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The map label for this gene is ggt [H]

Identifier: 146337490

GI number: 146337490

Start: 347463

End: 349169

Strand: Reverse

Name: ggt [H]

Synonym: BRADO0336

Alternate gene names: 146337490

Gene position: 349169-347463 (Counterclockwise)

Preceding gene: 146337492

Following gene: 146337489

Centisome position: 4.68

GC content: 69.07

Gene sequence:

>1707_bases
ATGCTGCTGCTGGCCGGCTGCTGGCCGGCGCATGCGCTCGATCCGCAAGGCGTCGACGTTCCGCAGCCGCCGAACGTCGC
CGCACCAGCGCAAGCCCCGGCGCATGGCATGGTGGTGGCGCAGGAGCGCATCGCCGCCGAGGTCGGCCAGCGCGTTCTCG
CGCTCGGCGGCAACGCTGTCGATGCCGCGGTCGCCACCGGCTTCGCGATGGCCGTGACCTATCCGGTCGCCGGCAATATC
GGCGGTGGCGGCTTCATGGTCATTCATCTCGCGAAGACCAATGAGGACGTCGCGATCGACTACCGCGAGACCGGCCCAGC
GGCGATGACGCGCGGCATCTTCCTCGGCGCCGACGGCAGGCCCGACAATGCCAAGTCGCGCGATTCGGCGCTGTCGATCG
GCGTTCCCGGCTCCGTGGCGGGCCTGGCGCTGGCGCTGGAGAAATACGGCTCGGGCAAATTCACGCTGGCGCAGCTCGTC
GCGCCCGCGATCGTGCTGGCGCGCGACGGCATCCCGGTGGCGGATGATGTTGCCTTCACCCTGCCCATGATGGCGCCGCG
GCTCGCGAAATGGCCGTCCTCGGCTGCGATCTTCATTCGTCCCGACGGGACCGTGCTGAAGGAAGGCGACCGGCTGGTGC
AGCGCGACCTCGCGGCCACGCTCGCCGCCATCGCCGAGCGGGGTCCGCGCGGCTTCTACGAGGGCCCGGTGGCCGAGAAG
CTCGCCAAGGCGATCCAGGCCGCCGGCGGCATCATGACAGCAGACGATCTCAAGGCCTATCAGCCGGTGCTGCGTACACC
TGTGCGCGGCACCTATCGCGGGTACGACATCGTCTCGATGCCGCTGCCCTCCTCGGGCGGCACCGTGCTGGTCGAGACGC
TGAACATCCTCGAAGGCTTCAAGCTGAGCGAGCTGAAGCAGGGTTCGCCGGCGTCGCTGCATCTGCTGATCGAGGCGATG
AAGCGCGCCTATGCCGACCGCGCCCGCTATCTCGGCGACCCCGCCTTCGTGGATGCGCCCGTGCGCGCGATGCTGTCGAA
GGACTACGCGGCCCAGCAGCGCGCCGGCATCGACCCCGCCCGCGCCACTGGCGCCGGCGACGTGCTGAACATCAAGCCGC
TGCGCGAGGGCAGCAACACCACGCATTTCTCGGTGGTCGACAATGACGGCAATGCGGTCAGCAACACCTATACGCTGAAC
TTTCCCTACGGCGTCGGCCTGATCGCCGAGGGCACCGGCGTGCTGCTCAACAACGAGCTCGACGATTTCACCGCCGCACC
CGGCGCGTCCAACGCGTTCGGACTGGTCGGCTTCGAGGCCAATCTCCCCGGGCCGGGCAAGCGGCCGCTGTCGTCGATGT
CGCCGACCATCGTGCTGAAGGACGGCAAGCCGGTGCTGGTCACGGGCTCGCCCGGCGGCAGCCGCATCATCTCGACGGTG
CTGCAGGTGATCGTCAACGTGCTCGACTATGAGATGGACGTGCCCCAGGCCGTGAGCGCGCCGCGGCTGCATCATCAATG
GATGCCGGACGAGGTCCGCATCGAGAAGGGCTTTGGCGACGACGTGCTGGCCGATCTGCGGGCCCGCGGCCACAAGATCG
AGGAACCGATGGGACGGACCTCGGCCAACTCGATCCTGGTGACATCGGATGGCCTGGTCGGCGCGCCCGATCCGCGCAGC
AAGGGGGCGACCGCGGCCGGGCGCTAG

Upstream 100 bases:

>100_bases
GTGGCCCTATAACATCCGACGATCCCGGGCGAATGTCAGCAGCGGCAGAATTGCAATGATCCTCTTCACGATTGATCGAC
GACGACTCCTTGCAGGCGTC

Downstream 100 bases:

>100_bases
AGTCAGGTATCTGCATCCGGCTGGTCCGTTCCTGGCGAGGGCCGGAGGACGATTTGCCGCCGCCTGATGGACGCGTTCCA
TGGCGTCGCTCCGTTGGCGA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MLLLAGCWPAHALDPQGVDVPQPPNVAAPAQAPAHGMVVAQERIAAEVGQRVLALGGNAVDAAVATGFAMAVTYPVAGNI
GGGGFMVIHLAKTNEDVAIDYRETGPAAMTRGIFLGADGRPDNAKSRDSALSIGVPGSVAGLALALEKYGSGKFTLAQLV
APAIVLARDGIPVADDVAFTLPMMAPRLAKWPSSAAIFIRPDGTVLKEGDRLVQRDLAATLAAIAERGPRGFYEGPVAEK
LAKAIQAAGGIMTADDLKAYQPVLRTPVRGTYRGYDIVSMPLPSSGGTVLVETLNILEGFKLSELKQGSPASLHLLIEAM
KRAYADRARYLGDPAFVDAPVRAMLSKDYAAQQRAGIDPARATGAGDVLNIKPLREGSNTTHFSVVDNDGNAVSNTYTLN
FPYGVGLIAEGTGVLLNNELDDFTAAPGASNAFGLVGFEANLPGPGKRPLSSMSPTIVLKDGKPVLVTGSPGGSRIISTV
LQVIVNVLDYEMDVPQAVSAPRLHHQWMPDEVRIEKGFGDDVLADLRARGHKIEEPMGRTSANSILVTSDGLVGAPDPRS
KGATAAGR

Sequences:

>Translated_568_residues
MLLLAGCWPAHALDPQGVDVPQPPNVAAPAQAPAHGMVVAQERIAAEVGQRVLALGGNAVDAAVATGFAMAVTYPVAGNI
GGGGFMVIHLAKTNEDVAIDYRETGPAAMTRGIFLGADGRPDNAKSRDSALSIGVPGSVAGLALALEKYGSGKFTLAQLV
APAIVLARDGIPVADDVAFTLPMMAPRLAKWPSSAAIFIRPDGTVLKEGDRLVQRDLAATLAAIAERGPRGFYEGPVAEK
LAKAIQAAGGIMTADDLKAYQPVLRTPVRGTYRGYDIVSMPLPSSGGTVLVETLNILEGFKLSELKQGSPASLHLLIEAM
KRAYADRARYLGDPAFVDAPVRAMLSKDYAAQQRAGIDPARATGAGDVLNIKPLREGSNTTHFSVVDNDGNAVSNTYTLN
FPYGVGLIAEGTGVLLNNELDDFTAAPGASNAFGLVGFEANLPGPGKRPLSSMSPTIVLKDGKPVLVTGSPGGSRIISTV
LQVIVNVLDYEMDVPQAVSAPRLHHQWMPDEVRIEKGFGDDVLADLRARGHKIEEPMGRTSANSILVTSDGLVGAPDPRS
KGATAAGR
>Mature_568_residues
MLLLAGCWPAHALDPQGVDVPQPPNVAAPAQAPAHGMVVAQERIAAEVGQRVLALGGNAVDAAVATGFAMAVTYPVAGNI
GGGGFMVIHLAKTNEDVAIDYRETGPAAMTRGIFLGADGRPDNAKSRDSALSIGVPGSVAGLALALEKYGSGKFTLAQLV
APAIVLARDGIPVADDVAFTLPMMAPRLAKWPSSAAIFIRPDGTVLKEGDRLVQRDLAATLAAIAERGPRGFYEGPVAEK
LAKAIQAAGGIMTADDLKAYQPVLRTPVRGTYRGYDIVSMPLPSSGGTVLVETLNILEGFKLSELKQGSPASLHLLIEAM
KRAYADRARYLGDPAFVDAPVRAMLSKDYAAQQRAGIDPARATGAGDVLNIKPLREGSNTTHFSVVDNDGNAVSNTYTLN
FPYGVGLIAEGTGVLLNNELDDFTAAPGASNAFGLVGFEANLPGPGKRPLSSMSPTIVLKDGKPVLVTGSPGGSRIISTV
LQVIVNVLDYEMDVPQAVSAPRLHHQWMPDEVRIEKGFGDDVLADLRARGHKIEEPMGRTSANSILVTSDGLVGAPDPRS
KGATAAGR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=541, Percent_Identity=35.4898336414048, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI73915090, Length=541, Percent_Identity=35.4898336414048, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI73915096, Length=541, Percent_Identity=35.4898336414048, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI73915094, Length=541, Percent_Identity=35.4898336414048, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI113429324, Length=541, Percent_Identity=34.0110905730129, Blast_Score=245, Evalue=8e-65,
Organism=Homo sapiens, GI113429326, Length=546, Percent_Identity=33.8827838827839, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=32.0582877959927, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI153266885, Length=517, Percent_Identity=31.7214700193424, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI153266901, Length=518, Percent_Identity=31.8532818532818, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI153266907, Length=517, Percent_Identity=30.3675048355899, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI30581157, Length=196, Percent_Identity=38.7755102040816, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI30581155, Length=196, Percent_Identity=38.7755102040816, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI218505805, Length=229, Percent_Identity=35.8078602620087, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI310124095, Length=229, Percent_Identity=33.1877729257642, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI1789856, Length=551, Percent_Identity=51.5426497277677, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17506189, Length=574, Percent_Identity=34.4947735191638, Blast_Score=263, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI193208247, Length=558, Percent_Identity=33.6917562724014, Blast_Score=238, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI193208245, Length=560, Percent_Identity=33.5714285714286, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI72000294, Length=564, Percent_Identity=32.4468085106383, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI212646519, Length=564, Percent_Identity=32.4468085106383, Blast_Score=237, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17542894, Length=532, Percent_Identity=32.7067669172932, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17564448, Length=428, Percent_Identity=26.4018691588785, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI72001497, Length=246, Percent_Identity=26.4227642276423, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=234, Percent_Identity=27.3504273504274, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=543, Percent_Identity=29.8342541436464, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI161077880, Length=557, Percent_Identity=33.213644524237, Blast_Score=235, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24642670, Length=557, Percent_Identity=33.213644524237, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24642666, Length=557, Percent_Identity=33.213644524237, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI161077878, Length=557, Percent_Identity=33.213644524237, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI45551474, Length=557, Percent_Identity=33.213644524237, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI161077496, Length=538, Percent_Identity=33.457249070632, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI18859893, Length=542, Percent_Identity=33.3948339483395, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI18859741, Length=545, Percent_Identity=28.8073394495413, Blast_Score=189, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59134; Mature: 59134

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLAGCWPAHALDPQGVDVPQPPNVAAPAQAPAHGMVVAQERIAAEVGQRVLALGGNAV
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHEECCCCCHH
DAAVATGFAMAVTYPVAGNIGGGGFMVIHLAKTNEDVAIDYRETGPAAMTRGIFLGADGR
HHHHHHCEEEEEEECCCCCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHCCEEEECCCC
PDNAKSRDSALSIGVPGSVAGLALALEKYGSGKFTLAQLVAPAIVLARDGIPVADDVAFT
CCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHEEECCCCCCCCHHHHH
LPMMAPRLAKWPSSAAIFIRPDGTVLKEGDRLVQRDLAATLAAIAERGPRGFYEGPVAEK
HHHHHHHHHCCCCCCEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LAKAIQAAGGIMTADDLKAYQPVLRTPVRGTYRGYDIVSMPLPSSGGTVLVETLNILEGF
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEHHHHCCC
KLSELKQGSPASLHLLIEAMKRAYADRARYLGDPAFVDAPVRAMLSKDYAAQQRAGIDPA
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHCCCCHH
RATGAGDVLNIKPLREGSNTTHFSVVDNDGNAVSNTYTLNFPYGVGLIAEGTGVLLNNEL
HCCCCCCEEEEEECCCCCCCEEEEEEECCCCEECCEEEEECCCCCEEEECCCEEEECCCC
DDFTAAPGASNAFGLVGFEANLPGPGKRPLSSMSPTIVLKDGKPVLVTGSPGGSRIISTV
CHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHH
LQVIVNVLDYEMDVPQAVSAPRLHHQWMPDEVRIEKGFGDDVLADLRARGHKIEEPMGRT
HHHHHHHHHCCCCCCHHHCCCCHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCC
SANSILVTSDGLVGAPDPRSKGATAAGR
CCCEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLLLAGCWPAHALDPQGVDVPQPPNVAAPAQAPAHGMVVAQERIAAEVGQRVLALGGNAV
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHEECCCCCHH
DAAVATGFAMAVTYPVAGNIGGGGFMVIHLAKTNEDVAIDYRETGPAAMTRGIFLGADGR
HHHHHHCEEEEEEECCCCCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHCCEEEECCCC
PDNAKSRDSALSIGVPGSVAGLALALEKYGSGKFTLAQLVAPAIVLARDGIPVADDVAFT
CCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHEEECCCCCCCCHHHHH
LPMMAPRLAKWPSSAAIFIRPDGTVLKEGDRLVQRDLAATLAAIAERGPRGFYEGPVAEK
HHHHHHHHHCCCCCCEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LAKAIQAAGGIMTADDLKAYQPVLRTPVRGTYRGYDIVSMPLPSSGGTVLVETLNILEGF
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEHHHHCCC
KLSELKQGSPASLHLLIEAMKRAYADRARYLGDPAFVDAPVRAMLSKDYAAQQRAGIDPA
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHCCCCHH
RATGAGDVLNIKPLREGSNTTHFSVVDNDGNAVSNTYTLNFPYGVGLIAEGTGVLLNNEL
HCCCCCCEEEEEECCCCCCCEEEEEEECCCCEECCEEEEECCCCCEEEECCCEEEECCCC
DDFTAAPGASNAFGLVGFEANLPGPGKRPLSSMSPTIVLKDGKPVLVTGSPGGSRIISTV
CHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHH
LQVIVNVLDYEMDVPQAVSAPRLHHQWMPDEVRIEKGFGDDVLADLRARGHKIEEPMGRT
HHHHHHHHHCCCCCCHHHCCCCHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCC
SANSILVTSDGLVGAPDPRSKGATAAGR
CCCEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]