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The map label for this gene is cobT

Identifier: 146341799

GI number: 146341799

Start: 5117782

End: 5118837

Strand: Reverse

Name: cobT

Synonym: BRADO4918

Alternate gene names: 146341799

Gene position: 5118837-5117782 (Counterclockwise)

Preceding gene: 146341802

Following gene: 146341798

Centisome position: 68.65

GC content: 71.4

Gene sequence:

>1056_bases
GTGCTCCCTGACTGGATCAATTCGGAGTGTCCGGCGCCATCCGGGGCGCACCGCGAATCGGCCTTGGCGCGCCAGGCGCA
ACTGACCAAGCCGCTCGGTGCGCTGGGACGGCTGGAGGAGGTCGCGGTCGAACTGGCGGCGCTGCAGGCCGCCGAGAAGC
CTGCGGCTGAGCGTGTCCCGGTGGTGCTGTTCGCCGGCGACCATGGGATCGCGGCCCAGGGGGTCTCGGCCTATCCGCCG
GAAGTGACGGTGCAGATGCTGCACAATTTCGCCGGCGGCGGCGCGGCGATCGCGGTGCTGGCGCACAGCCTGGGATGTCC
GCTTGAGGTGGTCGACGTGGGCACGCTGGCGGATGGTCAGATGCGCGGCGTGGTCGTCGACAAGCCGCGGCGCGGCACGC
GCGATTTCAGCGTGGAGCAGGCGTTGACGCCGGCGGACGTGGCCTTTGTCTCGGAGGCGGGGCTACGGGCCGTCGCACGC
CAGGCCGACCACGCGCCTGACCTCGTGATCTTCGGCGAGATGGGCATCGGCAACACGACCTCAGCGGCGGCGATCGCGGC
TGCGCTGCTGGCGTGCGCGCCCGCCGACATCGTCGGTAGTGGCACAGGGCTTGATGCCGAGGGGCGAGCCCGAAAGGCAA
AGGTCATCGAGGACGCGTTGACGCGCCATGGCCTGACCGCGGCGACGCCTGTTGCGGAGGTGCTGGCGGCCGTCGGCGGC
CTGGAGATCATCGCGATGGCCGGGGCGATCGTCGCCGCCGCACAGCGGAGCTGGCCGGTCCTGGTCGACGGCTTCATCGT
CTCGGTCGCGGCGCTGGTGGCGACGAGGCTCAATCCGTCGTGCCGGCCCTGGCTGCTGTTCTCGCACCGCTCGGCCGAGC
GCGGCCATGCCGTGGTGCTCGACGCCCTTGGTGCCCGTCCGCTAATCGATCTCGATCTCCGGCTCGGCGAGGCCTCGGGC
GCTGCGACGGCGCTACCGATCCTGAGGCTCGCCTGCGCGCTTCACAACGGCATGGCCACCTTCGCGGAGGCGGCTGTCTC
GGGACGCGAGGCCTGA

Upstream 100 bases:

>100_bases
CCGGCTGTTTCACGTCCTGCACCTGACGCACGGCGGCGCTTGTCCTGGCCGTGATACGGTGGCAATCGTCCGGCACCGAG
CAACGCCAAAAGGACAGATC

Downstream 100 bases:

>100_bases
TGCGGCTCGACCTGCTGCGGCATGGCACCACCGGGCGCAACGGCCATCTCGACGGCCGCACCGATCCCCCGCTGAGCGAG
GCGGGTTGGGAGCAATTCCG

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MLPDWINSECPAPSGAHRESALARQAQLTKPLGALGRLEEVAVELAALQAAEKPAAERVPVVLFAGDHGIAAQGVSAYPP
EVTVQMLHNFAGGGAAIAVLAHSLGCPLEVVDVGTLADGQMRGVVVDKPRRGTRDFSVEQALTPADVAFVSEAGLRAVAR
QADHAPDLVIFGEMGIGNTTSAAAIAAALLACAPADIVGSGTGLDAEGRARKAKVIEDALTRHGLTAATPVAEVLAAVGG
LEIIAMAGAIVAAAQRSWPVLVDGFIVSVAALVATRLNPSCRPWLLFSHRSAERGHAVVLDALGARPLIDLDLRLGEASG
AATALPILRLACALHNGMATFAEAAVSGREA

Sequences:

>Translated_351_residues
MLPDWINSECPAPSGAHRESALARQAQLTKPLGALGRLEEVAVELAALQAAEKPAAERVPVVLFAGDHGIAAQGVSAYPP
EVTVQMLHNFAGGGAAIAVLAHSLGCPLEVVDVGTLADGQMRGVVVDKPRRGTRDFSVEQALTPADVAFVSEAGLRAVAR
QADHAPDLVIFGEMGIGNTTSAAAIAAALLACAPADIVGSGTGLDAEGRARKAKVIEDALTRHGLTAATPVAEVLAAVGG
LEIIAMAGAIVAAAQRSWPVLVDGFIVSVAALVATRLNPSCRPWLLFSHRSAERGHAVVLDALGARPLIDLDLRLGEASG
AATALPILRLACALHNGMATFAEAAVSGREA
>Mature_351_residues
MLPDWINSECPAPSGAHRESALARQAQLTKPLGALGRLEEVAVELAALQAAEKPAAERVPVVLFAGDHGIAAQGVSAYPP
EVTVQMLHNFAGGGAAIAVLAHSLGCPLEVVDVGTLADGQMRGVVVDKPRRGTRDFSVEQALTPADVAFVSEAGLRAVAR
QADHAPDLVIFGEMGIGNTTSAAAIAAALLACAPADIVGSGTGLDAEGRARKAKVIEDALTRHGLTAATPVAEVLAAVGG
LEIIAMAGAIVAAAQRSWPVLVDGFIVSVAALVATRLNPSCRPWLLFSHRSAERGHAVVLDALGARPLIDLDLRLGEASG
AATALPILRLACALHNGMATFAEAAVSGREA

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=349, Percent_Identity=33.2378223495702, Blast_Score=177, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_BRASO (A4YXK4)

Other databases:

- EMBL:   CU234118
- RefSeq:   YP_001206847.1
- ProteinModelPortal:   A4YXK4
- SMR:   A4YXK4
- STRING:   A4YXK4
- GeneID:   5116742
- GenomeReviews:   CU234118_GR
- KEGG:   bra:BRADO4918
- eggNOG:   COG2038
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- ProtClustDB:   PRK00105
- BioCyc:   BSP376:BRADO4918-MONOMER
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 35772; Mature: 35772

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: ACT_SITE 317-317

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPDWINSECPAPSGAHRESALARQAQLTKPLGALGRLEEVAVELAALQAAEKPAAERVP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
VVLFAGDHGIAAQGVSAYPPEVTVQMLHNFAGGGAAIAVLAHSLGCPLEVVDVGTLADGQ
EEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
MRGVVVDKPRRGTRDFSVEQALTPADVAFVSEAGLRAVARQADHAPDLVIFGEMGIGNTT
CCEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCH
SAAAIAAALLACAPADIVGSGTGLDAEGRARKAKVIEDALTRHGLTAATPVAEVLAAVGG
HHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
LEIIAMAGAIVAAAQRSWPVLVDGFIVSVAALVATRLNPSCRPWLLFSHRSAERGHAVVL
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEE
DALGARPLIDLDLRLGEASGAATALPILRLACALHNGMATFAEAAVSGREA
ECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MLPDWINSECPAPSGAHRESALARQAQLTKPLGALGRLEEVAVELAALQAAEKPAAERVP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
VVLFAGDHGIAAQGVSAYPPEVTVQMLHNFAGGGAAIAVLAHSLGCPLEVVDVGTLADGQ
EEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
MRGVVVDKPRRGTRDFSVEQALTPADVAFVSEAGLRAVARQADHAPDLVIFGEMGIGNTT
CCEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCH
SAAAIAAALLACAPADIVGSGTGLDAEGRARKAKVIEDALTRHGLTAATPVAEVLAAVGG
HHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
LEIIAMAGAIVAAAQRSWPVLVDGFIVSVAALVATRLNPSCRPWLLFSHRSAERGHAVVL
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEE
DALGARPLIDLDLRLGEASGAATALPILRLACALHNGMATFAEAAVSGREA
ECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA