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The map label for this gene is lon [H]

Identifier: 146341125

GI number: 146341125

Start: 4394627

End: 4397050

Strand: Reverse

Name: lon [H]

Synonym: BRADO4196

Alternate gene names: 146341125

Gene position: 4397050-4394627 (Counterclockwise)

Preceding gene: 146341126

Following gene: 146341123

Centisome position: 58.97

GC content: 63.74

Gene sequence:

>2424_bases
ATGACGACCCCCAAACCCCGGCCGACCATCGTCTACGGCGAGAGCCACGCCTATCCGGTGCTGCCGCTCCGCGACATCGT
CGTCTTCCCGCACAACATCGTTCCGCTGTTCGTCGGCCGCGAGAAATCGATCCGCGCCCTCGAAGAGGTGATGAAGAACG
ACGCGCTCGTGATGCTGGCGACGCAGAAGAACGCGTCCGATGATGATCCAGCTCCGGATGCGATCTACGAGACCGGGACG
CTCGCCAGCGTGCTGCAACTCCTCAAGCTGCCCGACGGCACCGTGAAGGTGCTGGTCGAGGGCCTGGAGCGCGCGCGCGT
CGAGAAGTACACCGATCGCGCCGACTACTACGAAGCGACTGCCGTTGCGCTCGAGGACACCGACGCCAAGTCGGTGGAAG
CCGAGGCGCTGGGCCGCTCCGTCGTGTCGGACTTCGAGAGCTATGTGAAGCTGAACAAGAAGATCTCGGCGGAGGTCGTC
GGCGTCGTTCAGTCGATCACCGATTTCGGCAAGCTGGCCGACACGGTCGCCTCGCATCTTGCCGTCAAGATCGCCGATCG
CCAGGGCATCCTGGAGACGCTGTCCGTCACCACGCGCCTGGAGAAGGTGCTGGGCCTGATGGAGAGTGAGATCTCGGTCT
TGCAGGTCGAGAAGCGCATCCGCTCGCGCGTGAAGCGCCAGATGGAGAAGACCCAGCGCGAGTACTACCTGAATGAGCAG
ATGAAGGCCATTCAGAAGGAGTTGGGCGACGAGGACGGCCGCGACGAGCTCGCCGATCTGGAAGAGCGCATCAACAAGAC
CAAGCTCTCCAAGGAAGCGCGCGAGAAGGCCCAGCACGAGCTGAAGAAGCTGCGCCAGATGTCGCCGATGTCCGCGGAAG
CGACCGTCGTGCGCAACTACCTGGATTGGCTGCTGTCGATTCCGTGGAACAAGAAGTCCAAGGTGAAGAAGGATCTGGAG
GCCGCGCAGGCGGTCCTGGATGCGGATCACTATGGTCTGGAGAAGGTCAAGGACCGCATCGTCGAGTATCTCGCGGTGCA
GTCGCGCGCCAACAAGCTGACCGGCCCGATCCTGTGCCTGGTCGGACCTCCCGGCGTCGGCAAGACCTCGCTCGGCAAGT
CGATCGCGAAGGCGACGGGGCGCGAATTCGTTCGCGTGTCGCTCGGCGGCGTGCGCGACGAGGCGGAGATCCGCGGCCAT
CGCCGGACCTATATCGGTTCGATGCCCGGCAAGATCATCCAGTCGATGCGCAAGGCCAAGACCTCGAACCCGCTCTTCCT
GCTGGACGAGATCGACAAGATGGGCTCGGACTTCCGGGGTGACCCGTCGTCGGCGCTGCTGGAGGTCCTCGACCCCGAGC
AGAACACGACGTTCAACGATCACTATCTGGAGGTCGACTACGATCTGTCGAACGTCATGTTCATCACGACCGCGAATACG
TTGAATATTCCCGGACCGCTGATGGACCGCATGGAGATCATCCGCATCGCGGGCTACACCGAGACCGAGAAGGTCGAGAT
CGCCCGCAAGCACCTGATCCCCAGCGCGATCTCCAAGCACGGCCTGGACTCGAAAGAGTGGTCGATCGACGACGACGCGC
TGCTGCTCGTGATCCGGCGCTACACCCGCGAGGCGGGCGTGCGTAACCTGGAGCGTGAGATTTCCACACTGGCCCGCAAG
GCCGTGAAGGAGCTCATGATGTCCAAGAAGAAGTCGGTGAAGATCACCGAGAAGACCGTTGAGGAATTCTTGGGTGTTCC
GAAGTACCGCTTCGGCGAGATCGAGAGCGACGACCAGGTTGGCATCGTGACGGGCTTGGCCTGGACCGATGTCGGCGGCG
AGCTGCTGACGATCGAAGGCGTCATGATGCCTGGCAAGGGCAAGATGACGGTGACGGGCAATCTGCGCGACGTCATGAAG
GAGTCGATCTCGGCGGCGGCCTCGTTCGTCCGCTCCAGGGCGATCAACTACGGCATCGAGCCGCCGTTGTTCGACCGGCG
CGACATCCACGTCCACGTGCCGGAGGGGGCGACCCCGAAGGACGGCCCCTCGGCCGGCGTGGCCATGGCGACGACCATCA
TCTCGGTGATGACCGGCATTCCGGTTCGTCACGACGTCGCGATGACCGGCGAGATCACCTTGCGTGGTCGCGTGCTGCCG
ATCGGCGGTCTGAAGGAGAAGCTCTTGGCGGCCGCTCGCGGCGGCATCAAGACGGTGCTGATCCCCGAGGACAACGCCAA
GGATCTCACGGAGATTTCCGATGCGATCAAGGGCGGCATGGAGATCATCCCGGTCTCCCGTCTCGACGACGTCGTCGCCC
GGGCCCTGGTCCGCAAGCCCGTGCCGATCGTCTGGGAGGAGGACACCAAGGTGCCCGTGAAGGCCGATGGCGACGAAGCC
GCCGGCGGCCTGACCGCCCACTGA

Upstream 100 bases:

>100_bases
GATATCGACGCGTCAGTGAAGTCCGGATCAGATCGCACCTTGTGGCGGTTGCGCACGATGGCGGACTGCGTGCAAGGGGG
CTAAACAAAAGGAACAGGCC

Downstream 100 bases:

>100_bases
AGGCTGAAGTGATCCAGGGAAGCGGCGCCCGAAAGGGCGCCGTTTTCGTTTGCGGGGTGACCCTCGCTTGCCCGGGCGCC
CGAAGGTCGCGCCCGCCAGC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MTTPKPRPTIVYGESHAYPVLPLRDIVVFPHNIVPLFVGREKSIRALEEVMKNDALVMLATQKNASDDDPAPDAIYETGT
LASVLQLLKLPDGTVKVLVEGLERARVEKYTDRADYYEATAVALEDTDAKSVEAEALGRSVVSDFESYVKLNKKISAEVV
GVVQSITDFGKLADTVASHLAVKIADRQGILETLSVTTRLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQ
MKAIQKELGDEDGRDELADLEERINKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNYLDWLLSIPWNKKSKVKKDLE
AAQAVLDADHYGLEKVKDRIVEYLAVQSRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGH
RRTYIGSMPGKIIQSMRKAKTSNPLFLLDEIDKMGSDFRGDPSSALLEVLDPEQNTTFNDHYLEVDYDLSNVMFITTANT
LNIPGPLMDRMEIIRIAGYTETEKVEIARKHLIPSAISKHGLDSKEWSIDDDALLLVIRRYTREAGVRNLEREISTLARK
AVKELMMSKKKSVKITEKTVEEFLGVPKYRFGEIESDDQVGIVTGLAWTDVGGELLTIEGVMMPGKGKMTVTGNLRDVMK
ESISAAASFVRSRAINYGIEPPLFDRRDIHVHVPEGATPKDGPSAGVAMATTIISVMTGIPVRHDVAMTGEITLRGRVLP
IGGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGMEIIPVSRLDDVVARALVRKPVPIVWEEDTKVPVKADGDEA
AGGLTAH

Sequences:

>Translated_807_residues
MTTPKPRPTIVYGESHAYPVLPLRDIVVFPHNIVPLFVGREKSIRALEEVMKNDALVMLATQKNASDDDPAPDAIYETGT
LASVLQLLKLPDGTVKVLVEGLERARVEKYTDRADYYEATAVALEDTDAKSVEAEALGRSVVSDFESYVKLNKKISAEVV
GVVQSITDFGKLADTVASHLAVKIADRQGILETLSVTTRLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQ
MKAIQKELGDEDGRDELADLEERINKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNYLDWLLSIPWNKKSKVKKDLE
AAQAVLDADHYGLEKVKDRIVEYLAVQSRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGH
RRTYIGSMPGKIIQSMRKAKTSNPLFLLDEIDKMGSDFRGDPSSALLEVLDPEQNTTFNDHYLEVDYDLSNVMFITTANT
LNIPGPLMDRMEIIRIAGYTETEKVEIARKHLIPSAISKHGLDSKEWSIDDDALLLVIRRYTREAGVRNLEREISTLARK
AVKELMMSKKKSVKITEKTVEEFLGVPKYRFGEIESDDQVGIVTGLAWTDVGGELLTIEGVMMPGKGKMTVTGNLRDVMK
ESISAAASFVRSRAINYGIEPPLFDRRDIHVHVPEGATPKDGPSAGVAMATTIISVMTGIPVRHDVAMTGEITLRGRVLP
IGGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGMEIIPVSRLDDVVARALVRKPVPIVWEEDTKVPVKADGDEA
AGGLTAH
>Mature_806_residues
TTPKPRPTIVYGESHAYPVLPLRDIVVFPHNIVPLFVGREKSIRALEEVMKNDALVMLATQKNASDDDPAPDAIYETGTL
ASVLQLLKLPDGTVKVLVEGLERARVEKYTDRADYYEATAVALEDTDAKSVEAEALGRSVVSDFESYVKLNKKISAEVVG
VVQSITDFGKLADTVASHLAVKIADRQGILETLSVTTRLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQM
KAIQKELGDEDGRDELADLEERINKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNYLDWLLSIPWNKKSKVKKDLEA
AQAVLDADHYGLEKVKDRIVEYLAVQSRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGHR
RTYIGSMPGKIIQSMRKAKTSNPLFLLDEIDKMGSDFRGDPSSALLEVLDPEQNTTFNDHYLEVDYDLSNVMFITTANTL
NIPGPLMDRMEIIRIAGYTETEKVEIARKHLIPSAISKHGLDSKEWSIDDDALLLVIRRYTREAGVRNLEREISTLARKA
VKELMMSKKKSVKITEKTVEEFLGVPKYRFGEIESDDQVGIVTGLAWTDVGGELLTIEGVMMPGKGKMTVTGNLRDVMKE
SISAAASFVRSRAINYGIEPPLFDRRDIHVHVPEGATPKDGPSAGVAMATTIISVMTGIPVRHDVAMTGEITLRGRVLPI
GGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGMEIIPVSRLDDVVARALVRKPVPIVWEEDTKVPVKADGDEAA
GGLTAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=646, Percent_Identity=42.5696594427245, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=45.6483126110124, Blast_Score=512, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=63.0890052356021, Blast_Score=992, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=695, Percent_Identity=40.1438848920863, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=800, Percent_Identity=33.375, Blast_Score=445, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319449, Length=720, Percent_Identity=41.1111111111111, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221513036, Length=621, Percent_Identity=44.7665056360709, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24666867, Length=621, Percent_Identity=44.7665056360709, Blast_Score=515, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89083; Mature: 88952

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPKPRPTIVYGESHAYPVLPLRDIVVFPHNIVPLFVGREKSIRALEEVMKNDALVMLA
CCCCCCCCEEEECCCCCCCCCCHHHEEECCCCCEEEEECCCHHHHHHHHHHCCCCEEEEE
TQKNASDDDPAPDAIYETGTLASVLQLLKLPDGTVKVLVEGLERARVEKYTDRADYYEAT
ECCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AVALEDTDAKSVEAEALGRSVVSDFESYVKLNKKISAEVVGVVQSITDFGKLADTVASHL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKIADRQGILETLSVTTRLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQ
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAIQKELGDEDGRDELADLEERINKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LDWLLSIPWNKKSKVKKDLEAAQAVLDADHYGLEKVKDRIVEYLAVQSRANKLTGPILCL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAK
ECCCCCCHHHHHHHHHHHCCHHEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHC
TSNPLFLLDEIDKMGSDFRGDPSSALLEVLDPEQNTTFNDHYLEVDYDLSNVMFITTANT
CCCCEEEHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCC
LNIPGPLMDRMEIIRIAGYTETEKVEIARKHLIPSAISKHGLDSKEWSIDDDALLLVIRR
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCHHHHHHHHH
YTREAGVRNLEREISTLARKAVKELMMSKKKSVKITEKTVEEFLGVPKYRFGEIESDDQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCE
GIVTGLAWTDVGGELLTIEGVMMPGKGKMTVTGNLRDVMKESISAAASFVRSRAINYGIE
EEEEEEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCC
PPLFDRRDIHVHVPEGATPKDGPSAGVAMATTIISVMTGIPVRHDVAMTGEITLRGRVLP
CCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEEE
IGGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGMEIIPVSRLDDVVARALVRKP
CCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCC
VPIVWEEDTKVPVKADGDEAAGGLTAH
CCEEECCCCCCCEECCCCCCCCCCCCC
>Mature Secondary Structure 
TTPKPRPTIVYGESHAYPVLPLRDIVVFPHNIVPLFVGREKSIRALEEVMKNDALVMLA
CCCCCCCEEEECCCCCCCCCCHHHEEECCCCCEEEEECCCHHHHHHHHHHCCCCEEEEE
TQKNASDDDPAPDAIYETGTLASVLQLLKLPDGTVKVLVEGLERARVEKYTDRADYYEAT
ECCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AVALEDTDAKSVEAEALGRSVVSDFESYVKLNKKISAEVVGVVQSITDFGKLADTVASHL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKIADRQGILETLSVTTRLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQ
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAIQKELGDEDGRDELADLEERINKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LDWLLSIPWNKKSKVKKDLEAAQAVLDADHYGLEKVKDRIVEYLAVQSRANKLTGPILCL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAK
ECCCCCCHHHHHHHHHHHCCHHEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHC
TSNPLFLLDEIDKMGSDFRGDPSSALLEVLDPEQNTTFNDHYLEVDYDLSNVMFITTANT
CCCCEEEHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCC
LNIPGPLMDRMEIIRIAGYTETEKVEIARKHLIPSAISKHGLDSKEWSIDDDALLLVIRR
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCHHHHHHHHH
YTREAGVRNLEREISTLARKAVKELMMSKKKSVKITEKTVEEFLGVPKYRFGEIESDDQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCE
GIVTGLAWTDVGGELLTIEGVMMPGKGKMTVTGNLRDVMKESISAAASFVRSRAINYGIE
EEEEEEEEECCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCC
PPLFDRRDIHVHVPEGATPKDGPSAGVAMATTIISVMTGIPVRHDVAMTGEITLRGRVLP
CCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEEE
IGGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGMEIIPVSRLDDVVARALVRKP
CCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCC
VPIVWEEDTKVPVKADGDEAAGGLTAH
CCEEECCCCCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA