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The map label for this gene is fabG [H]

Identifier: 146340360

GI number: 146340360

Start: 3582454

End: 3583134

Strand: Reverse

Name: fabG [H]

Synonym: BRADO3388

Alternate gene names: 146340360

Gene position: 3583134-3582454 (Counterclockwise)

Preceding gene: 146340363

Following gene: 146340359

Centisome position: 48.05

GC content: 65.35

Gene sequence:

>681_bases
ATGAACGGAGCGGTGATTGTCATTACAGGGGCGCAGGGAGCGCTCGGGCGCAGCGTTGCCGATCTTGCGCTGGCGCGTGG
CGCGCATGTTGCCGGCATTGATCACGCCCAGGCTGAAATCCCCGCCAGTGACGACCGCATCGAGCTCGGCGGCGTCGATC
TTTCCGATCCCGAGCAGGCCAAGGTCGCGATCGACTCGGTGGCCGCGCATTTCGGCACGCTGGACGCGCTCATCAACATT
GCAGGCGCTTTTGCCTTCGAGCAGACCGCCGACGGCGACGACAGCGTCTGGGAGAAGATGCATGCGCGCAATCTGATGAC
GGCACTGCACGCTTCTCGCGCCGCGATCCCGCATCTGGTTCGCTCAAGCACCGGCCGCATCGTCAATATCGGCGCAATGG
GCGCGCTGCAGGCCGGCGCCGGCATGGGCCCCTATGCCGCGTCGAAGTCGGGCGTGCATCGGCTCACCGAAGCGCTGGCG
GCGGAATGGAAAGGCAAGATCACTGTCAACGCGGTGCTGCCCTCCACCATCGACACGCCCGCCAACCGCGCCAGCATGCC
GAAGGCTGACTTTGACAAATGGGTGACACCGCAAGAACTTGCCGAGGTGATCCTGTTTCTTGCCAGCGAGGCCGCGAGCG
GCGTGACCGGCGCCTTGATACCGGTGGTCGGCCGCATGTAG

Upstream 100 bases:

>100_bases
GCAAATCAATGCAGCAGCCGCGTAGCCATTGCAACTCGCCCGCTTGGCCATAGTATAACGGACGGCGCTGCGGGGCGTGC
GAACGGGGACCGGGGACGGA

Downstream 100 bases:

>100_bases
CAGCGTGATCGCTCACGAGCCGAGTTGGCGCTGACATCGTGCGGTGCATCAGGCTAGACTCGCCTGCCTGAGTCGCAACG
ATGGACGGCCCTTGGAAACC

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNGAVIVITGAQGALGRSVADLALARGAHVAGIDHAQAEIPASDDRIELGGVDLSDPEQAKVAIDSVAAHFGTLDALINI
AGAFAFEQTADGDDSVWEKMHARNLMTALHASRAAIPHLVRSSTGRIVNIGAMGALQAGAGMGPYAASKSGVHRLTEALA
AEWKGKITVNAVLPSTIDTPANRASMPKADFDKWVTPQELAEVILFLASEAASGVTGALIPVVGRM

Sequences:

>Translated_226_residues
MNGAVIVITGAQGALGRSVADLALARGAHVAGIDHAQAEIPASDDRIELGGVDLSDPEQAKVAIDSVAAHFGTLDALINI
AGAFAFEQTADGDDSVWEKMHARNLMTALHASRAAIPHLVRSSTGRIVNIGAMGALQAGAGMGPYAASKSGVHRLTEALA
AEWKGKITVNAVLPSTIDTPANRASMPKADFDKWVTPQELAEVILFLASEAASGVTGALIPVVGRM
>Mature_226_residues
MNGAVIVITGAQGALGRSVADLALARGAHVAGIDHAQAEIPASDDRIELGGVDLSDPEQAKVAIDSVAAHFGTLDALINI
AGAFAFEQTADGDDSVWEKMHARNLMTALHASRAAIPHLVRSSTGRIVNIGAMGALQAGAGMGPYAASKSGVHRLTEALA
AEWKGKITVNAVLPSTIDTPANRASMPKADFDKWVTPQELAEVILFLASEAASGVTGALIPVVGRM

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI208973246, Length=234, Percent_Identity=32.0512820512821, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=28.8537549407115, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI31542939, Length=194, Percent_Identity=28.8659793814433, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI66933014, Length=242, Percent_Identity=26.8595041322314, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503817, Length=191, Percent_Identity=26.1780104712042, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40254986, Length=190, Percent_Identity=28.9473684210526, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI19923817, Length=250, Percent_Identity=24.4, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI7705925, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI224922801, Length=172, Percent_Identity=28.4883720930233, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4504505, Length=227, Percent_Identity=25.5506607929515, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=237, Percent_Identity=29.1139240506329, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=31.1475409836066, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790717, Length=242, Percent_Identity=25.2066115702479, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1786812, Length=237, Percent_Identity=27.4261603375527, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788459, Length=239, Percent_Identity=28.0334728033473, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=26.7489711934156, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI87082100, Length=244, Percent_Identity=27.4590163934426, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367365, Length=228, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=31.3253012048193, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=30.4878048780488, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=234, Percent_Identity=29.4871794871795, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=245, Percent_Identity=28.9795918367347, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=239, Percent_Identity=25.9414225941423, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=242, Percent_Identity=26.4462809917355, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=242, Percent_Identity=27.6859504132231, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=247, Percent_Identity=23.8866396761134, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=241, Percent_Identity=28.2157676348548, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17554872, Length=235, Percent_Identity=26.8085106382979, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=246, Percent_Identity=27.6422764227642, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=209, Percent_Identity=27.7511961722488, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=175, Percent_Identity=27.4285714285714, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=222, Percent_Identity=27.9279279279279, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI62472128, Length=233, Percent_Identity=31.3304721030043, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17647337, Length=233, Percent_Identity=31.3304721030043, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI62472140, Length=233, Percent_Identity=31.3304721030043, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=28.7449392712551, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357673, Length=216, Percent_Identity=28.2407407407407, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355319, Length=243, Percent_Identity=27.5720164609054, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI23397609, Length=244, Percent_Identity=25.4098360655738, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28571526, Length=243, Percent_Identity=26.3374485596708, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581726, Length=192, Percent_Identity=28.6458333333333, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 23205; Mature: 23205

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAVIVITGAQGALGRSVADLALARGAHVAGIDHAQAEIPASDDRIELGGVDLSDPEQA
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEECCCCCCCCHHH
KVAIDSVAAHFGTLDALINIAGAFAFEQTADGDDSVWEKMHARNLMTALHASRAAIPHLV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSSTGRIVNIGAMGALQAGAGMGPYAASKSGVHRLTEALAAEWKGKITVNAVLPSTIDTP
HCCCCCEEEECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
ANRASMPKADFDKWVTPQELAEVILFLASEAASGVTGALIPVVGRM
CCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure
MNGAVIVITGAQGALGRSVADLALARGAHVAGIDHAQAEIPASDDRIELGGVDLSDPEQA
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEECCCCCCCCHHH
KVAIDSVAAHFGTLDALINIAGAFAFEQTADGDDSVWEKMHARNLMTALHASRAAIPHLV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSSTGRIVNIGAMGALQAGAGMGPYAASKSGVHRLTEALAAEWKGKITVNAVLPSTIDTP
HCCCCCEEEECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
ANRASMPKADFDKWVTPQELAEVILFLASEAASGVTGALIPVVGRM
CCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]