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The map label for this gene is thrC [H]

Identifier: 146343464

GI number: 146343464

Start: 6954777

End: 6956192

Strand: Reverse

Name: thrC [H]

Synonym: BRADO6693

Alternate gene names: 146343464

Gene position: 6956192-6954777 (Counterclockwise)

Preceding gene: 146343467

Following gene: 146343463

Centisome position: 93.29

GC content: 67.51

Gene sequence:

>1416_bases
TTGACGCGCTACGTTTCGACCCGCGGGGAGGCCCCCGCGCTCACCTTCTGCGATGTGATGCTGACCGGGCTCGCCCGGGA
CGGCGGCCTGTACGTGCCCGAGACCTGGCCGCAGCTGACGCCCGCGACCATCGCCTCGTTCTTCGGCAGGCCCTATTGGG
AGGTCGCCGTCGAGGTCATCAAGCCGTTCGTCGCCGGCGAGATCTCCGATGCCGAACTCGGCCGCATGGCCAACGAGGCC
TACGCCACCTTCCGCCATCCCGCGGTGGTGCCGCTCGACCAGACCGCCCCGCATCAGTTCGTCCTCGAGCTGTTCCACGG
CCCGACCTTGGCCTTCAAGGACGTGGCGATGCAGCTGATTTCGCGGCTGATGGACCACGTGCTGGCCAAGCGCGGCGAGC
GCACCACGATCGTGGTGGCGACCTCAGGCGATACCGGCGGCGCCGCCGTCGACGCCTTCGCCGGCCGCGACAATGCCGAT
TTGATCGTGCTGTATCCGCATGGCCGCATCTCCGAGGTGCAGCGGCGGATGATGACGACGTCGGGCGCCGCGAACGTGCA
TGCGCTGGCGATCGAAGGCCATTTCGATGATTGCCAGGCGATCGTGAAGGGCCTGTTCAATCATCATGCCTTCCGTGACG
CGGTGTCGCTGTCCGGCGTCAACTCGATCAACTGGGCGCGAATCGTCGCCCAGGTCGTCTACTACTTCACCTCGGCGGTC
GCCGTCGGCGCGCCGCATCGCGCCGTCGACTTCACCGTGCCGACCGGCAATTTCGGCGATATTTTCGCCGGCTACGTCGC
CAAGCGCATGGGCCTGCCGGTGCGCAAGCTTCGTGTCGCCACCAACGTCAACGACATTCTCGCCCGCACGCTCGCGACCG
GCATTTACGAGGTGCGCGAGGTCCACGCGACGGCGTCGCCGTCGATGGATATCCAGGTGTCCTCGAATTTCGAGCGGTTG
TTGTTCGAGGCGGGCGGCCGCGACGCCGGCACGGTGCGGCGGCTGATGGAGAGCCTGAAGCAGTCCGGCCGCTTCGTGCT
GCCGGATGCGATGCTGGCGGCGATCAGCGCCGATTTCGACGCCGGCCGCGCCGACGAGACCGAGACGGCGGCGGCGATCC
GCGCGGCCTTCCGCGAGGCCGGCGATCTCGTCGACCCGCACACGGCCGTGGCGCTGGCGGTGGCCGATCGCGACGACACC
GATCGGTCAGTGCCGAATATCGTGCTGGCGACGGCGCATCCGGCCAAATTTCCCGACGCGGTCGAGGCCGCTTGCGGGCA
GCGTCCGCAGCTGCCGGTCTGGCTCGAAGGACTGATGAGCAAGCGCGAGGACGCAAAGATCATGCGGAACGAGCAGGCCG
AGGTGGAAAAATTCATCCGCTCGGTCAGCCGGGCCGCCAAGCAGGGAATTGCATGA

Upstream 100 bases:

>100_bases
CCAAAACCATTATGGTGCCGGACCATGTTGCCGCCAGGCGGTTCCGATTTCGAATTCAATCAACGGGTTATGGCCTGGTG
ACGCAGGTCAGGAGAGCGGT

Downstream 100 bases:

>100_bases
TGGGTGTGGAAGTCACGAAGCTGCCGACCGGACTGACCGTCGTCACCGACACGATGCCGCATCTGGAGACCGCCGCGCTC
GGCGTCTGGGCCGGCGTCGG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTRYVSTRGEAPALTFCDVMLTGLARDGGLYVPETWPQLTPATIASFFGRPYWEVAVEVIKPFVAGEISDAELGRMANEA
YATFRHPAVVPLDQTAPHQFVLELFHGPTLAFKDVAMQLISRLMDHVLAKRGERTTIVVATSGDTGGAAVDAFAGRDNAD
LIVLYPHGRISEVQRRMMTTSGAANVHALAIEGHFDDCQAIVKGLFNHHAFRDAVSLSGVNSINWARIVAQVVYYFTSAV
AVGAPHRAVDFTVPTGNFGDIFAGYVAKRMGLPVRKLRVATNVNDILARTLATGIYEVREVHATASPSMDIQVSSNFERL
LFEAGGRDAGTVRRLMESLKQSGRFVLPDAMLAAISADFDAGRADETETAAAIRAAFREAGDLVDPHTAVALAVADRDDT
DRSVPNIVLATAHPAKFPDAVEAACGQRPQLPVWLEGLMSKREDAKIMRNEQAEVEKFIRSVSRAAKQGIA

Sequences:

>Translated_471_residues
MTRYVSTRGEAPALTFCDVMLTGLARDGGLYVPETWPQLTPATIASFFGRPYWEVAVEVIKPFVAGEISDAELGRMANEA
YATFRHPAVVPLDQTAPHQFVLELFHGPTLAFKDVAMQLISRLMDHVLAKRGERTTIVVATSGDTGGAAVDAFAGRDNAD
LIVLYPHGRISEVQRRMMTTSGAANVHALAIEGHFDDCQAIVKGLFNHHAFRDAVSLSGVNSINWARIVAQVVYYFTSAV
AVGAPHRAVDFTVPTGNFGDIFAGYVAKRMGLPVRKLRVATNVNDILARTLATGIYEVREVHATASPSMDIQVSSNFERL
LFEAGGRDAGTVRRLMESLKQSGRFVLPDAMLAAISADFDAGRADETETAAAIRAAFREAGDLVDPHTAVALAVADRDDT
DRSVPNIVLATAHPAKFPDAVEAACGQRPQLPVWLEGLMSKREDAKIMRNEQAEVEKFIRSVSRAAKQGIA
>Mature_470_residues
TRYVSTRGEAPALTFCDVMLTGLARDGGLYVPETWPQLTPATIASFFGRPYWEVAVEVIKPFVAGEISDAELGRMANEAY
ATFRHPAVVPLDQTAPHQFVLELFHGPTLAFKDVAMQLISRLMDHVLAKRGERTTIVVATSGDTGGAAVDAFAGRDNADL
IVLYPHGRISEVQRRMMTTSGAANVHALAIEGHFDDCQAIVKGLFNHHAFRDAVSLSGVNSINWARIVAQVVYYFTSAVA
VGAPHRAVDFTVPTGNFGDIFAGYVAKRMGLPVRKLRVATNVNDILARTLATGIYEVREVHATASPSMDIQVSSNFERLL
FEAGGRDAGTVRRLMESLKQSGRFVLPDAMLAAISADFDAGRADETETAAAIRAAFREAGDLVDPHTAVALAVADRDDTD
RSVPNIVLATAHPAKFPDAVEAACGQRPQLPVWLEGLMSKREDAKIMRNEQAEVEKFIRSVSRAAKQGIA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=455, Percent_Identity=35.8241758241758, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI153792148, Length=453, Percent_Identity=35.5408388520971, Blast_Score=261, Evalue=1e-69,
Organism=Escherichia coli, GI1786185, Length=422, Percent_Identity=34.1232227488152, Blast_Score=223, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319901, Length=456, Percent_Identity=42.5438596491228, Blast_Score=346, Evalue=5e-96,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50989; Mature: 50857

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYVSTRGEAPALTFCDVMLTGLARDGGLYVPETWPQLTPATIASFFGRPYWEVAVEVI
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHCCHHHHHHHHHH
KPFVAGEISDAELGRMANEAYATFRHPAVVPLDQTAPHQFVLELFHGPTLAFKDVAMQLI
HHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHH
SRLMDHVLAKRGERTTIVVATSGDTGGAAVDAFAGRDNADLIVLYPHGRISEVQRRMMTT
HHHHHHHHHCCCCCEEEEEEECCCCCCCEEHHHCCCCCCCEEEECCCCCHHHHHHHHHHC
SGAANVHALAIEGHFDDCQAIVKGLFNHHAFRDAVSLSGVNSINWARIVAQVVYYFTSAV
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AVGAPHRAVDFTVPTGNFGDIFAGYVAKRMGLPVRKLRVATNVNDILARTLATGIYEVRE
HCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHH
VHATASPSMDIQVSSNFERLLFEAGGRDAGTVRRLMESLKQSGRFVLPDAMLAAISADFD
HHHCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHCCCC
AGRADETETAAAIRAAFREAGDLVDPHTAVALAVADRDDTDRSVPNIVLATAHPAKFPDA
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCHH
VEAACGQRPQLPVWLEGLMSKREDAKIMRNEQAEVEKFIRSVSRAAKQGIA
HHHHHCCCCCCCHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRYVSTRGEAPALTFCDVMLTGLARDGGLYVPETWPQLTPATIASFFGRPYWEVAVEVI
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHCCHHHHHHHHHH
KPFVAGEISDAELGRMANEAYATFRHPAVVPLDQTAPHQFVLELFHGPTLAFKDVAMQLI
HHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHH
SRLMDHVLAKRGERTTIVVATSGDTGGAAVDAFAGRDNADLIVLYPHGRISEVQRRMMTT
HHHHHHHHHCCCCCEEEEEEECCCCCCCEEHHHCCCCCCCEEEECCCCCHHHHHHHHHHC
SGAANVHALAIEGHFDDCQAIVKGLFNHHAFRDAVSLSGVNSINWARIVAQVVYYFTSAV
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AVGAPHRAVDFTVPTGNFGDIFAGYVAKRMGLPVRKLRVATNVNDILARTLATGIYEVRE
HCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHH
VHATASPSMDIQVSSNFERLLFEAGGRDAGTVRRLMESLKQSGRFVLPDAMLAAISADFD
HHHCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHCCCC
AGRADETETAAAIRAAFREAGDLVDPHTAVALAVADRDDTDRSVPNIVLATAHPAKFPDA
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCHH
VEAACGQRPQLPVWLEGLMSKREDAKIMRNEQAEVEKFIRSVSRAAKQGIA
HHHHHCCCCCCCHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]