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The map label for this gene is ndk [H]

Identifier: 147673453

GI number: 147673453

Start: 298677

End: 299105

Strand: Direct

Name: ndk [H]

Synonym: VC0395_A0285

Alternate gene names: 147673453

Gene position: 298677-299105 (Clockwise)

Preceding gene: 147675760

Following gene: 147675306

Centisome position: 9.88

GC content: 47.79

Gene sequence:

>429_bases
ATGGCTCTAGAAAGAACATTTTCGATCATTAAGCCGGATGCGGTGAAGCGTAACTTGATTGGTGAGATTTACCACCGTAT
TGAAAAAGCCGGTTTGCAGATCATTGCCGCGAAAATGGTTCACCTGTCGGAAGAGCAAGCCAGTGGCTTTTACGCTGAGC
ATGAAGGCAAACCGTTTTTTGAACCTCTGAAAGAATTTATGACCTCAGGCCCGATCATGGTGCAGGTCTTAGAGGGTGAA
AACGCAATTGCACGTTACCGTGAATTGATGGGGAAAACTAACCCAGAAGAAGCCGCCTGCGGTACTCTGCGTGCCGATTA
TGCACTGAGCATGCGTTACAACTCAGTACACGGTAGCGACAGTCCTGCATCAGCCGCTCGTGAAATTGAATTCTTCTTTC
CAGAATCAGAAATCTGCCCTCGTCCATAG

Upstream 100 bases:

>100_bases
ATAGTGTGTCTATGCTGATGGAGGTGAACTCCCTTGCCGACTACCTGTGACGCCAAGTCGCTTGGGTATAACATAAGCAC
AATAAACAAAAGGAAATTTT

Downstream 100 bases:

>100_bases
TCTTTAAGACAGATTAATTAGGCTCCTAGTGTGGAGCCTAAATTTTGCACAAAATATAACCTGTCTTGAATTAACACCTT
AGAAAAGACGCGGTTTTGCA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MALERTFSIIKPDAVKRNLIGEIYHRIEKAGLQIIAAKMVHLSEEQASGFYAEHEGKPFFEPLKEFMTSGPIMVQVLEGE
NAIARYRELMGKTNPEEAACGTLRADYALSMRYNSVHGSDSPASAAREIEFFFPESEICPRP

Sequences:

>Translated_142_residues
MALERTFSIIKPDAVKRNLIGEIYHRIEKAGLQIIAAKMVHLSEEQASGFYAEHEGKPFFEPLKEFMTSGPIMVQVLEGE
NAIARYRELMGKTNPEEAACGTLRADYALSMRYNSVHGSDSPASAAREIEFFFPESEICPRP
>Mature_141_residues
ALERTFSIIKPDAVKRNLIGEIYHRIEKAGLQIIAAKMVHLSEEQASGFYAEHEGKPFFEPLKEFMTSGPIMVQVLEGEN
AIARYRELMGKTNPEEAACGTLRADYALSMRYNSVHGSDSPASAAREIEFFFPESEICPRP

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=41.9117647058824, Blast_Score=123, Evalue=5e-29,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=41.6058394160584, Blast_Score=123, Evalue=5e-29,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=41.6058394160584, Blast_Score=123, Evalue=5e-29,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=41.6058394160584, Blast_Score=123, Evalue=5e-29,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=41.6058394160584, Blast_Score=123, Evalue=5e-29,
Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=43.0656934306569, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=40, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=40, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=37.5, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=41.0071942446043, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=41.0071942446043, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4505413, Length=143, Percent_Identity=39.8601398601399, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=40.5797101449275, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI30023828, Length=136, Percent_Identity=36.0294117647059, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=65.9574468085106, Blast_Score=202, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=40.7407407407407, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=43.3823529411765, Blast_Score=129, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=39.7058823529412, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=36.7647058823529, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15925; Mature: 15794

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALERTFSIIKPDAVKRNLIGEIYHRIEKAGLQIIAAKMVHLSEEQASGFYAEHEGKPFF
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EPLKEFMTSGPIMVQVLEGENAIARYRELMGKTNPEEAACGTLRADYALSMRYNSVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHCCEEEEEEECCCCCCC
SPASAAREIEFFFPESEICPRP
CCHHHHHHHHEECCCCCCCCCC
>Mature Secondary Structure 
ALERTFSIIKPDAVKRNLIGEIYHRIEKAGLQIIAAKMVHLSEEQASGFYAEHEGKPFF
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EPLKEFMTSGPIMVQVLEGENAIARYRELMGKTNPEEAACGTLRADYALSMRYNSVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHCCEEEEEEECCCCCCC
SPASAAREIEFFFPESEICPRP
CCHHHHHHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA