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The map label for this gene is etfA [H]

Identifier: 146343271

GI number: 146343271

Start: 6740848

End: 6741783

Strand: Reverse

Name: etfA [H]

Synonym: BRADO6491

Alternate gene names: 146343271

Gene position: 6741783-6740848 (Counterclockwise)

Preceding gene: 146343272

Following gene: 146343270

Centisome position: 90.41

GC content: 67.84

Gene sequence:

>936_bases
ATGGCCACGCTGCTGATTGCCGAACACGACAACGCTGGAATCAAGGACGCGACCAACAAGGCGTTGACGGCGGCCGCCGC
GCTCGGCGCCGATGTCGACGTGCTGGTCGCGGGCCAGGGCGCCAAGGGCGCGGCGGACGCCGCCGCCAAGCTCGCCGGCG
TCAAGAAGGTCCTGCTCGCGGACGATGCCGCCTATGCGCATGATCTCGCCGAGCCGCTCGCCGACCTCGTCGTCAAGCTC
GCCGCCAACTACGACGCGGTCGTCGCGCCCGCCACCTCGCGCTTCAAGAACGTGATGCCGCGCATCGCCGCGCTGCTCGA
CGTGATGCAGGTGTCGGAGATCATCAAGGTCGTCGCGCCCGACACGTTCGAGCGGCCGATCTATGCCGGCAACGCGATCC
AGACCGTGAAGTCGAAGGACGCCAAGAAGGTCATCACCGTCCGCACCTCCACCTTCGCCGCCGCGGGCGATGGTGGCGGC
GCGTCGGTGGAGACGGTCGCGGCGGCCGGTGATCCGGCGCTGTCGACGTTTGTTGGCGAAGAGGTCGCCAAGAGCGATCG
CCCCGAGCTGACCTCGGCCAAGATCATCGTCTCCGGCGGCCGCGCGATGCAGAGCCGCGAGAACTTCGCCAAATATATCG
AGCCGCTCGCCGACAAGCTCGGCGCCGGCGTCGGCGCCTCGCGTGCCGCGGTCGACGCGGGCTACGCGCCGAACGACTGG
CAGGTCGGCCAGACCGGCAAGGTGGTCGCTCCGGAACTCTACGTGGCGGTCGGCATTTCAGGCGCCATTCAGCATCTGGC
CGGCATGAAGGACTCCAAGGTGATCGTCGCGATCAACAAGGACGAGGATGCGCCGATCTTCCAGGTCGCCGATTACGGCC
TGGTCGCGGACCTCTACCAGGCGGTTCCGGAGCTGACGGAAGCGCTCGGCAAGTAA

Upstream 100 bases:

>100_bases
TGCTCAAGACCGCGGAGCCCGCGGGCCGCAAGGCGGGCGTCAAGGTGAAGGACGTCGCGGAGCTCGTTTCCAAACTCAAG
ACCGAGGCGGGGGTGCTCTG

Downstream 100 bases:

>100_bases
CGTGGGATACACCGGCCGCGGAGGGGACTGTCGCGGCCGGTGTCTTATTCTGTTAGGGCATGGATGGGCGCAGATGTCTG
CGCCGCTCCGGTGGATGACG

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MATLLIAEHDNAGIKDATNKALTAAAALGADVDVLVAGQGAKGAADAAAKLAGVKKVLLADDAAYAHDLAEPLADLVVKL
AANYDAVVAPATSRFKNVMPRIAALLDVMQVSEIIKVVAPDTFERPIYAGNAIQTVKSKDAKKVITVRTSTFAAAGDGGG
ASVETVAAAGDPALSTFVGEEVAKSDRPELTSAKIIVSGGRAMQSRENFAKYIEPLADKLGAGVGASRAAVDAGYAPNDW
QVGQTGKVVAPELYVAVGISGAIQHLAGMKDSKVIVAINKDEDAPIFQVADYGLVADLYQAVPELTEALGK

Sequences:

>Translated_311_residues
MATLLIAEHDNAGIKDATNKALTAAAALGADVDVLVAGQGAKGAADAAAKLAGVKKVLLADDAAYAHDLAEPLADLVVKL
AANYDAVVAPATSRFKNVMPRIAALLDVMQVSEIIKVVAPDTFERPIYAGNAIQTVKSKDAKKVITVRTSTFAAAGDGGG
ASVETVAAAGDPALSTFVGEEVAKSDRPELTSAKIIVSGGRAMQSRENFAKYIEPLADKLGAGVGASRAAVDAGYAPNDW
QVGQTGKVVAPELYVAVGISGAIQHLAGMKDSKVIVAINKDEDAPIFQVADYGLVADLYQAVPELTEALGK
>Mature_310_residues
ATLLIAEHDNAGIKDATNKALTAAAALGADVDVLVAGQGAKGAADAAAKLAGVKKVLLADDAAYAHDLAEPLADLVVKLA
ANYDAVVAPATSRFKNVMPRIAALLDVMQVSEIIKVVAPDTFERPIYAGNAIQTVKSKDAKKVITVRTSTFAAAGDGGGA
SVETVAAAGDPALSTFVGEEVAKSDRPELTSAKIIVSGGRAMQSRENFAKYIEPLADKLGAGVGASRAAVDAGYAPNDWQ
VGQTGKVVAPELYVAVGISGAIQHLAGMKDSKVIVAINKDEDAPIFQVADYGLVADLYQAVPELTEALGK

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=313, Percent_Identity=54.9520766773163, Blast_Score=317, Evalue=6e-87,
Organism=Homo sapiens, GI189181759, Length=277, Percent_Identity=56.3176895306859, Blast_Score=291, Evalue=4e-79,
Organism=Escherichia coli, GI1786226, Length=250, Percent_Identity=34.4, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787990, Length=124, Percent_Identity=41.9354838709677, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082157, Length=219, Percent_Identity=31.0502283105023, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506929, Length=311, Percent_Identity=54.983922829582, Blast_Score=321, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6325261, Length=292, Percent_Identity=47.6027397260274, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI17136898, Length=312, Percent_Identity=58.6538461538462, Blast_Score=332, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24652801, Length=312, Percent_Identity=58.6538461538462, Blast_Score=332, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31807; Mature: 31676

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLLIAEHDNAGIKDATNKALTAAAALGADVDVLVAGQGAKGAADAAAKLAGVKKVLLA
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDAAYAHDLAEPLADLVVKLAANYDAVVAPATSRFKNVMPRIAALLDVMQVSEIIKVVAP
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTFERPIYAGNAIQTVKSKDAKKVITVRTSTFAAAGDGGGASVETVAAAGDPALSTFVGE
CCCCCCEECCCHHHHHHCCCCCEEEEEEECEEEECCCCCCCCCEEEECCCCHHHHHHHHH
EVAKSDRPELTSAKIIVSGGRAMQSRENFAKYIEPLADKLGAGVGASRAAVDAGYAPNDW
HHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCC
QVGQTGKVVAPELYVAVGISGAIQHLAGMKDSKVIVAINKDEDAPIFQVADYGLVADLYQ
CCCCCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHH
AVPELTEALGK
HHHHHHHHHCC
>Mature Secondary Structure 
ATLLIAEHDNAGIKDATNKALTAAAALGADVDVLVAGQGAKGAADAAAKLAGVKKVLLA
EEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDAAYAHDLAEPLADLVVKLAANYDAVVAPATSRFKNVMPRIAALLDVMQVSEIIKVVAP
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTFERPIYAGNAIQTVKSKDAKKVITVRTSTFAAAGDGGGASVETVAAAGDPALSTFVGE
CCCCCCEECCCHHHHHHCCCCCEEEEEEECEEEECCCCCCCCCEEEECCCCHHHHHHHHH
EVAKSDRPELTSAKIIVSGGRAMQSRENFAKYIEPLADKLGAGVGASRAAVDAGYAPNDW
HHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCC
QVGQTGKVVAPELYVAVGISGAIQHLAGMKDSKVIVAINKDEDAPIFQVADYGLVADLYQ
CCCCCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHH
AVPELTEALGK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8599534; 12597275 [H]