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The map label for this gene is metC [H]

Identifier: 146340483

GI number: 146340483

Start: 3713379

End: 3714560

Strand: Direct

Name: metC [H]

Synonym: BRADO3525

Alternate gene names: 146340483

Gene position: 3713379-3714560 (Clockwise)

Preceding gene: 146340482

Following gene: 146340484

Centisome position: 49.8

GC content: 68.19

Gene sequence:

>1182_bases
ATGCACGATCTCACCCGCTGCGTTCAGCATCCCGCCGTGTCGCATGACGGCTTCAAGTCGCTCGCCGTTCCCACCTATCG
CGCCTCGACGATCGTCTATGACGATCCGCAGGATTTTGCCAGGCGCGCCGGGCGCGGCCTCGACGGCTACACCTATGGCC
TGCATGGCACGCCGACGACGCGCACCCTCGAGGCGCAGATCACGGCGCTGCATGCCGGCGAGCGCACCGTGCTGGTGCCG
TCCGGACAGGCTGCAGTCGCAATCACGATGCTCGCGGTGCTGAAGCCGGGCGACACGGTGCTGATCCCCGATCATGTCTA
TCCGCCGGTGCGGCATCTCTGCACGAACTATCTCGCCTCGCGCGGCATCGCCCATCGCGTCTATGATCCGCTGATCGGCG
CGGGGATCGCTGACCTCATCGATGCCAATACGAAGCTGGTCTGGATGGAGTCGCCGGGCTCGGGCACGATGGAGGTGCAG
GACGTGCCGGCGATCGCGCAGGCCGCGAAGGTGCGCGGCGTGCTCACCGGCTGCGACAACACCTGGGCGAGCCCGCTTTT
GTTCAAGCCGCTGGCGCATGGCGTCGACTTCGCGGTGGAGGCGCTGACCAAATATGTCGGCGGTCATTCCGACCTGCTGC
TCGGCTCGATCACGGTCAAGGAGCTCGGCCTGCGCAAGGCGCTGAAGGATGTGCTGGGCGTGCTCGGCATCGGCGTCTCG
CCGGACGAGGCGGCGCTGGCGCTGCGCGGCATCGAGACCATGGGCGTGCGCATGGCGCATTCCGGTCGCGTCGCGCGCGA
CTTTGCCGAGCGGCTGCAGGCCGCGCCCGCGGTGGCGCGGGTGCTGCATCCGGCGCTGCCGTCCTGTCCCGGCCACGAGA
TCTTCGCGCGCGATTTCAAGGCCGCGAGCACCGTGTTCAGCCTCGTCATCAAGCCGGAGTTCGCGCCGCGGATCTATCCC
GCGCTTGGCCAGCTCAGGCTGTTCGCGATCGGCGCCTCCTGGGGCGGCACGCACAGCCTGATCGCGCCGATGGACGTGGT
CGCCGATCGCACCGTTCGGCCGTGGAATCCGGCGGAAGGATTGGTGCGCCTGAGCATCGGTCTCGAGGAGCCCGGCGAGC
TGTGGGAGGACCTGTCGCGATTCCTCGATGCACTCGAAGGAGCGACGTCCGTGAGCGGCTAG

Upstream 100 bases:

>100_bases
TGCTTCGTCGCTGCGCGCCTTGCAATGACGAGCGAGACCGAGTCCCTGACCTCGCGCGATTGCGCTACGATGCCGGCACG
CATTGTCTCACGAGGTGTCC

Downstream 100 bases:

>100_bases
CGTTGTGGCCGGCCTGCATCACATCCTCACTCCTGAGGACTGTCCGGAGTCCTCCGGTCTCGCCGCGAGCCCGCCGTAAT
GGTGTTTGGACAGCGCCGAT

Product: putative cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MHDLTRCVQHPAVSHDGFKSLAVPTYRASTIVYDDPQDFARRAGRGLDGYTYGLHGTPTTRTLEAQITALHAGERTVLVP
SGQAAVAITMLAVLKPGDTVLIPDHVYPPVRHLCTNYLASRGIAHRVYDPLIGAGIADLIDANTKLVWMESPGSGTMEVQ
DVPAIAQAAKVRGVLTGCDNTWASPLLFKPLAHGVDFAVEALTKYVGGHSDLLLGSITVKELGLRKALKDVLGVLGIGVS
PDEAALALRGIETMGVRMAHSGRVARDFAERLQAAPAVARVLHPALPSCPGHEIFARDFKAASTVFSLVIKPEFAPRIYP
ALGQLRLFAIGASWGGTHSLIAPMDVVADRTVRPWNPAEGLVRLSIGLEEPGELWEDLSRFLDALEGATSVSG

Sequences:

>Translated_393_residues
MHDLTRCVQHPAVSHDGFKSLAVPTYRASTIVYDDPQDFARRAGRGLDGYTYGLHGTPTTRTLEAQITALHAGERTVLVP
SGQAAVAITMLAVLKPGDTVLIPDHVYPPVRHLCTNYLASRGIAHRVYDPLIGAGIADLIDANTKLVWMESPGSGTMEVQ
DVPAIAQAAKVRGVLTGCDNTWASPLLFKPLAHGVDFAVEALTKYVGGHSDLLLGSITVKELGLRKALKDVLGVLGIGVS
PDEAALALRGIETMGVRMAHSGRVARDFAERLQAAPAVARVLHPALPSCPGHEIFARDFKAASTVFSLVIKPEFAPRIYP
ALGQLRLFAIGASWGGTHSLIAPMDVVADRTVRPWNPAEGLVRLSIGLEEPGELWEDLSRFLDALEGATSVSG
>Mature_393_residues
MHDLTRCVQHPAVSHDGFKSLAVPTYRASTIVYDDPQDFARRAGRGLDGYTYGLHGTPTTRTLEAQITALHAGERTVLVP
SGQAAVAITMLAVLKPGDTVLIPDHVYPPVRHLCTNYLASRGIAHRVYDPLIGAGIADLIDANTKLVWMESPGSGTMEVQ
DVPAIAQAAKVRGVLTGCDNTWASPLLFKPLAHGVDFAVEALTKYVGGHSDLLLGSITVKELGLRKALKDVLGVLGIGVS
PDEAALALRGIETMGVRMAHSGRVARDFAERLQAAPAVARVLHPALPSCPGHEIFARDFKAASTVFSLVIKPEFAPRIYP
ALGQLRLFAIGASWGGTHSLIAPMDVVADRTVRPWNPAEGLVRLSIGLEEPGELWEDLSRFLDALEGATSVSG

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=326, Percent_Identity=30.3680981595092, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI299473759, Length=235, Percent_Identity=32.3404255319149, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI25453487, Length=326, Percent_Identity=25.7668711656442, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789383, Length=360, Percent_Identity=39.1666666666667, Blast_Score=227, Evalue=8e-61,
Organism=Escherichia coli, GI1790375, Length=341, Percent_Identity=30.4985337243402, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71980708, Length=375, Percent_Identity=29.8666666666667, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=355, Percent_Identity=29.5774647887324, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17538055, Length=334, Percent_Identity=30.2395209580838, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6321170, Length=316, Percent_Identity=42.4050632911392, Blast_Score=245, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6319307, Length=355, Percent_Identity=29.8591549295775, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321904, Length=399, Percent_Identity=26.8170426065163, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321254, Length=384, Percent_Identity=26.5625, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323333, Length=309, Percent_Identity=25.2427184466019, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922554, Length=383, Percent_Identity=33.1592689295039, Blast_Score=174, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41899; Mature: 41899

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDLTRCVQHPAVSHDGFKSLAVPTYRASTIVYDDPQDFARRAGRGLDGYTYGLHGTPTT
CCHHHHHHHCCCCCCCCCHHHCCCCEECCEEEECCHHHHHHHHCCCCCCEEECCCCCCCC
RTLEAQITALHAGERTVLVPSGQAAVAITMLAVLKPGDTVLIPDHVYPPVRHLCTNYLAS
EEEEEEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
RGIAHRVYDPLIGAGIADLIDANTKLVWMESPGSGTMEVQDVPAIAQAAKVRGVLTGCDN
CCCHHHHHHHHHHCCHHHHHCCCCEEEEEECCCCCCEEECCCHHHHHHHHHHHHEECCCC
TWASPLLFKPLAHGVDFAVEALTKYVGGHSDLLLGSITVKELGLRKALKDVLGVLGIGVS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
PDEAALALRGIETMGVRMAHSGRVARDFAERLQAAPAVARVLHPALPSCPGHEIFARDFK
CCHHHHHHHCHHHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
AASTVFSLVIKPEFAPRIYPALGQLRLFAIGASWGGTHSLIAPMDVVADRTVRPWNPAEG
HHHHHHHHHCCCCCCCHHHHHHCCEEEEEEECCCCCCCCHHCHHHHHHCCCCCCCCCCCC
LVRLSIGLEEPGELWEDLSRFLDALEGATSVSG
EEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHDLTRCVQHPAVSHDGFKSLAVPTYRASTIVYDDPQDFARRAGRGLDGYTYGLHGTPTT
CCHHHHHHHCCCCCCCCCHHHCCCCEECCEEEECCHHHHHHHHCCCCCCEEECCCCCCCC
RTLEAQITALHAGERTVLVPSGQAAVAITMLAVLKPGDTVLIPDHVYPPVRHLCTNYLAS
EEEEEEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
RGIAHRVYDPLIGAGIADLIDANTKLVWMESPGSGTMEVQDVPAIAQAAKVRGVLTGCDN
CCCHHHHHHHHHHCCHHHHHCCCCEEEEEECCCCCCEEECCCHHHHHHHHHHHHEECCCC
TWASPLLFKPLAHGVDFAVEALTKYVGGHSDLLLGSITVKELGLRKALKDVLGVLGIGVS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
PDEAALALRGIETMGVRMAHSGRVARDFAERLQAAPAVARVLHPALPSCPGHEIFARDFK
CCHHHHHHHCHHHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
AASTVFSLVIKPEFAPRIYPALGQLRLFAIGASWGGTHSLIAPMDVVADRTVRPWNPAEG
HHHHHHHHHCCCCCCCHHHHHHCCEEEEEEECCCCCCCCHHCHHHHHHCCCCCCCCCCCC
LVRLSIGLEEPGELWEDLSRFLDALEGATSVSG
EEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]