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The map label for this gene is tyrA [H]

Identifier: 147674187

GI number: 147674187

Start: 235397

End: 236524

Strand: Direct

Name: tyrA [H]

Synonym: VC0395_A0227

Alternate gene names: 147674187

Gene position: 235397-236524 (Clockwise)

Preceding gene: 147673285

Following gene: 147673203

Centisome position: 7.78

GC content: 49.47

Gene sequence:

>1128_bases
ATGGCCGTAGAGTTGAATCAGTTACGCGACCAAATCGATGAAGTCGATAAGCAGATGGTGGAGCTACTGGCGCGCCGTCT
GGCATTGGTGGAGCAGGTCGGGCAAGTGAAAAGTCGATATGGGTTACCGATTTATGCTCCCGATCGTGAAGCGGCAATGC
TCGCTTCACGTCGAGCGGAAGCGGAAAGCAAAGGTGTTCCGCCACAACTGATTGAAGATATTTTGCGCCGAACCATGCGT
GAATCCTACGCCAGTGAAAAGGACTCCGGCTTTAAATGCCTCAATCCTGAGTTACGTTCCGTGGTGATCATCGGTGGTAA
CGGTCAGCTTGGGCGACTATTTGGCCGTATGTTTAAACTCTCTGGCTATCAAGTCAAAGTGCTGGGTAGCCAAGATTGGG
ACAAAGCGGATGAACTGCTCAGTGATGCTGGCTTAGTGATAGTCACGGTACCTATCCATTTGACGCTCGGTGTTATCGAA
AAGCTGCGCCAGTTGCCGGACGATTGCATTTTGTGCGATCTCACCTCAATCAAAGCCAAGCCGCTTGCCGCTATGCTACA
AGTGCACAAAGGTCCAGTGGTTGGGCTGCACCCTATGTTTGGCCCTGATGTTCCAAGCCTGGCGAAGCAGGTGATTGTTT
ACTGTGATGGTCGAGGCAATGAACACTACCAATGGCTCTTGCAACAGTTTGCTATTTGGGGTGCAAGCTTGTGTCAGATT
GATGCGACTGAACATGATCGTGGTATGACGCTTATTCAAGCTCTGCGCCACTTCACTTCCTTTGCTTATGGCTTGCATCT
GACCAAAGAGAACCCGAACTTGGCACAACTGCTGAAACTCAGTTCACCGATTTACCGTTTAGAGCTTGCTATGGTCGGAC
GGCTATTTGGGCAAGATCCCCATCTATACGGCGATATTATTCTCTCATCACCAGAAAATATTGAGATGATCCAGCGTTTT
CATCGCTGCTTAAGCGAGGCGGTTGAGTTGGTGAGCGCGGGCGATAAGGCGAGTTTTGTGGCTCAATTTGAACGAGTTAG
CCAGTGGTTTGGTGATTATTCACAGCAGTTTATGCATGAGAGCCAAAACTTGCTCAAACAAGCGAATGATGCGATCCACA
GAGGTTAA

Upstream 100 bases:

>100_bases
CTGTATAAATTGGTCAACGACTGAGGCATTATTACGTCGTGCGCATCAGGAACTTATTCCCTTTTTGCACAATCGTTTGC
AAGGATAACAAGGATAGAAC

Downstream 100 bases:

>100_bases
CGCATCATTCGCCTCTCACCGTCACTCTCACTGTCAATAACATCCCAAGTCCATTTGGGCTTGGGATTACTCATGCAGTC
CTAAATCAGAAAGATGCTCT

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MAVELNQLRDQIDEVDKQMVELLARRLALVEQVGQVKSRYGLPIYAPDREAAMLASRRAEAESKGVPPQLIEDILRRTMR
ESYASEKDSGFKCLNPELRSVVIIGGNGQLGRLFGRMFKLSGYQVKVLGSQDWDKADELLSDAGLVIVTVPIHLTLGVIE
KLRQLPDDCILCDLTSIKAKPLAAMLQVHKGPVVGLHPMFGPDVPSLAKQVIVYCDGRGNEHYQWLLQQFAIWGASLCQI
DATEHDRGMTLIQALRHFTSFAYGLHLTKENPNLAQLLKLSSPIYRLELAMVGRLFGQDPHLYGDIILSSPENIEMIQRF
HRCLSEAVELVSAGDKASFVAQFERVSQWFGDYSQQFMHESQNLLKQANDAIHRG

Sequences:

>Translated_375_residues
MAVELNQLRDQIDEVDKQMVELLARRLALVEQVGQVKSRYGLPIYAPDREAAMLASRRAEAESKGVPPQLIEDILRRTMR
ESYASEKDSGFKCLNPELRSVVIIGGNGQLGRLFGRMFKLSGYQVKVLGSQDWDKADELLSDAGLVIVTVPIHLTLGVIE
KLRQLPDDCILCDLTSIKAKPLAAMLQVHKGPVVGLHPMFGPDVPSLAKQVIVYCDGRGNEHYQWLLQQFAIWGASLCQI
DATEHDRGMTLIQALRHFTSFAYGLHLTKENPNLAQLLKLSSPIYRLELAMVGRLFGQDPHLYGDIILSSPENIEMIQRF
HRCLSEAVELVSAGDKASFVAQFERVSQWFGDYSQQFMHESQNLLKQANDAIHRG
>Mature_374_residues
AVELNQLRDQIDEVDKQMVELLARRLALVEQVGQVKSRYGLPIYAPDREAAMLASRRAEAESKGVPPQLIEDILRRTMRE
SYASEKDSGFKCLNPELRSVVIIGGNGQLGRLFGRMFKLSGYQVKVLGSQDWDKADELLSDAGLVIVTVPIHLTLGVIEK
LRQLPDDCILCDLTSIKAKPLAAMLQVHKGPVVGLHPMFGPDVPSLAKQVIVYCDGRGNEHYQWLLQQFAIWGASLCQID
ATEHDRGMTLIQALRHFTSFAYGLHLTKENPNLAQLLKLSSPIYRLELAMVGRLFGQDPHLYGDIILSSPENIEMIQRFH
RCLSEAVELVSAGDKASFVAQFERVSQWFGDYSQQFMHESQNLLKQANDAIHRG

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=370, Percent_Identity=64.5945945945946, Blast_Score=508, Evalue=1e-145,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42063; Mature: 41932

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVELNQLRDQIDEVDKQMVELLARRLALVEQVGQVKSRYGLPIYAPDREAAMLASRRAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
AESKGVPPQLIEDILRRTMRESYASEKDSGFKCLNPELRSVVIIGGNGQLGRLFGRMFKL
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHC
SGYQVKVLGSQDWDKADELLSDAGLVIVTVPIHLTLGVIEKLRQLPDDCILCDLTSIKAK
CCCEEEEECCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEEHHHCCCH
PLAAMLQVHKGPVVGLHPMFGPDVPSLAKQVIVYCDGRGNEHYQWLLQQFAIWGASLCQI
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCHHHEE
DATEHDRGMTLIQALRHFTSFAYGLHLTKENPNLAQLLKLSSPIYRLELAMVGRLFGQDP
ECCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCC
HLYGDIILSSPENIEMIQRFHRCLSEAVELVSAGDKASFVAQFERVSQWFGDYSQQFMHE
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SQNLLKQANDAIHRG
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVELNQLRDQIDEVDKQMVELLARRLALVEQVGQVKSRYGLPIYAPDREAAMLASRRAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
AESKGVPPQLIEDILRRTMRESYASEKDSGFKCLNPELRSVVIIGGNGQLGRLFGRMFKL
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHC
SGYQVKVLGSQDWDKADELLSDAGLVIVTVPIHLTLGVIEKLRQLPDDCILCDLTSIKAK
CCCEEEEECCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEEHHHCCCH
PLAAMLQVHKGPVVGLHPMFGPDVPSLAKQVIVYCDGRGNEHYQWLLQQFAIWGASLCQI
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCHHHEE
DATEHDRGMTLIQALRHFTSFAYGLHLTKENPNLAQLLKLSSPIYRLELAMVGRLFGQDP
ECCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCC
HLYGDIILSSPENIEMIQRFHRCLSEAVELVSAGDKASFVAQFERVSQWFGDYSQQFMHE
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SQNLLKQANDAIHRG
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512561 [H]