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The map label for this gene is garR [H]

Identifier: 146343526

GI number: 146343526

Start: 7020192

End: 7021073

Strand: Reverse

Name: garR [H]

Synonym: BRADO6761

Alternate gene names: 146343526

Gene position: 7021073-7020192 (Counterclockwise)

Preceding gene: 146343527

Following gene: 146343518

Centisome position: 94.16

GC content: 68.82

Gene sequence:

>882_bases
ATGAGTCGTGTTGTCGCATTGATCGGCGCAGGCGCCATGGGGGGAGCGATCGGGGCGCGGCTGGCGCAGACCGGAACCCG
CCTCGTCGTGTTCGATCTCGATGCGGCCAAAATCGCGGCGCTCGTTGCGCAGGGGGCAACCGCCGCTGCTTCGGCCGCGA
AGGCGGCAGCGGAAGCCAGTGCCGTCATCCTCAGCCTCAACTCGCCTAAGATCGTGCGCGCAGCCGTATTCGGCACGGAC
GGTGTCGCCGCTGGCGCGCGCAAGGGCACGCTCATCATCGATATGTCCTCGATCGATCCCGACGCGACGCGCGCGCTCGC
GGCGGATGCCGCGGCTGCAGGCCTGCGCTGGGTCGACAGTCCGCTCTCGGGCGGCGCGCCCAAGGCCGCGATCGGCCAAC
TGACCTGCATGGCCGGCGGCGAGGCTCCCGATGTCGCCGACGCCCGCGCGGTGCTGGCCGAGGTCGCGTCGAACTACACG
CATATGGGGCCGAGCGGTGCGGGGCAGGTTACAAAGCTGATCAACCAGGTGCTGTGCGGCCTCAACTTCATGGCGGTGGC
CGAGGCGACCGCGCTGGCGCAGGCGGCCGGAGTCAATGCGGCGAAGATCCCGCAGGCGCTGCGCGGCGGGCGAGCTGATA
GCGCCATCCTGCAGGAATACATGCCTCGGTTCGTGACGCGCGACTATCGTCCGACTGGGCGGATCGACAACATGGTCAAG
GATCTCAATGGCGCGCAGGATCTTGCGCGGCAGACCGGAATCGCGATGCCGATGACCGCCGTTTGCGCCGAGATCCATCG
GCTGCTCACGGCGGTCGGGCTCGGCGCGATGGACCAGGCCGCGCTGATGGAATATTGGGCGGCGCGAACGCCGCCCGAAT
GA

Upstream 100 bases:

>100_bases
GTTTGTCAATGGCCATGTGCTCTATGTCGACGGCGGCATCACTGCCTCGCTCTGAGGCACGCTGTCGTCTCATCCCCCGT
GTTGCTTGCGGAGTGCCGTC

Downstream 100 bases:

>100_bases
TCGTGTCGCGTCAGTTAGTCCCATCTAGGTTCCATGGGCGTTGACGAAGATCGCGTAGAGCGACGTCTGCGCGGTGATGT
AGAGCCGGTTGCGCTTCGGG

Product: tartronate semialdehyde reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSRVVALIGAGAMGGAIGARLAQTGTRLVVFDLDAAKIAALVAQGATAAASAAKAAAEASAVILSLNSPKIVRAAVFGTD
GVAAGARKGTLIIDMSSIDPDATRALAADAAAAGLRWVDSPLSGGAPKAAIGQLTCMAGGEAPDVADARAVLAEVASNYT
HMGPSGAGQVTKLINQVLCGLNFMAVAEATALAQAAGVNAAKIPQALRGGRADSAILQEYMPRFVTRDYRPTGRIDNMVK
DLNGAQDLARQTGIAMPMTAVCAEIHRLLTAVGLGAMDQAALMEYWAARTPPE

Sequences:

>Translated_293_residues
MSRVVALIGAGAMGGAIGARLAQTGTRLVVFDLDAAKIAALVAQGATAAASAAKAAAEASAVILSLNSPKIVRAAVFGTD
GVAAGARKGTLIIDMSSIDPDATRALAADAAAAGLRWVDSPLSGGAPKAAIGQLTCMAGGEAPDVADARAVLAEVASNYT
HMGPSGAGQVTKLINQVLCGLNFMAVAEATALAQAAGVNAAKIPQALRGGRADSAILQEYMPRFVTRDYRPTGRIDNMVK
DLNGAQDLARQTGIAMPMTAVCAEIHRLLTAVGLGAMDQAALMEYWAARTPPE
>Mature_292_residues
SRVVALIGAGAMGGAIGARLAQTGTRLVVFDLDAAKIAALVAQGATAAASAAKAAAEASAVILSLNSPKIVRAAVFGTDG
VAAGARKGTLIIDMSSIDPDATRALAADAAAAGLRWVDSPLSGGAPKAAIGQLTCMAGGEAPDVADARAVLAEVASNYTH
MGPSGAGQVTKLINQVLCGLNFMAVAEATALAQAAGVNAAKIPQALRGGRADSAILQEYMPRFVTRDYRPTGRIDNMVKD
LNGAQDLARQTGIAMPMTAVCAEIHRLLTAVGLGAMDQAALMEYWAARTPPE

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=28.125, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI40556376, Length=281, Percent_Identity=24.9110320284698, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI145693186, Length=284, Percent_Identity=41.1971830985916, Blast_Score=187, Evalue=6e-49,
Organism=Escherichia coli, GI1786719, Length=282, Percent_Identity=32.9787234042553, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1790315, Length=282, Percent_Identity=34.7517730496454, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789092, Length=295, Percent_Identity=30.8474576271186, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17557316, Length=284, Percent_Identity=30.6338028169014, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=29.4117647058824, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=29.4117647058824, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574115, Length=283, Percent_Identity=23.321554770318, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29548; Mature: 29417

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVVALIGAGAMGGAIGARLAQTGTRLVVFDLDAAKIAALVAQGATAAASAAKAAAEAS
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHC
AVILSLNSPKIVRAAVFGTDGVAAGARKGTLIIDMSSIDPDATRALAADAAAAGLRWVDS
EEEEECCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
PLSGGAPKAAIGQLTCMAGGEAPDVADARAVLAEVASNYTHMGPSGAGQVTKLINQVLCG
CCCCCCCCHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
LNFMAVAEATALAQAAGVNAAKIPQALRGGRADSAILQEYMPRFVTRDYRPTGRIDNMVK
CHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
DLNGAQDLARQTGIAMPMTAVCAEIHRLLTAVGLGAMDQAALMEYWAARTPPE
HCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRVVALIGAGAMGGAIGARLAQTGTRLVVFDLDAAKIAALVAQGATAAASAAKAAAEAS
CCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHC
AVILSLNSPKIVRAAVFGTDGVAAGARKGTLIIDMSSIDPDATRALAADAAAAGLRWVDS
EEEEECCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
PLSGGAPKAAIGQLTCMAGGEAPDVADARAVLAEVASNYTHMGPSGAGQVTKLINQVLCG
CCCCCCCCHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
LNFMAVAEATALAQAAGVNAAKIPQALRGGRADSAILQEYMPRFVTRDYRPTGRIDNMVK
CHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
DLNGAQDLARQTGIAMPMTAVCAEIHRLLTAVGLGAMDQAALMEYWAARTPPE
HCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]