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The map label for this gene is phoQ [H]

Identifier: 146341964

GI number: 146341964

Start: 5300477

End: 5301895

Strand: Reverse

Name: phoQ [H]

Synonym: BRADO5100

Alternate gene names: 146341964

Gene position: 5301895-5300477 (Counterclockwise)

Preceding gene: 146341965

Following gene: 146341962

Centisome position: 71.1

GC content: 71.67

Gene sequence:

>1419_bases
ATGAGGCTGGGCTCGCTGCGGCTGCGGCTGGTCGCGGCAGGCACCATCGCCATCCTCGTTGCGCTCGGTGTCGCCGGCGC
CGGCATGGTGGTGCTGTTCAAGCGCCACGTCGCGCGCACGCTCGCCTCCGATCTCGATGTTCACCTGCGCCAGCTGCTCA
ACGGTCTGGAGGTCGACGCCGACGGACGCATCGCGGTGCCGCGGCCGCCCGCCGATCCACGCTTCACGGTGCCGCTGTCC
GGCCTGTACTGGCAGATCTCGGACGATCACGGCCAGCTCCTGCGCTCGCGCTCGCTGTGGGACACGATCCTGCCGCTGCC
GATCGACGAGCCCGGGCCGAGCGACGTGCATCAGCACGAGCTGATCGGCCCCGTCGGCGCGCGCGTTCTGGTCGCCGAGC
GCGGCATCCTGATGAATCCGGACAGCCAGATCCGGGTGCGTGCTGCTGTCGCCTACGATCTCGATGGCGCGACCAGCGCG
GTGCGCACCTTCGCCAAGGACCTGTCGATCGCGCTCGCCGTGCTCGCCATCATTCTCGCGGTCGGCACCTCCGTTCAGGT
CAGTCTCGGCCTGCAGCCGCTGGCGGTGCTGCGGCGCGGCGTTGCCGAGATCCGCAGCGGCCAGCGTCGGCATCTTCCGA
TGCAAGTGCCGACCGAGGTCGCGCCGCTGGTCGAGGAGGTGAACGCGCTGCTCGATGCGCAGAGCCGCGAGATCCTGCGC
TCGCGCAGCCGCGCCGCCGATCTCGCGCACGGCTTCAAGACGCCGCTCGCGGCGCTGATCGCGGACGCGGCGCGGCTGAA
GCAGCTCGGTCAGCTCGAGCTCGCGCGCAATGTCGAGGACGTTGCCGAGGCGATGAGTCGTCAGGTCGACCGTGAGCTGG
CGCTGGCGCGGCTGCGCGGCAAGCTGCGCGGCGAGCCGGCGGCGGCGACCGAACTGGGGCCGCTGGTCGAGGCGCTGCTC
GGCACCCTGGCGCGCACCCCGGCGGCGGCACATGTCAGCTTCGAGGGGCAAGTGCCTGCTGGCCTGCGCGTGCCGATGGA
TCGCACCGATCTCGCCGAGGTACTCGGCAATTTGCTGGAGAATGCGGCGCGTCACGCCGCGAGCACGGTGCGCATCGTCG
CGGGCGCGAGCCCGCTGGTCGTGACGGTGGAGGATGACGGTCCCGGCATCCCGGACGCGCAGATCGGCCGCGTGCTCGAG
CGCGGCGGCCGTCTCGACGAGCAGGGGCCGGGCAGCGGCCTCGGCCTTGCCATCGTGCAGGACGTGCTCGAGGCCTATGG
CTGGCGGCTGCAGATCGGTCGCGCCGAGCTCGGCGGCGCCCGGATCGCGATCGCGCCGGCCATGGTGCCGGCGCTGAGCG
CGTCGCAGCGCGCGGTTTCGAAGGCGAGTTACTCGTCTTCCATTCTGACCGCAGGCTGA

Upstream 100 bases:

>100_bases
ACGCGCTGGAGGTGCTGATCCGCCGCGTCCGCAAGAAGCTCGGCGCCGACATCATCGAGACCCGCCGCGGCTTCGGCTAC
ATGATTCCGGAGACCGCCGA

Downstream 100 bases:

>100_bases
GGAAGCAGTGAGCACGAACGACATGACGTGCGCGGTCGTGGGATCATGAGGAGGACAGGTCGGGATCATAGCCCTGAAGC
CGGTCGACCAGCCGGATGAT

Product: putative two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MRLGSLRLRLVAAGTIAILVALGVAGAGMVVLFKRHVARTLASDLDVHLRQLLNGLEVDADGRIAVPRPPADPRFTVPLS
GLYWQISDDHGQLLRSRSLWDTILPLPIDEPGPSDVHQHELIGPVGARVLVAERGILMNPDSQIRVRAAVAYDLDGATSA
VRTFAKDLSIALAVLAIILAVGTSVQVSLGLQPLAVLRRGVAEIRSGQRRHLPMQVPTEVAPLVEEVNALLDAQSREILR
SRSRAADLAHGFKTPLAALIADAARLKQLGQLELARNVEDVAEAMSRQVDRELALARLRGKLRGEPAAATELGPLVEALL
GTLARTPAAAHVSFEGQVPAGLRVPMDRTDLAEVLGNLLENAARHAASTVRIVAGASPLVVTVEDDGPGIPDAQIGRVLE
RGGRLDEQGPGSGLGLAIVQDVLEAYGWRLQIGRAELGGARIAIAPAMVPALSASQRAVSKASYSSSILTAG

Sequences:

>Translated_472_residues
MRLGSLRLRLVAAGTIAILVALGVAGAGMVVLFKRHVARTLASDLDVHLRQLLNGLEVDADGRIAVPRPPADPRFTVPLS
GLYWQISDDHGQLLRSRSLWDTILPLPIDEPGPSDVHQHELIGPVGARVLVAERGILMNPDSQIRVRAAVAYDLDGATSA
VRTFAKDLSIALAVLAIILAVGTSVQVSLGLQPLAVLRRGVAEIRSGQRRHLPMQVPTEVAPLVEEVNALLDAQSREILR
SRSRAADLAHGFKTPLAALIADAARLKQLGQLELARNVEDVAEAMSRQVDRELALARLRGKLRGEPAAATELGPLVEALL
GTLARTPAAAHVSFEGQVPAGLRVPMDRTDLAEVLGNLLENAARHAASTVRIVAGASPLVVTVEDDGPGIPDAQIGRVLE
RGGRLDEQGPGSGLGLAIVQDVLEAYGWRLQIGRAELGGARIAIAPAMVPALSASQRAVSKASYSSSILTAG
>Mature_472_residues
MRLGSLRLRLVAAGTIAILVALGVAGAGMVVLFKRHVARTLASDLDVHLRQLLNGLEVDADGRIAVPRPPADPRFTVPLS
GLYWQISDDHGQLLRSRSLWDTILPLPIDEPGPSDVHQHELIGPVGARVLVAERGILMNPDSQIRVRAAVAYDLDGATSA
VRTFAKDLSIALAVLAIILAVGTSVQVSLGLQPLAVLRRGVAEIRSGQRRHLPMQVPTEVAPLVEEVNALLDAQSREILR
SRSRAADLAHGFKTPLAALIADAARLKQLGQLELARNVEDVAEAMSRQVDRELALARLRGKLRGEPAAATELGPLVEALL
GTLARTPAAAHVSFEGQVPAGLRVPMDRTDLAEVLGNLLENAARHAASTVRIVAGASPLVVTVEDDGPGIPDAQIGRVLE
RGGRLDEQGPGSGLGLAIVQDVLEAYGWRLQIGRAELGGARIAIAPAMVPALSASQRAVSKASYSSSILTAG

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=263, Percent_Identity=30.0380228136882, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=28.9156626506024, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=245, Percent_Identity=30.2040816326531, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788279, Length=274, Percent_Identity=27.007299270073, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=29.3577981651376, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49778; Mature: 49778

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGSLRLRLVAAGTIAILVALGVAGAGMVVLFKRHVARTLASDLDVHLRQLLNGLEVDA
CCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DGRIAVPRPPADPRFTVPLSGLYWQISDDHGQLLRSRSLWDTILPLPIDEPGPSDVHQHE
CCEEECCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
LIGPVGARVLVAERGILMNPDSQIRVRAAVAYDLDGATSAVRTFAKDLSIALAVLAIILA
HHCHHCCEEEEECCCEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGTSVQVSLGLQPLAVLRRGVAEIRSGQRRHLPMQVPTEVAPLVEEVNALLDAQSREILR
HCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRSRAADLAHGFKTPLAALIADAARLKQLGQLELARNVEDVAEAMSRQVDRELALARLRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KLRGEPAAATELGPLVEALLGTLARTPAAAHVSFEGQVPAGLRVPMDRTDLAEVLGNLLE
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
NAARHAASTVRIVAGASPLVVTVEDDGPGIPDAQIGRVLERGGRLDEQGPGSGLGLAIVQ
HHHHHHHHHEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
DVLEAYGWRLQIGRAELGGARIAIAPAMVPALSASQRAVSKASYSSSILTAG
HHHHHCCCEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRLGSLRLRLVAAGTIAILVALGVAGAGMVVLFKRHVARTLASDLDVHLRQLLNGLEVDA
CCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DGRIAVPRPPADPRFTVPLSGLYWQISDDHGQLLRSRSLWDTILPLPIDEPGPSDVHQHE
CCEEECCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
LIGPVGARVLVAERGILMNPDSQIRVRAAVAYDLDGATSAVRTFAKDLSIALAVLAIILA
HHCHHCCEEEEECCCEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGTSVQVSLGLQPLAVLRRGVAEIRSGQRRHLPMQVPTEVAPLVEEVNALLDAQSREILR
HCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRSRAADLAHGFKTPLAALIADAARLKQLGQLELARNVEDVAEAMSRQVDRELALARLRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KLRGEPAAATELGPLVEALLGTLARTPAAAHVSFEGQVPAGLRVPMDRTDLAEVLGNLLE
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
NAARHAASTVRIVAGASPLVVTVEDDGPGIPDAQIGRVLERGGRLDEQGPGSGLGLAIVQ
HHHHHHHHHEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
DVLEAYGWRLQIGRAELGGARIAIAPAMVPALSASQRAVSKASYSSSILTAG
HHHHHCCCEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA