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The map label for this gene is adk [H]

Identifier: 146340078

GI number: 146340078

Start: 3284126

End: 3285007

Strand: Direct

Name: adk [H]

Synonym: BRADO3087

Alternate gene names: 146340078

Gene position: 3284126-3285007 (Clockwise)

Preceding gene: 146340077

Following gene: 146340079

Centisome position: 44.04

GC content: 66.1

Gene sequence:

>882_bases
ATGAGACTCATTCTCTTGGGACCGCCCGGTTCGGGCAAGGGCACGCAGGCGCAGCGTCTGGTGCAGCAATATGGTATCGT
CCAGCTCTCGACCGGCGACATGCTGCGCGCCGCGGTCGCGGCGCAGACGCCGATCGGGCTGAAGGCCAAGGACATCATGG
CCGCCGGCGGCCTGGTGCCGGACGAGGTCGTGGTCGGCATCATCGCCGACCGGATCGAGCAGCCTGACGCGGCCAATGGC
TTCATCCTGGACGGCTTCCCGCGCACGGTGCCGCAGGCCGAGGCGCTGGATGCGCTGCTCAAGCAGAAGCAGATGAATCT
CGACGCGGTCATCGAGCTCCGGGTCAACGAGGGTGTGCTGCTGGAGCGCGTCGAGCGCCGCGCTGCCGAAACCCGCGCCC
GCGGTGAGGCGGTGCGCGCCGATGACACTCCCGAGGTGTTGACCAAGCGGCTGCACAGCTATCGCGACCAGACCGAGCCG
CTGATCCACTATTATTCCGACCACCGGATGCTGGCGACTGTCGACGGCATGATGCCGATCGAAGAGGTCACCGAGGAGAT
CGGCCGGATCCTGGCTGCGGTGGGCAAGAGCGCGGGCAGCCGGGCGGCCAAGAAGGCGAGCCCCGCCAAGCGCAGCGCCA
AGACGGCGGCCCCACCTAAGGCGGCCAAAAAGGCGGCCAAGAGGGCGTCCAAGACCGCCGCGCCCGCCAAGAAAGCGGCC
AAGAAGGCTGCCAAGCCGGCTAAAACCGCCAAGAAGGCGGCCAAGACCGTGAAAAAGACCGTGAAAAAGGCCGCGAAGAA
GTCCTCCAAGGCCGCTGCCAAGGCGACCAAGGGAACCCGGAAAACCTCTTCAAAATCTGCAAAAAAGCGCAGCAAGGGGT
GA

Upstream 100 bases:

>100_bases
CGCCGCCGCTGACAGCGGCGGATCGCGGCCCGGGAACCAAAAAGCCAAGAACAAGGTGTGCGGGAGGATCGCTCACCGTG
TGCCGGGGGGCGAAATTTAG

Downstream 100 bases:

>100_bases
CCGAATCTTCTAGGAGCGGTTGACGACCGCCGTGTGAATCCATTAATAAGCCCGCATCCAAGTCGGATAGTTTTCCAAAG
ATGCCGGGCCCCACGAATCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MRLILLGPPGSGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAQTPIGLKAKDIMAAGGLVPDEVVVGIIADRIEQPDAANG
FILDGFPRTVPQAEALDALLKQKQMNLDAVIELRVNEGVLLERVERRAAETRARGEAVRADDTPEVLTKRLHSYRDQTEP
LIHYYSDHRMLATVDGMMPIEEVTEEIGRILAAVGKSAGSRAAKKASPAKRSAKTAAPPKAAKKAAKRASKTAAPAKKAA
KKAAKPAKTAKKAAKTVKKTVKKAAKKSSKAAAKATKGTRKTSSKSAKKRSKG

Sequences:

>Translated_293_residues
MRLILLGPPGSGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAQTPIGLKAKDIMAAGGLVPDEVVVGIIADRIEQPDAANG
FILDGFPRTVPQAEALDALLKQKQMNLDAVIELRVNEGVLLERVERRAAETRARGEAVRADDTPEVLTKRLHSYRDQTEP
LIHYYSDHRMLATVDGMMPIEEVTEEIGRILAAVGKSAGSRAAKKASPAKRSAKTAAPPKAAKKAAKRASKTAAPAKKAA
KKAAKPAKTAKKAAKTVKKTVKKAAKKSSKAAAKATKGTRKTSSKSAKKRSKG
>Mature_293_residues
MRLILLGPPGSGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAQTPIGLKAKDIMAAGGLVPDEVVVGIIADRIEQPDAANG
FILDGFPRTVPQAEALDALLKQKQMNLDAVIELRVNEGVLLERVERRAAETRARGEAVRADDTPEVLTKRLHSYRDQTEP
LIHYYSDHRMLATVDGMMPIEEVTEEIGRILAAVGKSAGSRAAKKASPAKRSAKTAAPPKAAKKAAKRASKTAAPAKKAA
KKAAKPAKTAKKAAKTVKKTVKKAAKKSSKAAAKATKGTRKTSSKSAKKRSKG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=196, Percent_Identity=41.8367346938776, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI4502013, Length=196, Percent_Identity=41.8367346938776, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=34.5177664974619, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4502011, Length=195, Percent_Identity=33.8461538461538, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=34.010152284264, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=34.010152284264, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=34.010152284264, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=34.010152284264, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI28144899, Length=164, Percent_Identity=32.3170731707317, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI7706497, Length=198, Percent_Identity=29.2929292929293, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI28144897, Length=164, Percent_Identity=32.3170731707317, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=34.6456692913386, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=44.4954128440367, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=39.4366197183099, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=32.4324324324324, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=192, Percent_Identity=31.7708333333333, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=195, Percent_Identity=28.2051282051282, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=200, Percent_Identity=28.5, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147457, Length=193, Percent_Identity=24.3523316062176, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=41.1483253588517, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=38.0710659898477, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=29.7872340425532, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=44.8087431693989, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=36.0406091370558, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=36.0406091370558, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24663208, Length=205, Percent_Identity=27.8048780487805, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17647141, Length=205, Percent_Identity=27.8048780487805, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221459597, Length=194, Percent_Identity=27.319587628866, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21356893, Length=194, Percent_Identity=27.319587628866, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 31052; Mature: 31052

Theoretical pI: Translated: 11.13; Mature: 11.13

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGSGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAQTPIGLKAKDIMAAGGLVP
CEEEEECCCCCCCCHHHHHHHHHHCEEEECCCHHHHHHHHHCCCCCCCHHHHHHHCCCCH
DEVVVGIIADRIEQPDAANGFILDGFPRTVPQAEALDALLKQKQMNLDAVIELRVNEGVL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHH
LERVERRAAETRARGEAVRADDTPEVLTKRLHSYRDQTEPLIHYYSDHRMLATVDGMMPI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCEEEEHHCCCCCH
EEVTEEIGRILAAVGKSAGSRAAKKASPAKRSAKTAAPPKAAKKAAKRASKTAAPAKKAA
HHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHH
KKAAKPAKTAKKAAKTVKKTVKKAAKKSSKAAAKATKGTRKTSSKSAKKRSKG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLILLGPPGSGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAQTPIGLKAKDIMAAGGLVP
CEEEEECCCCCCCCHHHHHHHHHHCEEEECCCHHHHHHHHHCCCCCCCHHHHHHHCCCCH
DEVVVGIIADRIEQPDAANGFILDGFPRTVPQAEALDALLKQKQMNLDAVIELRVNEGVL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHH
LERVERRAAETRARGEAVRADDTPEVLTKRLHSYRDQTEPLIHYYSDHRMLATVDGMMPI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCEEEEHHCCCCCH
EEVTEEIGRILAAVGKSAGSRAAKKASPAKRSAKTAAPPKAAKKAAKRASKTAAPAKKAA
HHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHH
KKAAKPAKTAKKAAKTVKKTVKKAAKKSSKAAAKATKGTRKTSSKSAKKRSKG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA