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The map label for this gene is clpP [H]

Identifier: 146341127

GI number: 146341127

Start: 4399096

End: 4399728

Strand: Reverse

Name: clpP [H]

Synonym: BRADO4198

Alternate gene names: 146341127

Gene position: 4399728-4399096 (Counterclockwise)

Preceding gene: 146341129

Following gene: 146341126

Centisome position: 59.0

GC content: 63.35

Gene sequence:

>633_bases
ATGCGCGATCCCGTTGAAACCTATATGAACCTTGTGCCCATGGTGGTCGAACAGACCAACCGCGGTGAGCGCGCCTACGA
CATCTTCTCGCGCCTCCTGAAGGAGCGCATCATCTTCGTGACCGGCCCGGTCGAAGACGGCATGGCGACGCTGATCGTCG
CGCAGCTGCTCTTCCTCGAGGCCGAGAACCCGAAGAAGGAGATCGCGATGTACATCAACTCGCCGGGCGGCGTGGTGACG
TCGGGTCTCGCGATCTACGACACGATGCAGTTCATCCGTCCGGCGGTGTCGACGCTGTGCACCGGCCAAGCCGCCTCGAT
GGGCTCGCTGCTGCTCTGCGCCGGCCACAAGGACATGCGCTTCTCGCTGCCGAACTCGCGCATCATGGTGCATCAGCCGT
CCGGCGGCTTCCAGGGCCAGGCGACCGATATCATGCTGCACGCCCAGGAGATCCTGAGCCTCAAGAAGCGGCTCAACGAG
ATCTACGTGAAGCATACCGGCCAGCCGTACAAGGCGATCGAGGATGCGCTGGAACGCGACAAATTCCTGACGGCGGAAGC
CGCCCAGGAGTTCGGGCTCATCGACAAGGTGCTCGACAAGCGGCCGGAAGACCCGGCGGCGATGGGCAAGTGA

Upstream 100 bases:

>100_bases
GTTCTGCATCACGGGGCCACTGTCCGTCGCTGCTCGCTGAACGAGCCTCACCTGCGGCGGCCAGTCGTCTTCAACTGCTG
GTCCAACCCTTGGGTGATTC

Downstream 100 bases:

>100_bases
GCCGTAGCTGAGTAAGGCGAGGTCCGTGCGACGGGCCTCGGTGCATCACGGCATCGCCTTTGCCGGCTCCGGCCGGCGAA
GGTACTAAGGTGGGGTCCCA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVTGPVEDGMATLIVAQLLFLEAENPKKEIAMYINSPGGVVT
SGLAIYDTMQFIRPAVSTLCTGQAASMGSLLLCAGHKDMRFSLPNSRIMVHQPSGGFQGQATDIMLHAQEILSLKKRLNE
IYVKHTGQPYKAIEDALERDKFLTAEAAQEFGLIDKVLDKRPEDPAAMGK

Sequences:

>Translated_210_residues
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVTGPVEDGMATLIVAQLLFLEAENPKKEIAMYINSPGGVVT
SGLAIYDTMQFIRPAVSTLCTGQAASMGSLLLCAGHKDMRFSLPNSRIMVHQPSGGFQGQATDIMLHAQEILSLKKRLNE
IYVKHTGQPYKAIEDALERDKFLTAEAAQEFGLIDKVLDKRPEDPAAMGK
>Mature_210_residues
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVTGPVEDGMATLIVAQLLFLEAENPKKEIAMYINSPGGVVT
SGLAIYDTMQFIRPAVSTLCTGQAASMGSLLLCAGHKDMRFSLPNSRIMVHQPSGGFQGQATDIMLHAQEILSLKKRLNE
IYVKHTGQPYKAIEDALERDKFLTAEAAQEFGLIDKVLDKRPEDPAAMGK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=64.2857142857143, Blast_Score=269, Evalue=1e-72,
Organism=Escherichia coli, GI1786641, Length=200, Percent_Identity=65.5, Blast_Score=283, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=60.2150537634409, Blast_Score=243, Evalue=5e-65,
Organism=Drosophila melanogaster, GI20129427, Length=201, Percent_Identity=61.1940298507463, Blast_Score=268, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23304; Mature: 23304

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVTGPVEDGMATLIVAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHC
AENPKKEIAMYINSPGGVVTSGLAIYDTMQFIRPAVSTLCTGQAASMGSLLLCAGHKDMR
CCCCHHHEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEE
FSLPNSRIMVHQPSGGFQGQATDIMLHAQEILSLKKRLNEIYVKHTGQPYKAIEDALERD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KFLTAEAAQEFGLIDKVLDKRPEDPAAMGK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVTGPVEDGMATLIVAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHC
AENPKKEIAMYINSPGGVVTSGLAIYDTMQFIRPAVSTLCTGQAASMGSLLLCAGHKDMR
CCCCHHHEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEE
FSLPNSRIMVHQPSGGFQGQATDIMLHAQEILSLKKRLNEIYVKHTGQPYKAIEDALERD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KFLTAEAAQEFGLIDKVLDKRPEDPAAMGK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA