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The map label for this gene is pyrC [H]

Identifier: 146341413

GI number: 146341413

Start: 4702268

End: 4703569

Strand: Direct

Name: pyrC [H]

Synonym: BRADO4503

Alternate gene names: 146341413

Gene position: 4702268-4703569 (Clockwise)

Preceding gene: 146341412

Following gene: 146341414

Centisome position: 63.06

GC content: 69.74

Gene sequence:

>1302_bases
ATGCTGACCGATCGCCGCCCGATCCTGCTCGCCAATGCGCGCGTCATCGATCCCTCCCGCGACATCGACGGTCCCGGTGA
CGTGCTGATCGCCGACGGCGTCATCCGCGACCTCAAGCGCGGCATCGGCGCGGCCGGCGTGCCCGAGGGAACCGACGTCG
TCAACTGCGCCGGCAAGATCGTCGCGCCCGGCCTGGTCGACATGTGCGCCTTCGTCGGCGAGCCCGGCCTCGGCCACCGC
GAGACCTTCGCGAGCGCCAGCCAGGCCGCGGCGACCGGCGGCATCACCACCATCATCTGCCAGCCCGGCACCGAGCCGGT
CATCGACAACTCCGCGACCGTCGACTTCGTTTTGCGCCGCGCCCGCGACACCGCGATCGTCAACATCCAGCCGATGGCGG
CGCTGACCAAGGGGCTGCGCGGCGAGGAGATGACCGAGATCGGTCTCTTGCGCGCCGCCGGCGCGGTGGCCTTCTCCAAC
GGCCATAGCAGCGTCATGAACGCCCAGGTGATGCGCCGGGCGCTGACCTATGCGCGCGACTTCGACGCGCTGATCGTGCA
TCACACCGAGGACCCCCACCTCGTCGGCGAAGGCGTCATGAACGAGGGCGAGTTTGCCTCGCGCCTCGGCCTGTCCGGCA
TTCCCGCCGCGGCGGAAGCCGTGGTGCTCGAACGCGACATGCGCCTCGTGGCGCTCACCAAGGGCCGCTACCACGCCGCA
GCGCTGAGTTCGGTCGACTCGCTCGATGTGCTCAAGCGCGCGCGCGACGCGGGCCTCGCGGTCAGCGCCTCGGTGTCGAT
CAACCACGTCACGCTGAACGAAAACGACATCGGTCCCTACCGCACCTTCCTCAAGCTGACGCCGCCGCTGCGCACCGAGG
TCGACCGCCGCGCGCTGGTCGAGGCGCTGGCCTCAGGGCTGATCGACGTCATCATGTCCGACCACAATCCGCAGGACGTC
GAGGTGAAGCGGCTGCCGTTCGCGGAAGCCGCCAGCGGCGCGGTGGGGTTGGAGACGATGCTCGCGGCCTCGCTGCGGCT
GGTGCACAGCGGCGAGCTGAGCTGGACCACGCTGATCCGCGCGATGTCCACGCGGCCTGCGGAACTGCTCGGCCTGCCCG
GCGGCACCTTGCGCGCCGGGGCGCCGGCCGACATCATCGTCATCGATCCGGACGTGCCCTGGATCCTCGATCCGGCCGAC
CTCAAATCGCTGTGCAAGAACACGCCGTTCGATGAAGCCCGCTTCACCGGTCGCGTGGTCCGCACGATCGTCGGCGGCCG
CACCGTGTTCGAACATGTCTGA

Upstream 100 bases:

>100_bases
GGGAACAGGTCGAAATGGGCGTCGCCGTGCGCATGGCCGTGCTCGAGGCGCTGGCCCGCAACCTGCCCAACGCTTGAGAT
CAAAGTCGGGACGAAACGAC

Downstream 100 bases:

>100_bases
CGCCGGACGAAGCGTCGAGGGAGTCGCGTGATGGGATCCGAAGCCATGCTGCCGGTCGCGCTGCTGATCGGCTATCTCCT
CGGTTCCATTCCATTCGGCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLTDRRPILLANARVIDPSRDIDGPGDVLIADGVIRDLKRGIGAAGVPEGTDVVNCAGKIVAPGLVDMCAFVGEPGLGHR
ETFASASQAAATGGITTIICQPGTEPVIDNSATVDFVLRRARDTAIVNIQPMAALTKGLRGEEMTEIGLLRAAGAVAFSN
GHSSVMNAQVMRRALTYARDFDALIVHHTEDPHLVGEGVMNEGEFASRLGLSGIPAAAEAVVLERDMRLVALTKGRYHAA
ALSSVDSLDVLKRARDAGLAVSASVSINHVTLNENDIGPYRTFLKLTPPLRTEVDRRALVEALASGLIDVIMSDHNPQDV
EVKRLPFAEAASGAVGLETMLAASLRLVHSGELSWTTLIRAMSTRPAELLGLPGGTLRAGAPADIIVIDPDVPWILDPAD
LKSLCKNTPFDEARFTGRVVRTIVGGRTVFEHV

Sequences:

>Translated_433_residues
MLTDRRPILLANARVIDPSRDIDGPGDVLIADGVIRDLKRGIGAAGVPEGTDVVNCAGKIVAPGLVDMCAFVGEPGLGHR
ETFASASQAAATGGITTIICQPGTEPVIDNSATVDFVLRRARDTAIVNIQPMAALTKGLRGEEMTEIGLLRAAGAVAFSN
GHSSVMNAQVMRRALTYARDFDALIVHHTEDPHLVGEGVMNEGEFASRLGLSGIPAAAEAVVLERDMRLVALTKGRYHAA
ALSSVDSLDVLKRARDAGLAVSASVSINHVTLNENDIGPYRTFLKLTPPLRTEVDRRALVEALASGLIDVIMSDHNPQDV
EVKRLPFAEAASGAVGLETMLAASLRLVHSGELSWTTLIRAMSTRPAELLGLPGGTLRAGAPADIIVIDPDVPWILDPAD
LKSLCKNTPFDEARFTGRVVRTIVGGRTVFEHV
>Mature_433_residues
MLTDRRPILLANARVIDPSRDIDGPGDVLIADGVIRDLKRGIGAAGVPEGTDVVNCAGKIVAPGLVDMCAFVGEPGLGHR
ETFASASQAAATGGITTIICQPGTEPVIDNSATVDFVLRRARDTAIVNIQPMAALTKGLRGEEMTEIGLLRAAGAVAFSN
GHSSVMNAQVMRRALTYARDFDALIVHHTEDPHLVGEGVMNEGEFASRLGLSGIPAAAEAVVLERDMRLVALTKGRYHAA
ALSSVDSLDVLKRARDAGLAVSASVSINHVTLNENDIGPYRTFLKLTPPLRTEVDRRALVEALASGLIDVIMSDHNPQDV
EVKRLPFAEAASGAVGLETMLAASLRLVHSGELSWTTLIRAMSTRPAELLGLPGGTLRAGAPADIIVIDPDVPWILDPAD
LKSLCKNTPFDEARFTGRVVRTIVGGRTVFEHV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=389, Percent_Identity=25.9640102827763, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1786722, Length=419, Percent_Identity=24.582338902148, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082175, Length=444, Percent_Identity=24.5495495495495, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=372, Percent_Identity=26.0752688172043, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI86575075, Length=442, Percent_Identity=25.1131221719457, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=402, Percent_Identity=24.8756218905473, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24642586, Length=410, Percent_Identity=23.1707317073171, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18859883, Length=442, Percent_Identity=25.5656108597285, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45822; Mature: 45822

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDRRPILLANARVIDPSRDIDGPGDVLIADGVIRDLKRGIGAAGVPEGTDVVNCAGKI
CCCCCCCEEEECCEEECCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
VAPGLVDMCAFVGEPGLGHRETFASASQAAATGGITTIICQPGTEPVIDNSATVDFVLRR
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHH
ARDTAIVNIQPMAALTKGLRGEEMTEIGLLRAAGAVAFSNGHSSVMNAQVMRRALTYARD
CCCCEEEEECHHHHHHCCCCCCHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHCC
FDALIVHHTEDPHLVGEGVMNEGEFASRLGLSGIPAAAEAVVLERDMRLVALTKGRYHAA
CCEEEEEECCCCCEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCHHHH
ALSSVDSLDVLKRARDAGLAVSASVSINHVTLNENDIGPYRTFLKLTPPLRTEVDRRALV
HHHCCHHHHHHHHHHHCCEEEEEEEEEEEEEECCCCCCHHHHHEECCCCHHHHHHHHHHH
EALASGLIDVIMSDHNPQDVEVKRLPFAEAASGAVGLETMLAASLRLVHSGELSWTTLIR
HHHHHHHHHHHHCCCCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
AMSTRPAELLGLPGGTLRAGAPADIIVIDPDVPWILDPADLKSLCKNTPFDEARFTGRVV
HHCCCCHHHEECCCCCCCCCCCCEEEEECCCCCEEECHHHHHHHHCCCCCCHHHHHHHHH
RTIVGGRTVFEHV
HHHHCCHHHHHCC
>Mature Secondary Structure
MLTDRRPILLANARVIDPSRDIDGPGDVLIADGVIRDLKRGIGAAGVPEGTDVVNCAGKI
CCCCCCCEEEECCEEECCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
VAPGLVDMCAFVGEPGLGHRETFASASQAAATGGITTIICQPGTEPVIDNSATVDFVLRR
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHH
ARDTAIVNIQPMAALTKGLRGEEMTEIGLLRAAGAVAFSNGHSSVMNAQVMRRALTYARD
CCCCEEEEECHHHHHHCCCCCCHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHCC
FDALIVHHTEDPHLVGEGVMNEGEFASRLGLSGIPAAAEAVVLERDMRLVALTKGRYHAA
CCEEEEEECCCCCEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCHHHH
ALSSVDSLDVLKRARDAGLAVSASVSINHVTLNENDIGPYRTFLKLTPPLRTEVDRRALV
HHHCCHHHHHHHHHHHCCEEEEEEEEEEEEEECCCCCCHHHHHEECCCCHHHHHHHHHHH
EALASGLIDVIMSDHNPQDVEVKRLPFAEAASGAVGLETMLAASLRLVHSGELSWTTLIR
HHHHHHHHHHHHCCCCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
AMSTRPAELLGLPGGTLRAGAPADIIVIDPDVPWILDPADLKSLCKNTPFDEARFTGRVV
HHCCCCHHHEECCCCCCCCCCCCEEEEECCCCCEEECHHHHHHHHCCCCCCHHHHHHHHH
RTIVGGRTVFEHV
HHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA