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The map label for this gene is hisC1 [H]

Identifier: 146340482

GI number: 146340482

Start: 3712086

End: 3713228

Strand: Direct

Name: hisC1 [H]

Synonym: BRADO3524

Alternate gene names: 146340482

Gene position: 3712086-3713228 (Clockwise)

Preceding gene: 146340480

Following gene: 146340483

Centisome position: 49.78

GC content: 66.84

Gene sequence:

>1143_bases
ATGCCGCACGTGCCCAGCCGCTTCCCGCACAACGACATCATCAGCCTGACCACCCAGCCGGTCTGCTACGATCTCGCCGA
GAGCATTGGTCCGGATCTCAGGCTCGGCGGGCTGCTCACAGACAGCGACGCATTGCAGGAACTCGTGCTGAGCTACGGTC
CGACTGAAGGCCACGCCGAGCTGCGCGAACTGATCGCGGCCCGGCATGGGGTCGGGGCTGACGATGTCATCACCACCGTG
GGCGGCATGCAGGCGCTGTTCCTGATCGCCTTCGTTCTCGGCGAGCCGGGCGCGGAGGCCGTCATTGGACGTCCTGCATT
TCCCAATGCGCGCAACGTCCTCGCATCGGTGGGCTTGCGCGTCATCGACCTGATGCTGCACTTCGACGACGGCTATCGTC
TCGATACCGGCCGCCTGCGATCGCTGCTGAGCGCGCGCACGCGGCTGGTCAGCCTGGCCTCACCGCAGAACCCATCCGGC
GTCGCGCTGTCCGATGCGGAGCTGCGTGACGTGCTCGCGGCCATGGACGAGATCTGTCCCGAGGCGTTCCTGCTGATCGA
CGAGACCTATCGCGAGGCCGTCCATGGCGACGCCGCGCCGCGGCCGAGCCTGGTGGGCCGTGATCGTCGCATCATCAGCT
GTGCATCGTTCTCGAAATGTCATGGCGCGCCGGGCATCCGCACCGGATGGGTGATCACCCGCGACCCGGCGCTGCGCGCG
CAGCTCGTGCTCGGCAAGTTCAACACGACGATCTCGAACTCGGTCGTCGACGAGGCGATCGCGCTGCGAATTCTGCGCGA
GCTGGACACGATCATGCGCGACCGGCGCGGTCATCTCGCTGCGTGCCTGGCGCGCACCGCCGCGTTCGTAGCCGACAATG
GCAAACTGATTGAATGGATCAGGCCGGAGGCCGGCGCGCTGTGTTGCGTCAGACTCAGGCGCGAGATGTTCGACGAGGCG
GCCGTGGCTCGCTTCCATCGCGAGCTGAGCGTGCGTGAGACGCGCGTTGCGCCAGGATCGTGGTTCGGCGACGAGGCGCG
GGTGTTCCGGCTCGGTTTTGGCGTGCTGGCGTTGCCCGAGCTCGACGAAGCGCTGCAGCGTGTGGCGCAGACGTTGACGT
CGGCGTCGATGATGACGGTCTAG

Upstream 100 bases:

>100_bases
ATCCAATCGCAGATCTGTACTGGTAGCAATCGCGCATTTCTGTATCTGTCAGCGCCGATCCCCAGAGCGGTAGCTTGAAC
GTGTCATTTGGAGCTTCGCC

Downstream 100 bases:

>100_bases
CTCCGTCATGTCGAGCGAAGCAATCCAGGGCTGCGAAAGCCACTCCGGATTGCTTCGTCGCTGCGCGCCTTGCAATGACG
AGCGAGACCGAGTCCCTGAC

Product: putative aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MPHVPSRFPHNDIISLTTQPVCYDLAESIGPDLRLGGLLTDSDALQELVLSYGPTEGHAELRELIAARHGVGADDVITTV
GGMQALFLIAFVLGEPGAEAVIGRPAFPNARNVLASVGLRVIDLMLHFDDGYRLDTGRLRSLLSARTRLVSLASPQNPSG
VALSDAELRDVLAAMDEICPEAFLLIDETYREAVHGDAAPRPSLVGRDRRIISCASFSKCHGAPGIRTGWVITRDPALRA
QLVLGKFNTTISNSVVDEAIALRILRELDTIMRDRRGHLAACLARTAAFVADNGKLIEWIRPEAGALCCVRLRREMFDEA
AVARFHRELSVRETRVAPGSWFGDEARVFRLGFGVLALPELDEALQRVAQTLTSASMMTV

Sequences:

>Translated_380_residues
MPHVPSRFPHNDIISLTTQPVCYDLAESIGPDLRLGGLLTDSDALQELVLSYGPTEGHAELRELIAARHGVGADDVITTV
GGMQALFLIAFVLGEPGAEAVIGRPAFPNARNVLASVGLRVIDLMLHFDDGYRLDTGRLRSLLSARTRLVSLASPQNPSG
VALSDAELRDVLAAMDEICPEAFLLIDETYREAVHGDAAPRPSLVGRDRRIISCASFSKCHGAPGIRTGWVITRDPALRA
QLVLGKFNTTISNSVVDEAIALRILRELDTIMRDRRGHLAACLARTAAFVADNGKLIEWIRPEAGALCCVRLRREMFDEA
AVARFHRELSVRETRVAPGSWFGDEARVFRLGFGVLALPELDEALQRVAQTLTSASMMTV
>Mature_379_residues
PHVPSRFPHNDIISLTTQPVCYDLAESIGPDLRLGGLLTDSDALQELVLSYGPTEGHAELRELIAARHGVGADDVITTVG
GMQALFLIAFVLGEPGAEAVIGRPAFPNARNVLASVGLRVIDLMLHFDDGYRLDTGRLRSLLSARTRLVSLASPQNPSGV
ALSDAELRDVLAAMDEICPEAFLLIDETYREAVHGDAAPRPSLVGRDRRIISCASFSKCHGAPGIRTGWVITRDPALRAQ
LVLGKFNTTISNSVVDEAIALRILRELDTIMRDRRGHLAACLARTAAFVADNGKLIEWIRPEAGALCCVRLRREMFDEAA
VARFHRELSVRETRVAPGSWFGDEARVFRLGFGVLALPELDEALQRVAQTLTSASMMTV

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=238, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787710, Length=232, Percent_Identity=27.1551724137931, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790797, Length=347, Percent_Identity=25.9365994236311, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786816, Length=198, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI18859735, Length=226, Percent_Identity=25.6637168141593, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41334; Mature: 41203

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHVPSRFPHNDIISLTTQPVCYDLAESIGPDLRLGGLLTDSDALQELVLSYGPTEGHAE
CCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCEECCEECCHHHHHHHHHHCCCCCCHHH
LRELIAARHGVGADDVITTVGGMQALFLIAFVLGEPGAEAVIGRPAFPNARNVLASVGLR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHH
VIDLMLHFDDGYRLDTGRLRSLLSARTRLVSLASPQNPSGVALSDAELRDVLAAMDEICP
HHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHCC
EAFLLIDETYREAVHGDAAPRPSLVGRDRRIISCASFSKCHGAPGIRTGWVITRDPALRA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHCCCCCCCCCEEEECCCHHHH
QLVLGKFNTTISNSVVDEAIALRILRELDTIMRDRRGHLAACLARTAAFVADNGKLIEWI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEE
RPEAGALCCVRLRREMFDEAAVARFHRELSVRETRVAPGSWFGDEARVFRLGFGVLALPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHCCCH
LDEALQRVAQTLTSASMMTV
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PHVPSRFPHNDIISLTTQPVCYDLAESIGPDLRLGGLLTDSDALQELVLSYGPTEGHAE
CCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCEECCEECCHHHHHHHHHHCCCCCCHHH
LRELIAARHGVGADDVITTVGGMQALFLIAFVLGEPGAEAVIGRPAFPNARNVLASVGLR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHH
VIDLMLHFDDGYRLDTGRLRSLLSARTRLVSLASPQNPSGVALSDAELRDVLAAMDEICP
HHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHCC
EAFLLIDETYREAVHGDAAPRPSLVGRDRRIISCASFSKCHGAPGIRTGWVITRDPALRA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHCCCCCCCCCEEEECCCHHHH
QLVLGKFNTTISNSVVDEAIALRILRELDTIMRDRRGHLAACLARTAAFVADNGKLIEWI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEE
RPEAGALCCVRLRREMFDEAAVARFHRELSVRETRVAPGSWFGDEARVFRLGFGVLALPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHCCCH
LDEALQRVAQTLTSASMMTV
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]