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The map label for this gene is pdhR [H]

Identifier: 147673255

GI number: 147673255

Start: 2140843

End: 2141613

Strand: Reverse

Name: pdhR [H]

Synonym: VC0395_A1991

Alternate gene names: 147673255

Gene position: 2141613-2140843 (Counterclockwise)

Preceding gene: 147674577

Following gene: 147675572

Centisome position: 70.82

GC content: 49.68

Gene sequence:

>771_bases
ATGGCTTATCAAAGGATCCGTCAGCCAAAGCTCTCCGATGTGATTGAACAAGAACTGGAGAGACTGATAGTGGAAGGAAC
ACTCTCACCCGGTCAGCAACTTCCTCCGGAACGCGAACTGGCCAAACAGTTTGAAGTGTCTCGCCCCTCGATCAGAGAAG
CCATACAACGCTTGGAAGCCAAACGCTTGCTTACCCGCCGTCAAGGTGGCGGTACATTCGTTAGTGACCGAATTTGGCAG
AGCTTTTCTGATCCTCTGCTAAATTTATTGTCTAGCCACTCCGAAACTCAACTGGATCTGCTGGAAGCGCGTCATGCGCT
GGAAGGTATTTGCGCCTATTTTGCGGCGTTGCGTGGTACCGAAGAAGATTTTGCTCGTATTCAGCACTGTGTCACGCGTA
TCGCGGAGGCTCAGGCATTGAATAATGTGGATGAAGAAGCAGAGCGGGTGATGGCCTTTTTGATTGCCATTACTGAAGCG
GCGCACAACGTTGTGCTTCTGCACATCGTACGCAGCTTGAGTCCACTGCTTGAGCAGAATATTCGTCAGAATTTTAAACT
CTTACATCGCCGCCCTGAAGCGGTAGAGAAAGTAAGCAAACACCGGGCTAACATTGTGGATGCGATTGTTTCGGGTCAGC
CGGAAAAGGCACGTGAAATGTCCCATTCTCACTTAGCTTATATCGAAGAAACGTTGTTGGATTTGACTCGTGAACAGACT
CGCCGTGAGCGATCTCTGCGTCGAATTCAACAAGGTAATGAGCCGCAATAG

Upstream 100 bases:

>100_bases
GCTGGACACTGGCGTTTTAATTATGTTAATTTCTGCACCAACTTAAAATTGGTATTACCAATTGCCAGCAAGAAGAATAA
GAGTAGAAGAACAATAAATT

Downstream 100 bases:

>100_bases
CGGCCATTGCGATTCAACTTAAATCCAACCAACAGAAGGATAGATCGCCATGTCTGACATGAAGCATGACGTAGATGCAC
TGGAAACTCAGGAGTGGCTT

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MAYQRIRQPKLSDVIEQELERLIVEGTLSPGQQLPPERELAKQFEVSRPSIREAIQRLEAKRLLTRRQGGGTFVSDRIWQ
SFSDPLLNLLSSHSETQLDLLEARHALEGICAYFAALRGTEEDFARIQHCVTRIAEAQALNNVDEEAERVMAFLIAITEA
AHNVVLLHIVRSLSPLLEQNIRQNFKLLHRRPEAVEKVSKHRANIVDAIVSGQPEKAREMSHSHLAYIEETLLDLTREQT
RRERSLRRIQQGNEPQ

Sequences:

>Translated_256_residues
MAYQRIRQPKLSDVIEQELERLIVEGTLSPGQQLPPERELAKQFEVSRPSIREAIQRLEAKRLLTRRQGGGTFVSDRIWQ
SFSDPLLNLLSSHSETQLDLLEARHALEGICAYFAALRGTEEDFARIQHCVTRIAEAQALNNVDEEAERVMAFLIAITEA
AHNVVLLHIVRSLSPLLEQNIRQNFKLLHRRPEAVEKVSKHRANIVDAIVSGQPEKAREMSHSHLAYIEETLLDLTREQT
RRERSLRRIQQGNEPQ
>Mature_255_residues
AYQRIRQPKLSDVIEQELERLIVEGTLSPGQQLPPERELAKQFEVSRPSIREAIQRLEAKRLLTRRQGGGTFVSDRIWQS
FSDPLLNLLSSHSETQLDLLEARHALEGICAYFAALRGTEEDFARIQHCVTRIAEAQALNNVDEEAERVMAFLIAITEAA
HNVVLLHIVRSLSPLLEQNIRQNFKLLHRRPEAVEKVSKHRANIVDAIVSGQPEKAREMSHSHLAYIEETLLDLTREQTR
RERSLRRIQQGNEPQ

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=234, Percent_Identity=65.8119658119658, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI1790032, Length=249, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1789353, Length=235, Percent_Identity=31.063829787234, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790780, Length=223, Percent_Identity=30.9417040358744, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994955, Length=171, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29385; Mature: 29254

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYQRIRQPKLSDVIEQELERLIVEGTLSPGQQLPPERELAKQFEVSRPSIREAIQRLEA
CCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
KRLLTRRQGGGTFVSDRIWQSFSDPLLNLLSSHSETQLDLLEARHALEGICAYFAALRGT
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
EEDFARIQHCVTRIAEAQALNNVDEEAERVMAFLIAITEAAHNVVLLHIVRSLSPLLEQN
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRQNFKLLHRRPEAVEKVSKHRANIVDAIVSGQPEKAREMSHSHLAYIEETLLDLTREQT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRERSLRRIQQGNEPQ
HHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AYQRIRQPKLSDVIEQELERLIVEGTLSPGQQLPPERELAKQFEVSRPSIREAIQRLEA
CHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
KRLLTRRQGGGTFVSDRIWQSFSDPLLNLLSSHSETQLDLLEARHALEGICAYFAALRGT
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
EEDFARIQHCVTRIAEAQALNNVDEEAERVMAFLIAITEAAHNVVLLHIVRSLSPLLEQN
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRQNFKLLHRRPEAVEKVSKHRANIVDAIVSGQPEKAREMSHSHLAYIEETLLDLTREQT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRERSLRRIQQGNEPQ
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]