Click here to switch to the map view.

The map label for this gene is apt [H]

Identifier: 146339039

GI number: 146339039

Start: 2117541

End: 2118080

Strand: Direct

Name: apt [H]

Synonym: BRADO1992

Alternate gene names: 146339039

Gene position: 2117541-2118080 (Clockwise)

Preceding gene: 146339038

Following gene: 146339042

Centisome position: 28.4

GC content: 67.22

Gene sequence:

>540_bases
ATGACGTTCGATCTGGACATCAAGAACACGGTCCGCACCATTCCGGACTATCCCAAGCCCGGCATCCTGTTCCGGGACAT
CACGACCTTGCTGGCGGACGCCCGCGCGTTCCGCCGCGCGGTCGACGAGCTGGTGCATCCCTGGGCCGGCTCGAAGATCG
ACAAGGTCGCGGGCATCGAGGCGCGCGGCTTCATCCTCGGCGGCGCGGTCGCGCACCAGCTTTCGGCCGGCTTCGTGCCG
ATCAGGAAAAAAGGCAAGCTGCCGCACAAGACGGTCAGCATGTCCTACGCGCTGGAATACGGCACCGACGAGATGGAGAT
GCATGTCGACGCGGTGCAGCCCGGCGAGCGGGTCATCCTGGTTGACGACCTCATCGCCACCGGCGGCACGGCCGAGGGCG
CGGTGAAGCTGCTGCGCCAGATCGGCGCCACCGTTGTGGCCGCCTGCTTCATCATCGACCTGCCGGATCTCGGCGGCGCC
GCCAAGCTGCGCGCGCTCGACGTGCCGGTGCGCTCGCTGATCGCGTTCGATGGACACTGA

Upstream 100 bases:

>100_bases
AGGAGCGAAGCGACGAAGCAATCCAGTCCTTTGTTGCGGCCCCTGGATTGCTTCGCTTCGCTCGCAATGACGGCAATACA
TAGAGTGGGATGAGAGCACG

Downstream 100 bases:

>100_bases
AGCAGGGCGTCAGGAGCGCTGCATCACCAGCTCCACCTCGATCTCGCGGAACGCATAATAATTGCGCCGGATCCATTGAT
AGAGCTCGGTCGAGGGGTCG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MTFDLDIKNTVRTIPDYPKPGILFRDITTLLADARAFRRAVDELVHPWAGSKIDKVAGIEARGFILGGAVAHQLSAGFVP
IRKKGKLPHKTVSMSYALEYGTDEMEMHVDAVQPGERVILVDDLIATGGTAEGAVKLLRQIGATVVAACFIIDLPDLGGA
AKLRALDVPVRSLIAFDGH

Sequences:

>Translated_179_residues
MTFDLDIKNTVRTIPDYPKPGILFRDITTLLADARAFRRAVDELVHPWAGSKIDKVAGIEARGFILGGAVAHQLSAGFVP
IRKKGKLPHKTVSMSYALEYGTDEMEMHVDAVQPGERVILVDDLIATGGTAEGAVKLLRQIGATVVAACFIIDLPDLGGA
AKLRALDVPVRSLIAFDGH
>Mature_178_residues
TFDLDIKNTVRTIPDYPKPGILFRDITTLLADARAFRRAVDELVHPWAGSKIDKVAGIEARGFILGGAVAHQLSAGFVPI
RKKGKLPHKTVSMSYALEYGTDEMEMHVDAVQPGERVILVDDLIATGGTAEGAVKLLRQIGATVVAACFIIDLPDLGGAA
KLRALDVPVRSLIAFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=42.5287356321839, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=46.4, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=53.757225433526, Blast_Score=199, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17509087, Length=175, Percent_Identity=42.8571428571429, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=177, Percent_Identity=36.7231638418079, Blast_Score=111, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=36.9942196531792, Blast_Score=98, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17136334, Length=172, Percent_Identity=39.5348837209302, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19228; Mature: 19096

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDLDIKNTVRTIPDYPKPGILFRDITTLLADARAFRRAVDELVHPWAGSKIDKVAGIE
CEEECCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCC
ARGFILGGAVAHQLSAGFVPIRKKGKLPHKTVSMSYALEYGTDEMEMHVDAVQPGERVIL
CCCEEEHHHHHHHHHCCCCEECCCCCCCCHHEEEEEEEECCCCHHEEEEECCCCCCEEEE
VDDLIATGGTAEGAVKLLRQIGATVVAACFIIDLPDLGGAAKLRALDVPVRSLIAFDGH
EECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHCCCCC
>Mature Secondary Structure 
TFDLDIKNTVRTIPDYPKPGILFRDITTLLADARAFRRAVDELVHPWAGSKIDKVAGIE
EEECCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCC
ARGFILGGAVAHQLSAGFVPIRKKGKLPHKTVSMSYALEYGTDEMEMHVDAVQPGERVIL
CCCEEEHHHHHHHHHCCCCEECCCCCCCCHHEEEEEEEECCCCHHEEEEECCCCCCEEEE
VDDLIATGGTAEGAVKLLRQIGATVVAACFIIDLPDLGGAAKLRALDVPVRSLIAFDGH
EECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA