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The map label for this gene is gdh [H]

Identifier: 146339505

GI number: 146339505

Start: 2662599

End: 2663897

Strand: Direct

Name: gdh [H]

Synonym: BRADO2494

Alternate gene names: 146339505

Gene position: 2662599-2663897 (Clockwise)

Preceding gene: 146339502

Following gene: 146339506

Centisome position: 35.71

GC content: 64.67

Gene sequence:

>1299_bases
ATGGTTGCCGGCCTGCAGGAGCAGATTCGGGAGTGGAAGATGACTGTCTATGCGGGTCCGGTCTTCGAGATGGCCGCCAA
TCAGTTCAACGTGATCGCCGATCACCTTGGCATCCCAGGCGACGAGCGCGACCGGCTGCTGCTCCCGAAGCGGGCGATCA
CCGTCTCGTGTCCGATCCACAAGGACGACGGCACCATTGCCGTGTTCGAGGGGTATCGTGTTCAGCATCTCCTGACCATG
GGGCCGACCAAGGGCGGCACCCGTTTTGCGCCGACCGTCGACATCGGCGAGGTCGCGGCGCTTGCGATCTGGATGAGCTG
GAAATGCGCGCTGGTGGGCTTGCCCTATGGCGGCGCCAAGGGCGGCGTCAATGTGGACCTCTCCAAGCTGTCCCGCCGTG
AGCTGGAGTCGCTCTCCCGCCGCTACATGCAGGAAATGATCCCCTTCGTCGGCCCGCATACCGACGTGATGGCGCCGGAC
ATGGGCACCAACGAGCAGGTGATGGCGTGGTTCATGGATACGTACTCCATGTATCAGGGCCAGACCGTGACCGAGATCGT
CACCGGCAAGCCGGTGTTCTCGGGCGGCACGCTCGGCCGCCGCGAGGCGACCGGCCGCGGCGTCGCTCACGTGTCGCGGC
GGGTGATGGATCTGCTGGGCATCGATCCCGCCAAGTCCACCGTCGTTGTTCAGGGCTTCGGCAATGTCGGCTCCTACGCT
GCGCTCGGCTTTCACCAGATGGGCATGAAGGTGATTGCGGTCAGCGATCATACCGGCGCGCTCCACGATGCCAGAGGCCT
CGACATTCCCGCACTGATGGCGCATGCAAGCAAGCACGGCAGCATCGCTGGCTTCTCCACCGAGCTCGCCTTCGATCCCA
AGGACATCCTGACGCTCGCCTGCGACATCCTGGTGCCGGCGGCGATCGAGCGCGTCATCGACGCCAAGGTGGCGGCGAAC
CTGAAATGCCGCGTCATCGCGGAAGCCGCCAACGGCCCGACCACGCCGGATGCCGACCTGGTGCTCGACCAGCGCCGCAA
GGAGATCTTCCTCATTCCCGACATTCTCTGCAACTCCGGCGGCGTCATCGTCAGCTATTTCGAATGGGTGCAGGATCTGC
AGCAGCTGTTCTGGGAGGAGGAGGAGGTGATGCGGCGCGAGTACCAGATCCTCGATCGTGCCTTCGAGAAGATGGTCGCG
CGCGCCAAGGCCGACGACATCGCGCACCGGACGGCGGCGATGGCGATCGGCGTCGAGAAGGTGCGCAACGCCAAGAACAC
GCGAGGGCTGTTCCCGTGA

Upstream 100 bases:

>100_bases
GCGGATCAACGCTGAAATTCTTCGTCAAATCGTCACCATGGTGGTTGAGATCGCCCCCTTGCAACCGGCGGCCCCCTGCC
GCCGGCGCAAGGGTCGCGCT

Downstream 100 bases:

>100_bases
TCACCGGCCTCGACCACATCGTCGTCCTGCTCGAGGACATCAAGGCCGGCAGCGCCACGTTCGAGACGCTGCTCGGCCGC
AAGCCGTCGTGGCAGAACTC

Product: glutamate dehydrogenase (NAD(P)+) oxidoreductase protein

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MVAGLQEQIREWKMTVYAGPVFEMAANQFNVIADHLGIPGDERDRLLLPKRAITVSCPIHKDDGTIAVFEGYRVQHLLTM
GPTKGGTRFAPTVDIGEVAALAIWMSWKCALVGLPYGGAKGGVNVDLSKLSRRELESLSRRYMQEMIPFVGPHTDVMAPD
MGTNEQVMAWFMDTYSMYQGQTVTEIVTGKPVFSGGTLGRREATGRGVAHVSRRVMDLLGIDPAKSTVVVQGFGNVGSYA
ALGFHQMGMKVIAVSDHTGALHDARGLDIPALMAHASKHGSIAGFSTELAFDPKDILTLACDILVPAAIERVIDAKVAAN
LKCRVIAEAANGPTTPDADLVLDQRRKEIFLIPDILCNSGGVIVSYFEWVQDLQQLFWEEEEVMRREYQILDRAFEKMVA
RAKADDIAHRTAAMAIGVEKVRNAKNTRGLFP

Sequences:

>Translated_432_residues
MVAGLQEQIREWKMTVYAGPVFEMAANQFNVIADHLGIPGDERDRLLLPKRAITVSCPIHKDDGTIAVFEGYRVQHLLTM
GPTKGGTRFAPTVDIGEVAALAIWMSWKCALVGLPYGGAKGGVNVDLSKLSRRELESLSRRYMQEMIPFVGPHTDVMAPD
MGTNEQVMAWFMDTYSMYQGQTVTEIVTGKPVFSGGTLGRREATGRGVAHVSRRVMDLLGIDPAKSTVVVQGFGNVGSYA
ALGFHQMGMKVIAVSDHTGALHDARGLDIPALMAHASKHGSIAGFSTELAFDPKDILTLACDILVPAAIERVIDAKVAAN
LKCRVIAEAANGPTTPDADLVLDQRRKEIFLIPDILCNSGGVIVSYFEWVQDLQQLFWEEEEVMRREYQILDRAFEKMVA
RAKADDIAHRTAAMAIGVEKVRNAKNTRGLFP
>Mature_432_residues
MVAGLQEQIREWKMTVYAGPVFEMAANQFNVIADHLGIPGDERDRLLLPKRAITVSCPIHKDDGTIAVFEGYRVQHLLTM
GPTKGGTRFAPTVDIGEVAALAIWMSWKCALVGLPYGGAKGGVNVDLSKLSRRELESLSRRYMQEMIPFVGPHTDVMAPD
MGTNEQVMAWFMDTYSMYQGQTVTEIVTGKPVFSGGTLGRREATGRGVAHVSRRVMDLLGIDPAKSTVVVQGFGNVGSYA
ALGFHQMGMKVIAVSDHTGALHDARGLDIPALMAHASKHGSIAGFSTELAFDPKDILTLACDILVPAAIERVIDAKVAAN
LKCRVIAEAANGPTTPDADLVLDQRRKEIFLIPDILCNSGGVIVSYFEWVQDLQQLFWEEEEVMRREYQILDRAFEKMVA
RAKADDIAHRTAAMAIGVEKVRNAKNTRGLFP

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=348, Percent_Identity=42.2413793103448, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI4885281, Length=348, Percent_Identity=42.2413793103448, Blast_Score=268, Evalue=7e-72,
Organism=Escherichia coli, GI1788059, Length=358, Percent_Identity=30.7262569832402, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17544676, Length=343, Percent_Identity=40.2332361516035, Blast_Score=252, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6324951, Length=383, Percent_Identity=28.9817232375979, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319256, Length=394, Percent_Identity=28.9340101522843, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45553475, Length=339, Percent_Identity=40.4129793510324, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI45549226, Length=339, Percent_Identity=40.4129793510324, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24649283, Length=340, Percent_Identity=39.7058823529412, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24649460, Length=287, Percent_Identity=40.418118466899, Blast_Score=225, Evalue=6e-59,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 47270; Mature: 47270

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGLQEQIREWKMTVYAGPVFEMAANQFNVIADHLGIPGDERDRLLLPKRAITVSCPIH
CCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEECCEE
KDDGTIAVFEGYRVQHLLTMGPTKGGTRFAPTVDIGEVAALAIWMSWKCALVGLPYGGAK
CCCCCEEEEECCEEEEEEEECCCCCCCEECCCCCHHHHHHHHHHHCCEEEEEECCCCCCC
GGVNVDLSKLSRRELESLSRRYMQEMIPFVGPHTDVMAPDMGTNEQVMAWFMDTYSMYQG
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
QTVTEIVTGKPVFSGGTLGRREATGRGVAHVSRRVMDLLGIDPAKSTVVVQGFGNVGSYA
CEEEHEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHH
ALGFHQMGMKVIAVSDHTGALHDARGLDIPALMAHASKHGSIAGFSTELAFDPKDILTLA
HHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHH
CDILVPAAIERVIDAKVAANLKCRVIAEAANGPTTPDADLVLDQRRKEIFLIPDILCNSG
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEEEHHHHHCCC
GVIVSYFEWVQDLQQLFWEEEEVMRREYQILDRAFEKMVARAKADDIAHRTAAMAIGVEK
CEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRNAKNTRGLFP
HHCCCCCCCCCC
>Mature Secondary Structure
MVAGLQEQIREWKMTVYAGPVFEMAANQFNVIADHLGIPGDERDRLLLPKRAITVSCPIH
CCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEECCEE
KDDGTIAVFEGYRVQHLLTMGPTKGGTRFAPTVDIGEVAALAIWMSWKCALVGLPYGGAK
CCCCCEEEEECCEEEEEEEECCCCCCCEECCCCCHHHHHHHHHHHCCEEEEEECCCCCCC
GGVNVDLSKLSRRELESLSRRYMQEMIPFVGPHTDVMAPDMGTNEQVMAWFMDTYSMYQG
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
QTVTEIVTGKPVFSGGTLGRREATGRGVAHVSRRVMDLLGIDPAKSTVVVQGFGNVGSYA
CEEEHEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHH
ALGFHQMGMKVIAVSDHTGALHDARGLDIPALMAHASKHGSIAGFSTELAFDPKDILTLA
HHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHH
CDILVPAAIERVIDAKVAANLKCRVIAEAANGPTTPDADLVLDQRRKEIFLIPDILCNSG
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEEEHHHHHCCC
GVIVSYFEWVQDLQQLFWEEEEVMRREYQILDRAFEKMVARAKADDIAHRTAAMAIGVEK
CEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRNAKNTRGLFP
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9680336; 10360571; 9135121; 9654452; 10366510 [H]