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The map label for this gene is ttuC [H]

Identifier: 146341958

GI number: 146341958

Start: 5293637

End: 5294710

Strand: Reverse

Name: ttuC [H]

Synonym: BRADO5094

Alternate gene names: 146341958

Gene position: 5294710-5293637 (Counterclockwise)

Preceding gene: 146341960

Following gene: 146341957

Centisome position: 71.01

GC content: 65.55

Gene sequence:

>1074_bases
ATGCGCACCCATTCCATTGCCGCCATTCCCGCCGACGGTATCGGCCCCGAGGTGATCTCCGCCGGCGTCCGCGTGCTCGA
AGCCCTGGCCAGGCGCGCAGGCGACATCAGCTTCAATGTGAAGACCTTCGACTGGGGCTCGGACTACTACAAGAAGCACG
GCGTGATGATGCCGGCCGACGGTCTCGTCGAATTGAAGAGATTCGACGCGATCTATTTTGGCGCGGTCGGCGCGCCCGAC
GTGCCGGATCACATCACACTGTGGGGCCTGCGGCTGCCGATCTGCCAGGGCTTCGATCAATACGCCAATGTGCGCCCGAC
CAAGATCCTGCCCGGGGTGGCCTCGCCGCTGCGCAATGTCGGCGTCGGCGATCTCGACTGGGTGATCGTGCGCGAGAATT
CGGAAGGCGAATATGCCGGGATGGGCGGCCGCGCGCATCGTGGCCTGCCTGAAGAGGTCGGCACCGAGGTCGCGGTGTTC
ACCCGCGTCGGTGTCACCCGCATCATGCGATACGCGTTCAGGCTGGCGCAGTCGCGGCCGCGCAAGCTTCTCACCGTTGT
GACCAAGTCGAATGCGCAGCGCCACGGCATGGTGATGTGGGACGAGATCGCCGCGGAAGTCGCGCGCGAATTCCCCGACG
TGACCTGGGACAAGATGCTGGTCGACGCGATGACCGTGCGCATGACGCTGCAGCCGAAGAGCCTCGACACCATCGTCGCG
ACCAATCTGCACGCCGACATTCTCTCTGATCTCGCCGGCGCGCTCGCCGGCAGCCTCGGCGTCGCGCCCACCGGCAACAT
CGATCCGGAGCGGCGCTACCCGTCGATGTTCGAGCCGATCCACGGCTCGGCCTTCGATATTACCGGCAAGGGCATCGCCA
ATCCCGTCGCGACGTTCTGGACCGGGGCCCAGATGCTCGAGCATCTCGGTGAGAAGGACGCTGCCGCGAGACTGATGGCC
GCGGTGGAGAAGGTGTGTGCAGCGGGCGTCCTGACGCCCGATGTCGGCGGCAAGGCGACAACCAAGGAGGTGACGGACGC
CGTGATCGACGCAATCCATGGCTCCAACGTCTGA

Upstream 100 bases:

>100_bases
CAGCCTGCCGGGGTCTCCGCCACGCTGACCCTGTTGCTCTTGCTATCCCGCAATGTCGGGGCCGACGCGGCCACGCAATC
CCTCACACGGAGCTCATTCC

Downstream 100 bases:

>100_bases
CGGGTGCCTCCTTCTCGTGCAATCCGAGCGTGTTGTGCGAACCGCTTGCAATGGACGCCGCGGGGCGTATACAGCCGCTT
CCGCTGCGTCCACGCATGCT

Product: tartrate dehydrogenase/decarboxylase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRTHSIAAIPADGIGPEVISAGVRVLEALARRAGDISFNVKTFDWGSDYYKKHGVMMPADGLVELKRFDAIYFGAVGAPD
VPDHITLWGLRLPICQGFDQYANVRPTKILPGVASPLRNVGVGDLDWVIVRENSEGEYAGMGGRAHRGLPEEVGTEVAVF
TRVGVTRIMRYAFRLAQSRPRKLLTVVTKSNAQRHGMVMWDEIAAEVAREFPDVTWDKMLVDAMTVRMTLQPKSLDTIVA
TNLHADILSDLAGALAGSLGVAPTGNIDPERRYPSMFEPIHGSAFDITGKGIANPVATFWTGAQMLEHLGEKDAAARLMA
AVEKVCAAGVLTPDVGGKATTKEVTDAVIDAIHGSNV

Sequences:

>Translated_357_residues
MRTHSIAAIPADGIGPEVISAGVRVLEALARRAGDISFNVKTFDWGSDYYKKHGVMMPADGLVELKRFDAIYFGAVGAPD
VPDHITLWGLRLPICQGFDQYANVRPTKILPGVASPLRNVGVGDLDWVIVRENSEGEYAGMGGRAHRGLPEEVGTEVAVF
TRVGVTRIMRYAFRLAQSRPRKLLTVVTKSNAQRHGMVMWDEIAAEVAREFPDVTWDKMLVDAMTVRMTLQPKSLDTIVA
TNLHADILSDLAGALAGSLGVAPTGNIDPERRYPSMFEPIHGSAFDITGKGIANPVATFWTGAQMLEHLGEKDAAARLMA
AVEKVCAAGVLTPDVGGKATTKEVTDAVIDAIHGSNV
>Mature_357_residues
MRTHSIAAIPADGIGPEVISAGVRVLEALARRAGDISFNVKTFDWGSDYYKKHGVMMPADGLVELKRFDAIYFGAVGAPD
VPDHITLWGLRLPICQGFDQYANVRPTKILPGVASPLRNVGVGDLDWVIVRENSEGEYAGMGGRAHRGLPEEVGTEVAVF
TRVGVTRIMRYAFRLAQSRPRKLLTVVTKSNAQRHGMVMWDEIAAEVAREFPDVTWDKMLVDAMTVRMTLQPKSLDTIVA
TNLHADILSDLAGALAGSLGVAPTGNIDPERRYPSMFEPIHGSAFDITGKGIANPVATFWTGAQMLEHLGEKDAAARLMA
AVEKVCAAGVLTPDVGGKATTKEVTDAVIDAIHGSNV

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=346, Percent_Identity=31.5028901734104, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI4758582, Length=352, Percent_Identity=28.9772727272727, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI28178816, Length=350, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI28178838, Length=321, Percent_Identity=28.3489096573209, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI28178821, Length=347, Percent_Identity=27.9538904899135, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI28178819, Length=195, Percent_Identity=29.2307692307692, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788101, Length=359, Percent_Identity=52.0891364902507, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI87081683, Length=359, Percent_Identity=32.8690807799443, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1787381, Length=394, Percent_Identity=25.8883248730964, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71986051, Length=341, Percent_Identity=32.258064516129, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144293, Length=352, Percent_Identity=28.125, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17550882, Length=349, Percent_Identity=29.2263610315186, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17505779, Length=357, Percent_Identity=26.890756302521, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322097, Length=365, Percent_Identity=37.8082191780822, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324709, Length=355, Percent_Identity=33.8028169014084, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324291, Length=354, Percent_Identity=30.225988700565, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319830, Length=364, Percent_Identity=29.1208791208791, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24643268, Length=351, Percent_Identity=30.7692307692308, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24643270, Length=351, Percent_Identity=30.7692307692308, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24661184, Length=355, Percent_Identity=30.1408450704225, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI281362242, Length=346, Percent_Identity=29.4797687861272, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24648872, Length=346, Percent_Identity=29.4797687861272, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI161078635, Length=366, Percent_Identity=27.3224043715847, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161078637, Length=366, Percent_Identity=27.3224043715847, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161078633, Length=366, Percent_Identity=27.3224043715847, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24650122, Length=366, Percent_Identity=27.3224043715847, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161078639, Length=353, Percent_Identity=27.7620396600567, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI20130355, Length=261, Percent_Identity=29.8850574712644, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 38428; Mature: 38428

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTHSIAAIPADGIGPEVISAGVRVLEALARRAGDISFNVKTFDWGSDYYKKHGVMMPAD
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCCCCC
GLVELKRFDAIYFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGVASPLRNV
CHHHHHHHCEEEECCCCCCCCCCCEEEEEEHHHHHCCHHHHCCCCCCHHCCCHHHHHHHC
GVGDLDWVIVRENSEGEYAGMGGRAHRGLPEEVGTEVAVFTRVGVTRIMRYAFRLAQSRP
CCCCCEEEEEEECCCCCCCCCCCHHCCCCCHHHCCCEEHHHHHHHHHHHHHHHHHHHCCC
RKLLTVVTKSNAQRHGMVMWDEIAAEVAREFPDVTWDKMLVDAMTVRMTLQPKSLDTIVA
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCHHHH
TNLHADILSDLAGALAGSLGVAPTGNIDPERRYPSMFEPIHGSAFDITGKGIANPVATFW
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCHHCCCCCCEEEECCCCCCCHHHHHH
TGAQMLEHLGEKDAAARLMAAVEKVCAAGVLTPDVGGKATTKEVTDAVIDAIHGSNV
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRTHSIAAIPADGIGPEVISAGVRVLEALARRAGDISFNVKTFDWGSDYYKKHGVMMPAD
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCCCCC
GLVELKRFDAIYFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGVASPLRNV
CHHHHHHHCEEEECCCCCCCCCCCEEEEEEHHHHHCCHHHHCCCCCCHHCCCHHHHHHHC
GVGDLDWVIVRENSEGEYAGMGGRAHRGLPEEVGTEVAVFTRVGVTRIMRYAFRLAQSRP
CCCCCEEEEEEECCCCCCCCCCCHHCCCCCHHHCCCEEHHHHHHHHHHHHHHHHHHHCCC
RKLLTVVTKSNAQRHGMVMWDEIAAEVAREFPDVTWDKMLVDAMTVRMTLQPKSLDTIVA
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCHHHH
TNLHADILSDLAGALAGSLGVAPTGNIDPERRYPSMFEPIHGSAFDITGKGIANPVATFW
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCHHCCCCCCEEEECCCCCCCHHHHHH
TGAQMLEHLGEKDAAARLMAAVEKVCAAGVLTPDVGGKATTKEVTDAVIDAIHGSNV
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]