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The map label for this gene is pleC [H]

Identifier: 146341839

GI number: 146341839

Start: 5160446

End: 5162770

Strand: Direct

Name: pleC [H]

Synonym: BRADO4968

Alternate gene names: 146341839

Gene position: 5160446-5162770 (Clockwise)

Preceding gene: 146341838

Following gene: 146341842

Centisome position: 69.21

GC content: 66.19

Gene sequence:

>2325_bases
ATGGCGCGTGCGCATGCCGCGAACGCGTGCGTCCAATCTTCTGATTCCATCAAGGGGTTGGCGCAATCGATCGCGAAACC
GGCCTATCAGAGGCTGCTGACTGCTGAGCCGGTATTGCGTCGTGCTGTCCCCACTTTGATCATTGCCTTTCTCGTCACCA
TCTGCCTCGGCGCCTTTGTCCAGGTGCTGGATCACAGCCGGCAGAAGCGCGGCGCGACCAAGCGCGACCTCGCGGCGATC
TCGGACCTGCTGGCCGATCGGATCGGCCACATCGCCATGCGTCCGGACCGCATCGCCAACATCGAGCATCTGCAGGCTTT
GCTGCCGGATCTCATTCCGGCCTGGGGCTCCGCACCCGGCCGCCACGTCATCGTCACCGGCGCCGATCACCGCATCCTCG
CCCGCGTGCCGGTCGACACCGGTCTCGGCGAGAACGACCGCATCCTCGACCTGATCTCGACCGCGCAGCTCTTGGCCACG
CCCGGCCTGCAGGGCGCGGTCACCGAGATCACGCTGCCGAATGGCCGGCCCGCCTTCGCCGTGTCGCAGCTGATCAAGGC
GCTGCCCGGCCGCGTCGTCGTGATCCAGGAGAAGCTCGAGCCGATCTGGGGTTCGGATGCCGCGCTGTCGATCACACTGT
CGGCGACGACCGGCTTCGTCGTCCTGATCCTCGGCTTCGCCTTCCACTGGCAGTCGACCCGCGCCCGCGAGGGCGACCTG
ATCAACGACGCCGTGCGCGGCCGCATCGACACCGCGCTCAACCGCGGCCGCTGCGGCCTGTGGGACTGGGACCTGTCGCG
CGGCCGGATCTTCTGGTCGAACTCGATGTTCGCGATGCTCGGCCTCGACAACCGCACCGACCTGCTCACCTTCGGGGAGG
TCAACGCGCTGGTGAACTCCGACGACATCGACCTGTTCGCGATCGCCGACCAGCTCGTCGCCGGCGAGCTCCGCCACATC
GACCAGAGCTTCCGCATGCGCCACACCGAGGGCCACTGGATCTGGCTGCGGGTGCGCTGCGAGCTCTCCCAGGGCACCAC
GGACTCCGGCCTGCACCTGATCGGCATCGCCGTCGACGTCACCGAGCAGAAGAGCCTGGTCGAGAAGACCGTCGAGGCCG
ACTTGCGGCTGCGCGACGCCATCGAGACGATCTCGGAAGCATTCGTTCTCTGGGACTCCAACAACCGCCTCGTGCTGTGC
AACTCGCACTTCCAGAAGCTGCACAAGCTGCCGGACTCCGCCGTCACCCCCGGCACGTCCTATGAGACCGTGATCGAGGT
CGGCAAGATGCCGGAGATCCGCACAAGGCTGCACGACAACAGCCAGCAGGCGCAGGGCGGCCGCACCTTCGAGGCGCAGC
TCGACGATGGCAGCTGGCTGCACATCTCCGAGCGCCGCACCAAGGACGGCGGCTACGTCTCGGTCGGCACCGACATCACC
CGCATCAAGGAGCACGAGCAGAAGCTCGTCGACAACGACCTCCGTCTGCGCGCCACCGTCATCGACCTGCAGCGCTCGCA
GAGCGCGCTGGAGCGTCAGGCGATCGAGCTCGCCGATCTCGCAGAGAAATACTCGCAGGAAAAGACACGGGCCGAGGAAG
CCAACCAGACCAAGTCGAAATTCCTCGCCAATATGAGCCACGAGCTGCGCACGCCGCTCAACGCCATCATCGGCTTCTCC
GAGATCATGGGTTCGGGCATGTTCGGCTCGCTCGGCTCGGAGAAGTATCAGGAATACTGCCACGACATCCTGACCTCGGG
TCAGTATCTGCTCGAGGTGATCAACGACATCCTCGACATGTCGAAGATCGAGGCCGGCCGCATGAAGCTCGACATGGAGC
CGCTCGATCTCGCCAAGACGCTCGCGGAATCGCTGCGCGTCGTCTCCGGCCGCGCCCAGGACAAGAGCCTGGTGCTCGAT
GCCGATATCGAGGGCAACATCCCGGTCATCGCCGACCGCCGCGCCACCAAGCAGATCATGGTGAACCTGCTGTCGAATGC
GGTGAAGTTCACCCCCGAAGGCGGCCGCGTCACGATGCGCAGCCGGGTGTTCGAGGACAAGGTGGTGCTGATCATCGCCG
ACACCGGCATCGGCATCCCCGCGCAGTCGCTGGCCCGGCTCGGCCGTCCGTTCGAGCAGGTCGAGAGCCAGATGACCAAG
ACCTATCACGGCTCCGGCCTTGGCCTCGCCATCGCCCGCTCGCTGGCACAGCTGCACGGCGGCTCGATGCGCCTGCGCTC
ACGCCTCGAACACGGCACCGTCGTCCGCGTCACCCTCCCCCGCGACGCCTACAAGGCCACAGCGAGCATCTCGGTCGCGG
CGTGA

Upstream 100 bases:

>100_bases
CGACAGCCCGAGAAATCTGGATTCAAATCAACTTGATTCGGAAGCGGCTGGGGCTCTTTCGAAATTCGGGTATCCAAGGA
AAGTTTCGGGGGTCTACAGC

Downstream 100 bases:

>100_bases
GCGGCGTGCGCTGCTGAGCGACCACGAAGAGCGCCATCGTAGAGCTTGTGAGCCAATTTGAGTTCAGGGCTGAGTTTGCG
ACGAGGGGGCTGTCGCCGCG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MARAHAANACVQSSDSIKGLAQSIAKPAYQRLLTAEPVLRRAVPTLIIAFLVTICLGAFVQVLDHSRQKRGATKRDLAAI
SDLLADRIGHIAMRPDRIANIEHLQALLPDLIPAWGSAPGRHVIVTGADHRILARVPVDTGLGENDRILDLISTAQLLAT
PGLQGAVTEITLPNGRPAFAVSQLIKALPGRVVVIQEKLEPIWGSDAALSITLSATTGFVVLILGFAFHWQSTRAREGDL
INDAVRGRIDTALNRGRCGLWDWDLSRGRIFWSNSMFAMLGLDNRTDLLTFGEVNALVNSDDIDLFAIADQLVAGELRHI
DQSFRMRHTEGHWIWLRVRCELSQGTTDSGLHLIGIAVDVTEQKSLVEKTVEADLRLRDAIETISEAFVLWDSNNRLVLC
NSHFQKLHKLPDSAVTPGTSYETVIEVGKMPEIRTRLHDNSQQAQGGRTFEAQLDDGSWLHISERRTKDGGYVSVGTDIT
RIKEHEQKLVDNDLRLRATVIDLQRSQSALERQAIELADLAEKYSQEKTRAEEANQTKSKFLANMSHELRTPLNAIIGFS
EIMGSGMFGSLGSEKYQEYCHDILTSGQYLLEVINDILDMSKIEAGRMKLDMEPLDLAKTLAESLRVVSGRAQDKSLVLD
ADIEGNIPVIADRRATKQIMVNLLSNAVKFTPEGGRVTMRSRVFEDKVVLIIADTGIGIPAQSLARLGRPFEQVESQMTK
TYHGSGLGLAIARSLAQLHGGSMRLRSRLEHGTVVRVTLPRDAYKATASISVAA

Sequences:

>Translated_774_residues
MARAHAANACVQSSDSIKGLAQSIAKPAYQRLLTAEPVLRRAVPTLIIAFLVTICLGAFVQVLDHSRQKRGATKRDLAAI
SDLLADRIGHIAMRPDRIANIEHLQALLPDLIPAWGSAPGRHVIVTGADHRILARVPVDTGLGENDRILDLISTAQLLAT
PGLQGAVTEITLPNGRPAFAVSQLIKALPGRVVVIQEKLEPIWGSDAALSITLSATTGFVVLILGFAFHWQSTRAREGDL
INDAVRGRIDTALNRGRCGLWDWDLSRGRIFWSNSMFAMLGLDNRTDLLTFGEVNALVNSDDIDLFAIADQLVAGELRHI
DQSFRMRHTEGHWIWLRVRCELSQGTTDSGLHLIGIAVDVTEQKSLVEKTVEADLRLRDAIETISEAFVLWDSNNRLVLC
NSHFQKLHKLPDSAVTPGTSYETVIEVGKMPEIRTRLHDNSQQAQGGRTFEAQLDDGSWLHISERRTKDGGYVSVGTDIT
RIKEHEQKLVDNDLRLRATVIDLQRSQSALERQAIELADLAEKYSQEKTRAEEANQTKSKFLANMSHELRTPLNAIIGFS
EIMGSGMFGSLGSEKYQEYCHDILTSGQYLLEVINDILDMSKIEAGRMKLDMEPLDLAKTLAESLRVVSGRAQDKSLVLD
ADIEGNIPVIADRRATKQIMVNLLSNAVKFTPEGGRVTMRSRVFEDKVVLIIADTGIGIPAQSLARLGRPFEQVESQMTK
TYHGSGLGLAIARSLAQLHGGSMRLRSRLEHGTVVRVTLPRDAYKATASISVAA
>Mature_773_residues
ARAHAANACVQSSDSIKGLAQSIAKPAYQRLLTAEPVLRRAVPTLIIAFLVTICLGAFVQVLDHSRQKRGATKRDLAAIS
DLLADRIGHIAMRPDRIANIEHLQALLPDLIPAWGSAPGRHVIVTGADHRILARVPVDTGLGENDRILDLISTAQLLATP
GLQGAVTEITLPNGRPAFAVSQLIKALPGRVVVIQEKLEPIWGSDAALSITLSATTGFVVLILGFAFHWQSTRAREGDLI
NDAVRGRIDTALNRGRCGLWDWDLSRGRIFWSNSMFAMLGLDNRTDLLTFGEVNALVNSDDIDLFAIADQLVAGELRHID
QSFRMRHTEGHWIWLRVRCELSQGTTDSGLHLIGIAVDVTEQKSLVEKTVEADLRLRDAIETISEAFVLWDSNNRLVLCN
SHFQKLHKLPDSAVTPGTSYETVIEVGKMPEIRTRLHDNSQQAQGGRTFEAQLDDGSWLHISERRTKDGGYVSVGTDITR
IKEHEQKLVDNDLRLRATVIDLQRSQSALERQAIELADLAEKYSQEKTRAEEANQTKSKFLANMSHELRTPLNAIIGFSE
IMGSGMFGSLGSEKYQEYCHDILTSGQYLLEVINDILDMSKIEAGRMKLDMEPLDLAKTLAESLRVVSGRAQDKSLVLDA
DIEGNIPVIADRRATKQIMVNLLSNAVKFTPEGGRVTMRSRVFEDKVVLIIADTGIGIPAQSLARLGRPFEQVESQMTKT
YHGSGLGLAIARSLAQLHGGSMRLRSRLEHGTVVRVTLPRDAYKATASISVAA

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=261, Percent_Identity=38.3141762452107, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI87081816, Length=273, Percent_Identity=35.5311355311355, Blast_Score=142, Evalue=1e-34,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=37.0689655172414, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1788713, Length=301, Percent_Identity=31.8936877076412, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=34.1463414634146, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=29.3617021276596, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=27.3092369477912, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1786783, Length=250, Percent_Identity=26.8, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1790861, Length=247, Percent_Identity=28.7449392712551, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87082128, Length=223, Percent_Identity=28.2511210762332, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=25.6637168141593, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=273, Percent_Identity=24.1758241758242, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=24.5762711864407, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790346, Length=258, Percent_Identity=24.4186046511628, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 85170; Mature: 85038

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN ; PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARAHAANACVQSSDSIKGLAQSIAKPAYQRLLTAEPVLRRAVPTLIIAFLVTICLGAFV
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVLDHSRQKRGATKRDLAAISDLLADRIGHIAMRPDRIANIEHLQALLPDLIPAWGSAPG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEECCHHHCCHHHHHHHHHHHHHHCCCCCC
RHVIVTGADHRILARVPVDTGLGENDRILDLISTAQLLATPGLQGAVTEITLPNGRPAFA
CEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHH
VSQLIKALPGRVVVIQEKLEPIWGSDAALSITLSATTGFVVLILGFAFHWQSTRAREGDL
HHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCH
INDAVRGRIDTALNRGRCGLWDWDLSRGRIFWSNSMFAMLGLDNRTDLLTFGEVNALVNS
HHHHHHHHHHHHHCCCCCCCEECCCCCCEEEECCCEEEEEECCCCCCEEEECCHHHEECC
DDIDLFAIADQLVAGELRHIDQSFRMRHTEGHWIWLRVRCELSQGTTDSGLHLIGIAVDV
CCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEEECCCCCCCCEEEEEEEEEC
TEQKSLVEKTVEADLRLRDAIETISEAFVLWDSNNRLVLCNSHFQKLHKLPDSAVTPGTS
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECHHHHHHHCCCCCCCCCCCC
YETVIEVGKMPEIRTRLHDNSQQAQGGRTFEAQLDDGSWLHISERRTKDGGYVSVGTDIT
HHHHHHHCCCCHHHHHHCCCCHHCCCCCEEEEEECCCCEEEEECCCCCCCCEEEECCCHH
RIKEHEQKLVDNDLRLRATVIDLQRSQSALERQAIELADLAEKYSQEKTRAEEANQTKSK
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLANMSHELRTPLNAIIGFSEIMGSGMFGSLGSEKYQEYCHDILTSGQYLLEVINDILDM
HHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
SKIEAGRMKLDMEPLDLAKTLAESLRVVSGRAQDKSLVLDADIEGNIPVIADRRATKQIM
HHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEECCHHHHHHH
VNLLSNAVKFTPEGGRVTMRSRVFEDKVVLIIADTGIGIPAQSLARLGRPFEQVESQMTK
HHHHHHHHEECCCCCEEEHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHH
TYHGSGLGLAIARSLAQLHGGSMRLRSRLEHGTVVRVTLPRDAYKATASISVAA
HHCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEECCCHHHHCCCEEEECC
>Mature Secondary Structure 
ARAHAANACVQSSDSIKGLAQSIAKPAYQRLLTAEPVLRRAVPTLIIAFLVTICLGAFV
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVLDHSRQKRGATKRDLAAISDLLADRIGHIAMRPDRIANIEHLQALLPDLIPAWGSAPG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEECCHHHCCHHHHHHHHHHHHHHCCCCCC
RHVIVTGADHRILARVPVDTGLGENDRILDLISTAQLLATPGLQGAVTEITLPNGRPAFA
CEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHH
VSQLIKALPGRVVVIQEKLEPIWGSDAALSITLSATTGFVVLILGFAFHWQSTRAREGDL
HHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCH
INDAVRGRIDTALNRGRCGLWDWDLSRGRIFWSNSMFAMLGLDNRTDLLTFGEVNALVNS
HHHHHHHHHHHHHCCCCCCCEECCCCCCEEEECCCEEEEEECCCCCCEEEECCHHHEECC
DDIDLFAIADQLVAGELRHIDQSFRMRHTEGHWIWLRVRCELSQGTTDSGLHLIGIAVDV
CCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEEECCCCCCCCEEEEEEEEEC
TEQKSLVEKTVEADLRLRDAIETISEAFVLWDSNNRLVLCNSHFQKLHKLPDSAVTPGTS
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECHHHHHHHCCCCCCCCCCCC
YETVIEVGKMPEIRTRLHDNSQQAQGGRTFEAQLDDGSWLHISERRTKDGGYVSVGTDIT
HHHHHHHCCCCHHHHHHCCCCHHCCCCCEEEEEECCCCEEEEECCCCCCCCEEEECCCHH
RIKEHEQKLVDNDLRLRATVIDLQRSQSALERQAIELADLAEKYSQEKTRAEEANQTKSK
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLANMSHELRTPLNAIIGFSEIMGSGMFGSLGSEKYQEYCHDILTSGQYLLEVINDILDM
HHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
SKIEAGRMKLDMEPLDLAKTLAESLRVVSGRAQDKSLVLDADIEGNIPVIADRRATKQIM
HHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEECCHHHHHHH
VNLLSNAVKFTPEGGRVTMRSRVFEDKVVLIIADTGIGIPAQSLARLGRPFEQVESQMTK
HHHHHHHHEECCCCCEEEHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHH
TYHGSGLGLAIARSLAQLHGGSMRLRSRLEHGTVVRVTLPRDAYKATASISVAA
HHCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEECCCHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]