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The map label for this gene is trpE(G) [H]

Identifier: 146339038

GI number: 146339038

Start: 2115259

End: 2117424

Strand: Direct

Name: trpE(G) [H]

Synonym: BRADO1991

Alternate gene names: 146339038

Gene position: 2115259-2117424 (Clockwise)

Preceding gene: 146339037

Following gene: 146339039

Centisome position: 28.37

GC content: 67.59

Gene sequence:

>2166_bases
ATGAACAGGACCGTTTTCGCCCTTCCGGCCCGCAGCGACTACCGCACCTCGAGCGGGCTCGCGATCACGCGCGCCGTCGA
GCAGTTTTCCGGCGGCGCCAGCCGGCTCGACGACCTGATCGACCTGCTGGACCGCCGCCGCGGCGTGGTGCTGTCCTCGG
GCACGACCGTGCCCGGCCGCTACGAGAGTTTCGACCTCGGCTTCGCCGATCCGCCGTTGGTGCTGGAGACGAAGGGGACC
GATTTCACGCTGCAGGCCCTGAACAAGCGCGGCGAGGTCCTGATCGCCTTCCTGAAGGACACCCTGCGCGAGCCCTGCGT
CGTCATCACCGCAGCCTCGCCAGCGCGGCTCGCCGGCCATATCGTCCGCGGGCCCGCGCCGGTCGAGGAGGACCAGCGCA
CCCGGCGCGCCAGCGTGATGTCGCTGGTGCGGGCGATGATCGCGACGCTCGCAGCCAATGACGATCCGCTGCTCGGCCTG
TTCGGCGCCTTCGCCTATGATCTCGTGTTCCAGATCGAGGACCTCGTCCAAAAGCGCCCGCGCGAGAAGGACCAGCGCGA
TATCGTGCTCTACGTGCCCGATCGCCTGCTGGCCTACGACCGCGCCACTGGTCGCGGCGTGGTTCTGTCTTACGATTTTT
CCTGGAACGGCCAGTCGACATCAGGCCTGCCGCGCGACACGGACGCCAGCGTCTATCTGAAGGAACCCCGCCAGGGTTTT
GCCGACCACGCGCCGGGCGAATACCAGGCGACGGTGGACAAGGCCCGCGCGGCGTTCGCCCGCGGTGACCTGTTCGAGGC
GGTGCCCGGCCAGCTGTTCGCCGAGCCCTGCGAGCGTTCGCCGGCCGAGGTGTTCCAGCGGCTCTGCCGCATCAACCCGT
CGCCCTACGGCGCGCTGATGAATCTCGGCGATGGCGAATTCCTCGTTTCCGCGTCGCCGGAGATGTTCGTGCGCTCCGAC
GGCCGCCGCGTCGAGACCTGTCCGATCTCCGGCACCATCGCGCGCGGCCGCGACGCCATCGGCGACGCCGAGCAGATCCG
CCAGCTCCTGAACTCCGAGAAGGACGAGTTCGAGCTCAACATGTGCACCGACGTCGACCGCAACGACAAGGCGCGCATTT
GCGTGCCCGGCACCATCAAGGTGCTGGCGCGCCGGCAGATCGAGACCTACTCGAAACTGTTCCACACCGTCGATCACGTC
GAGGGCATGCTGCGGCCGGGCTTTGACGCGCTCGATGCGTTTTTGACTCACGCCTGGGCGGTCACAGTGACCGGCGCGCC
AAAACTGTGGGCGATGCAGTTCGTCGAGGACCATGAGCGCTCGCCGCGGCGCTGGTACGCCGGCGCGATCGGCGCGGTGA
ATTTCGACGGCTCGATCAATACCGGGCTGACCATCCGGACCATTCGCATGAAGGACGGGCTCGCCGAGGTTCGCGTCGGC
GCCACCTGTTTGTTCGATAGCGACCCGGCGGCCGAGGATCGCGAGTGCCAGGTCAAGGCGGCGGCGCTGTTTCAGGCGCT
GCGGGGCGATCCGCCGAAGCCGCTGTCCTCGACAGCGCCGGATGCCACCGGCTCGGGCAAGAACGTGCTGCTGATCGATC
ACGACGACTCGTTCGTGCACATGCTTGCGGATTATTTCCGCCAGGTCGGCGCCAACGTGACCGTGGTGCGTTACGTCCAT
GCGCTGACCATGCTGGCCGAGCGCAGCTGGGATCTCATCGTGCTGTCGCCGGGCCCTGGCCGGCCGGAAGACTTCAAGAT
CTCCACGACCATCGACGCCGCGCTCGCCAAGAAGCTGCCGATCTTCGGCGTCTGCCTGGGCGTGCAGGCGATGGGCGAGT
ATTTTGGCGGCCAGCTCGGTCAGCTCGCCCAGCCCGCGCATGGCCGGCCGTCGCGCGTGCAGGTGCGCGGCGGACGCTTG
ATGCAGGGGCTGCCGAACGAGATCGTGATCGGCCGCTACCATTCGCTGTTCGTCGAGCGCGACAGCATGCCCGAGGTGCT
GACGGTGACGGCGGCGACCGAGGATGGGGTGGCGATGGCGATCGAGCACAAGACGCTGCCGGTCGGCGGCGTGCAGTTCC
ATCCGGAATCGCTGATGTCGCTCGGCGATGCCGTGGGCTTGAGGATCGTGGAGAATGCGTTCCGGCTCAATCAGCCGGGG
AGTTGA

Upstream 100 bases:

>100_bases
CATTCGATCGCAGAGGGGCCGCCACGCAGCGGCGGCTTCCGGTTGGTCCTGTGTGGCGTTTCCTCGGCAAATTCCGTAAG
AGGACGCCCAAGAGGACCCC

Downstream 100 bases:

>100_bases
TCACGCCCTCATTGCGAGGAGCGAAGCGACGAAGCAATCCAGTCCTTTGTTGCGGCCCCTGGATTGCTTCGCTTCGCTCG
CAATGACGGCAATACATAGA

Product: anthranilate synthase

Products: NA

Alternate protein names: Glutamine amidotransferase [H]

Number of amino acids: Translated: 721; Mature: 721

Protein sequence:

>721_residues
MNRTVFALPARSDYRTSSGLAITRAVEQFSGGASRLDDLIDLLDRRRGVVLSSGTTVPGRYESFDLGFADPPLVLETKGT
DFTLQALNKRGEVLIAFLKDTLREPCVVITAASPARLAGHIVRGPAPVEEDQRTRRASVMSLVRAMIATLAANDDPLLGL
FGAFAYDLVFQIEDLVQKRPREKDQRDIVLYVPDRLLAYDRATGRGVVLSYDFSWNGQSTSGLPRDTDASVYLKEPRQGF
ADHAPGEYQATVDKARAAFARGDLFEAVPGQLFAEPCERSPAEVFQRLCRINPSPYGALMNLGDGEFLVSASPEMFVRSD
GRRVETCPISGTIARGRDAIGDAEQIRQLLNSEKDEFELNMCTDVDRNDKARICVPGTIKVLARRQIETYSKLFHTVDHV
EGMLRPGFDALDAFLTHAWAVTVTGAPKLWAMQFVEDHERSPRRWYAGAIGAVNFDGSINTGLTIRTIRMKDGLAEVRVG
ATCLFDSDPAAEDRECQVKAAALFQALRGDPPKPLSSTAPDATGSGKNVLLIDHDDSFVHMLADYFRQVGANVTVVRYVH
ALTMLAERSWDLIVLSPGPGRPEDFKISTTIDAALAKKLPIFGVCLGVQAMGEYFGGQLGQLAQPAHGRPSRVQVRGGRL
MQGLPNEIVIGRYHSLFVERDSMPEVLTVTAATEDGVAMAIEHKTLPVGGVQFHPESLMSLGDAVGLRIVENAFRLNQPG
S

Sequences:

>Translated_721_residues
MNRTVFALPARSDYRTSSGLAITRAVEQFSGGASRLDDLIDLLDRRRGVVLSSGTTVPGRYESFDLGFADPPLVLETKGT
DFTLQALNKRGEVLIAFLKDTLREPCVVITAASPARLAGHIVRGPAPVEEDQRTRRASVMSLVRAMIATLAANDDPLLGL
FGAFAYDLVFQIEDLVQKRPREKDQRDIVLYVPDRLLAYDRATGRGVVLSYDFSWNGQSTSGLPRDTDASVYLKEPRQGF
ADHAPGEYQATVDKARAAFARGDLFEAVPGQLFAEPCERSPAEVFQRLCRINPSPYGALMNLGDGEFLVSASPEMFVRSD
GRRVETCPISGTIARGRDAIGDAEQIRQLLNSEKDEFELNMCTDVDRNDKARICVPGTIKVLARRQIETYSKLFHTVDHV
EGMLRPGFDALDAFLTHAWAVTVTGAPKLWAMQFVEDHERSPRRWYAGAIGAVNFDGSINTGLTIRTIRMKDGLAEVRVG
ATCLFDSDPAAEDRECQVKAAALFQALRGDPPKPLSSTAPDATGSGKNVLLIDHDDSFVHMLADYFRQVGANVTVVRYVH
ALTMLAERSWDLIVLSPGPGRPEDFKISTTIDAALAKKLPIFGVCLGVQAMGEYFGGQLGQLAQPAHGRPSRVQVRGGRL
MQGLPNEIVIGRYHSLFVERDSMPEVLTVTAATEDGVAMAIEHKTLPVGGVQFHPESLMSLGDAVGLRIVENAFRLNQPG
S
>Mature_721_residues
MNRTVFALPARSDYRTSSGLAITRAVEQFSGGASRLDDLIDLLDRRRGVVLSSGTTVPGRYESFDLGFADPPLVLETKGT
DFTLQALNKRGEVLIAFLKDTLREPCVVITAASPARLAGHIVRGPAPVEEDQRTRRASVMSLVRAMIATLAANDDPLLGL
FGAFAYDLVFQIEDLVQKRPREKDQRDIVLYVPDRLLAYDRATGRGVVLSYDFSWNGQSTSGLPRDTDASVYLKEPRQGF
ADHAPGEYQATVDKARAAFARGDLFEAVPGQLFAEPCERSPAEVFQRLCRINPSPYGALMNLGDGEFLVSASPEMFVRSD
GRRVETCPISGTIARGRDAIGDAEQIRQLLNSEKDEFELNMCTDVDRNDKARICVPGTIKVLARRQIETYSKLFHTVDHV
EGMLRPGFDALDAFLTHAWAVTVTGAPKLWAMQFVEDHERSPRRWYAGAIGAVNFDGSINTGLTIRTIRMKDGLAEVRVG
ATCLFDSDPAAEDRECQVKAAALFQALRGDPPKPLSSTAPDATGSGKNVLLIDHDDSFVHMLADYFRQVGANVTVVRYVH
ALTMLAERSWDLIVLSPGPGRPEDFKISTTIDAALAKKLPIFGVCLGVQAMGEYFGGQLGQLAQPAHGRPSRVQVRGGRL
MQGLPNEIVIGRYHSLFVERDSMPEVLTVTAATEDGVAMAIEHKTLPVGGVQFHPESLMSLGDAVGLRIVENAFRLNQPG
S

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=409, Percent_Identity=32.0293398533007, Blast_Score=163, Evalue=4e-41,
Organism=Escherichia coli, GI1789760, Length=174, Percent_Identity=43.6781609195402, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1787517, Length=195, Percent_Identity=37.9487179487179, Blast_Score=120, Evalue=4e-28,
Organism=Escherichia coli, GI1788114, Length=261, Percent_Identity=29.8850574712644, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1786809, Length=229, Percent_Identity=28.82096069869, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=368, Percent_Identity=32.0652173913043, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322638, Length=190, Percent_Identity=37.8947368421053, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324361, Length=215, Percent_Identity=31.6279069767442, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR006805
- InterPro:   IPR006220
- InterPro:   IPR010112
- InterPro:   IPR015890
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind; PF00117 GATase [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 78832; Mature: 78832

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTVFALPARSDYRTSSGLAITRAVEQFSGGASRLDDLIDLLDRRRGVVLSSGTTVPGR
CCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCCC
YESFDLGFADPPLVLETKGTDFTLQALNKRGEVLIAFLKDTLREPCVVITAASPARLAGH
CCCEECCCCCCCEEEEECCCCEEHHHHCCCCCEEEHHHHHHHCCCEEEEECCCCHHHHHH
IVRGPAPVEEDQRTRRASVMSLVRAMIATLAANDDPLLGLFGAFAYDLVFQIEDLVQKRP
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
REKDQRDIVLYVPDRLLAYDRATGRGVVLSYDFSWNGQSTSGLPRDTDASVYLKEPRQGF
CCCCCCCEEEEECCHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCC
ADHAPGEYQATVDKARAAFARGDLFEAVPGQLFAEPCERSPAEVFQRLCRINPSPYGALM
CCCCCCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHCCCHHHHHHHHHCCCCCCCHHEE
NLGDGEFLVSASPEMFVRSDGRRVETCPISGTIARGRDAIGDAEQIRQLLNSEKDEFELN
ECCCCCEEEECCCCEEEECCCCEEEECCCCCCHHCCCCCCCCHHHHHHHHCCCCCCEEEE
MCTDVDRNDKARICVPGTIKVLARRQIETYSKLFHTVDHVEGMLRPGFDALDAFLTHAWA
EECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCEEE
VTVTGAPKLWAMQFVEDHERSPRRWYAGAIGAVNFDGSINTGLTIRTIRMKDGLAEVRVG
EEECCCCHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCEEEEEEEECCCHHHHEEC
ATCLFDSDPAAEDRECQVKAAALFQALRGDPPKPLSSTAPDATGSGKNVLLIDHDDSFVH
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
MLADYFRQVGANVTVVRYVHALTMLAERSWDLIVLSPGPGRPEDFKISTTIDAALAKKLP
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEHHHHHHHHCCC
IFGVCLGVQAMGEYFGGQLGQLAQPAHGRPSRVQVRGGRLMQGLPNEIVIGRYHSLFVER
HHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCHHHCCCCCCEEEECHHEEEEEC
DSMPEVLTVTAATEDGVAMAIEHKTLPVGGVQFHPESLMSLGDAVGLRIVENAFRLNQPG
CCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCC
S
C
>Mature Secondary Structure
MNRTVFALPARSDYRTSSGLAITRAVEQFSGGASRLDDLIDLLDRRRGVVLSSGTTVPGR
CCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCCC
YESFDLGFADPPLVLETKGTDFTLQALNKRGEVLIAFLKDTLREPCVVITAASPARLAGH
CCCEECCCCCCCEEEEECCCCEEHHHHCCCCCEEEHHHHHHHCCCEEEEECCCCHHHHHH
IVRGPAPVEEDQRTRRASVMSLVRAMIATLAANDDPLLGLFGAFAYDLVFQIEDLVQKRP
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
REKDQRDIVLYVPDRLLAYDRATGRGVVLSYDFSWNGQSTSGLPRDTDASVYLKEPRQGF
CCCCCCCEEEEECCHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCC
ADHAPGEYQATVDKARAAFARGDLFEAVPGQLFAEPCERSPAEVFQRLCRINPSPYGALM
CCCCCCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHCCCHHHHHHHHHCCCCCCCHHEE
NLGDGEFLVSASPEMFVRSDGRRVETCPISGTIARGRDAIGDAEQIRQLLNSEKDEFELN
ECCCCCEEEECCCCEEEECCCCEEEECCCCCCHHCCCCCCCCHHHHHHHHCCCCCCEEEE
MCTDVDRNDKARICVPGTIKVLARRQIETYSKLFHTVDHVEGMLRPGFDALDAFLTHAWA
EECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCEEE
VTVTGAPKLWAMQFVEDHERSPRRWYAGAIGAVNFDGSINTGLTIRTIRMKDGLAEVRVG
EEECCCCHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCEEEEEEEECCCHHHHEEC
ATCLFDSDPAAEDRECQVKAAALFQALRGDPPKPLSSTAPDATGSGKNVLLIDHDDSFVH
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
MLADYFRQVGANVTVVRYVHALTMLAERSWDLIVLSPGPGRPEDFKISTTIDAALAKKLP
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEHHHHHHHHCCC
IFGVCLGVQAMGEYFGGQLGQLAQPAHGRPSRVQVRGGRLMQGLPNEIVIGRYHSLFVER
HHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCHHHCCCCCCEEEECHHEEEEEC
DSMPEVLTVTAATEDGVAMAIEHKTLPVGGVQFHPESLMSLGDAVGLRIVENAFRLNQPG
CCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8939798 [H]