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The map label for this gene is zraR [H]

Identifier: 146340225

GI number: 146340225

Start: 3446423

End: 3447778

Strand: Reverse

Name: zraR [H]

Synonym: BRADO3244

Alternate gene names: 146340225

Gene position: 3447778-3446423 (Counterclockwise)

Preceding gene: 146340226

Following gene: 146340224

Centisome position: 46.24

GC content: 68.29

Gene sequence:

>1356_bases
ATGGCCACCATCCTGATCGTCGACGACGATGCGGCGCTGCGCGACGGTCTCGCGGAGACGCTGACCGATCTCGGTCACGA
CACGCTAACGGCTGCATCGGGGCGCGAGGCGATCGGCATGGTCTCGGCCGAGACCGACGCCATCCTGCTCGACCTGCGCA
TGCCCGGGATCGACGGCATCGAGACCTTGCGTCGGATCCGTGCCGACGCCGAAGCGCCGCCGGTGATCGTGCTGACGGCC
TATGCAAGCCCGGAAAACACCATCGAGGCGATGCGGCTCGGCGCTTTCGATCATCTGGTCAAGCCAATCGGCCGCGACGC
CCTGCGTGAGTTGATCGAGCGGCTGCCGCCGCGAACCCGGCCGCAGCAGGACATTCGCGGCCGCGATGACAGCGGCCTGA
TCGGCACCAGCGAAGCGATGCGACGGGTGCAGAAGATCATCGGTCTCGCCGCCGACGCCGACGCGACGGTGCTAATCCGC
GGCGAGACCGGCACCGGCAAGGAGCTGGTCGCACGCGCGCTGCATGTCCACAGCCGGCGCAGCGCGAGCCCCTTCATCGC
CGTGAACTGCGCGGCGATCCCGCAGGACCTGCTCGAAAGCGAGTTGTTCGGCCATGTGAAGGGGTCCTTCACCGGCGCCA
CCTCGGATCGCTCCGGCGCATTTCGCGATGCCGGCGCGGGGACACTCTTCCTCGACGAGATCGGCGACATGCCGCCTGCG
ATGCAGGCCAAGATCCTGCGCGCGCTGCAGGAGCGCGTGATCGCGCCGGTCGGCGGCAAGCCGGTGAGGGTGGCCGCCCG
CGTCGTCGCTGCCACGCATCGCGATCTCGCCAGGCAAGTCGCGAGCGGCGCCTTCCGCGAGGATCTCTACTATCGCTTGA
ACGTCATCCCGATCGAGCTGCCGCCGCTGCGCGAGCGCAGCGAGGACATTCTGCTGCTCGCCGGTCACTTCCTCGCGCTC
GCTGCCAATGGGCGCGCGCGCCCGCAACTGAGCGAAGCGGCGATCGACAAGCTCGTTCGTGCGCCCTGGCCCGGCAATGT
GCGCGAGCTGCGCAATGTGATCGAGCGCGCCTGCGTGCTGACGCGTGGCGGCTTGATCGAAGCCGAGGACATCGACATCG
CCGCAGCCCCGATCGCTGAGGACATCGATCCGGCAACGGATCTGCCGGCTGCGGTCGCGCGGCTCGAGGAACGCATGATC
CGGCGCGCGCTCGCGGACTGCAGCGGCAACCGCACCGAAGCCGCGCGGCAGCTCAACATCAACCGGCAGCTGCTCTACAC
CAAGATGCAGCGCTACGGGCTCGCTGAAGAGGCGTCAGGAAATCTGACGCGCATCGTCGGGAAAGACGACGTCTAG

Upstream 100 bases:

>100_bases
GCCTCGGCCTCGCCATCGTGCGCGAGATCGCCCGCGCCCACCATGGCGAGGTGCAACTCGCACACACTCGTCACGGCTCC
AGCTTCGAGATCTCCCTCCC

Downstream 100 bases:

>100_bases
CGCGCGTCACGCTCATGCAACCCATTGATTTGTCGGCAACCCGCGATTGGCACGGCCGTTGCGAAACAGAACGCGTCACC
AACCAACGACAAGGAGTTCC

Product: putative response regulator in two-component reguatory system, sigma54 dependent transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MATILIVDDDAALRDGLAETLTDLGHDTLTAASGREAIGMVSAETDAILLDLRMPGIDGIETLRRIRADAEAPPVIVLTA
YASPENTIEAMRLGAFDHLVKPIGRDALRELIERLPPRTRPQQDIRGRDDSGLIGTSEAMRRVQKIIGLAADADATVLIR
GETGTGKELVARALHVHSRRSASPFIAVNCAAIPQDLLESELFGHVKGSFTGATSDRSGAFRDAGAGTLFLDEIGDMPPA
MQAKILRALQERVIAPVGGKPVRVAARVVAATHRDLARQVASGAFREDLYYRLNVIPIELPPLRERSEDILLLAGHFLAL
AANGRARPQLSEAAIDKLVRAPWPGNVRELRNVIERACVLTRGGLIEAEDIDIAAAPIAEDIDPATDLPAAVARLEERMI
RRALADCSGNRTEAARQLNINRQLLYTKMQRYGLAEEASGNLTRIVGKDDV

Sequences:

>Translated_451_residues
MATILIVDDDAALRDGLAETLTDLGHDTLTAASGREAIGMVSAETDAILLDLRMPGIDGIETLRRIRADAEAPPVIVLTA
YASPENTIEAMRLGAFDHLVKPIGRDALRELIERLPPRTRPQQDIRGRDDSGLIGTSEAMRRVQKIIGLAADADATVLIR
GETGTGKELVARALHVHSRRSASPFIAVNCAAIPQDLLESELFGHVKGSFTGATSDRSGAFRDAGAGTLFLDEIGDMPPA
MQAKILRALQERVIAPVGGKPVRVAARVVAATHRDLARQVASGAFREDLYYRLNVIPIELPPLRERSEDILLLAGHFLAL
AANGRARPQLSEAAIDKLVRAPWPGNVRELRNVIERACVLTRGGLIEAEDIDIAAAPIAEDIDPATDLPAAVARLEERMI
RRALADCSGNRTEAARQLNINRQLLYTKMQRYGLAEEASGNLTRIVGKDDV
>Mature_450_residues
ATILIVDDDAALRDGLAETLTDLGHDTLTAASGREAIGMVSAETDAILLDLRMPGIDGIETLRRIRADAEAPPVIVLTAY
ASPENTIEAMRLGAFDHLVKPIGRDALRELIERLPPRTRPQQDIRGRDDSGLIGTSEAMRRVQKIIGLAADADATVLIRG
ETGTGKELVARALHVHSRRSASPFIAVNCAAIPQDLLESELFGHVKGSFTGATSDRSGAFRDAGAGTLFLDEIGDMPPAM
QAKILRALQERVIAPVGGKPVRVAARVVAATHRDLARQVASGAFREDLYYRLNVIPIELPPLRERSEDILLLAGHFLALA
ANGRARPQLSEAAIDKLVRAPWPGNVRELRNVIERACVLTRGGLIEAEDIDIAAAPIAEDIDPATDLPAAVARLEERMIR
RALADCSGNRTEAARQLNINRQLLYTKMQRYGLAEEASGNLTRIVGKDDV

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=46.2585034013605, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=43.956043956044, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1788905, Length=441, Percent_Identity=43.0839002267574, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI1790299, Length=463, Percent_Identity=41.4686825053996, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=43.6532507739938, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=45.7943925233645, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789087, Length=312, Percent_Identity=46.474358974359, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082152, Length=341, Percent_Identity=43.4017595307918, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1786524, Length=329, Percent_Identity=37.9939209726444, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1787583, Length=317, Percent_Identity=38.1703470031546, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI87081872, Length=230, Percent_Identity=44.3478260869565, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1789828, Length=241, Percent_Identity=37.7593360995851, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081858, Length=292, Percent_Identity=32.8767123287671, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789402, Length=120, Percent_Identity=35.8333333333333, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787487, Length=111, Percent_Identity=34.2342342342342, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789809, Length=113, Percent_Identity=33.6283185840708, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48702; Mature: 48571

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATILIVDDDAALRDGLAETLTDLGHDTLTAASGREAIGMVSAETDAILLDLRMPGIDGI
CEEEEEECCCHHHHHHHHHHHHHCCCCCEECCCCCCCEEEEECCCCEEEEEEECCCCCHH
ETLRRIRADAEAPPVIVLTAYASPENTIEAMRLGAFDHLVKPIGRDALRELIERLPPRTR
HHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
PQQDIRGRDDSGLIGTSEAMRRVQKIIGLAADADATVLIRGETGTGKELVARALHVHSRR
CHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
SASPFIAVNCAAIPQDLLESELFGHVKGSFTGATSDRSGAFRDAGAGTLFLDEIGDMPPA
CCCCEEEEEHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCHH
MQAKILRALQERVIAPVGGKPVRVAARVVAATHRDLARQVASGAFREDLYYRLNVIPIEL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCEEEEEEEEECC
PPLRERSEDILLLAGHFLALAANGRARPQLSEAAIDKLVRAPWPGNVRELRNVIERACVL
CCCCCCCCCEEEEECHHHHEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TRGGLIEAEDIDIAAAPIAEDIDPATDLPAAVARLEERMIRRALADCSGNRTEAARQLNI
HCCCEEEECCCCEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
NRQLLYTKMQRYGLAEEASGNLTRIVGKDDV
CHHHHHHHHHHCCCCHHCCCCEEEECCCCCC
>Mature Secondary Structure 
ATILIVDDDAALRDGLAETLTDLGHDTLTAASGREAIGMVSAETDAILLDLRMPGIDGI
EEEEEECCCHHHHHHHHHHHHHCCCCCEECCCCCCCEEEEECCCCEEEEEEECCCCCHH
ETLRRIRADAEAPPVIVLTAYASPENTIEAMRLGAFDHLVKPIGRDALRELIERLPPRTR
HHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
PQQDIRGRDDSGLIGTSEAMRRVQKIIGLAADADATVLIRGETGTGKELVARALHVHSRR
CHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
SASPFIAVNCAAIPQDLLESELFGHVKGSFTGATSDRSGAFRDAGAGTLFLDEIGDMPPA
CCCCEEEEEHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCHH
MQAKILRALQERVIAPVGGKPVRVAARVVAATHRDLARQVASGAFREDLYYRLNVIPIEL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCEEEEEEEEECC
PPLRERSEDILLLAGHFLALAANGRARPQLSEAAIDKLVRAPWPGNVRELRNVIERACVL
CCCCCCCCCEEEEECHHHHEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TRGGLIEAEDIDIAAAPIAEDIDPATDLPAAVARLEERMIRRALADCSGNRTEAARQLNI
HCCCEEEECCCCEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
NRQLLYTKMQRYGLAEEASGNLTRIVGKDDV
CHHHHHHHHHHCCCCHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]