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The map label for this gene is ethA [H]

Identifier: 146342085

GI number: 146342085

Start: 5441320

End: 5442777

Strand: Reverse

Name: ethA [H]

Synonym: BRADO5227

Alternate gene names: 146342085

Gene position: 5442777-5441320 (Counterclockwise)

Preceding gene: 146342088

Following gene: 146342083

Centisome position: 72.99

GC content: 65.02

Gene sequence:

>1458_bases
ATGTCAACAGAGCATGTCGACGTGCTGATCGTCGGCGCCGGACTGTCCGGCATCGCCGCCGCCTATCATCTACAGCACAA
ATGCCCGGGCAAGCGCTTTGCGATCCTCGAAGGGCGGGGTGCGATCGGCGGCACCTGGGACCTGTTCCGCTATCCCGGCA
TCCGCTCCGACAGCGACATGTATACGCTCGGCTATTCGTTCAAGCCGTGGACCGATCCCAAGGCGATCGCCGACGGGCCG
CAGATCCTCAACTATGTCCGGGACACCGCGACCGAGAACGGCATCGATCAGCATATCCGCTTCAACCATCGCGTCATCAG
CGCCTCCTGGTCGAGCGCGGATGCACGCTGGACGGTGGAGGCTGAGCGCAAGACGGAGCAGGGCACTGAAACCGTGCGGA
TGACTTGCGGCTTCCTGTTCATGTGCTCCGGCTATTACCGCTACGAGAACGGCTATCTGCCGGACTTCAAGGGCATGGCC
GATTTCAAGGGCCGCATCGTGCATCCGCAGGCCTGGCCTGAGGATCTCGACTACGCCGGCAAGCGTGTCGTCGTCGTCGG
CTCCGGCGCCACCGCGGTGACGCTCGTGCCGGCCATGGCCAAGACCGCGGCCCATGTCACGATGCTGCAGCGCTCGCCGA
CCTATGTGGTGTCGCGCCCGGCGCAGGATGCCCTCGCCAACAAGCTGCGCCGGCACCTGCCGCCGAGCCTCGCCTATCAC
CTGATCCGCTGGCGCAACGTGCTGTTCGGGATGTATTTCTTCCAGCTCAGCCGGCGCAAGCCGGAACGCGTCAAGCAGCT
CATCCTCGGGGGCGTGCGCGCCGCGCTCGGCGCCGACTACGACATCGCCACCCATTTCACGCCGCGCTACAATCCCTGGG
ACCAGCGGCTGTGCCTGGTGCCGGACGGCGATCTGTTCAAGACCATCCGCGAGCAGCGCGCCTCGGTCGTCACCGCGGGG
ATCGAGACCTTCACCGAGCGCGGGCTGCGCCTGTCGGACGGCCGTGAGCTCGAAGCCGATGTCGTCGTCACCGCGACCGG
CCTGGTGCTGCAGGTGCTCGGCGGCATCGCGGTCGCGGTCGACGGCCGCACCGTCGATTTCGCCAAGACGCTCAACTACA
AGGGCATGATGTATTCCGACGTGCCGAACCTCGCGGCGACGCTGGGCTACACCAATGCGTCCTGGACCTTGAAATGCGAT
CTCACCTGCGAATATGTCTGCCGTCTCATCAACTACATGGACCGGAACGGCTACCGGCAATGCGTGCCGCACAATGACGA
CTCGACCGTCACGCCGCTGCCGTCGCTGAGCTTCAGCTCCGGCTATGTGCAGCGCTCGATCGCCGACCTGCCCAAGCAGG
GCTCGAAGCGGCCGTGGCGGCTGTATCAGAACTACGCCCTCGACATCGTCTCGCTGCGTTTCGGCAAGGTCGACGACGGA
GTGATGCGGTATTCGTGA

Upstream 100 bases:

>100_bases
GATCGATGACGAACGCGCCTGCGATTTGACACCGTCAAGCGGGGTTGCCACTGTCGGTCACCGGCGCGGGACGCCGGCCA
GGGAACGCCAGGATCACCTC

Downstream 100 bases:

>100_bases
GGGAGGACTGCGGTGAGCATGAGAGCCTCATGGTTCGAGACGCGCCGCATGCGCGCCCTACCTCGATTTCCTGCGGCACA
TTGATCGTGAGCGGAGTACT

Product: putative flavin-containing monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSTEHVDVLIVGAGLSGIAAAYHLQHKCPGKRFAILEGRGAIGGTWDLFRYPGIRSDSDMYTLGYSFKPWTDPKAIADGP
QILNYVRDTATENGIDQHIRFNHRVISASWSSADARWTVEAERKTEQGTETVRMTCGFLFMCSGYYRYENGYLPDFKGMA
DFKGRIVHPQAWPEDLDYAGKRVVVVGSGATAVTLVPAMAKTAAHVTMLQRSPTYVVSRPAQDALANKLRRHLPPSLAYH
LIRWRNVLFGMYFFQLSRRKPERVKQLILGGVRAALGADYDIATHFTPRYNPWDQRLCLVPDGDLFKTIREQRASVVTAG
IETFTERGLRLSDGRELEADVVVTATGLVLQVLGGIAVAVDGRTVDFAKTLNYKGMMYSDVPNLAATLGYTNASWTLKCD
LTCEYVCRLINYMDRNGYRQCVPHNDDSTVTPLPSLSFSSGYVQRSIADLPKQGSKRPWRLYQNYALDIVSLRFGKVDDG
VMRYS

Sequences:

>Translated_485_residues
MSTEHVDVLIVGAGLSGIAAAYHLQHKCPGKRFAILEGRGAIGGTWDLFRYPGIRSDSDMYTLGYSFKPWTDPKAIADGP
QILNYVRDTATENGIDQHIRFNHRVISASWSSADARWTVEAERKTEQGTETVRMTCGFLFMCSGYYRYENGYLPDFKGMA
DFKGRIVHPQAWPEDLDYAGKRVVVVGSGATAVTLVPAMAKTAAHVTMLQRSPTYVVSRPAQDALANKLRRHLPPSLAYH
LIRWRNVLFGMYFFQLSRRKPERVKQLILGGVRAALGADYDIATHFTPRYNPWDQRLCLVPDGDLFKTIREQRASVVTAG
IETFTERGLRLSDGRELEADVVVTATGLVLQVLGGIAVAVDGRTVDFAKTLNYKGMMYSDVPNLAATLGYTNASWTLKCD
LTCEYVCRLINYMDRNGYRQCVPHNDDSTVTPLPSLSFSSGYVQRSIADLPKQGSKRPWRLYQNYALDIVSLRFGKVDDG
VMRYS
>Mature_484_residues
STEHVDVLIVGAGLSGIAAAYHLQHKCPGKRFAILEGRGAIGGTWDLFRYPGIRSDSDMYTLGYSFKPWTDPKAIADGPQ
ILNYVRDTATENGIDQHIRFNHRVISASWSSADARWTVEAERKTEQGTETVRMTCGFLFMCSGYYRYENGYLPDFKGMAD
FKGRIVHPQAWPEDLDYAGKRVVVVGSGATAVTLVPAMAKTAAHVTMLQRSPTYVVSRPAQDALANKLRRHLPPSLAYHL
IRWRNVLFGMYFFQLSRRKPERVKQLILGGVRAALGADYDIATHFTPRYNPWDQRLCLVPDGDLFKTIREQRASVVTAGI
ETFTERGLRLSDGRELEADVVVTATGLVLQVLGGIAVAVDGRTVDFAKTLNYKGMMYSDVPNLAATLGYTNASWTLKCDL
TCEYVCRLINYMDRNGYRQCVPHNDDSTVTPLPSLSFSSGYVQRSIADLPKQGSKRPWRLYQNYALDIVSLRFGKVDDGV
MRYS

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI50541965, Length=361, Percent_Identity=24.6537396121884, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI50541961, Length=361, Percent_Identity=24.6537396121884, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561948, Length=387, Percent_Identity=24.5478036175711, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25145785, Length=362, Percent_Identity=24.585635359116, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555726, Length=392, Percent_Identity=23.7244897959184, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17541300, Length=225, Percent_Identity=26.2222222222222, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25150462, Length=232, Percent_Identity=25.4310344827586, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193202226, Length=238, Percent_Identity=25.2100840336134, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 54277; Mature: 54145

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEHVDVLIVGAGLSGIAAAYHLQHKCPGKRFAILEGRGAIGGTWDLFRYPGIRSDSDM
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCE
YTLGYSFKPWTDPKAIADGPQILNYVRDTATENGIDQHIRFNHRVISASWSSADARWTVE
EEEECCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCHHHEEECEEEEEECCCCCCCEEEEE
AERKTEQGTETVRMTCGFLFMCSGYYRYENGYLPDFKGMADFKGRIVHPQAWPEDLDYAG
HHHCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
KRVVVVGSGATAVTLVPAMAKTAAHVTMLQRSPTYVVSRPAQDALANKLRRHLPPSLAYH
CEEEEEECCCCEEEHHHHHHHHHHHHHEEECCCCEEEECCHHHHHHHHHHHHCCHHHHHH
LIRWRNVLFGMYFFQLSRRKPERVKQLILGGVRAALGADYDIATHFTPRYNPWDQRLCLV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHCEEEEC
PDGDLFKTIREQRASVVTAGIETFTERGLRLSDGRELEADVVVTATGLVLQVLGGIAVAV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHCCEEEEE
DGRTVDFAKTLNYKGMMYSDVPNLAATLGYTNASWTLKCDLTCEYVCRLINYMDRNGYRQ
CCCEEEHHHHCCCCCEEECCCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEE
CVPHNDDSTVTPLPSLSFSSGYVQRSIADLPKQGSKRPWRLYQNYALDIVSLRFGKVDDG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEECCCCCCC
VMRYS
CCCCC
>Mature Secondary Structure 
STEHVDVLIVGAGLSGIAAAYHLQHKCPGKRFAILEGRGAIGGTWDLFRYPGIRSDSDM
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCE
YTLGYSFKPWTDPKAIADGPQILNYVRDTATENGIDQHIRFNHRVISASWSSADARWTVE
EEEECCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCHHHEEECEEEEEECCCCCCCEEEEE
AERKTEQGTETVRMTCGFLFMCSGYYRYENGYLPDFKGMADFKGRIVHPQAWPEDLDYAG
HHHCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
KRVVVVGSGATAVTLVPAMAKTAAHVTMLQRSPTYVVSRPAQDALANKLRRHLPPSLAYH
CEEEEEECCCCEEEHHHHHHHHHHHHHEEECCCCEEEECCHHHHHHHHHHHHCCHHHHHH
LIRWRNVLFGMYFFQLSRRKPERVKQLILGGVRAALGADYDIATHFTPRYNPWDQRLCLV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHCEEEEC
PDGDLFKTIREQRASVVTAGIETFTERGLRLSDGRELEADVVVTATGLVLQVLGGIAVAV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHCCEEEEE
DGRTVDFAKTLNYKGMMYSDVPNLAATLGYTNASWTLKCDLTCEYVCRLINYMDRNGYRQ
CCCEEEHHHHCCCCCEEECCCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEE
CVPHNDDSTVTPLPSLSFSSGYVQRSIADLPKQGSKRPWRLYQNYALDIVSLRFGKVDDG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEECCCCCCC
VMRYS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]