Click here to switch to the map view.

The map label for this gene is hbdA [H]

Identifier: 146343270

GI number: 146343270

Start: 6739867

End: 6740808

Strand: Reverse

Name: hbdA [H]

Synonym: BRADO6490

Alternate gene names: 146343270

Gene position: 6740808-6739867 (Counterclockwise)

Preceding gene: 146343271

Following gene: 146343269

Centisome position: 90.4

GC content: 63.16

Gene sequence:

>942_bases
GTGTCTTATTCTGTTAGGGCATGGATGGGCGCAGATGTCTGCGCCGCTCCGGTGGATGACGACATGGCTCAGATCAACAA
GCTCGGTGTGATCGGCGCAGGACAGATGGGCAACGGCATCGCGCATGTCGCTGCGCTGGCCGGGCTCGACGTGGTGCTCA
ACGACGTCACCTCCGACCGTCTGAAATCCGGCATGGCCACCATCAACGGCAACCTGACCCGTCAGGTCGCCAAGAAGATG
ATTTCCGAGGACGCCCGCGGCCAGGCGTTGAAGCACATCTCGACCACCGACAGCCTCGATGGCCTCGCTGATTGCGATCT
CGTCATCGAGACCGCAATCGAGAAGGAGGACGTGAAGCGCAAGATCTTCCACGATCTCTGCGCGGTGCTGAAGCCCGAGG
CGATGATCGCCTCCAATACCTCGTCGATCTCGATCACGCGGCTCGCGGCCTGCACCGACCGTCCCGAGCGGTTCATCGGC
ATCCACTTCATGAATCCGGTTCCGTTGATGGAGCTGGTGGAACTGATCCGGGGCATCGCCACCGACGACGCGACCTTCGA
GGCGGCCAAGGAGTTTGTCGGCCGGCTCGGCAAGCAGGTGGCCGTCTCCGAGGATTTCCCGGCCTTCATCGTCAACCGCA
TCCTGCTGCCGATGATCAACGAGGCGATCTACACGCTGTATGAGGGCGTCGGCAACGTCGAGGCGATCGACGCCGCGATG
AAGCTCGGCGCGCATCATCCGATGGGCCCGCTGGAGCTCGCCGACTTCATCGGCCTCGATACCTGTCTCTCGATCATGCA
GGTGCTGCATGAGGGGCTGGCGGATTCCAAGTACCGCCCCTGTCCGCTGCTGGTGAAGTATGTCGAGGCCGGCTGGCTCG
GCCGCAAGTCGCAGCGCGGCTTCTACGACTATCGCGGCCCCAAGCCGGTGCCGACCCGGTAG

Upstream 100 bases:

>100_bases
CGGCCTGGTCGCGGACCTCTACCAGGCGGTTCCGGAGCTGACGGAAGCGCTCGGCAAGTAACGTGGGATACACCGGCCGC
GGAGGGGACTGTCGCGGCCG

Downstream 100 bases:

>100_bases
TTCAACCGTCCCTTGAAACGCCCGATCGATACGCTTCGTTAAGGCTGCCGGGATACGGTGCCATAACGAGGTATGAGCGT
ATGGATATGAGCTTGGTGGC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSYSVRAWMGADVCAAPVDDDMAQINKLGVIGAGQMGNGIAHVAALAGLDVVLNDVTSDRLKSGMATINGNLTRQVAKKM
ISEDARGQALKHISTTDSLDGLADCDLVIETAIEKEDVKRKIFHDLCAVLKPEAMIASNTSSISITRLAACTDRPERFIG
IHFMNPVPLMELVELIRGIATDDATFEAAKEFVGRLGKQVAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAM
KLGAHHPMGPLELADFIGLDTCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRGFYDYRGPKPVPTR

Sequences:

>Translated_313_residues
MSYSVRAWMGADVCAAPVDDDMAQINKLGVIGAGQMGNGIAHVAALAGLDVVLNDVTSDRLKSGMATINGNLTRQVAKKM
ISEDARGQALKHISTTDSLDGLADCDLVIETAIEKEDVKRKIFHDLCAVLKPEAMIASNTSSISITRLAACTDRPERFIG
IHFMNPVPLMELVELIRGIATDDATFEAAKEFVGRLGKQVAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAM
KLGAHHPMGPLELADFIGLDTCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRGFYDYRGPKPVPTR
>Mature_312_residues
SYSVRAWMGADVCAAPVDDDMAQINKLGVIGAGQMGNGIAHVAALAGLDVVLNDVTSDRLKSGMATINGNLTRQVAKKMI
SEDARGQALKHISTTDSLDGLADCDLVIETAIEKEDVKRKIFHDLCAVLKPEAMIASNTSSISITRLAACTDRPERFIGI
HFMNPVPLMELVELIRGIATDDATFEAAKEFVGRLGKQVAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAMK
LGAHHPMGPLELADFIGLDTCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRGFYDYRGPKPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=42.560553633218, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=41.042345276873, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI20127408, Length=292, Percent_Identity=32.5342465753425, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=29.6928327645051, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=29.6928327645051, Blast_Score=129, Evalue=3e-30,
Organism=Escherichia coli, GI1787661, Length=288, Percent_Identity=38.5416666666667, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1788682, Length=263, Percent_Identity=34.6007604562738, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=31.0861423220974, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17549919, Length=292, Percent_Identity=41.4383561643836, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=38.6206896551724, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=35.191637630662, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17508951, Length=291, Percent_Identity=34.020618556701, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI25144276, Length=291, Percent_Identity=34.020618556701, Blast_Score=153, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=291, Percent_Identity=34.020618556701, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=291, Percent_Identity=33.6769759450172, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=28.5211267605634, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=25.7142857142857, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=35.2739726027397, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=35.2739726027397, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=35.2739726027397, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI45549573, Length=238, Percent_Identity=26.4705882352941, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20129993, Length=237, Percent_Identity=22.7848101265823, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33944; Mature: 33813

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSVRAWMGADVCAAPVDDDMAQINKLGVIGAGQMGNGIAHVAALAGLDVVLNDVTSDR
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKSGMATINGNLTRQVAKKMISEDARGQALKHISTTDSLDGLADCDLVIETAIEKEDVKR
HHHCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
KIFHDLCAVLKPEAMIASNTSSISITRLAACTDRPERFIGIHFMNPVPLMELVELIRGIA
HHHHHHHHHHCCCHHEECCCCCEEHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHC
TDDATFEAAKEFVGRLGKQVAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAM
CCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KLGAHHPMGPLELADFIGLDTCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCC
FYDYRGPKPVPTR
CCCCCCCCCCCCC
>Mature Secondary Structure 
SYSVRAWMGADVCAAPVDDDMAQINKLGVIGAGQMGNGIAHVAALAGLDVVLNDVTSDR
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKSGMATINGNLTRQVAKKMISEDARGQALKHISTTDSLDGLADCDLVIETAIEKEDVKR
HHHCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
KIFHDLCAVLKPEAMIASNTSSISITRLAACTDRPERFIGIHFMNPVPLMELVELIRGIA
HHHHHHHHHHCCCHHEECCCCCEEHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHC
TDDATFEAAKEFVGRLGKQVAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAM
CCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KLGAHHPMGPLELADFIGLDTCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCC
FYDYRGPKPVPTR
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]