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The map label for this gene is pyrC [H]

Identifier: 146339094

GI number: 146339094

Start: 2184018

End: 2185352

Strand: Direct

Name: pyrC [H]

Synonym: BRADO2048

Alternate gene names: 146339094

Gene position: 2184018-2185352 (Clockwise)

Preceding gene: 146339088

Following gene: 146339100

Centisome position: 29.29

GC content: 66.67

Gene sequence:

>1335_bases
ATGAGCCAGCGCTTCGACGTCATTCTGAAATCCGGCACGGTGGTCAATCAGGACGGCGAGGGTGTCCGCGACATCGGCAT
CACGGCGGGGCGCATCGTCGAGATCGGCGATCTCGGCATAGCTTCCGCGGCCGAGATCATCGACTGCAAGGGCCTTCACG
TGCTGCCCGGCGTGATCGACACCCAGGTGCATTTCCGCGAGCCCGGCCTCACCCACAAGGAGGATCTCGAAACCGGCTCG
CGCAGCGCGGTGATGGGCGGCGTCACCGCCGTGTTCGAGATGCCCAACACAAATCCGCTGACGGTCACCGAAGAGGCGTT
CACCGCCAAGATTGAAGCCGGCCGCCATCGCATGCATTGCGACTTCGCCTTTTTCATCGGCGGCACCCGCGAGAACGTCG
ATGAGCTGCCGGTGCTGGAGCGCGCCGAGGGCTGTGCGGGTGTGAAGGTGTTCGTCGGCTCCTCCACCGGCTCGCTGCTG
GTCGAGGACGATGACAGCCTGCGCCGAATCTTTCAGGTGATCCGCCGCCGTGCGGCCTTCCACGCCGAGGACGAGTACCG
CCTCAACGAGCGCAAGGGCCTGCGCGTCGAGAACGATCCGCGCTCGCACCCGGTGTGGCGCGACGAGGAGGCGGCGCTGC
GCGCCACCCAGCGCCTCGTCAATCTCGCGCATGAGACGGGCAAGCGCATCCACGTGCTGCACATCTCGACCAAGGAAGAG
ATCGTCTATCTGCGCGACCACAAGGACGTCGCCACCGTCGAAGCCACGCCGCATCATCTCACGCTCGCCGCGCCCGAGTG
CTACGAGCGGCTCGGCACCTACGCGCAGATGAATCCGCCGGTGCGCTCAGCCGATCATCGCGACGTGATCTGGTGGGGCG
TCCACCAGGGCATCGTCGACATCCTCGGCTCCGACCACGCGCCGCATACCGCCGAGGAAAAGGCGAAGACCTATCCGGCC
TCACCCTCCGGCATGACCGGCGTGCAGACCCTGGTGCCGATCATGCTCGATCACGTCAACGCCGGCCGGCTGTCGCTCGC
CCGTTTCGTCGACCTCACCAGCGCCGGCCCGGCGCGCATCTACAACATCGCCCGCAAGGGCCGCATCGCCGCCGGCTACG
ACGCCGATCTTACGATCGTCGATCTCAAGCGCAGCGAGACCATCACCAACAAATGGGTTGCTTCGAAAGCCGGCTGGACG
CCCTATGACGGCGTGCGCGTGACCGGCTGGCCGGTCGGCACCTTCGTGCGCGGCCAGCGCGTAATGTGGCAGGGCGAACT
GCTGACCCCGGCCACCGGCGAGCCGGTGCGCTTCATGGAGACGCTGCGGGCGTAA

Upstream 100 bases:

>100_bases
ATCGAGACGCGAGCGGCCTCGCAGACCAGCAAATGGGCAGGCGCGCAGCACGATCCATCTGCCTTGAGGTGATCAGGAGA
ATGAAATCCTAGAGGGGTTC

Downstream 100 bases:

>100_bases
CCGCGCCGCTCCGCGCCATGTTGCTGCGCTCGCAATGACGAGGAGCGGTTTCTCGTAGCCCGGATGAGCGCAAGCGACAT
CCGGGTTCACCTCCACAGCT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSQRFDVILKSGTVVNQDGEGVRDIGITAGRIVEIGDLGIASAAEIIDCKGLHVLPGVIDTQVHFREPGLTHKEDLETGS
RSAVMGGVTAVFEMPNTNPLTVTEEAFTAKIEAGRHRMHCDFAFFIGGTRENVDELPVLERAEGCAGVKVFVGSSTGSLL
VEDDDSLRRIFQVIRRRAAFHAEDEYRLNERKGLRVENDPRSHPVWRDEEAALRATQRLVNLAHETGKRIHVLHISTKEE
IVYLRDHKDVATVEATPHHLTLAAPECYERLGTYAQMNPPVRSADHRDVIWWGVHQGIVDILGSDHAPHTAEEKAKTYPA
SPSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPARIYNIARKGRIAAGYDADLTIVDLKRSETITNKWVASKAGWT
PYDGVRVTGWPVGTFVRGQRVMWQGELLTPATGEPVRFMETLRA

Sequences:

>Translated_444_residues
MSQRFDVILKSGTVVNQDGEGVRDIGITAGRIVEIGDLGIASAAEIIDCKGLHVLPGVIDTQVHFREPGLTHKEDLETGS
RSAVMGGVTAVFEMPNTNPLTVTEEAFTAKIEAGRHRMHCDFAFFIGGTRENVDELPVLERAEGCAGVKVFVGSSTGSLL
VEDDDSLRRIFQVIRRRAAFHAEDEYRLNERKGLRVENDPRSHPVWRDEEAALRATQRLVNLAHETGKRIHVLHISTKEE
IVYLRDHKDVATVEATPHHLTLAAPECYERLGTYAQMNPPVRSADHRDVIWWGVHQGIVDILGSDHAPHTAEEKAKTYPA
SPSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPARIYNIARKGRIAAGYDADLTIVDLKRSETITNKWVASKAGWT
PYDGVRVTGWPVGTFVRGQRVMWQGELLTPATGEPVRFMETLRA
>Mature_443_residues
SQRFDVILKSGTVVNQDGEGVRDIGITAGRIVEIGDLGIASAAEIIDCKGLHVLPGVIDTQVHFREPGLTHKEDLETGSR
SAVMGGVTAVFEMPNTNPLTVTEEAFTAKIEAGRHRMHCDFAFFIGGTRENVDELPVLERAEGCAGVKVFVGSSTGSLLV
EDDDSLRRIFQVIRRRAAFHAEDEYRLNERKGLRVENDPRSHPVWRDEEAALRATQRLVNLAHETGKRIHVLHISTKEEI
VYLRDHKDVATVEATPHHLTLAAPECYERLGTYAQMNPPVRSADHRDVIWWGVHQGIVDILGSDHAPHTAEEKAKTYPAS
PSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPARIYNIARKGRIAAGYDADLTIVDLKRSETITNKWVASKAGWTP
YDGVRVTGWPVGTFVRGQRVMWQGELLTPATGEPVRFMETLRA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=423, Percent_Identity=31.2056737588652, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=26.9736842105263, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4503379, Length=448, Percent_Identity=25.2232142857143, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI4503051, Length=449, Percent_Identity=24.9443207126949, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI62422571, Length=450, Percent_Identity=25.3333333333333, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI190194363, Length=461, Percent_Identity=25.5965292841649, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI4503375, Length=458, Percent_Identity=25.1091703056769, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4503377, Length=448, Percent_Identity=25, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1786722, Length=436, Percent_Identity=32.1100917431193, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI87082175, Length=453, Percent_Identity=27.3730684326711, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI193204318, Length=401, Percent_Identity=29.426433915212, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71989490, Length=464, Percent_Identity=25.6465517241379, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17539558, Length=452, Percent_Identity=26.5486725663717, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI86575075, Length=441, Percent_Identity=24.2630385487528, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=390, Percent_Identity=29.4871794871795, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24642586, Length=388, Percent_Identity=32.2164948453608, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=27.4725274725275, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI17137462, Length=448, Percent_Identity=27.6785714285714, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18859883, Length=413, Percent_Identity=27.3607748184019, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24644287, Length=248, Percent_Identity=28.2258064516129, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644289, Length=241, Percent_Identity=28.2157676348548, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 49008; Mature: 48877

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRFDVILKSGTVVNQDGEGVRDIGITAGRIVEIGDLGIASAAEIIDCKGLHVLPGVID
CCCCEEEEEECCEEECCCCCCCEEECCCCCCEEEECCCCCCCHHHHHCCCCCEECCCCCC
TQVHFREPGLTHKEDLETGSRSAVMGGVTAVFEMPNTNPLTVTEEAFTAKIEAGRHRMHC
CEEEECCCCCCCHHHHCCCCCCHHHCCEEEEEECCCCCCEEEEHHHHEEEECCCCCEEEE
DFAFFIGGTRENVDELPVLERAEGCAGVKVFVGSSTGSLLVEDDDSLRRIFQVIRRRAAF
EEEEEECCCCCCHHHCCHHHHCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHC
HAEDEYRLNERKGLRVENDPRSHPVWRDEEAALRATQRLVNLAHETGKRIHVLHISTKEE
CCCCCCCCHHCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCE
IVYLRDHKDVATVEATPHHLTLAAPECYERLGTYAQMNPPVRSADHRDVIWWGVHQGIVD
EEEEECCCCEEEEECCCCEEEEECHHHHHHHCCCEECCCCCCCCCCCCEEEEEHHHHHHH
ILGSDHAPHTAEEKAKTYPASPSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPARI
HHCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHH
YNIARKGRIAAGYDADLTIVDLKRSETITNKWVASKAGWTPYDGVRVTGWPVGTFVRGQR
HHHHHCCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCEECCCE
VMWQGELLTPATGEPVRFMETLRA
EEEECCEECCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SQRFDVILKSGTVVNQDGEGVRDIGITAGRIVEIGDLGIASAAEIIDCKGLHVLPGVID
CCCEEEEEECCEEECCCCCCCEEECCCCCCEEEECCCCCCCHHHHHCCCCCEECCCCCC
TQVHFREPGLTHKEDLETGSRSAVMGGVTAVFEMPNTNPLTVTEEAFTAKIEAGRHRMHC
CEEEECCCCCCCHHHHCCCCCCHHHCCEEEEEECCCCCCEEEEHHHHEEEECCCCCEEEE
DFAFFIGGTRENVDELPVLERAEGCAGVKVFVGSSTGSLLVEDDDSLRRIFQVIRRRAAF
EEEEEECCCCCCHHHCCHHHHCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHC
HAEDEYRLNERKGLRVENDPRSHPVWRDEEAALRATQRLVNLAHETGKRIHVLHISTKEE
CCCCCCCCHHCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCE
IVYLRDHKDVATVEATPHHLTLAAPECYERLGTYAQMNPPVRSADHRDVIWWGVHQGIVD
EEEEECCCCEEEEECCCCEEEEECHHHHHHHCCCEECCCCCCCCCCCCEEEEEHHHHHHH
ILGSDHAPHTAEEKAKTYPASPSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPARI
HHCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHH
YNIARKGRIAAGYDADLTIVDLKRSETITNKWVASKAGWTPYDGVRVTGWPVGTFVRGQR
HHHHHCCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCEECCCE
VMWQGELLTPATGEPVRFMETLRA
EEEECCEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]