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The map label for this gene is yeaE [H]

Identifier: 146339488

GI number: 146339488

Start: 2640683

End: 2641531

Strand: Direct

Name: yeaE [H]

Synonym: BRADO2477

Alternate gene names: 146339488

Gene position: 2640683-2641531 (Clockwise)

Preceding gene: 146339487

Following gene: 146339489

Centisome position: 35.41

GC content: 66.67

Gene sequence:

>849_bases
ATGAAGCACAAGACATTCGGAACCGGCGGCGCCGGCGTGTCCGTCATCGGGCAGGGCACCTGGTATCTCGACCACGCCGA
CCGCAAGCGCGCCATCACGACGTTGCAGCGCGGCCTCGACCGCGGCATGACGCATATCGACACGGCGGAGATGTATGGCG
ACGCCGAGCTCGTCATCGCCGACGCCATCACCGGCCGCCGCGACGAAGTGTTCCTGGTCTCGAAAGTGCTGCCCAGCAAC
GCCTCGCGAAAGGGGACCATCACCGCCTGCGAGCGCTCGCTGAAGCGGCTGAGGACGGATCGCCTCGACTGCTATCTGCT
GCATTGGCCTGGCTCGCATCCGCTCGAAGAGACGGTGGCTGCATTCGAGGAACTCAAAGCCGCCGGCAAGATCGCGTCCT
GGGGCGTCAGCAATTTCGACGTCGACGATCTCGACGATCTCGACGAGCTGCTCGACGTCGCAGGCCGGGGCAAGATCGCC
TGCAATCAGGTGCTCTATCATCTGCAGGAGCGTGCCATCGAGCACGCGGTCATTCCATGGTGCGGCCAGCATGGCGTCGC
CGTGGTCGCCTATTCGCCATTCGGCCATGACGACTTCCCGGAGCGCCGCAGCACGGGCGGCGAGGTGCTGCAGCGCATCG
CCGAGCAGCATCACGCGACGCCGCACCAGATCGCGCTCGCCTTCCTGACCCGCGCCTCGTCGCTGCTCGCGATCCCCAAG
GCGTCGCGGCCCGAACATGCCGAGGAGAATGCCGCGGCCGGCGAGATCGAGCTGACCGCCGCCGACATTGCAGCGATCGA
TCGTGCTTTCCCGCGCGGTCCGAAGCCGCGCGGTCTGCCGATGCTGTAG

Upstream 100 bases:

>100_bases
CAGAGTCCCGCGACGGCTCTGGATTGCTTTGTCGCTTCGCTTCTCGCAATGACGGCAGTGGCCGATCGACGCGCCGCGCC
ATATCCTCTATGATTGTCCT

Downstream 100 bases:

>100_bases
TGCAGCATCACGGAGTATTACGGATGTTTGCTACTCCGGCGCGTAGCCAGCGCATAGATGCTGCCCGCTTTCGACGGGTT
GTCGCGGCGCCGTGATTGGC

Product: putative aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKHKTFGTGGAGVSVIGQGTWYLDHADRKRAITTLQRGLDRGMTHIDTAEMYGDAELVIADAITGRRDEVFLVSKVLPSN
ASRKGTITACERSLKRLRTDRLDCYLLHWPGSHPLEETVAAFEELKAAGKIASWGVSNFDVDDLDDLDELLDVAGRGKIA
CNQVLYHLQERAIEHAVIPWCGQHGVAVVAYSPFGHDDFPERRSTGGEVLQRIAEQHHATPHQIALAFLTRASSLLAIPK
ASRPEHAEENAAAGEIELTAADIAAIDRAFPRGPKPRGLPML

Sequences:

>Translated_282_residues
MKHKTFGTGGAGVSVIGQGTWYLDHADRKRAITTLQRGLDRGMTHIDTAEMYGDAELVIADAITGRRDEVFLVSKVLPSN
ASRKGTITACERSLKRLRTDRLDCYLLHWPGSHPLEETVAAFEELKAAGKIASWGVSNFDVDDLDDLDELLDVAGRGKIA
CNQVLYHLQERAIEHAVIPWCGQHGVAVVAYSPFGHDDFPERRSTGGEVLQRIAEQHHATPHQIALAFLTRASSLLAIPK
ASRPEHAEENAAAGEIELTAADIAAIDRAFPRGPKPRGLPML
>Mature_282_residues
MKHKTFGTGGAGVSVIGQGTWYLDHADRKRAITTLQRGLDRGMTHIDTAEMYGDAELVIADAITGRRDEVFLVSKVLPSN
ASRKGTITACERSLKRLRTDRLDCYLLHWPGSHPLEETVAAFEELKAAGKIASWGVSNFDVDDLDDLDELLDVAGRGKIA
CNQVLYHLQERAIEHAVIPWCGQHGVAVVAYSPFGHDDFPERRSTGGEVLQRIAEQHHATPHQIALAFLTRASSLLAIPK
ASRPEHAEENAAAGEIELTAADIAAIDRAFPRGPKPRGLPML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=276, Percent_Identity=32.6086956521739, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=28.3737024221453, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI24497585, Length=293, Percent_Identity=29.6928327645051, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI45446745, Length=296, Percent_Identity=31.0810810810811, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4503285, Length=296, Percent_Identity=31.0810810810811, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI310109920, Length=296, Percent_Identity=31.0810810810811, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI5453543, Length=295, Percent_Identity=29.8305084745763, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI291291012, Length=261, Percent_Identity=29.1187739463602, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4502049, Length=301, Percent_Identity=28.9036544850498, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI24497583, Length=293, Percent_Identity=30.0341296928328, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=26.4604810996564, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=26.4604810996564, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI5174695, Length=300, Percent_Identity=26, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI300116273, Length=283, Percent_Identity=26.5017667844523, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788081, Length=275, Percent_Identity=45.8181818181818, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1786400, Length=259, Percent_Identity=31.2741312741313, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788070, Length=319, Percent_Identity=27.8996865203762, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082198, Length=275, Percent_Identity=30.5454545454545, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87081735, Length=321, Percent_Identity=27.4143302180685, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787674, Length=294, Percent_Identity=28.2312925170068, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1789199, Length=326, Percent_Identity=28.2208588957055, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789375, Length=328, Percent_Identity=23.1707317073171, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17552492, Length=281, Percent_Identity=27.0462633451957, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=29.4520547945205, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17537075, Length=307, Percent_Identity=29.3159609120521, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17564128, Length=296, Percent_Identity=27.7027027027027, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17561300, Length=265, Percent_Identity=26.7924528301887, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561298, Length=285, Percent_Identity=27.719298245614, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17566692, Length=293, Percent_Identity=24.9146757679181, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17550248, Length=294, Percent_Identity=25.8503401360544, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71998625, Length=238, Percent_Identity=27.3109243697479, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538386, Length=282, Percent_Identity=23.4042553191489, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324694, Length=290, Percent_Identity=28.6206896551724, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320079, Length=290, Percent_Identity=26.8965517241379, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644950, Length=306, Percent_Identity=28.7581699346405, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24657054, Length=292, Percent_Identity=27.7397260273973, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24662789, Length=298, Percent_Identity=27.8523489932886, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21356425, Length=306, Percent_Identity=25.4901960784314, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24663317, Length=290, Percent_Identity=25.5172413793103, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129731, Length=291, Percent_Identity=26.8041237113402, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24662781, Length=284, Percent_Identity=25.3521126760563, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30795; Mature: 30795

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHKTFGTGGAGVSVIGQGTWYLDHADRKRAITTLQRGLDRGMTHIDTAEMYGDAELVIA
CCCCCCCCCCCCEEEEECCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEE
DAITGRRDEVFLVSKVLPSNASRKGTITACERSLKRLRTDRLDCYLLHWPGSHPLEETVA
ECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
AFEELKAAGKIASWGVSNFDVDDLDDLDELLDVAGRGKIACNQVLYHLQERAIEHAVIPW
HHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
CGQHGVAVVAYSPFGHDDFPERRSTGGEVLQRIAEQHHATPHQIALAFLTRASSLLAIPK
CCCCCEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCC
ASRPEHAEENAAAGEIELTAADIAAIDRAFPRGPKPRGLPML
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKHKTFGTGGAGVSVIGQGTWYLDHADRKRAITTLQRGLDRGMTHIDTAEMYGDAELVIA
CCCCCCCCCCCCEEEEECCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEE
DAITGRRDEVFLVSKVLPSNASRKGTITACERSLKRLRTDRLDCYLLHWPGSHPLEETVA
ECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
AFEELKAAGKIASWGVSNFDVDDLDDLDELLDVAGRGKIACNQVLYHLQERAIEHAVIPW
HHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
CGQHGVAVVAYSPFGHDDFPERRSTGGEVLQRIAEQHHATPHQIALAFLTRASSLLAIPK
CCCCCEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCC
ASRPEHAEENAAAGEIELTAADIAAIDRAFPRGPKPRGLPML
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]