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The map label for this gene is moaB [H]

Identifier: 146339058

GI number: 146339058

Start: 2139278

End: 2139838

Strand: Direct

Name: moaB [H]

Synonym: BRADO2012

Alternate gene names: 146339058

Gene position: 2139278-2139838 (Clockwise)

Preceding gene: 146339057

Following gene: 146339062

Centisome position: 28.69

GC content: 66.13

Gene sequence:

>561_bases
ATGGCGATCGATGAGAGCAAGAGCTTCATCCCCCTCAACATCGCCGTGCTGACGGTGTCAGACACCCGATCGCTCGCCGA
CGACAAGTCCGGCAATACCCTGAGCGATCGGCTGACCGCCGCCGGCCACACGCTCGCCGCGCGCGACATCGTCACCGATG
ACGTAGAGAAGATCCGCAGCGTGGTGAAGGCATGGATCGCCGATCCCGGCGTCGATGTCGTCATCACCACAGGGGGCACC
GGCTTCACCGGCCGCGACGTCACGCCGGAGGCGATCGAGCCGCTGTTCGAAAAACGCATGGACGGTTTCTCGATCGCGTT
CCATCTGCTGAGCCACGCCAAGATCGGGACGTCCACGATCCAGAGCCGTGCGACCGCGGGCGTGGCGGGCGCCACCTACA
TCTTCTGTCTGCCGGGCTCGCCTGGCGCCTGTCGCGACGGCTGGGACGGCATCCTCGCCGCCCAGCTCGATTATCGCACC
AGGCCCTGCAACTTCGTCGAGATCATGCCTCGGCTCGACGAGCATCTACGCCGGCCGAAGGCCCAGGGTGCGACGGCGTA
G

Upstream 100 bases:

>100_bases
CGGCCGCGCAGCGCAAGCGCTGGTTCATGACCGGCTACCAGCAGGGCACGGTGCAGGCCTGCAATACGTTCGGCGCCAAT
TCGCTTTAGGAGACGCGATC

Downstream 100 bases:

>100_bases
CCGCGCGCCGTCATTCCGGGGCAGGCTCGGATATGCAGCCGCACAGCGACTGCGTGTCGGCGCCTGAACCTGGAATCTCG
AGCTCGTTGACGCGCGCACG

Product: molybdenum cofactor biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MAIDESKSFIPLNIAVLTVSDTRSLADDKSGNTLSDRLTAAGHTLAARDIVTDDVEKIRSVVKAWIADPGVDVVITTGGT
GFTGRDVTPEAIEPLFEKRMDGFSIAFHLLSHAKIGTSTIQSRATAGVAGATYIFCLPGSPGACRDGWDGILAAQLDYRT
RPCNFVEIMPRLDEHLRRPKAQGATA

Sequences:

>Translated_186_residues
MAIDESKSFIPLNIAVLTVSDTRSLADDKSGNTLSDRLTAAGHTLAARDIVTDDVEKIRSVVKAWIADPGVDVVITTGGT
GFTGRDVTPEAIEPLFEKRMDGFSIAFHLLSHAKIGTSTIQSRATAGVAGATYIFCLPGSPGACRDGWDGILAAQLDYRT
RPCNFVEIMPRLDEHLRRPKAQGATA
>Mature_185_residues
AIDESKSFIPLNIAVLTVSDTRSLADDKSGNTLSDRLTAAGHTLAARDIVTDDVEKIRSVVKAWIADPGVDVVITTGGTG
FTGRDVTPEAIEPLFEKRMDGFSIAFHLLSHAKIGTSTIQSRATAGVAGATYIFCLPGSPGACRDGWDGILAAQLDYRTR
PCNFVEIMPRLDEHLRRPKAQGATA

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=148, Percent_Identity=36.4864864864865, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI66932975, Length=148, Percent_Identity=36.4864864864865, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI1787000, Length=160, Percent_Identity=53.125, Blast_Score=171, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17564954, Length=145, Percent_Identity=37.2413793103448, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136978, Length=145, Percent_Identity=35.8620689655172, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24638841, Length=145, Percent_Identity=35.8620689655172, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19871; Mature: 19740

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDESKSFIPLNIAVLTVSDTRSLADDKSGNTLSDRLTAAGHTLAARDIVTDDVEKIRS
CCCCCCCCEEEEEEEEEEECCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VVKAWIADPGVDVVITTGGTGFTGRDVTPEAIEPLFEKRMDGFSIAFHLLSHAKIGTSTI
HHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
QSRATAGVAGATYIFCLPGSPGACRDGWDGILAAQLDYRTRPCNFVEIMPRLDEHLRRPK
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
AQGATA
CCCCCC
>Mature Secondary Structure 
AIDESKSFIPLNIAVLTVSDTRSLADDKSGNTLSDRLTAAGHTLAARDIVTDDVEKIRS
CCCCCCCEEEEEEEEEEECCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VVKAWIADPGVDVVITTGGTGFTGRDVTPEAIEPLFEKRMDGFSIAFHLLSHAKIGTSTI
HHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
QSRATAGVAGATYIFCLPGSPGACRDGWDGILAAQLDYRTRPCNFVEIMPRLDEHLRRPK
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
AQGATA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]