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The map label for this gene is zntA [H]

Identifier: 148243755

GI number: 148243755

Start: 147823

End: 148968

Strand: Reverse

Name: zntA [H]

Synonym: Acry_3233

Alternate gene names: 148243755

Gene position: 148968-147823 (Counterclockwise)

Preceding gene: 148243756

Following gene: 148243754

Centisome position: 73.17

GC content: 62.48

Gene sequence:

>1146_bases
TTGGCTGTCCTGCTGATCGCCTGCCCCTGCGCGCTGGTGATCTCAACACCTGCGGCTATTGCATCGGGACTCGCGAGCGG
TGCCCGGTACGGGTTGCTGATCAAGGGCGGCGCGGCGCTGGAGACACTCGGCAAGATCAGAACGGTCGCCTTCGACAAGA
CCGGCACACTGACGATGGGGCAGCCTCAGGTGACTGACGTCGTCCCCGTCGAGGGCGATGTTGCGAACGTGTTGGCGAAG
GCCGCGGCCGTGGAACGCGGATCCAGCCACCCGCTCGGCGCGGCGATCGTCAAGGAAGCTGAACTTCGCGGCCTTGATAT
GCCGCGAGTGTTCGGCGGCACCGTGGCGGCGCCGGGCAAGTCCGTCATGGGGCGGATCAGCTCCGGTTTCGTGACGGTCG
CCTCGCCGCTTCATGCCGCTGAACAGGCATTGCTCGATGATACGGCACAGGAACGGATTTCAGCCCTCGAGGATGAGGGA
AAAACCGTCGTCACGGTGTGCGAAGGCAAGCGCCTGATCGGTCTGATCGCATTGCGGGACGAACTGAGAGCCGATGCTTC
CGAAGCTGTGCGGACACTGCGTGCGCTTGGCATTCGACCGGTCATGCTCACCGGCGACAACCTTCGGTGCGCACAAGGGA
TCGCCGACGCCGCGGGGATCGAGGTTCGTGCCAGTCTTCTGCCGGATGACAAGCTTGCCGCTATCTCGGGTTACAAGGCC
GAGGCGCCGATCGCGATGGTCGGTGATGGCATCAACGACGCGCCAGCCCTGGCAGCTTCGTCGGTTGGTGTCGCAATGGG
GAGCGGGACGGATGTTGCGCTCGAAACGGCGGACGCCGCACTCCTGAAGAACCGGGTCACCGGCGTCGCCGAAATGGTGA
CCCTATCGCGCGCAACCATCATCAATATCTGGCAGAACATCGCGTTGGCTCTCGGGCTCAAGAGCGTGTTCCTGGTCACC
AGCCTGTCCGGCATCACGCCGCTCTGGATGGCGATCCTTGCCGATACCGGGGCCACGGTACTCGTCACGGCCAACGCACT
TCGCCTTCTGCGCTTCAAACCGCAAACTCAGGAGAACGCCATAATCGTTCATTCAAGTATCAATGCAAATGGATCACGCC
CGAAAATTAGTTCGCAAATCGCATGA

Upstream 100 bases:

>100_bases
GTCAAATCTCGATGGAATTCCCGGGTCACTTCTCAGTGGAAATCAACAGGGTCCGCCTCTCGCCCTTGGCGCCGACTGGT
TCACCTGGATCTATCGGGGG

Downstream 100 bases:

>100_bases
TCGACCCAAATTGATCGCTAGATTGGACTTCTACCTCGGCAATCCATTGCCGTTCACTTAATGTCCATGCCTAGCATACA
TGAAAAGCACTTTCATGTTG

Product: ATPase, P-type (transporting), HAD superfamily, subfamily IC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MAVLLIACPCALVISTPAAIASGLASGARYGLLIKGGAALETLGKIRTVAFDKTGTLTMGQPQVTDVVPVEGDVANVLAK
AAAVERGSSHPLGAAIVKEAELRGLDMPRVFGGTVAAPGKSVMGRISSGFVTVASPLHAAEQALLDDTAQERISALEDEG
KTVVTVCEGKRLIGLIALRDELRADASEAVRTLRALGIRPVMLTGDNLRCAQGIADAAGIEVRASLLPDDKLAAISGYKA
EAPIAMVGDGINDAPALAASSVGVAMGSGTDVALETADAALLKNRVTGVAEMVTLSRATIINIWQNIALALGLKSVFLVT
SLSGITPLWMAILADTGATVLVTANALRLLRFKPQTQENAIIVHSSINANGSRPKISSQIA

Sequences:

>Translated_381_residues
MAVLLIACPCALVISTPAAIASGLASGARYGLLIKGGAALETLGKIRTVAFDKTGTLTMGQPQVTDVVPVEGDVANVLAK
AAAVERGSSHPLGAAIVKEAELRGLDMPRVFGGTVAAPGKSVMGRISSGFVTVASPLHAAEQALLDDTAQERISALEDEG
KTVVTVCEGKRLIGLIALRDELRADASEAVRTLRALGIRPVMLTGDNLRCAQGIADAAGIEVRASLLPDDKLAAISGYKA
EAPIAMVGDGINDAPALAASSVGVAMGSGTDVALETADAALLKNRVTGVAEMVTLSRATIINIWQNIALALGLKSVFLVT
SLSGITPLWMAILADTGATVLVTANALRLLRFKPQTQENAIIVHSSINANGSRPKISSQIA
>Mature_380_residues
AVLLIACPCALVISTPAAIASGLASGARYGLLIKGGAALETLGKIRTVAFDKTGTLTMGQPQVTDVVPVEGDVANVLAKA
AAVERGSSHPLGAAIVKEAELRGLDMPRVFGGTVAAPGKSVMGRISSGFVTVASPLHAAEQALLDDTAQERISALEDEGK
TVVTVCEGKRLIGLIALRDELRADASEAVRTLRALGIRPVMLTGDNLRCAQGIADAAGIEVRASLLPDDKLAAISGYKAE
APIAMVGDGINDAPALAASSVGVAMGSGTDVALETADAALLKNRVTGVAEMVTLSRATIINIWQNIALALGLKSVFLVTS
LSGITPLWMAILADTGATVLVTANALRLLRFKPQTQENAIIVHSSINANGSRPKISSQIA

Specific function: Involved in export of lead, cadmium, zinc and mercury [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=355, Percent_Identity=36.9014084507042, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI55743073, Length=355, Percent_Identity=36.9014084507042, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI115529486, Length=170, Percent_Identity=40, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI118498343, Length=240, Percent_Identity=28.3333333333333, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789879, Length=355, Percent_Identity=54.9295774647887, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1786691, Length=363, Percent_Identity=41.0468319559229, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1786914, Length=279, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI2367363, Length=389, Percent_Identity=24.6786632390745, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556548, Length=371, Percent_Identity=32.6145552560647, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320475, Length=362, Percent_Identity=33.1491712707182, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319772, Length=322, Percent_Identity=29.1925465838509, Blast_Score=116, Evalue=5e-27,
Organism=Drosophila melanogaster, GI221329854, Length=187, Percent_Identity=39.572192513369, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006404
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 38978; Mature: 38847

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00141 ASP_PROTEASE ; PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLLIACPCALVISTPAAIASGLASGARYGLLIKGGAALETLGKIRTVAFDKTGTLTMG
CEEEEEECCHHHHHCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEEEECCCCCEECC
QPQVTDVVPVEGDVANVLAKAAAVERGSSHPLGAAIVKEAELRGLDMPRVFGGTVAAPGK
CCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHCCCCCCCCCH
SVMGRISSGFVTVASPLHAAEQALLDDTAQERISALEDEGKTVVTVCEGKRLIGLIALRD
HHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEHH
ELRADASEAVRTLRALGIRPVMLTGDNLRCAQGIADAAGIEVRASLLPDDKLAAISGYKA
HHCCCHHHHHHHHHHHCCCEEEEECCCCHHHHCCCCCCCCEEEEECCCCCCCCEECCCCC
EAPIAMVGDGINDAPALAASSVGVAMGSGTDVALETADAALLKNRVTGVAEMVTLSRATI
CCCEEEECCCCCCCHHHHHCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
INIWQNIALALGLKSVFLVTSLSGITPLWMAILADTGATVLVTANALRLLRFKPQTQENA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCE
IIVHSSINANGSRPKISSQIA
EEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVLLIACPCALVISTPAAIASGLASGARYGLLIKGGAALETLGKIRTVAFDKTGTLTMG
EEEEEECCHHHHHCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEEEECCCCCEECC
QPQVTDVVPVEGDVANVLAKAAAVERGSSHPLGAAIVKEAELRGLDMPRVFGGTVAAPGK
CCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHCCCCCCCCCH
SVMGRISSGFVTVASPLHAAEQALLDDTAQERISALEDEGKTVVTVCEGKRLIGLIALRD
HHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEHH
ELRADASEAVRTLRALGIRPVMLTGDNLRCAQGIADAAGIEVRASLLPDDKLAAISGYKA
HHCCCHHHHHHHHHHHCCCEEEEECCCCHHHHCCCCCCCCEEEEECCCCCCCCEECCCCC
EAPIAMVGDGINDAPALAASSVGVAMGSGTDVALETADAALLKNRVTGVAEMVTLSRATI
CCCEEEECCCCCCCHHHHHCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
INIWQNIALALGLKSVFLVTSLSGITPLWMAILADTGATVLVTANALRLLRFKPQTQENA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCE
IIVHSSINANGSRPKISSQIA
EEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 9405611; 9364914; 10660539; 12417201 [H]