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The map label for this gene is irlR [H]

Identifier: 148243637

GI number: 148243637

Start: 2212

End: 2889

Strand: Direct

Name: irlR [H]

Synonym: Acry_3106

Alternate gene names: 148243637

Gene position: 2212-2889 (Clockwise)

Preceding gene: 148243636

Following gene: 148243638

Centisome position: 1.09

GC content: 63.42

Gene sequence:

>678_bases
ATGAGGGTTCTTATCGTCGAGGACGAGGCGAAGACCGCGGCTTATCTCCGAAAGGGTCTCGAAGAGAACGGCTTCACGGC
GGATGTGGCTACTGATGGAGAGACGGGGCTCGAATTCGCCCGCCACGGCGGCTACGATGCCATTATTCTCGACATCATGC
TGCCACGGCGCAACGGCTTCGAAATCCTCGACGAAATCCGGCGGCGAGACAGTCAGACCGCCGTGCTTCTACTCACGGCG
CGGGACCAGGTGACAGATCGCGTCGCCGGGCTGGAGGCCGGGGCTGACGATTACCTCGTCAAGCCCTTCGCGTTTTCCGA
GCTGCTTGCCCGTGTGCGCACCATTCTGCGGCGAGGGCACGCGCGGCAACCGGCGCTGATCCAGATCGCCGATCTCGAGA
TCGACCTCTCGGGACACCGGGCAACGCGAGCGGGTCAGGCGCTCGATCTGACGCCGAAGGAGTTCCGCCTGCTTTCGTTG
TTGGCCCGCCGCGCGGGCGATGTCATCTCCCGAACGGTCATTGCCGAACAGGTCTGGGACATCAATTTCGATTCTGGCAC
GAACGTCGTCGACGTCCACATGTACCGCCTCCGCGCCAAGCTGGACGACCCGTTCTCCCGCCGCCTGATCCACACCGTTC
GTGGCGTGGGTTACGTGCTCGAAGACTGTGGCGGCTGA

Upstream 100 bases:

>100_bases
TGGTGACGCGTGCCGCCGATGGCGCCACCGTCCTGCTCGCCGGTGATCGTGCCGTGGATACGGAGGGATGCCTGACGCAG
CACCGTGGGGACGGTGCGCA

Downstream 100 bases:

>100_bases
TCCTGAAGCGCCGAGCGCTGGCGGATCGATGTCCCTGCGGATGACCGCGTGGTATGCAGGGACGGCGTTCCTGCTCGTCC
TGCTGGCCACTAGTCTCCTG

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRVLIVEDEAKTAAYLRKGLEENGFTADVATDGETGLEFARHGGYDAIILDIMLPRRNGFEILDEIRRRDSQTAVLLLTA
RDQVTDRVAGLEAGADDYLVKPFAFSELLARVRTILRRGHARQPALIQIADLEIDLSGHRATRAGQALDLTPKEFRLLSL
LARRAGDVISRTVIAEQVWDINFDSGTNVVDVHMYRLRAKLDDPFSRRLIHTVRGVGYVLEDCGG

Sequences:

>Translated_225_residues
MRVLIVEDEAKTAAYLRKGLEENGFTADVATDGETGLEFARHGGYDAIILDIMLPRRNGFEILDEIRRRDSQTAVLLLTA
RDQVTDRVAGLEAGADDYLVKPFAFSELLARVRTILRRGHARQPALIQIADLEIDLSGHRATRAGQALDLTPKEFRLLSL
LARRAGDVISRTVIAEQVWDINFDSGTNVVDVHMYRLRAKLDDPFSRRLIHTVRGVGYVLEDCGG
>Mature_225_residues
MRVLIVEDEAKTAAYLRKGLEENGFTADVATDGETGLEFARHGGYDAIILDIMLPRRNGFEILDEIRRRDSQTAVLLLTA
RDQVTDRVAGLEAGADDYLVKPFAFSELLARVRTILRRGHARQPALIQIADLEIDLSGHRATRAGQALDLTPKEFRLLSL
LARRAGDVISRTVIAEQVWDINFDSGTNVVDVHMYRLRAKLDDPFSRRLIHTVRGVGYVLEDCGG

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=55.4054054054054, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=53.2110091743119, Blast_Score=224, Evalue=4e-60,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=41.8181818181818, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=36.8181818181818, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=37.10407239819, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=39.2694063926941, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=38.1165919282511, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=37.5, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=38.7387387387387, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=32.1266968325792, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=30.3964757709251, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=33.1858407079646, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=30.1724137931034, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788550, Length=155, Percent_Identity=31.6129032258064, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=27.7056277056277, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=38.8349514563107, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI48994928, Length=164, Percent_Identity=31.0975609756098, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=30.7086614173228, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790299, Length=206, Percent_Identity=27.1844660194175, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=32.2314049586777, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25112; Mature: 25112

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIVEDEAKTAAYLRKGLEENGFTADVATDGETGLEFARHGGYDAIILDIMLPRRNGF
CEEEEEECCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEEECCCCCH
EILDEIRRRDSQTAVLLLTARDQVTDRVAGLEAGADDYLVKPFAFSELLARVRTILRRGH
HHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
ARQPALIQIADLEIDLSGHRATRAGQALDLTPKEFRLLSLLARRAGDVISRTVIAEQVWD
CCCCCEEEEEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INFDSGTNVVDVHMYRLRAKLDDPFSRRLIHTVRGVGYVLEDCGG
CCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVLIVEDEAKTAAYLRKGLEENGFTADVATDGETGLEFARHGGYDAIILDIMLPRRNGF
CEEEEEECCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEEECCCCCH
EILDEIRRRDSQTAVLLLTARDQVTDRVAGLEAGADDYLVKPFAFSELLARVRTILRRGH
HHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
ARQPALIQIADLEIDLSGHRATRAGQALDLTPKEFRLLSLLARRAGDVISRTVIAEQVWD
CCCCCEEEEEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INFDSGTNVVDVHMYRLRAKLDDPFSRRLIHTVRGVGYVLEDCGG
CCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]