ALGELLEGVAAGRARAGIEGLIGLVPRTARRVRGDAIETVPVETLAIGDVVTVRAGDRVP
HHHHHHHHHHHCHHHCCHHHHHHHCCHHHHHHCCCCEEECCCCEEEECCEEEEECCCCCC
SDGTVVGGTSQVNEAPVTGESAPVVKAEGAPVYAGSIAGHGELRIEITRTSADNTIARII
CCCEEECCCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCEEEEEEEECCCCHHHHHHH
HMVEEAQATKAPTARFIDRFSRWYTPAAMAFSALVMLGPPVDFH
HHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AAAISVKLKIEGMDCGGCAVKIENAMKRLPGVTDVSVSFSTASLSLMLDEDRTARTMIE
CCEEEEEEEEECCCCCCCEEEHHHHHHHCCCCCEEEEEEEEEEEEEEECCCHHHHHHHH
ARIRALGFTPLGGTRQADADKVRTESASGNVWWKTRKVRLVGVTGLLLALGFVVTQAEPA
HHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHCCCCCC
WSPWPYVAAALVGLLPIVRRALAGMRTGTPFTMETLMSIASIGALAIGEGADAAIVVFLF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHH
ALGELLEGVAAGRARAGIEGLIGLVPRTARRVRGDAIETVPVETLAIGDVVTVRAGDRVP
HHHHHHHHHHHCHHHCCHHHHHHHCCHHHHHHCCCCEEECCCCEEEECCEEEEECCCCCC
SDGTVVGGTSQVNEAPVTGESAPVVKAEGAPVYAGSIAGHGELRIEITRTSADNTIARII
CCCEEECCCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCEEEEEEEECCCCHHHHHHH
HMVEEAQATKAPTARFIDRFSRWYTPAAMAFSALVMLGPPVDFH
HHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 9405611; 9364914; 10660539; 12417201 [H]