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The map label for this gene is hyi [H]

Identifier: 146341818

GI number: 146341818

Start: 5136081

End: 5136872

Strand: Reverse

Name: hyi [H]

Synonym: BRADO4945

Alternate gene names: 146341818

Gene position: 5136872-5136081 (Counterclockwise)

Preceding gene: 146341819

Following gene: 146341817

Centisome position: 68.89

GC content: 66.04

Gene sequence:

>792_bases
ATGCCGCACTTTGCCGCCAACCTGACGATGCTGTTCAACGAGCTGCCGTTTCTGGAGCGTTTCGCCGCCGCCAAGGCGGC
CGGGTTCAGCGGCGTCGAGTATCTGTTTCCCTACGAGTTCGACAAGGCCGAGCTGCGCGAGCAGCTCGCCCGCCACGGCC
TGACCCAGGTGCTGCACAATCTGCCCGCCGGCAACTGGGCCGCCGGCGAGCGCGGCATCGCCATCCTGCCGGACCGCGTC
GACGATTTTCGCGAGGGCGTCCGCCGCGGTATCGAATACGCCCGGGCGCTCGACTGCCGTCAGCTCAACTGCCTCGTCGG
CATCGCGCCCGATGGTGCCGATCCGCGCGAGCTCAATCAGACGCTGCTGCGCAATCTGCGCTTCGCCGCGACCGCGCTGA
AGGCGCAGGGCATCAAGCTCCTGATCGAGCCGATCAACACGCTCGACATTCCCGGCTTCTTCCTCAACCGCACCGCTCAG
GCGCTGCAGCTGATCTCCGATGTCGAGTCCGACAACCTGTTCGTCCAATACGACATCTATCACATGCAGATCATGGAGGG
CGATCTCGCGCGCACCCTACAGAAGCATCTCGCCCGCATCGCCCACATCCAGCTCGCCGACAACCCCGGCCGCCACGAGC
CCGGCACCGGCGAGATCAACTACGCGTATCTGTTCCGCCACCTCGATGCGATCGGCTATGCCGGCTGGGTCGGCTGCGAG
TACAAGCCGAGGACGAAGACCGAGGAGGGGCTCGGCTGGCTGACGGAGCGCGCGGCCGTGACGTCGAGTTGA

Upstream 100 bases:

>100_bases
GGAGGTGCTCGACCTGCCGGTGGACGAGACGCCGGCCGAGTCGCAGCGCACCCTGCAGCCGGCGTGATCGCAGCCAACGC
ATTCAGTCGAGGACCACCCT

Downstream 100 bases:

>100_bases
GGTCGGCGATCGACAGGTTCAGCCCGCCGCTGCCGGCTCCGCGTGCAAGCTCGAGGCAGAGCCGCTGTCGCGCATCTATC
TCATGGCCACGCTGCCCGCG

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MPHFAANLTMLFNELPFLERFAAAKAAGFSGVEYLFPYEFDKAELREQLARHGLTQVLHNLPAGNWAAGERGIAILPDRV
DDFREGVRRGIEYARALDCRQLNCLVGIAPDGADPRELNQTLLRNLRFAATALKAQGIKLLIEPINTLDIPGFFLNRTAQ
ALQLISDVESDNLFVQYDIYHMQIMEGDLARTLQKHLARIAHIQLADNPGRHEPGTGEINYAYLFRHLDAIGYAGWVGCE
YKPRTKTEEGLGWLTERAAVTSS

Sequences:

>Translated_263_residues
MPHFAANLTMLFNELPFLERFAAAKAAGFSGVEYLFPYEFDKAELREQLARHGLTQVLHNLPAGNWAAGERGIAILPDRV
DDFREGVRRGIEYARALDCRQLNCLVGIAPDGADPRELNQTLLRNLRFAATALKAQGIKLLIEPINTLDIPGFFLNRTAQ
ALQLISDVESDNLFVQYDIYHMQIMEGDLARTLQKHLARIAHIQLADNPGRHEPGTGEINYAYLFRHLDAIGYAGWVGCE
YKPRTKTEEGLGWLTERAAVTSS
>Mature_262_residues
PHFAANLTMLFNELPFLERFAAAKAAGFSGVEYLFPYEFDKAELREQLARHGLTQVLHNLPAGNWAAGERGIAILPDRVD
DFREGVRRGIEYARALDCRQLNCLVGIAPDGADPRELNQTLLRNLRFAATALKAQGIKLLIEPINTLDIPGFFLNRTAQA
LQLISDVESDNLFVQYDIYHMQIMEGDLARTLQKHLARIAHIQLADNPGRHEPGTGEINYAYLFRHLDAIGYAGWVGCEY
KPRTKTEEGLGWLTERAAVTSS

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=258, Percent_Identity=41.8604651162791, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI300068964, Length=242, Percent_Identity=40.0826446280992, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1786718, Length=254, Percent_Identity=56.6929133858268, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1789095, Length=254, Percent_Identity=42.9133858267717, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17552022, Length=238, Percent_Identity=39.4957983193277, Blast_Score=170, Evalue=6e-43,
Organism=Drosophila melanogaster, GI17530883, Length=257, Percent_Identity=35.408560311284, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29478; Mature: 29347

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHFAANLTMLFNELPFLERFAAAKAAGFSGVEYLFPYEFDKAELREQLARHGLTQVLHN
CCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
LPAGNWAAGERGIAILPDRVDDFREGVRRGIEYARALDCRQLNCLVGIAPDGADPRELNQ
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
TLLRNLRFAATALKAQGIKLLIEPINTLDIPGFFLNRTAQALQLISDVESDNLFVQYDIY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEE
HMQIMEGDLARTLQKHLARIAHIQLADNPGRHEPGTGEINYAYLFRHLDAIGYAGWVGCE
EEEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCC
YKPRTKTEEGLGWLTERAAVTSS
CCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PHFAANLTMLFNELPFLERFAAAKAAGFSGVEYLFPYEFDKAELREQLARHGLTQVLHN
CCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
LPAGNWAAGERGIAILPDRVDDFREGVRRGIEYARALDCRQLNCLVGIAPDGADPRELNQ
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
TLLRNLRFAATALKAQGIKLLIEPINTLDIPGFFLNRTAQALQLISDVESDNLFVQYDIY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEE
HMQIMEGDLARTLQKHLARIAHIQLADNPGRHEPGTGEINYAYLFRHLDAIGYAGWVGCE
EEEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCC
YKPRTKTEEGLGWLTERAAVTSS
CCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]