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The map label for this gene is adh [H]

Identifier: 146339469

GI number: 146339469

Start: 2617472

End: 2618563

Strand: Direct

Name: adh [H]

Synonym: BRADO2457

Alternate gene names: 146339469

Gene position: 2617472-2618563 (Clockwise)

Preceding gene: 146339468

Following gene: 146339470

Centisome position: 35.1

GC content: 66.58

Gene sequence:

>1092_bases
GTGCCGGACCACGGGAGTGAAAGCATGAAGAGCTTCAAGGTCACCGATTTCAACGCGCCGCTGACCGAGGTCGACGAGCC
GACGCCGCAGCCGTTTGGCAAGCAGGTGCTGATCAAGGTGAAGGCGGCCGGCGTCTGCCATAGCGACCTGCACATCTGGG
AAGGTGGCTATGACCTTGGCCACGGCCGCAAGCCGCTGTCCTTGAAGGATCGCGGCGTCTCGCTGCCGCGGACCATGGGA
CACGAGAGCGCCGGTGAGATCGTGGCGTTCGGGCCCGAGGTCACCGAAGCCGAGAAAGGGGGCTTGAAGGTTGGCGACGT
CGCGCTGGTCTATCCCTGGATCGGCTGCGGCAAATGTGCCACTTGCCTCGCCGGCGACGAGAACATGTGTCTGAAACCGG
CCTCGCTCGGCGTCTATTGCGACGGCGGTTATGCCGATCACATGACGGTGCCGCATCCGCGCCACCTGATCGATCTCAAG
GGTCTCGATCCCGTGACGACCGCGCCTTATGCCTGCTCGGGCGTGACGACCTACAGCGCGCTTAAAAAGGTCGAGACGGA
TTTTGATACGCCGATCGTCATCTTCGGCGCCGGCGGTCTCGGCCTGATGGCGCTGTCCTTGCTCAAGGCGATGGGCGGCA
AGGGCGCCATCGTCGTCGACATCGACGCCCGCAAGCGCGAGGCCGCGCTCGCGGCAGGCGCGCTGGCCGCCGTCGACGGC
AAGGCGCCGGATGCGCTGGAGCAGTTGAACAAGGCGGCGGGCGAGCCGATCCGGGCGGTGATCGACCTGGTCGGCAATGC
CGCCACGGCGCAGCTCGGCTTCGACTGCCTGACCAAGGGCGGCAAGCTCGTCATCGTCGGCCTGTTCGGCGGCGGCGCGC
CCTGGGCGCTGCCGCTCATTCCGATCAAGGCGGTGACGATCCAGGGCAGCTATGTCGGCAATCTGCGCGAGACCAAGGAA
CTGCTCGACCTCGTCCGCGCCAAGAACATCGCGCCGATCCCGGTGACCCCGATGCCGCTCGCGAGGGCCAATGATGCCCT
GCACGAGCTGCAAAAGGGCCAGCTGGTCGGCCGCGCGGTGCTGACGCCGTAG

Upstream 100 bases:

>100_bases
TCCGCCGGACGCGCCATGCCGGGAGGAGATGTCGAGGCCCGCTTGCCCCAGCGCAAGCCGTCGCCCGTCGGTCCCGTCGT
GACGCCGTCCGGTCCTGCTA

Downstream 100 bases:

>100_bases
CCGTTGCTCTCACATTCGTCATTGCGAGGAGCGAATCGACGAAGCAATCCAGAGTCTTAACCTTGGCCCTGGATTGCTTC
GCTTCGCTCGCAATGACGGC

Product: putative NAD-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MPDHGSESMKSFKVTDFNAPLTEVDEPTPQPFGKQVLIKVKAAGVCHSDLHIWEGGYDLGHGRKPLSLKDRGVSLPRTMG
HESAGEIVAFGPEVTEAEKGGLKVGDVALVYPWIGCGKCATCLAGDENMCLKPASLGVYCDGGYADHMTVPHPRHLIDLK
GLDPVTTAPYACSGVTTYSALKKVETDFDTPIVIFGAGGLGLMALSLLKAMGGKGAIVVDIDARKREAALAAGALAAVDG
KAPDALEQLNKAAGEPIRAVIDLVGNAATAQLGFDCLTKGGKLVIVGLFGGGAPWALPLIPIKAVTIQGSYVGNLRETKE
LLDLVRAKNIAPIPVTPMPLARANDALHELQKGQLVGRAVLTP

Sequences:

>Translated_363_residues
MPDHGSESMKSFKVTDFNAPLTEVDEPTPQPFGKQVLIKVKAAGVCHSDLHIWEGGYDLGHGRKPLSLKDRGVSLPRTMG
HESAGEIVAFGPEVTEAEKGGLKVGDVALVYPWIGCGKCATCLAGDENMCLKPASLGVYCDGGYADHMTVPHPRHLIDLK
GLDPVTTAPYACSGVTTYSALKKVETDFDTPIVIFGAGGLGLMALSLLKAMGGKGAIVVDIDARKREAALAAGALAAVDG
KAPDALEQLNKAAGEPIRAVIDLVGNAATAQLGFDCLTKGGKLVIVGLFGGGAPWALPLIPIKAVTIQGSYVGNLRETKE
LLDLVRAKNIAPIPVTPMPLARANDALHELQKGQLVGRAVLTP
>Mature_362_residues
PDHGSESMKSFKVTDFNAPLTEVDEPTPQPFGKQVLIKVKAAGVCHSDLHIWEGGYDLGHGRKPLSLKDRGVSLPRTMGH
ESAGEIVAFGPEVTEAEKGGLKVGDVALVYPWIGCGKCATCLAGDENMCLKPASLGVYCDGGYADHMTVPHPRHLIDLKG
LDPVTTAPYACSGVTTYSALKKVETDFDTPIVIFGAGGLGLMALSLLKAMGGKGAIVVDIDARKREAALAAGALAAVDGK
APDALEQLNKAAGEPIRAVIDLVGNAATAQLGFDCLTKGGKLVIVGLFGGGAPWALPLIPIKAVTIQGSYVGNLRETKEL
LDLVRAKNIAPIPVTPMPLARANDALHELQKGQLVGRAVLTP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=348, Percent_Identity=25.2873563218391, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4501933, Length=379, Percent_Identity=24.802110817942, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI34577061, Length=379, Percent_Identity=24.802110817942, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI226510992, Length=286, Percent_Identity=31.1188811188811, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI87081918, Length=328, Percent_Identity=29.2682926829268, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082401, Length=357, Percent_Identity=28.0112044817927, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790045, Length=346, Percent_Identity=22.5433526011561, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787863, Length=289, Percent_Identity=29.0657439446367, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082125, Length=277, Percent_Identity=29.6028880866426, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788073, Length=289, Percent_Identity=28.3737024221453, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786518, Length=363, Percent_Identity=28.6501377410468, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788407, Length=342, Percent_Identity=23.0994152046784, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=24.4186046511628, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790718, Length=344, Percent_Identity=21.2209302325581, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=360, Percent_Identity=28.0555555555556, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=359, Percent_Identity=27.5766016713092, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=350, Percent_Identity=25.7142857142857, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=349, Percent_Identity=25.214899713467, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=243, Percent_Identity=28.3950617283951, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=361, Percent_Identity=31.3019390581717, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324486, Length=360, Percent_Identity=31.1111111111111, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323729, Length=344, Percent_Identity=31.3953488372093, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319621, Length=360, Percent_Identity=29.1666666666667, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323980, Length=351, Percent_Identity=29.0598290598291, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=381, Percent_Identity=24.1469816272966, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=353, Percent_Identity=26.628895184136, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=319, Percent_Identity=25.705329153605, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=318, Percent_Identity=25.1572327044025, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137530, Length=266, Percent_Identity=28.9473684210526, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737897, Length=266, Percent_Identity=26.6917293233083, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37848; Mature: 37717

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDHGSESMKSFKVTDFNAPLTEVDEPTPQPFGKQVLIKVKAAGVCHSDLHIWEGGYDLG
CCCCCCCHHHEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCEEECCCEEECCCCCCC
HGRKPLSLKDRGVSLPRTMGHESAGEIVAFGPEVTEAEKGGLKVGDVALVYPWIGCGKCA
CCCCCCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCCCCCCEEECCEEEEECCCCCCCHH
TCLAGDENMCLKPASLGVYCDGGYADHMTVPHPRHLIDLKGLDPVTTAPYACSGVTTYSA
HHCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHH
LKKVETDFDTPIVIFGAGGLGLMALSLLKAMGGKGAIVVDIDARKREAALAAGALAAVDG
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHEEECC
KAPDALEQLNKAAGEPIRAVIDLVGNAATAQLGFDCLTKGGKLVIVGLFGGGAPWALPLI
CCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCHHHHCCCCCEEEEEEECCCCCCEEEEE
PIKAVTIQGSYVGNLRETKELLDLVRAKNIAPIPVTPMPLARANDALHELQKGQLVGRAV
EEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEECEEE
LTP
CCC
>Mature Secondary Structure 
PDHGSESMKSFKVTDFNAPLTEVDEPTPQPFGKQVLIKVKAAGVCHSDLHIWEGGYDLG
CCCCCCHHHEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCEEECCCEEECCCCCCC
HGRKPLSLKDRGVSLPRTMGHESAGEIVAFGPEVTEAEKGGLKVGDVALVYPWIGCGKCA
CCCCCCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCCCCCCEEECCEEEEECCCCCCCHH
TCLAGDENMCLKPASLGVYCDGGYADHMTVPHPRHLIDLKGLDPVTTAPYACSGVTTYSA
HHCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHH
LKKVETDFDTPIVIFGAGGLGLMALSLLKAMGGKGAIVVDIDARKREAALAAGALAAVDG
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHEEECC
KAPDALEQLNKAAGEPIRAVIDLVGNAATAQLGFDCLTKGGKLVIVGLFGGGAPWALPLI
CCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCHHHHCCCCCEEEEEEECCCCCCEEEEE
PIKAVTIQGSYVGNLRETKELLDLVRAKNIAPIPVTPMPLARANDALHELQKGQLVGRAV
EEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEECEEE
LTP
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]