| Definition | Vibrio cholerae O395 chromosome 2, complete sequence. |
|---|---|
| Accession | NC_009457 |
| Length | 3,024,069 |
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The map label for this gene is ftsI [H]
Identifier: 147674985
GI number: 147674985
Start: 2130748
End: 2132490
Strand: Reverse
Name: ftsI [H]
Synonym: VC0395_A1985
Alternate gene names: 147674985
Gene position: 2132490-2130748 (Counterclockwise)
Preceding gene: 147674513
Following gene: 147674384
Centisome position: 70.52
GC content: 51.52
Gene sequence:
>1743_bases ATGAAGAAGAAAGCCCCAGCCAAAGCCTCCCGAGTTTCTCCCCGTGTTACCACGGCTGAGCCTGCACCTATCTTTATCCG CTGGCGTTTCTATCTGCTGCTGTTTTTTGTGCTAACGGCGTTCTGCGCTTTGGTTGCACGAGTGGCTTATATCCAAATTA TTGAACCTGACAATCTGATTAAAGAAGGGGATTTGCGCTCGATTCGCGCCAAAACCTTGCAATCAGCGCGCGGCATTATT TCCGATCGTAATGGCGAAGCGTTAGCGGTGAGTGTGCCAGTCGAAGCGGTCTGGGCCGATCCTGTCGCTATTTATAAAGA AGGCGGTCTGGTTGAGAAAGACCGTTGGTATGCGCTGGCCGATGTGCTCGGACTGGATCGTCAGGAGATGATGAAGAAAA TCGAGGATAACCGTTCGCGCCGCTTTATCTATCTGCAACGTCAGGTTAGCCCTGCGATGGCCAAATACATCCGTGAACTC AAATTAGCGGGGATTGGCCTAAAAGAAGAGTCACGCCGCTATTATCCCGCAGGTGAGGTGAGTGCCCACTTAGTCGGGGT GACCGGAATTGATGGCCACGGTCTTGAAGGGGTAGAGCGCAGCTTTGATAGCACCTTAACGGGTGAGTCAGGTAAAAGCG TGACGCGTAAAGATAAGTTCGGGCGAGTGGTGGAAAACATTGCCCTGGAAGAGCGTGAAGAAGGTAAGCCTATCCAGCTC ACCATTGACCAGCGCTTACAAGCGATCGCTTTTCGTGCCGTGAAACAGGCGATGGCGGATTATCGTGCGACTTCTGCATC GGCAGTGATGTTGGATGTGAAAACCGGCGCGGTACTGGCGATGGTGAATGCGCCTTCTTACAACCCGAATAATCGCAATG ACTGGCAAAGCTTTAAAATGCGTAACCGAGTGATAACCGATGCGTTTGAACCCGGTTCAACGGTTAAGCCTTTTGTGGTC TTGGCGGCGCTCGCCAATGGTATCGCCGACAAAAACACCATCATAGATACCGGAGATGGCACCATGCAGATTGGCGGTAG CCGCGTGCGTGATACCTCCAAAGTTGGCAAAGCCGATCTCACGCTGATTTTGAAAAAGTCGAGCAACATTGGTGTGGCTA AATTAGCCTTAGAAATGCCGTTAGAGGCGTTATTGGGCATGTATAGCTCGGTGGGCTTGGGCGAAATGTCTGGCTTGGAT TTGGTGGGCGAAACGATCGGTATTTTCCCGAATCGCCGCCGTTGGTCACAGTTTGAAATCGCCACCTTATCGTTTGGCTA TGGTTTGGCGATCACGCCTATTCAGTTGGCTCACGCCTACGCGACCTTAGGCAACCATGGTAAATACCAACCTATTCATA TTATTAAAGGTGATCAACATGGCGAGACGCGCCAAGTGGTTGATCCTAAATATGTCAATCAGGTGCTCGAAATGCTGGAA ACGGTAACTCAGCCCGGCGGAACGGCAACGCGTGCAGCGGTACCGGGGTATCGTATTGCGGCCAAATCCGGTACGTCACG TAAAGCGATTGCGGGCGGTTATAGTGATGAATATTTTGCCTACACCGCAGGGGTGGCTCCGGTGAGCGACCCAAGAATTT CACTGGTGGTCATGGTCAATGAGCCGCAAGGCGACTCTTACTATGGCGGCGCAGTGGCCGGTCCGGTTTTCTCGGAAATC ATGAAGGGCGCATTACAAATCCTCAACATTGCTCCTGATGAAAACCGCTTCCAAAACAAATAA
Upstream 100 bases:
>100_bases AAACTGCTTTGGCTGAGCACAGCCGAGTACAACAATTAGCAAGAAAAGATCTGGAGATGAAACGTCCAGATTCAGACAAA GAAGTCGTGATCAACCTTAA
Downstream 100 bases:
>100_bases TAGTGTGAGACGGAACATGAACACGCATTCAGCGATCTCCGAACTGATCGCGCCATGGCTAGAGCTGACCGACCCTAAGT TGGCCGCGCTGGTCATTACT
Product: penicillin-binding protein 3
Products: NA
Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]
Number of amino acids: Translated: 580; Mature: 580
Protein sequence:
>580_residues MKKKAPAKASRVSPRVTTAEPAPIFIRWRFYLLLFFVLTAFCALVARVAYIQIIEPDNLIKEGDLRSIRAKTLQSARGII SDRNGEALAVSVPVEAVWADPVAIYKEGGLVEKDRWYALADVLGLDRQEMMKKIEDNRSRRFIYLQRQVSPAMAKYIREL KLAGIGLKEESRRYYPAGEVSAHLVGVTGIDGHGLEGVERSFDSTLTGESGKSVTRKDKFGRVVENIALEEREEGKPIQL TIDQRLQAIAFRAVKQAMADYRATSASAVMLDVKTGAVLAMVNAPSYNPNNRNDWQSFKMRNRVITDAFEPGSTVKPFVV LAALANGIADKNTIIDTGDGTMQIGGSRVRDTSKVGKADLTLILKKSSNIGVAKLALEMPLEALLGMYSSVGLGEMSGLD LVGETIGIFPNRRRWSQFEIATLSFGYGLAITPIQLAHAYATLGNHGKYQPIHIIKGDQHGETRQVVDPKYVNQVLEMLE TVTQPGGTATRAAVPGYRIAAKSGTSRKAIAGGYSDEYFAYTAGVAPVSDPRISLVVMVNEPQGDSYYGGAVAGPVFSEI MKGALQILNIAPDENRFQNK
Sequences:
>Translated_580_residues MKKKAPAKASRVSPRVTTAEPAPIFIRWRFYLLLFFVLTAFCALVARVAYIQIIEPDNLIKEGDLRSIRAKTLQSARGII SDRNGEALAVSVPVEAVWADPVAIYKEGGLVEKDRWYALADVLGLDRQEMMKKIEDNRSRRFIYLQRQVSPAMAKYIREL KLAGIGLKEESRRYYPAGEVSAHLVGVTGIDGHGLEGVERSFDSTLTGESGKSVTRKDKFGRVVENIALEEREEGKPIQL TIDQRLQAIAFRAVKQAMADYRATSASAVMLDVKTGAVLAMVNAPSYNPNNRNDWQSFKMRNRVITDAFEPGSTVKPFVV LAALANGIADKNTIIDTGDGTMQIGGSRVRDTSKVGKADLTLILKKSSNIGVAKLALEMPLEALLGMYSSVGLGEMSGLD LVGETIGIFPNRRRWSQFEIATLSFGYGLAITPIQLAHAYATLGNHGKYQPIHIIKGDQHGETRQVVDPKYVNQVLEMLE TVTQPGGTATRAAVPGYRIAAKSGTSRKAIAGGYSDEYFAYTAGVAPVSDPRISLVVMVNEPQGDSYYGGAVAGPVFSEI MKGALQILNIAPDENRFQNK >Mature_580_residues MKKKAPAKASRVSPRVTTAEPAPIFIRWRFYLLLFFVLTAFCALVARVAYIQIIEPDNLIKEGDLRSIRAKTLQSARGII SDRNGEALAVSVPVEAVWADPVAIYKEGGLVEKDRWYALADVLGLDRQEMMKKIEDNRSRRFIYLQRQVSPAMAKYIREL KLAGIGLKEESRRYYPAGEVSAHLVGVTGIDGHGLEGVERSFDSTLTGESGKSVTRKDKFGRVVENIALEEREEGKPIQL TIDQRLQAIAFRAVKQAMADYRATSASAVMLDVKTGAVLAMVNAPSYNPNNRNDWQSFKMRNRVITDAFEPGSTVKPFVV LAALANGIADKNTIIDTGDGTMQIGGSRVRDTSKVGKADLTLILKKSSNIGVAKLALEMPLEALLGMYSSVGLGEMSGLD LVGETIGIFPNRRRWSQFEIATLSFGYGLAITPIQLAHAYATLGNHGKYQPIHIIKGDQHGETRQVVDPKYVNQVLEMLE TVTQPGGTATRAAVPGYRIAAKSGTSRKAIAGGYSDEYFAYTAGVAPVSDPRISLVVMVNEPQGDSYYGGAVAGPVFSEI MKGALQILNIAPDENRFQNK
Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]
COG id: COG0768
COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2
Gene ontology:
Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786272, Length=550, Percent_Identity=50.9090909090909, Blast_Score=578, Evalue=1e-166, Organism=Escherichia coli, GI1786854, Length=634, Percent_Identity=26.813880126183, Blast_Score=148, Evalue=8e-37,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR005311 - InterPro: IPR001460 [H]
Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]
EC number: =2.4.1.129 [H]
Molecular weight: Translated: 63351; Mature: 63351
Theoretical pI: Translated: 9.74; Mature: 9.74
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKKAPAKASRVSPRVTTAEPAPIFIRWRFYLLLFFVLTAFCALVARVAYIQIIEPDNLI CCCCCCCCHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC KEGDLRSIRAKTLQSARGIISDRNGEALAVSVPVEAVWADPVAIYKEGGLVEKDRWYALA CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCEEEEECCCCCCCCHHHHHH DVLGLDRQEMMKKIEDNRSRRFIYLQRQVSPAMAKYIRELKLAGIGLKEESRRYYPAGEV HHHCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC SAHLVGVTGIDGHGLEGVERSFDSTLTGESGKSVTRKDKFGRVVENIALEEREEGKPIQL CEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE TIDQRLQAIAFRAVKQAMADYRATSASAVMLDVKTGAVLAMVNAPSYNPNNRNDWQSFKM EHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHH RNRVITDAFEPGSTVKPFVVLAALANGIADKNTIIDTGDGTMQIGGSRVRDTSKVGKADL HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCHHCCHHHCCCCEE TLILKKSSNIGVAKLALEMPLEALLGMYSSVGLGEMSGLDLVGETIGIFPNRRRWSQFEI EEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEE ATLSFGYGLAITPIQLAHAYATLGNHGKYQPIHIIKGDQHGETRQVVDPKYVNQVLEMLE EEEECCCCEEECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH TVTQPGGTATRAAVPGYRIAAKSGTSRKAIAGGYSDEYFAYTAGVAPVSDPRISLVVMVN HHCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCEEEEECCCCCCCCCCEEEEEEEE EPQGDSYYGGAVAGPVFSEIMKGALQILNIAPDENRFQNK CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCC >Mature Secondary Structure MKKKAPAKASRVSPRVTTAEPAPIFIRWRFYLLLFFVLTAFCALVARVAYIQIIEPDNLI CCCCCCCCHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC KEGDLRSIRAKTLQSARGIISDRNGEALAVSVPVEAVWADPVAIYKEGGLVEKDRWYALA CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCEEEEECCCCCCCCHHHHHH DVLGLDRQEMMKKIEDNRSRRFIYLQRQVSPAMAKYIRELKLAGIGLKEESRRYYPAGEV HHHCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC SAHLVGVTGIDGHGLEGVERSFDSTLTGESGKSVTRKDKFGRVVENIALEEREEGKPIQL CEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE TIDQRLQAIAFRAVKQAMADYRATSASAVMLDVKTGAVLAMVNAPSYNPNNRNDWQSFKM EHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHH RNRVITDAFEPGSTVKPFVVLAALANGIADKNTIIDTGDGTMQIGGSRVRDTSKVGKADL HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCHHCCHHHCCCCEE TLILKKSSNIGVAKLALEMPLEALLGMYSSVGLGEMSGLDLVGETIGIFPNRRRWSQFEI EEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEE ATLSFGYGLAITPIQLAHAYATLGNHGKYQPIHIIKGDQHGETRQVVDPKYVNQVLEMLE EEEECCCCEEECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH TVTQPGGTATRAAVPGYRIAAKSGTSRKAIAGGYSDEYFAYTAGVAPVSDPRISLVVMVN HHCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCEEEEECCCCCCCCCCEEEEEEEE EPQGDSYYGGAVAGPVFSEIMKGALQILNIAPDENRFQNK CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]