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The map label for this gene is panE [H]

Identifier: 146337482

GI number: 146337482

Start: 339114

End: 340037

Strand: Reverse

Name: panE [H]

Synonym: BRADO0328

Alternate gene names: 146337482

Gene position: 340037-339114 (Counterclockwise)

Preceding gene: 146337483

Following gene: 146337479

Centisome position: 4.56

GC content: 66.45

Gene sequence:

>924_bases
ATGCGTATTCTCGTCGTCGGCGCCGGCGCGATCGGCGGCTATTTCGGCGGCCGGCTGCTGCAGTCCGGTGCTGATGTCAC
CTTCCTCGTTCGTCCCCGCCGCGCCGCCGAGCTCACGAACGCCGGTCTCGTGATCCGCAGTGCGAGCGGCGACGTCACGC
TGCCTAACCCACCGACGGTGCAGGCCGACAGCCTGAAGCAGCATTTCGACGTCGTGCTGCTGAGCTGCAAGGCCTATGAC
CTCGACGACGCGATTGCGTCATTCGCGCCGGCCGTCGGTGCTGATACAGCGATCATTCCGCTGCTCAACGGCATGAAGCA
TCTCGACGTGCTCGACGCCAAATTCGGCCGCGCGCGCGTGCTCGGCGGTCTTTGCGCCATTGCGGCGACGCTGAATGAGA
AACGCGAGGTGGTGCAGCTGCAGCCGATGCAATCGCTGAACTTCGGCGAGCGCGACGGCGGATCCTCGGAGCGCGTGCGT
GCCATCTTCGAGATCTTCCAGCGCGGCAATTTCAACGCCGCCGCCAGCGACCACATCATGCAGGACATGTGGGAGAAGTG
GGTGTTCCTCGCCTCGCTCGCGGCGTCCACGACCTTGATGCGCGCGCCGGTCGGCGTGATCCTGACGGCGCCGGGCGGCA
AGGATTTCCTGCTCGGCATGCTCGACGAATGCAGCGCCACCGCTGCAGCCGCCGGTTACGCGCCGGCCGGCGCCTTCTTT
CAGCGCGTCTCCGGGATGATCACCACCGAGGGATCACCGATGACCGCCTCGATGTTCCGCGATCTCCGCGCCGGCCTGCC
GGTCGAGGCGGATCACGTCATCGGCGACCTCGTCGCCCGCGCGGATGCGGCGAAGGTGCCCGTGCCGCGCTTAAGGATTT
CGTACACGCAGCTGAAGGTATACGAGGCGCAACGGGGGAAGTGA

Upstream 100 bases:

>100_bases
AGGGGGTCGCTGATACCGAATGGTCGCCATCCCCATTCGCTACTCGCCATTCGCCATCGGCTTCTCCATGATGGTGCTCG
TTCTAAGAGAGGACCCACCC

Downstream 100 bases:

>100_bases
GCGCTGCCTCGTTGCGACGGACGCACAAAATTAGTTGACGAGGCGCGGTCCCGCCGCGCCGACCGCTGTCGTCCCGGCCT
TGAGCCGGGACCCATACCCA

Product: 2-dehydropantoate 2-reductase

Products: 2-dehydropantoate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRILVVGAGAIGGYFGGRLLQSGADVTFLVRPRRAAELTNAGLVIRSASGDVTLPNPPTVQADSLKQHFDVVLLSCKAYD
LDDAIASFAPAVGADTAIIPLLNGMKHLDVLDAKFGRARVLGGLCAIAATLNEKREVVQLQPMQSLNFGERDGGSSERVR
AIFEIFQRGNFNAAASDHIMQDMWEKWVFLASLAASTTLMRAPVGVILTAPGGKDFLLGMLDECSATAAAAGYAPAGAFF
QRVSGMITTEGSPMTASMFRDLRAGLPVEADHVIGDLVARADAAKVPVPRLRISYTQLKVYEAQRGK

Sequences:

>Translated_307_residues
MRILVVGAGAIGGYFGGRLLQSGADVTFLVRPRRAAELTNAGLVIRSASGDVTLPNPPTVQADSLKQHFDVVLLSCKAYD
LDDAIASFAPAVGADTAIIPLLNGMKHLDVLDAKFGRARVLGGLCAIAATLNEKREVVQLQPMQSLNFGERDGGSSERVR
AIFEIFQRGNFNAAASDHIMQDMWEKWVFLASLAASTTLMRAPVGVILTAPGGKDFLLGMLDECSATAAAAGYAPAGAFF
QRVSGMITTEGSPMTASMFRDLRAGLPVEADHVIGDLVARADAAKVPVPRLRISYTQLKVYEAQRGK
>Mature_307_residues
MRILVVGAGAIGGYFGGRLLQSGADVTFLVRPRRAAELTNAGLVIRSASGDVTLPNPPTVQADSLKQHFDVVLLSCKAYD
LDDAIASFAPAVGADTAIIPLLNGMKHLDVLDAKFGRARVLGGLCAIAATLNEKREVVQLQPMQSLNFGERDGGSSERVR
AIFEIFQRGNFNAAASDHIMQDMWEKWVFLASLAASTTLMRAPVGVILTAPGGKDFLLGMLDECSATAAAAGYAPAGAFF
QRVSGMITTEGSPMTASMFRDLRAGLPVEADHVIGDLVARADAAKVPVPRLRISYTQLKVYEAQRGK

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169

Molecular weight: Translated: 32606; Mature: 32606

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVGAGAIGGYFGGRLLQSGADVTFLVRPRRAAELTNAGLVIRSASGDVTLPNPPTV
CEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCEEEEECCCCEECCCCCCC
QADSLKQHFDVVLLSCKAYDLDDAIASFAPAVGADTAIIPLLNGMKHLDVLDAKFGRARV
CHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHCCCCHHHH
LGGLCAIAATLNEKREVVQLQPMQSLNFGERDGGSSERVRAIFEIFQRGNFNAAASDHIM
HHHHHHHHHHHHHHHHHEEECCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
QDMWEKWVFLASLAASTTLMRAPVGVILTAPGGKDFLLGMLDECSATAAAAGYAPAGAFF
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
QRVSGMITTEGSPMTASMFRDLRAGLPVEADHVIGDLVARADAAKVPVPRLRISYTQLKV
HHHCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEE
YEAQRGK
EECCCCC
>Mature Secondary Structure
MRILVVGAGAIGGYFGGRLLQSGADVTFLVRPRRAAELTNAGLVIRSASGDVTLPNPPTV
CEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCEEEEECCCCEECCCCCCC
QADSLKQHFDVVLLSCKAYDLDDAIASFAPAVGADTAIIPLLNGMKHLDVLDAKFGRARV
CHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHCCCCHHHH
LGGLCAIAATLNEKREVVQLQPMQSLNFGERDGGSSERVRAIFEIFQRGNFNAAASDHIM
HHHHHHHHHHHHHHHHHEEECCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
QDMWEKWVFLASLAASTTLMRAPVGVILTAPGGKDFLLGMLDECSATAAAAGYAPAGAFF
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
QRVSGMITTEGSPMTASMFRDLRAGLPVEADHVIGDLVARADAAKVPVPRLRISYTQLKV
HHHCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEE
YEAQRGK
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: (R)-pantoate; NADP+

Specific reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]