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The map label for this gene is pyrE [H]

Identifier: 146337863

GI number: 146337863

Start: 787819

End: 788376

Strand: Reverse

Name: pyrE [H]

Synonym: BRADO0748

Alternate gene names: 146337863

Gene position: 788376-787819 (Counterclockwise)

Preceding gene: 146337865

Following gene: 146337862

Centisome position: 10.57

GC content: 67.92

Gene sequence:

>558_bases
GTGTCCAAATCCGCCTCCCGCGCCCGCCTCCTCGAGATCATCCGCAGGCGCTCTTTCGGCCGCGGCGAGGTCACCCTGGC
CTCGGGCCGCAAGAGCGATTTCTATTTCAACCTGAAGCCGACCATGATGGACCCGGAGGGCGCCACCCTGCTCGCCGAGC
TCACCTACGAGGCGCTGAAGGACGACGGCTACGACTATATCGGCGGGCTGGAGATGGGTGCCGTGCCGCTGGCCGGCGCG
ATCGCGCAGATTTCGTGGATCAAGGGCCATCCGATCGCGGCCTTCTTCGTGCGCAAGAAGCCGAAGGAGCACGGCGCCAG
GCTCGCGATCGAGGGACTGACCCGGGACGAGACCCTGGCGGGAAAACGCATCGTCGTGGTCGAGGACGTCACCACGACGG
GCGGCTCGGCGATGAAGGCGGTCGAGACGTTGCGCGAGGCCGGCGCCGAGGTGTCGCTGGTGTTCACCATGGTCGACCGC
GAGGAAGGCGCCGCCGAGGCCTTCGCGGCCGCCGGCCTCTCGTTCCGCGCGCTCTACAAGGCGCGCGAATTTCTCTGA

Upstream 100 bases:

>100_bases
GTCCGAGGCCGATAGATTGCGCCACCCAAGAAGTCGCCAAGAAGCCGCCAAGAATCGACCGAGACCTCACTCAAGATCTG
ACCCCTCAAGGGAAAACGCC

Downstream 100 bases:

>100_bases
TCCGGTCCTCCGCGGCGCAATTCGCAACCGCGCACACCGCTCATTTACCAAAGGCTCGTTAAGGTTACTGCAAAGCTGAC
GGCGCCATGCCCTGGGGCAT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MSKSASRARLLEIIRRRSFGRGEVTLASGRKSDFYFNLKPTMMDPEGATLLAELTYEALKDDGYDYIGGLEMGAVPLAGA
IAQISWIKGHPIAAFFVRKKPKEHGARLAIEGLTRDETLAGKRIVVVEDVTTTGGSAMKAVETLREAGAEVSLVFTMVDR
EEGAAEAFAAAGLSFRALYKAREFL

Sequences:

>Translated_185_residues
MSKSASRARLLEIIRRRSFGRGEVTLASGRKSDFYFNLKPTMMDPEGATLLAELTYEALKDDGYDYIGGLEMGAVPLAGA
IAQISWIKGHPIAAFFVRKKPKEHGARLAIEGLTRDETLAGKRIVVVEDVTTTGGSAMKAVETLREAGAEVSLVFTMVDR
EEGAAEAFAAAGLSFRALYKAREFL
>Mature_184_residues
SKSASRARLLEIIRRRSFGRGEVTLASGRKSDFYFNLKPTMMDPEGATLLAELTYEALKDDGYDYIGGLEMGAVPLAGAI
AQISWIKGHPIAAFFVRKKPKEHGARLAIEGLTRDETLAGKRIVVVEDVTTTGGSAMKAVETLREAGAEVSLVFTMVDRE
EGAAEAFAAAGLSFRALYKAREFL

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=171, Percent_Identity=26.3157894736842, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=181, Percent_Identity=29.8342541436464, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508631, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 20077; Mature: 19946

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSASRARLLEIIRRRSFGRGEVTLASGRKSDFYFNLKPTMMDPEGATLLAELTYEALK
CCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCEECCCCCCHHHHHHHHHHH
DDGYDYIGGLEMGAVPLAGAIAQISWIKGHPIAAFFVRKKPKEHGARLAIEGLTRDETLA
CCCCCEECCCCCCCHHHHHHHHHEEEECCCCEEEEEEECCCHHCCCEEEEECCCCCCCCC
GKRIVVVEDVTTTGGSAMKAVETLREAGAEVSLVFTMVDREEGAAEAFAAAGLSFRALYK
CCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCHHHHHHH
AREFL
HHHCC
>Mature Secondary Structure 
SKSASRARLLEIIRRRSFGRGEVTLASGRKSDFYFNLKPTMMDPEGATLLAELTYEALK
CCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCEECCCCCCHHHHHHHHHHH
DDGYDYIGGLEMGAVPLAGAIAQISWIKGHPIAAFFVRKKPKEHGARLAIEGLTRDETLA
CCCCCEECCCCCCCHHHHHHHHHEEEECCCCEEEEEEECCCHHCCCEEEEECCCCCCCCC
GKRIVVVEDVTTTGGSAMKAVETLREAGAEVSLVFTMVDREEGAAEAFAAAGLSFRALYK
CCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCHHHHHHH
AREFL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA