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The map label for this gene is lysC [H]

Identifier: 146337705

GI number: 146337705

Start: 591070

End: 592326

Strand: Reverse

Name: lysC [H]

Synonym: BRADO0574

Alternate gene names: 146337705

Gene position: 592326-591070 (Counterclockwise)

Preceding gene: 146337708

Following gene: 146337704

Centisome position: 7.94

GC content: 65.16

Gene sequence:

>1257_bases
ATGGGTCGCCTCGTGCTGAAATTCGGCGGCACCTCCGTCGCCAACATCGACCGCATCCGCAACGTCGCGCGCCACGTCAA
GCGCGAGGTCGACGCGGGGCATGAGGTTGCCGTCGTGGTCTCGGCGATGTCCGGCAAGACCAACGAATTGGTCGCCTGGT
GCACCGAAGCGTCGCCGATGCATGACGCGCGCGAATACGACGCCGTGGTGGCCTCGGGCGAGCAGGTCACGTCGGGCCTG
CTCGCGATCGTGCTGCAGAGCATGGGCATCCAGGCCCGCTCCTGGCAGGGCTGGCAGATCCCGATCAAGACCAGCGACGC
CCATGCCTCGGCGCGAATCGTCGGCATCGACGGTTCCGAGCTGATCCAGCGGTTCCAGGAGCGCAAGGAGGTCGCGGTCA
TTGCCGGCTTCCAGGGCATCAATGCCGAGACCGGACGAATCACCACGCTTGGCCGTGGCGGCTCGGATACTTCTGCGGTC
GCGATCGCCGCGGCCATCAAGGCCGACCGCTGTGACATCTATACCGACGTCGACGGCGTCTACACCACCGATCCCCGCGT
GGTGCCCAAGGCCAAGCGGCTGGACAAGATCGCCTTCGAGGACATGCTGGAGCTGGCGTCCCAGGGCGCCAAGGTGCTGC
AGGTCCGCTCGGTGGAACTGGGCATGGTCCACAACATGCCGATCTTCGTCCGCTCCTCATTCGACAAGCCCGAGGATATC
GACCCGCACGCCAACCAGCCGCCGGGGACGCTGATCTGCAGCGAGGAACAAATCATGGAAAATCACGTCGTGACCGGCAT
CGCCTTCTCCAAGGACGAGGCCCAGATCTCGGTGCGCCAGATCGAGGACAAGCCGGGGATCGCCGCCTCGATCTTCGGGC
CGCTGGCGGATGCCAACATCAACGTCGACATGATCGTCCAGAACGTCTCCGAGGACGGCAAGACCACCGACCTGACCTTC
ACCGTGCCGGCGACCGACTATAATCGGGCCCGCGAGACCATCACGGCGGCCAAGGACAAGATCGGATACCAGCGCATGGA
CGCCGCTACCGACGTCGCCAAGGTGTCGGTGATCGGCTCGGGCATGCGCAGCCATGCCGGGGTCGCCGCCAAGGGTTTTG
CGGCGCTCGCCGCCCGCAACATCAACATTCGCGCGATCACGACCTCCGAGATCAAGTTCTCGGTGCTGATCGACGCCGCC
TATACCGAGCTGGCCGTCCGCACGCTGCATACGCTCTACGGATTGGACCAGGCCTAG

Upstream 100 bases:

>100_bases
CCGGCCGCGGCGCTATGTATACGCGCGTTTCGGCTGATGCGCCTCCGCTTTCGCGCCCGGCCGGTCAACTTATCCTCCTG
CTGGGAATGAGCGCGTCGTC

Downstream 100 bases:

>100_bases
AAAATTCTCCCCCGTCACGCCCGGTGTCCCGTTTCGTAACAGCGGGACATCGCGCAGACGTGCGCGAAAGCCGTTGACGT
CGCCGCCGCTGGCAGGCGTT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MGRLVLKFGGTSVANIDRIRNVARHVKREVDAGHEVAVVVSAMSGKTNELVAWCTEASPMHDAREYDAVVASGEQVTSGL
LAIVLQSMGIQARSWQGWQIPIKTSDAHASARIVGIDGSELIQRFQERKEVAVIAGFQGINAETGRITTLGRGGSDTSAV
AIAAAIKADRCDIYTDVDGVYTTDPRVVPKAKRLDKIAFEDMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDI
DPHANQPPGTLICSEEQIMENHVVTGIAFSKDEAQISVRQIEDKPGIAASIFGPLADANINVDMIVQNVSEDGKTTDLTF
TVPATDYNRARETITAAKDKIGYQRMDAATDVAKVSVIGSGMRSHAGVAAKGFAALAARNINIRAITTSEIKFSVLIDAA
YTELAVRTLHTLYGLDQA

Sequences:

>Translated_418_residues
MGRLVLKFGGTSVANIDRIRNVARHVKREVDAGHEVAVVVSAMSGKTNELVAWCTEASPMHDAREYDAVVASGEQVTSGL
LAIVLQSMGIQARSWQGWQIPIKTSDAHASARIVGIDGSELIQRFQERKEVAVIAGFQGINAETGRITTLGRGGSDTSAV
AIAAAIKADRCDIYTDVDGVYTTDPRVVPKAKRLDKIAFEDMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDI
DPHANQPPGTLICSEEQIMENHVVTGIAFSKDEAQISVRQIEDKPGIAASIFGPLADANINVDMIVQNVSEDGKTTDLTF
TVPATDYNRARETITAAKDKIGYQRMDAATDVAKVSVIGSGMRSHAGVAAKGFAALAARNINIRAITTSEIKFSVLIDAA
YTELAVRTLHTLYGLDQA
>Mature_417_residues
GRLVLKFGGTSVANIDRIRNVARHVKREVDAGHEVAVVVSAMSGKTNELVAWCTEASPMHDAREYDAVVASGEQVTSGLL
AIVLQSMGIQARSWQGWQIPIKTSDAHASARIVGIDGSELIQRFQERKEVAVIAGFQGINAETGRITTLGRGGSDTSAVA
IAAAIKADRCDIYTDVDGVYTTDPRVVPKAKRLDKIAFEDMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDID
PHANQPPGTLICSEEQIMENHVVTGIAFSKDEAQISVRQIEDKPGIAASIFGPLADANINVDMIVQNVSEDGKTTDLTFT
VPATDYNRARETITAAKDKIGYQRMDAATDVAKVSVIGSGMRSHAGVAAKGFAALAARNINIRAITTSEIKFSVLIDAAY
TELAVRTLHTLYGLDQA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=482, Percent_Identity=30.0829875518672, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1790455, Length=460, Percent_Identity=29.1304347826087, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790376, Length=268, Percent_Identity=27.6119402985075, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=504, Percent_Identity=25, Blast_Score=103, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44903; Mature: 44771

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLVLKFGGTSVANIDRIRNVARHVKREVDAGHEVAVVVSAMSGKTNELVAWCTEASPM
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEECCCCCC
HDAREYDAVVASGEQVTSGLLAIVLQSMGIQARSWQGWQIPIKTSDAHASARIVGIDGSE
CHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCEEEEECCHHH
LIQRFQERKEVAVIAGFQGINAETGRITTLGRGGSDTSAVAIAAAIKADRCDIYTDVDGV
HHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHEEEEEHHCCCCCEEEECCCCE
YTTDPRVVPKAKRLDKIAFEDMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDI
EECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCEEEECCCCCCCCC
DPHANQPPGTLICSEEQIMENHVVTGIAFSKDEAQISVRQIEDKPGIAASIFGPLADANI
CCCCCCCCCEEEECHHHHHHHHEEEEEEECCCCCEEEEEEECCCCCEEEEHHCCCCCCCC
NVDMIVQNVSEDGKTTDLTFTVPATDYNRARETITAAKDKIGYQRMDAATDVAKVSVIGS
CCEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHEEHHHHC
GMRSHAGVAAKGFAALAARNINIRAITTSEIKFSVLIDAAYTELAVRTLHTLYGLDQA
CHHHCCCCHHHHHHHHHCCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GRLVLKFGGTSVANIDRIRNVARHVKREVDAGHEVAVVVSAMSGKTNELVAWCTEASPM
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEECCCCCC
HDAREYDAVVASGEQVTSGLLAIVLQSMGIQARSWQGWQIPIKTSDAHASARIVGIDGSE
CHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCEEEEECCHHH
LIQRFQERKEVAVIAGFQGINAETGRITTLGRGGSDTSAVAIAAAIKADRCDIYTDVDGV
HHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHEEEEEHHCCCCCEEEECCCCE
YTTDPRVVPKAKRLDKIAFEDMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDI
EECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCEEEECCCCCCCCC
DPHANQPPGTLICSEEQIMENHVVTGIAFSKDEAQISVRQIEDKPGIAASIFGPLADANI
CCCCCCCCCEEEECHHHHHHHHEEEEEEECCCCCEEEEEEECCCCCEEEEHHCCCCCCCC
NVDMIVQNVSEDGKTTDLTFTVPATDYNRARETITAAKDKIGYQRMDAATDVAKVSVIGS
CCEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHEEHHHHC
GMRSHAGVAAKGFAALAARNINIRAITTSEIKFSVLIDAAYTELAVRTLHTLYGLDQA
CHHHCCCCHHHHHHHHHCCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]