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The map label for this gene is pbpC [H]

Identifier: 146340857

GI number: 146340857

Start: 4099664

End: 4101868

Strand: Reverse

Name: pbpC [H]

Synonym: BRADO3920

Alternate gene names: 146340857

Gene position: 4101868-4099664 (Counterclockwise)

Preceding gene: 146340858

Following gene: 146340856

Centisome position: 55.01

GC content: 68.84

Gene sequence:

>2205_bases
ATGGCACGCCGGAGCCACACACTCAGCCGTCATGCCCGGGCTTGTCCCGGGCATCCACGTCGGATGTCGCATACGCCGAA
CGACGTGGATGGCCGGGACAAGCCCGGCCATGACGGGAGGAGAGGGCGGGGCGTCAAACGGCTGCTTGCAGCTGCGCTCT
CGGTTGTCGCGTTGGCGGCCGTTGCCCTCACGACCTACACCGTCTCCCTCGGCCCGCTGCCGCTCCAAGAGGCCAAGGCG
CTGTCGACCACCGTGGTCGACCGCCACGGCAAGCTGCTGCGCGCCTATGCGATGGCGGATGGGCGGTGGCGGCTGCCGGT
CAGTGCGAGGAAGGACGTCGATCCGACCTATCTGAAGCTGCTGTTCGCCTACGAGGACCAGCGCTTCTCCGACCATCACG
GCGTCGACCCGCGGGCGCTGGCGCGCGCCGCGATCCAGTTCGGCTCGAACGGCCACATCGTCTCGGGCGGCTCGACCATC
ACGATGCAGCTGGCGCGGCTGCTCGAGCCCAGGCGTCAGCGATCGCTGCATGCCAAGCTGAGGCAGATCGTGCGCGCGCT
CGAGCTCGAGCGGAAGCTCAGCAAGGACGAGATTCTCGATCTCTATCTGACGCTCGCGCCTTACGGCGGCAATCTCGAAG
GCATCCGCGCCGCCTCCATCGCCTATTTCGGCAAGGAGCCGAAGCGGCTGTCGCTGGCGGAAGCCGCGCTGCTGGTGGCG
CTGCCGCAGTCGCCGGAGACGCGCCGGCTCGACCGCCATCTCGAGGCCGCGCGGCGCGGGCGCGATCGCGTGCTCGACCG
CATGGTCTCGGAGAACGTGATCTCCGCCGAGGAGGCCGCGCAGGCCAAGGCGCAGCCTGTACCGGCCTTCCGCAATCCAA
TGCCCATCCTGGCGCCGCATGCCGCCGACCAGGCCATGGCGCTCGTGAAGGACCAGCCGATCATCCGCCTGACGCTCGAT
TCGACCTTGCAGAAGGTGCTGGAGCCGCTGGCGCGCGATCGCGCGGTGGCGCTGGGGCCGAACGTCTCGGTCGGCATCAT
CGTCATCGATAATGACAGCGGCGATGTGCTCGCCCATGTCGGCTCCGCGGACTACTTCGATGAAAAGCGGGCGGGGCAGG
TCGACATGACCCGCGCGGTGCGTTCGCCGGGCTCGACGCTCAAGCCCTTCATCTATGGGCTCGCCTTCGAGGATGGTTTC
GTGCATCCGGAGAGCCTGATCGAGGACCGTCCGGTGCGCTTCGGTTCCTATGCGCCCGAGAATTTCGACATGACGTTCCA
GGGCACCGTGCCCGTGCGCAAGGCGCTGCAGCTGTCCCTGAACGTCCCCGCGATCGTGCTGCTCGATCGCGTCGGCGCCA
GCCGGCTGTCGTCGCGGCTGAAGCAGGCCGGCGGCAATCTCGTGTTGCCGAAGGACGAGGCACCGGGTCTCGCCATGGGT
CTTGGCGGCGTCGGCGTGAGCCTGCAGGATCTCGCGCAGCTCTATGCGGGGTTCCCGCGGCTCGGCACGACCAAGCCGCT
GCGCGAGATCATGACGGCTGATGAGAAGGACGATGCGCGCGAGCCGATGCGGCTGATGGATCCGGCCGCCGCGTGGCAGG
TGGGCAACGTGCTGCTCGGCACGCCGCCGCCGGAGAACGCTGCGCGCAACCGCATCGCGTTCAAGACCGGCACAAGCTAT
GGCTATCGCGACGCTTGGTCGGTCGGCTTCGACGGCCGCGTCACGATCGGCGTCTGGGTCGGCCGTCCCGACGGCGCGCC
AGTGCCCGGACTGATCGGTCGCGTCGCCGCGGCGCCGATCCTGTTCGATGCCTTCGCGCGCTCAGGCAAGCTGCCGGTCG
CCTTGCCCAAGCCGCCCAAGGGTGCGCTGGTCGCCAGCAATTCGAAGTTGCCGTTGCCGCTGCGCCGGTTCCGCCCGATC
GGCGAACTCGTGCGCAGCGGCGCGGAGCAGGCGCCGCACATCCAGTTTCCGCTGAACGGCTCGCGCATCGATGTCGACCG
CTCGGCCGGCCCTGAAGCGTCGGTGATGCCGGTGAAAGTCTCGGGCGGCGTGCTGCCGCTGACGATGATGGTCAACGGCC
TGCGGGTCGGCGAGATCGACAGCCGGCGCCAGCGCCTGATCGATCCGCCCGGGCCGGGCTTTGCGCGCCTCACCGTGATC
GACGCCACGGGCGCTGCGGACACAGTTGTGGTCAGAATCCAGTGA

Upstream 100 bases:

>100_bases
CGGGACAGGCGCCGTGGAGGTCCGCGCAGCGAAATGAGCGAGGGTGGAACGAGCGGTGATGGACTGATGACGGAGCCGCA
CACTCCCTCATCGCAATTGG

Downstream 100 bases:

>100_bases
CCGTTCGCTAAGCGGTTGTCGGCATGGTGGTTTCAGCGTATTCGGAACCCCATGGTCGAGACCTATGCCCGCCCCCGTTT
TGGAGAGCCGCGCGAGCCGA

Product: penicillin-binding protein 1C (PBP-1C)/penicillin-insensitive transglycosylase/transpeptidase-like protein

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 734; Mature: 733

Protein sequence:

>734_residues
MARRSHTLSRHARACPGHPRRMSHTPNDVDGRDKPGHDGRRGRGVKRLLAAALSVVALAAVALTTYTVSLGPLPLQEAKA
LSTTVVDRHGKLLRAYAMADGRWRLPVSARKDVDPTYLKLLFAYEDQRFSDHHGVDPRALARAAIQFGSNGHIVSGGSTI
TMQLARLLEPRRQRSLHAKLRQIVRALELERKLSKDEILDLYLTLAPYGGNLEGIRAASIAYFGKEPKRLSLAEAALLVA
LPQSPETRRLDRHLEAARRGRDRVLDRMVSENVISAEEAAQAKAQPVPAFRNPMPILAPHAADQAMALVKDQPIIRLTLD
STLQKVLEPLARDRAVALGPNVSVGIIVIDNDSGDVLAHVGSADYFDEKRAGQVDMTRAVRSPGSTLKPFIYGLAFEDGF
VHPESLIEDRPVRFGSYAPENFDMTFQGTVPVRKALQLSLNVPAIVLLDRVGASRLSSRLKQAGGNLVLPKDEAPGLAMG
LGGVGVSLQDLAQLYAGFPRLGTTKPLREIMTADEKDDAREPMRLMDPAAAWQVGNVLLGTPPPENAARNRIAFKTGTSY
GYRDAWSVGFDGRVTIGVWVGRPDGAPVPGLIGRVAAAPILFDAFARSGKLPVALPKPPKGALVASNSKLPLPLRRFRPI
GELVRSGAEQAPHIQFPLNGSRIDVDRSAGPEASVMPVKVSGGVLPLTMMVNGLRVGEIDSRRQRLIDPPGPGFARLTVI
DATGAADTVVVRIQ

Sequences:

>Translated_734_residues
MARRSHTLSRHARACPGHPRRMSHTPNDVDGRDKPGHDGRRGRGVKRLLAAALSVVALAAVALTTYTVSLGPLPLQEAKA
LSTTVVDRHGKLLRAYAMADGRWRLPVSARKDVDPTYLKLLFAYEDQRFSDHHGVDPRALARAAIQFGSNGHIVSGGSTI
TMQLARLLEPRRQRSLHAKLRQIVRALELERKLSKDEILDLYLTLAPYGGNLEGIRAASIAYFGKEPKRLSLAEAALLVA
LPQSPETRRLDRHLEAARRGRDRVLDRMVSENVISAEEAAQAKAQPVPAFRNPMPILAPHAADQAMALVKDQPIIRLTLD
STLQKVLEPLARDRAVALGPNVSVGIIVIDNDSGDVLAHVGSADYFDEKRAGQVDMTRAVRSPGSTLKPFIYGLAFEDGF
VHPESLIEDRPVRFGSYAPENFDMTFQGTVPVRKALQLSLNVPAIVLLDRVGASRLSSRLKQAGGNLVLPKDEAPGLAMG
LGGVGVSLQDLAQLYAGFPRLGTTKPLREIMTADEKDDAREPMRLMDPAAAWQVGNVLLGTPPPENAARNRIAFKTGTSY
GYRDAWSVGFDGRVTIGVWVGRPDGAPVPGLIGRVAAAPILFDAFARSGKLPVALPKPPKGALVASNSKLPLPLRRFRPI
GELVRSGAEQAPHIQFPLNGSRIDVDRSAGPEASVMPVKVSGGVLPLTMMVNGLRVGEIDSRRQRLIDPPGPGFARLTVI
DATGAADTVVVRIQ
>Mature_733_residues
ARRSHTLSRHARACPGHPRRMSHTPNDVDGRDKPGHDGRRGRGVKRLLAAALSVVALAAVALTTYTVSLGPLPLQEAKAL
STTVVDRHGKLLRAYAMADGRWRLPVSARKDVDPTYLKLLFAYEDQRFSDHHGVDPRALARAAIQFGSNGHIVSGGSTIT
MQLARLLEPRRQRSLHAKLRQIVRALELERKLSKDEILDLYLTLAPYGGNLEGIRAASIAYFGKEPKRLSLAEAALLVAL
PQSPETRRLDRHLEAARRGRDRVLDRMVSENVISAEEAAQAKAQPVPAFRNPMPILAPHAADQAMALVKDQPIIRLTLDS
TLQKVLEPLARDRAVALGPNVSVGIIVIDNDSGDVLAHVGSADYFDEKRAGQVDMTRAVRSPGSTLKPFIYGLAFEDGFV
HPESLIEDRPVRFGSYAPENFDMTFQGTVPVRKALQLSLNVPAIVLLDRVGASRLSSRLKQAGGNLVLPKDEAPGLAMGL
GGVGVSLQDLAQLYAGFPRLGTTKPLREIMTADEKDDAREPMRLMDPAAAWQVGNVLLGTPPPENAARNRIAFKTGTSYG
YRDAWSVGFDGRVTIGVWVGRPDGAPVPGLIGRVAAAPILFDAFARSGKLPVALPKPPKGALVASNSKLPLPLRRFRPIG
ELVRSGAEQAPHIQFPLNGSRIDVDRSAGPEASVMPVKVSGGVLPLTMMVNGLRVGEIDSRRQRLIDPPGPGFARLTVID
ATGAADTVVVRIQ

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=578, Percent_Identity=43.7716262975779, Blast_Score=424, Evalue=1e-119,
Organism=Escherichia coli, GI1786343, Length=590, Percent_Identity=27.6271186440678, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI87082258, Length=186, Percent_Identity=37.6344086021505, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI1789601, Length=204, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 79315; Mature: 79183

Theoretical pI: Translated: 10.64; Mature: 10.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRSHTLSRHARACPGHPRRMSHTPNDVDGRDKPGHDGRRGRGVKRLLAAALSVVALAA
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VALTTYTVSLGPLPLQEAKALSTTVVDRHGKLLRAYAMADGRWRLPVSARKDVDPTYLKL
HHHHHHEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEECCCCCCCCCCHHHHHE
LFAYEDQRFSDHHGVDPRALARAAIQFGSNGHIVSGGSTITMQLARLLEPRRQRSLHAKL
EHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCHHHHHHHHHHH
RQIVRALELERKLSKDEILDLYLTLAPYGGNLEGIRAASIAYFGKEPKRLSLAEAALLVA
HHHHHHHHHHHHCCHHHHEEEEEEEECCCCCCCCCEEEEEHCCCCCCCHHHHHHEEEEEE
LPQSPETRRLDRHLEAARRGRDRVLDRMVSENVISAEEAAQAKAQPVPAFRNPMPILAPH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCC
AADQAMALVKDQPIIRLTLDSTLQKVLEPLARDRAVALGPNVSVGIIVIDNDSGDVLAHV
CHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEECCCCCEEEEC
GSADYFDEKRAGQVDMTRAVRSPGSTLKPFIYGLAFEDGFVHPESLIEDRPVRFGSYAPE
CCCCCCCHHCCCCHHHHHHHCCCCCCCCHHHEEEEECCCCCCHHHHHCCCCCCCCCCCCC
NFDMTFQGTVPVRKALQLSLNVPAIVLLDRVGASRLSSRLKQAGGNLVLPKDEAPGLAMG
CCCEEEECCCHHHHHHHEECCCCEEEEEHHCCHHHHHHHHHHCCCCEEECCCCCCCEEEE
LGGVGVSLQDLAQLYAGFPRLGTTKPLREIMTADEKDDAREPMRLMDPAAAWQVGNVLLG
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHCCHHHHCCHHHHHHCCEEEC
TPPPENAARNRIAFKTGTSYGYRDAWSVGFDGRVTIGVWVGRPDGAPVPGLIGRVAAAPI
CCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHH
LFDAFARSGKLPVALPKPPKGALVASNSKLPLPLRRFRPIGELVRSGAEQAPHIQFPLNG
HHHHHHCCCCCCEECCCCCCCCEEECCCCCCCCHHHHCHHHHHHHCCCCCCCEEEECCCC
SRIDVDRSAGPEASVMPVKVSGGVLPLTMMVNGLRVGEIDSRRQRLIDPPGPGFARLTVI
CEEEECCCCCCCCCEEEEEECCCEEEHHHHHCCCEECCCCHHHHHCCCCCCCCEEEEEEE
DATGAADTVVVRIQ
ECCCCCCEEEEEEC
>Mature Secondary Structure 
ARRSHTLSRHARACPGHPRRMSHTPNDVDGRDKPGHDGRRGRGVKRLLAAALSVVALAA
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VALTTYTVSLGPLPLQEAKALSTTVVDRHGKLLRAYAMADGRWRLPVSARKDVDPTYLKL
HHHHHHEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEECCCCCCCCCCHHHHHE
LFAYEDQRFSDHHGVDPRALARAAIQFGSNGHIVSGGSTITMQLARLLEPRRQRSLHAKL
EHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCHHHHHHHHHHH
RQIVRALELERKLSKDEILDLYLTLAPYGGNLEGIRAASIAYFGKEPKRLSLAEAALLVA
HHHHHHHHHHHHCCHHHHEEEEEEEECCCCCCCCCEEEEEHCCCCCCCHHHHHHEEEEEE
LPQSPETRRLDRHLEAARRGRDRVLDRMVSENVISAEEAAQAKAQPVPAFRNPMPILAPH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCC
AADQAMALVKDQPIIRLTLDSTLQKVLEPLARDRAVALGPNVSVGIIVIDNDSGDVLAHV
CHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEECCCCCEEEEC
GSADYFDEKRAGQVDMTRAVRSPGSTLKPFIYGLAFEDGFVHPESLIEDRPVRFGSYAPE
CCCCCCCHHCCCCHHHHHHHCCCCCCCCHHHEEEEECCCCCCHHHHHCCCCCCCCCCCCC
NFDMTFQGTVPVRKALQLSLNVPAIVLLDRVGASRLSSRLKQAGGNLVLPKDEAPGLAMG
CCCEEEECCCHHHHHHHEECCCCEEEEEHHCCHHHHHHHHHHCCCCEEECCCCCCCEEEE
LGGVGVSLQDLAQLYAGFPRLGTTKPLREIMTADEKDDAREPMRLMDPAAAWQVGNVLLG
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHCCHHHHCCHHHHHHCCEEEC
TPPPENAARNRIAFKTGTSYGYRDAWSVGFDGRVTIGVWVGRPDGAPVPGLIGRVAAAPI
CCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHH
LFDAFARSGKLPVALPKPPKGALVASNSKLPLPLRRFRPIGELVRSGAEQAPHIQFPLNG
HHHHHHCCCCCCEECCCCCCCCEEECCCCCCCCHHHHCHHHHHHHCCCCCCCEEEECCCC
SRIDVDRSAGPEASVMPVKVSGGVLPLTMMVNGLRVGEIDSRRQRLIDPPGPGFARLTVI
CEEEECCCCCCCCCEEEEEECCCEEEHHHHHCCCEECCCCHHHHHCCCCCCCCEEEEEEE
DATGAADTVVVRIQ
ECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]