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The map label for this gene is htpX [H]

Identifier: 146343174

GI number: 146343174

Start: 6635395

End: 6636672

Strand: Direct

Name: htpX [H]

Synonym: BRADO6374

Alternate gene names: 146343174

Gene position: 6635395-6636672 (Clockwise)

Preceding gene: 146343173

Following gene: 146343175

Centisome position: 88.99

GC content: 57.43

Gene sequence:

>1278_bases
ATGCGTTTCGAATATTTTTTTCCCAATGATTGGGCGACGTTGGCCAAGCGCTATCTCGTGGTCAGCGCCATCCGTTACAT
TTGGATTTTGTCTTTCTCGTTTGATTTTTGGGCATCTGCTAGCGTCTTGTACCCCAACCCTCAAGTTCTGGTCGTGCTGC
AGCGAATAAGCGTCAATCCCTTACTCTTGATCGATGGCAGGTTCTTGCCGGCGCTGTTCAACTTGGTGCTGGCATTGATG
CAGGCCGGCATTGCTGCCGGAGCAATACGACTGATCGTAAGAATGTTTACCGGCCAAGGCGAGAACGCCAGCGGGGCTTC
TGTGGCTGAGGTCGATGGTCGCAAGCTACGGCGGCCGTGGTGGCTAACCCCGATCGCGATGACATTCTCACTTATCATCT
CGGCTTACATACTCGTCTGGGTCGCACTGCTGGTCTTCCAGGGCCCTAAAATGCAAACGCCCCGTTTGGGTTATGCGTTC
TACAGTGCAGGATCCATCCCCCTCTATATCGGGCTCGCACTTGGCTTTCTCGGGCTATTGTGGGGAAGCCGGTTCAATGC
TTCCGCACGCGCCATGGTCGGGAAGACGGCTGGCGTCCAACACCTGGCAAATGACCACTGGTTGACGCAGCGCGTCCACG
CGTTGGCGGCCAAGCTCGACCTGCCGCCTCCAACCGTGGGCGTGATGAACGCAGTGAACGCCTACGCGGCTGGCTCGAAG
CCAGAAGACGCAGCGGTGGTCCTTGGCGTTCCCCTCGTGAAGAAACTATCACCTGAAGAGCTGGACGCCGTCATCGGGCA
TGAACTCGGCCACATTGCATCCGGCGACATGCGCCGGATGCAGTTTGCGGAAGGCTATCAACGTATGTTTGGTACCATCC
TGGGCATGATTGGAACAATCGGGGTATCCATTGCGGCGCGCCAGAATGCGAGGGCAGCACCGCTCGTGCACCTGTTCAGC
AACCTCGCGAGGTTCACCTTCGCGATAGGTTCAGAGGTGATGGTCAAGGGACTATCTCGGTCCCGCGAGTACTATGCAGA
CGCGATAGGCGCTTCGGTCTCGTCACCCGAGGCGATGATCAGCGCCTTGCGCAGGCTCAGCAAGATCGAGGATGTGCCGA
CGGCGGTCGAGAACGAGTACGCCTACATGATGTTCAGGAACGGCCTGAAATTCTCCAGCCTGTTCTCGACCCATCCTACG
ATGGACAGGCGGTGTGCGGCACTGGAGGCCGGAACACACTTGAGGGCAATGCCACTCAAGAAACTGCCTACAGGCTAA

Upstream 100 bases:

>100_bases
GCGTGGGCCTCGCCCGTTCAAGGTTCATCTCACCGCATTCGATAAGAGCGAGACATGCCGGGCACGAACCGGGGCATTCC
TCAATAAATAGGATCGAACC

Downstream 100 bases:

>100_bases
AGGTCGCACCCCGCGCCCAGGACGTTCTGGATGCCGATGCTGCGCGTCAAGCAGGTTGTCGACTAACGGCGGGCCGCCAT
GTTCCGCTCGCCGCGGAGCT

Product: putative protease (heat shock protein)

Products: NA

Alternate protein names: Heat shock protein HtpX [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MRFEYFFPNDWATLAKRYLVVSAIRYIWILSFSFDFWASASVLYPNPQVLVVLQRISVNPLLLIDGRFLPALFNLVLALM
QAGIAAGAIRLIVRMFTGQGENASGASVAEVDGRKLRRPWWLTPIAMTFSLIISAYILVWVALLVFQGPKMQTPRLGYAF
YSAGSIPLYIGLALGFLGLLWGSRFNASARAMVGKTAGVQHLANDHWLTQRVHALAAKLDLPPPTVGVMNAVNAYAAGSK
PEDAAVVLGVPLVKKLSPEELDAVIGHELGHIASGDMRRMQFAEGYQRMFGTILGMIGTIGVSIAARQNARAAPLVHLFS
NLARFTFAIGSEVMVKGLSRSREYYADAIGASVSSPEAMISALRRLSKIEDVPTAVENEYAYMMFRNGLKFSSLFSTHPT
MDRRCAALEAGTHLRAMPLKKLPTG

Sequences:

>Translated_425_residues
MRFEYFFPNDWATLAKRYLVVSAIRYIWILSFSFDFWASASVLYPNPQVLVVLQRISVNPLLLIDGRFLPALFNLVLALM
QAGIAAGAIRLIVRMFTGQGENASGASVAEVDGRKLRRPWWLTPIAMTFSLIISAYILVWVALLVFQGPKMQTPRLGYAF
YSAGSIPLYIGLALGFLGLLWGSRFNASARAMVGKTAGVQHLANDHWLTQRVHALAAKLDLPPPTVGVMNAVNAYAAGSK
PEDAAVVLGVPLVKKLSPEELDAVIGHELGHIASGDMRRMQFAEGYQRMFGTILGMIGTIGVSIAARQNARAAPLVHLFS
NLARFTFAIGSEVMVKGLSRSREYYADAIGASVSSPEAMISALRRLSKIEDVPTAVENEYAYMMFRNGLKFSSLFSTHPT
MDRRCAALEAGTHLRAMPLKKLPTG
>Mature_425_residues
MRFEYFFPNDWATLAKRYLVVSAIRYIWILSFSFDFWASASVLYPNPQVLVVLQRISVNPLLLIDGRFLPALFNLVLALM
QAGIAAGAIRLIVRMFTGQGENASGASVAEVDGRKLRRPWWLTPIAMTFSLIISAYILVWVALLVFQGPKMQTPRLGYAF
YSAGSIPLYIGLALGFLGLLWGSRFNASARAMVGKTAGVQHLANDHWLTQRVHALAAKLDLPPPTVGVMNAVNAYAAGSK
PEDAAVVLGVPLVKKLSPEELDAVIGHELGHIASGDMRRMQFAEGYQRMFGTILGMIGTIGVSIAARQNARAAPLVHLFS
NLARFTFAIGSEVMVKGLSRSREYYADAIGASVSSPEAMISALRRLSKIEDVPTAVENEYAYMMFRNGLKFSSLFSTHPT
MDRRCAALEAGTHLRAMPLKKLPTG

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=220, Percent_Identity=30.4545454545455, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 46529; Mature: 46529

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFEYFFPNDWATLAKRYLVVSAIRYIWILSFSFDFWASASVLYPNPQVLVVLQRISVNP
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCEEEEEECCCCCE
LLLIDGRFLPALFNLVLALMQAGIAAGAIRLIVRMFTGQGENASGASVAEVDGRKLRRPW
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHCCCC
WLTPIAMTFSLIISAYILVWVALLVFQGPKMQTPRLGYAFYSAGSIPLYIGLALGFLGLL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
WGSRFNASARAMVGKTAGVQHLANDHWLTQRVHALAAKLDLPPPTVGVMNAVNAYAAGSK
HCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
PEDAAVVLGVPLVKKLSPEELDAVIGHELGHIASGDMRRMQFAEGYQRMFGTILGMIGTI
CCCCEEEECCHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVSIAARQNARAAPLVHLFSNLARFTFAIGSEVMVKGLSRSREYYADAIGASVSSPEAMI
HHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
SALRRLSKIEDVPTAVENEYAYMMFRNGLKFSSLFSTHPTMDRRCAALEAGTHLRAMPLK
HHHHHHHHHHHCCHHHCCCEEEEHHHCCCCHHHHHHCCCCHHHHHHHHHCCCCEEECCCC
KLPTG
CCCCC
>Mature Secondary Structure
MRFEYFFPNDWATLAKRYLVVSAIRYIWILSFSFDFWASASVLYPNPQVLVVLQRISVNP
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCEEEEEECCCCCE
LLLIDGRFLPALFNLVLALMQAGIAAGAIRLIVRMFTGQGENASGASVAEVDGRKLRRPW
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHCCCC
WLTPIAMTFSLIISAYILVWVALLVFQGPKMQTPRLGYAFYSAGSIPLYIGLALGFLGLL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
WGSRFNASARAMVGKTAGVQHLANDHWLTQRVHALAAKLDLPPPTVGVMNAVNAYAAGSK
HCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
PEDAAVVLGVPLVKKLSPEELDAVIGHELGHIASGDMRRMQFAEGYQRMFGTILGMIGTI
CCCCEEEECCHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVSIAARQNARAAPLVHLFSNLARFTFAIGSEVMVKGLSRSREYYADAIGASVSSPEAMI
HHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
SALRRLSKIEDVPTAVENEYAYMMFRNGLKFSSLFSTHPTMDRRCAALEAGTHLRAMPLK
HHHHHHHHHHHCCHHHCCCEEEEHHHCCCCHHHHHHCCCCHHHHHHHHHCCCCEEECCCC
KLPTG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA