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The map label for this gene is serA [H]

Identifier: 146340801

GI number: 146340801

Start: 4034170

End: 4035177

Strand: Direct

Name: serA [H]

Synonym: BRADO3860

Alternate gene names: 146340801

Gene position: 4034170-4035177 (Clockwise)

Preceding gene: 146340794

Following gene: 146340802

Centisome position: 54.1

GC content: 66.27

Gene sequence:

>1008_bases
TTGCCGCCAGCAAGCAGAGGCAGCGACATGCGGTACAAACTTCTCATCACCGGGCCCGCGCTCACCGCAGAGGCGACGGC
GATCGCCGCCCGGCGCGGCGCAGCGCTGGTTGACAATCCGCGCTATGCAAGCCCGCAGGAACTGGCGGAGATCACAGCCC
GCGAGCAGCCCGACGGCATCATCGTGCGGCAGGGCAAGATCGATGATCAGGTGATCGGCGCCTCGCAAAAGCTCAAGGCG
ATCGCCAAGCACGGCGTCGGCTACGACAATATCGATGTCGAGGCCGCCGACCGCCGCGGCATCCCGGTGTTCGTTGCGCG
CGGCGCCAATTCACAATCCGTGGCGGAACTCGCCTTCGCGCTGATGTTCGCGGTGGCTCGCGAGATCCCGCACCTCGATG
CACGGATCAAGACCGGGCATTGGGACAAGGCGACGACCAAGGGGGCCCAACTGCTCGGCCGCAGCCTGGGCGTCATCGGC
TTCGGCGAGATCGGCCGTATCCTGGTCGGTCTGGTTCAGCCGCTCCACATGGAGGTCCGCATCTTCGATCCTTATATGCC
CGCCGATGCCGAGATCTCAGGCGCCGAGCGCGCCGGCAGCCTGGACGAGATCCTGACGGCGAGCGACGTGATCAGCCTGC
ATTGCCCGTTGATGCCGCAGACGCGCAACATGATCGGCCGCGACCAGCTTGCGCGCATGCGCCGCAACGCGATCCTTATC
AATACCGCGCGGGGCGGGCTGATCGACGAGGCGGCCCTGTACGACGCGTTGCGCGACGGCGTCATCGCCGGCGCCGGTCT
GGATTCGTTTGCGGAGGAGCCGGCGAAGCCAGATCTTCCGCTGCTGGCCCTGTCCAATGTGGTGGTGACGCCGCATGCCG
GCGCCAGCACACAGGAGGCCCGTGATGCGATGGGCGTGATCGCGGTCAACCACGTCATGGACGTTCTGGAAGGCAAGACC
TTCGACCGGCGGGCGCTGGTCAACAAGACACAGCTCAGCTTCGCCTGA

Upstream 100 bases:

>100_bases
AAATTCGGCGCGGGAAACGGCCGGCATCTCGTCGAGGAGCGGCCTGCGGCGACAATGCCGCGGCTCGGCTGGGCCGCCCT
CGCGAGCCGGTCAGCGGGCG

Downstream 100 bases:

>100_bases
GCACACAACAACAAACAATCTGGGAGGATAACATGGCTGAAGCTGCGGCGGCGCCGAGTGCGCTCGAACGAACCACCATG
CGCCGTGTATCCTGGCGCAT

Product: putative D-3-phosphoglycerate dehydrogenase (PGDH)

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MPPASRGSDMRYKLLITGPALTAEATAIAARRGAALVDNPRYASPQELAEITAREQPDGIIVRQGKIDDQVIGASQKLKA
IAKHGVGYDNIDVEAADRRGIPVFVARGANSQSVAELAFALMFAVAREIPHLDARIKTGHWDKATTKGAQLLGRSLGVIG
FGEIGRILVGLVQPLHMEVRIFDPYMPADAEISGAERAGSLDEILTASDVISLHCPLMPQTRNMIGRDQLARMRRNAILI
NTARGGLIDEAALYDALRDGVIAGAGLDSFAEEPAKPDLPLLALSNVVVTPHAGASTQEARDAMGVIAVNHVMDVLEGKT
FDRRALVNKTQLSFA

Sequences:

>Translated_335_residues
MPPASRGSDMRYKLLITGPALTAEATAIAARRGAALVDNPRYASPQELAEITAREQPDGIIVRQGKIDDQVIGASQKLKA
IAKHGVGYDNIDVEAADRRGIPVFVARGANSQSVAELAFALMFAVAREIPHLDARIKTGHWDKATTKGAQLLGRSLGVIG
FGEIGRILVGLVQPLHMEVRIFDPYMPADAEISGAERAGSLDEILTASDVISLHCPLMPQTRNMIGRDQLARMRRNAILI
NTARGGLIDEAALYDALRDGVIAGAGLDSFAEEPAKPDLPLLALSNVVVTPHAGASTQEARDAMGVIAVNHVMDVLEGKT
FDRRALVNKTQLSFA
>Mature_334_residues
PPASRGSDMRYKLLITGPALTAEATAIAARRGAALVDNPRYASPQELAEITAREQPDGIIVRQGKIDDQVIGASQKLKAI
AKHGVGYDNIDVEAADRRGIPVFVARGANSQSVAELAFALMFAVAREIPHLDARIKTGHWDKATTKGAQLLGRSLGVIGF
GEIGRILVGLVQPLHMEVRIFDPYMPADAEISGAERAGSLDEILTASDVISLHCPLMPQTRNMIGRDQLARMRRNAILIN
TARGGLIDEAALYDALRDGVIAGAGLDSFAEEPAKPDLPLLALSNVVVTPHAGASTQEARDAMGVIAVNHVMDVLEGKTF
DRRALVNKTQLSFA

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=304, Percent_Identity=35.1973684210526, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI6912396, Length=258, Percent_Identity=30.2325581395349, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557497, Length=302, Percent_Identity=29.1390728476821, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI61743967, Length=302, Percent_Identity=29.1390728476821, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI145580578, Length=296, Percent_Identity=29.7297297297297, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI4557499, Length=296, Percent_Identity=29.7297297297297, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI145580575, Length=296, Percent_Identity=29.7297297297297, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1789279, Length=244, Percent_Identity=38.1147540983607, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87082289, Length=285, Percent_Identity=33.6842105263158, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787645, Length=269, Percent_Identity=28.996282527881, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87081824, Length=236, Percent_Identity=25.8474576271186, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=253, Percent_Identity=38.3399209486166, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=287, Percent_Identity=26.8292682926829, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=258, Percent_Identity=32.5581395348837, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322116, Length=258, Percent_Identity=31.3953488372093, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324055, Length=266, Percent_Identity=32.3308270676692, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=28.8808664259928, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325144, Length=183, Percent_Identity=27.8688524590164, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=136, Percent_Identity=28.6764705882353, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=249, Percent_Identity=39.3574297188755, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=36.2934362934363, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24585516, Length=326, Percent_Identity=27.9141104294479, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646446, Length=245, Percent_Identity=33.469387755102, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646448, Length=245, Percent_Identity=33.469387755102, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646452, Length=245, Percent_Identity=33.469387755102, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646450, Length=245, Percent_Identity=33.469387755102, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62472511, Length=269, Percent_Identity=31.5985130111524, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45551003, Length=251, Percent_Identity=29.8804780876494, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574284, Length=251, Percent_Identity=29.8804780876494, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552429, Length=251, Percent_Identity=29.8804780876494, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585514, Length=251, Percent_Identity=29.8804780876494, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574282, Length=251, Percent_Identity=29.8804780876494, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=29.0836653386454, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35762; Mature: 35630

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPASRGSDMRYKLLITGPALTAEATAIAARRGAALVDNPRYASPQELAEITAREQPDGI
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCCCCE
IVRQGKIDDQVIGASQKLKAIAKHGVGYDNIDVEAADRRGIPVFVARGANSQSVAELAFA
EEECCCCCHHHHCHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHH
LMFAVAREIPHLDARIKTGHWDKATTKGAQLLGRSLGVIGFGEIGRILVGLVQPLHMEVR
HHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCEEEEE
IFDPYMPADAEISGAERAGSLDEILTASDVISLHCPLMPQTRNMIGRDQLARMRRNAILI
EECCCCCCCCCCCCHHHCCCHHHHHHHHHHHEEECCCCCHHHHHCCHHHHHHHHCCEEEE
NTARGGLIDEAALYDALRDGVIAGAGLDSFAEEPAKPDLPLLALSNVVVTPHAGASTQEA
ECCCCCCHHHHHHHHHHHCCEEECCCCHHHHCCCCCCCCCEEEECCEEEECCCCCCHHHH
RDAMGVIAVNHVMDVLEGKTFDRRALVNKTQLSFA
HHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHCCC
>Mature Secondary Structure 
PPASRGSDMRYKLLITGPALTAEATAIAARRGAALVDNPRYASPQELAEITAREQPDGI
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCCCCE
IVRQGKIDDQVIGASQKLKAIAKHGVGYDNIDVEAADRRGIPVFVARGANSQSVAELAFA
EEECCCCCHHHHCHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHH
LMFAVAREIPHLDARIKTGHWDKATTKGAQLLGRSLGVIGFGEIGRILVGLVQPLHMEVR
HHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCEEEEE
IFDPYMPADAEISGAERAGSLDEILTASDVISLHCPLMPQTRNMIGRDQLARMRRNAILI
EECCCCCCCCCCCCHHHCCCHHHHHHHHHHHEEECCCCCHHHHHCCHHHHHHHHCCEEEE
NTARGGLIDEAALYDALRDGVIAGAGLDSFAEEPAKPDLPLLALSNVVVTPHAGASTQEA
ECCCCCCHHHHHHHHHHHCCEEECCCCHHHHCCCCCCCCCEEEECCEEEECCCCCCHHHH
RDAMGVIAVNHVMDVLEGKTFDRRALVNKTQLSFA
HHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]