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The map label for this gene is livM [H]

Identifier: 146339550

GI number: 146339550

Start: 2715662

End: 2716666

Strand: Direct

Name: livM [H]

Synonym: BRADO2541

Alternate gene names: 146339550

Gene position: 2715662-2716666 (Clockwise)

Preceding gene: 146339549

Following gene: 146339551

Centisome position: 36.42

GC content: 64.88

Gene sequence:

>1005_bases
ATGGACAAGGCATTCGTTCAACGCCGCCGGCGTGATCTCATCCTCGCCGCATTCCTCGCCGCGATGGCCGCGGCCGTGCC
GTTCTTCGTCAAGGACGTCTACGTCCAGAACATCATGGTGCTGACCCTGATGTATGCGGCGCTGTCGCAGAGCTGGAACA
TCCTGTCCGGCTATTGCGGCCAGATCTCGCTCGGGCACGCGCTGTATTTTGGCCTCGGCGCCTATACGACCGCGATCCTG
TTCACCAAGTTCGGCGTGCTGCCATGGTTCGGCATGCTCGCTGGCGGCCTGATCTCCGCTGTGATCGCGATGGCGCTCGG
CTATCCCTGCTTCCGGCTCGGCGGCCATTACTTCGTGATCGCCACCATCGTCATCGCCGAGATCACGCTGCTCCTGTTCC
AGAACTGGGACTTCGCAGGGGCCGCGCTCGGCATCGACATTCCGGTGCGGCGCGACTCCTGGCTGACGTTCCAGTTCACC
CGCTCGAAGCTGCCATACTTCTACTTCGCGCTCGTGCTGGCCTGCGTCGCCTGGTTCGTCACCTGGTGGCTGGAGGATTC
CAAATGGGGCTATTGGTGGCGCGCGGTGAAGGACAATCCGCTCGCGGCCGAGAGCCTCGGTGTCGACGTGTTCAATTCCA
AGATGGGCGCGGCTGCCGTGTCCGCCTTCCTGGTCGCGATCGGCGGCAGCTTCTATGCGCAGTTCGTCAGCTACATCGAT
CCCGAGAGCGTGATGGGCTTCCAGTTCTCGCTGCTGATGGCGTTGCCGGCCGTGCTCGGCGGCATCGGCACCCTCTGGGG
CCCGATGCTCGGCGCGGTCATCCTGATCCCGCTCACCGAGCTGACCCGTTCTTACATCGGTGGCTCCGGCCGCGGCGTCG
ACCTGATCGTCTATGGCGGCCTGATCATCGCGATCTCGCTGGCGCGGCCGCAGGGCCTGGTCAGCCTGTTCTCCCGCAAG
CCGAAGACGGCGGCGCAGCCGGCGCGAGAGGCGGTGGCGTCATGA

Upstream 100 bases:

>100_bases
CGACGCTGATCCTGCCGGCATCGCTCAAGACGGTCGGCATCTACGCGGTCTATCTCCTCGTCGTCTTCATCCGCCCGCGT
GGCCTGTTCGGATCGATCTG

Downstream 100 bases:

>100_bases
CCGCATTGTTGGAAACCCGCAACATCACCCAGCGCTTCTCGGGCCTGACCGCGAACTCCGACGTCTCGATCTCGGTCGGC
CGCGGCGAGATCGTCGGCCT

Product: putative ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MDKAFVQRRRRDLILAAFLAAMAAAVPFFVKDVYVQNIMVLTLMYAALSQSWNILSGYCGQISLGHALYFGLGAYTTAIL
FTKFGVLPWFGMLAGGLISAVIAMALGYPCFRLGGHYFVIATIVIAEITLLLFQNWDFAGAALGIDIPVRRDSWLTFQFT
RSKLPYFYFALVLACVAWFVTWWLEDSKWGYWWRAVKDNPLAAESLGVDVFNSKMGAAAVSAFLVAIGGSFYAQFVSYID
PESVMGFQFSLLMALPAVLGGIGTLWGPMLGAVILIPLTELTRSYIGGSGRGVDLIVYGGLIIAISLARPQGLVSLFSRK
PKTAAQPAREAVAS

Sequences:

>Translated_334_residues
MDKAFVQRRRRDLILAAFLAAMAAAVPFFVKDVYVQNIMVLTLMYAALSQSWNILSGYCGQISLGHALYFGLGAYTTAIL
FTKFGVLPWFGMLAGGLISAVIAMALGYPCFRLGGHYFVIATIVIAEITLLLFQNWDFAGAALGIDIPVRRDSWLTFQFT
RSKLPYFYFALVLACVAWFVTWWLEDSKWGYWWRAVKDNPLAAESLGVDVFNSKMGAAAVSAFLVAIGGSFYAQFVSYID
PESVMGFQFSLLMALPAVLGGIGTLWGPMLGAVILIPLTELTRSYIGGSGRGVDLIVYGGLIIAISLARPQGLVSLFSRK
PKTAAQPAREAVAS
>Mature_334_residues
MDKAFVQRRRRDLILAAFLAAMAAAVPFFVKDVYVQNIMVLTLMYAALSQSWNILSGYCGQISLGHALYFGLGAYTTAIL
FTKFGVLPWFGMLAGGLISAVIAMALGYPCFRLGGHYFVIATIVIAEITLLLFQNWDFAGAALGIDIPVRRDSWLTFQFT
RSKLPYFYFALVLACVAWFVTWWLEDSKWGYWWRAVKDNPLAAESLGVDVFNSKMGAAAVSAFLVAIGGSFYAQFVSYID
PESVMGFQFSLLMALPAVLGGIGTLWGPMLGAVILIPLTELTRSYIGGSGRGVDLIVYGGLIIAISLARPQGLVSLFSRK
PKTAAQPAREAVAS

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=325, Percent_Identity=28, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 36402; Mature: 36402

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKAFVQRRRRDLILAAFLAAMAAAVPFFVKDVYVQNIMVLTLMYAALSQSWNILSGYCG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
QISLGHALYFGLGAYTTAILFTKFGVLPWFGMLAGGLISAVIAMALGYPCFRLGGHYFVI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHH
ATIVIAEITLLLFQNWDFAGAALGIDIPVRRDSWLTFQFTRSKLPYFYFALVLACVAWFV
HHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
TWWLEDSKWGYWWRAVKDNPLAAESLGVDVFNSKMGAAAVSAFLVAIGGSFYAQFVSYID
HHHHCCCCCCEEEEEECCCCCCHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PESVMGFQFSLLMALPAVLGGIGTLWGPMLGAVILIPLTELTRSYIGGSGRGVDLIVYGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECH
LIIAISLARPQGLVSLFSRKPKTAAQPAREAVAS
HHHEEECCCCHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDKAFVQRRRRDLILAAFLAAMAAAVPFFVKDVYVQNIMVLTLMYAALSQSWNILSGYCG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
QISLGHALYFGLGAYTTAILFTKFGVLPWFGMLAGGLISAVIAMALGYPCFRLGGHYFVI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHH
ATIVIAEITLLLFQNWDFAGAALGIDIPVRRDSWLTFQFTRSKLPYFYFALVLACVAWFV
HHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
TWWLEDSKWGYWWRAVKDNPLAAESLGVDVFNSKMGAAAVSAFLVAIGGSFYAQFVSYID
HHHHCCCCCCEEEEEECCCCCCHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PESVMGFQFSLLMALPAVLGGIGTLWGPMLGAVILIPLTELTRSYIGGSGRGVDLIVYGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECH
LIIAISLARPQGLVSLFSRKPKTAAQPAREAVAS
HHHEEECCCCHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]