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The map label for this gene is tesB [H]

Identifier: 146337467

GI number: 146337467

Start: 324079

End: 324954

Strand: Reverse

Name: tesB [H]

Synonym: BRADO0310

Alternate gene names: 146337467

Gene position: 324954-324079 (Counterclockwise)

Preceding gene: 146337469

Following gene: 146337465

Centisome position: 4.36

GC content: 65.41

Gene sequence:

>876_bases
ATGTCCAAGGGATTGATCGACCTGATCTCGATCCTCGACCTCGAGCCGATCGAGGTGAACCTGTTCCGCGGCAACAGCCC
GAAGACGAGCTGGCAGCGGGTGTTCGGCGGGCAGGTGATCGGCCAGGCGATGATGGCGGCGTGCCGCACCGTCGAGGGCC
GGCTGCCGCACTCGCTGCATTGCTATTTCATCCTGCCGGGCGACCCGCAGGTGCCGATCATCTACCAGGTTGAGCGCCTG
CGCGACGGCAAGAGCTACGCGACGCGCCGCGTCACCGCGATCCAGCACGGCAACGCGATCTTCTCGATCATGGTCTCGTT
CCACTCCGACGAGGAGAGCGCCTTCAACCATCAGGACAAGGTGCCGGACGTTCCGCCGCCGGAGAAGCTGACGGCCGAGG
AGATCTCCAAGCAGCCGATGTTCCAGGAGGTCTTCCAGCGGATGCCCGACTTCATCCGCCGCTACTATGAATCCGATCGT
CCGATCGAACTGCGTCCGGTCGAGCTCAGCCGGTATTTCGGTGAGAAGATTGACGATGGCCGCATCCACGTCTGGATCAA
GACCGCGGCGACGTTGCCGGACGATCCGGCGCTGCACATGTGCGCGCTCGCCTATGCGTCGGACTTCTCGCTGCTCGACG
CTGTCATGGCGCGCTACGGCCGGACCCTGTTCGACAAGCGCATGATGCCGGCCTCGCTCGATCACGCGATGTGGTTTCAC
CGGCCGTTCCGCGCCGACGAATGGCTGCTATATGCGCAGGATTCGCCGAGCGCGCAGGGCGGCCGCGGGCTGACCCGCGG
CTCGATCTTCAAGCCCGACGGCACGCTGGTCGCCTCCGTCGCGCAGGAGGGATCGATCCGCGAGCGCTGGGCCTAG

Upstream 100 bases:

>100_bases
CCAAGGGCTGCGGCCCCAGGCCGTCAATTCGAGATGCCTGATCCTGCCATAACGGGGCCGGGACCGGATTGGACCGCAAC
ACCAGCGAAAGCACCACGCC

Downstream 100 bases:

>100_bases
CCCGATCAGACCGGCTGCGATCCGCGCGGCACGACTGCGAACTGCGACACGTACCAGGCGCTGTACCAGCGTAAGAGCCA
CGGGATCGGAATGATCACCG

Product: putative acyl-CoA thioesterase palmitoyl-CoA hydrolase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSKGLIDLISILDLEPIEVNLFRGNSPKTSWQRVFGGQVIGQAMMAACRTVEGRLPHSLHCYFILPGDPQVPIIYQVERL
RDGKSYATRRVTAIQHGNAIFSIMVSFHSDEESAFNHQDKVPDVPPPEKLTAEEISKQPMFQEVFQRMPDFIRRYYESDR
PIELRPVELSRYFGEKIDDGRIHVWIKTAATLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFH
RPFRADEWLLYAQDSPSAQGGRGLTRGSIFKPDGTLVASVAQEGSIRERWA

Sequences:

>Translated_291_residues
MSKGLIDLISILDLEPIEVNLFRGNSPKTSWQRVFGGQVIGQAMMAACRTVEGRLPHSLHCYFILPGDPQVPIIYQVERL
RDGKSYATRRVTAIQHGNAIFSIMVSFHSDEESAFNHQDKVPDVPPPEKLTAEEISKQPMFQEVFQRMPDFIRRYYESDR
PIELRPVELSRYFGEKIDDGRIHVWIKTAATLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFH
RPFRADEWLLYAQDSPSAQGGRGLTRGSIFKPDGTLVASVAQEGSIRERWA
>Mature_290_residues
SKGLIDLISILDLEPIEVNLFRGNSPKTSWQRVFGGQVIGQAMMAACRTVEGRLPHSLHCYFILPGDPQVPIIYQVERLR
DGKSYATRRVTAIQHGNAIFSIMVSFHSDEESAFNHQDKVPDVPPPEKLTAEEISKQPMFQEVFQRMPDFIRRYYESDRP
IELRPVELSRYFGEKIDDGRIHVWIKTAATLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFHR
PFRADEWLLYAQDSPSAQGGRGLTRGSIFKPDGTLVASVAQEGSIRERWA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=284, Percent_Identity=40.1408450704225, Blast_Score=211, Evalue=6e-55,
Organism=Escherichia coli, GI1786657, Length=289, Percent_Identity=43.2525951557093, Blast_Score=231, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17558508, Length=307, Percent_Identity=39.413680781759, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71988741, Length=305, Percent_Identity=37.3770491803279, Blast_Score=193, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI115532456, Length=271, Percent_Identity=35.4243542435424, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17531889, Length=271, Percent_Identity=35.4243542435424, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17531885, Length=271, Percent_Identity=35.4243542435424, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71982224, Length=296, Percent_Identity=32.7702702702703, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI212645202, Length=272, Percent_Identity=31.6176470588235, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322480, Length=333, Percent_Identity=26.1261261261261, Blast_Score=100, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33115; Mature: 32984

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGLIDLISILDLEPIEVNLFRGNSPKTSWQRVFGGQVIGQAMMAACRTVEGRLPHSLH
CCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
CYFILPGDPQVPIIYQVERLRDGKSYATRRVTAIQHGNAIFSIMVSFHSDEESAFNHQDK
EEEEECCCCCCEEEEEHHHHCCCHHHHHHHHEEEECCCEEEEEEEECCCCCHHHCCCCCC
VPDVPPPEKLTAEEISKQPMFQEVFQRMPDFIRRYYESDRPIELRPVELSRYFGEKIDDG
CCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCCC
RIHVWIKTAATLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFH
EEEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHC
RPFRADEWLLYAQDSPSAQGGRGLTRGSIFKPDGTLVASVAQEGSIRERWA
CCCCCCCEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEHHHCCCCHHCCC
>Mature Secondary Structure 
SKGLIDLISILDLEPIEVNLFRGNSPKTSWQRVFGGQVIGQAMMAACRTVEGRLPHSLH
CCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
CYFILPGDPQVPIIYQVERLRDGKSYATRRVTAIQHGNAIFSIMVSFHSDEESAFNHQDK
EEEEECCCCCCEEEEEHHHHCCCHHHHHHHHEEEECCCEEEEEEEECCCCCHHHCCCCCC
VPDVPPPEKLTAEEISKQPMFQEVFQRMPDFIRRYYESDRPIELRPVELSRYFGEKIDDG
CCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCCC
RIHVWIKTAATLPDDPALHMCALAYASDFSLLDAVMARYGRTLFDKRMMPASLDHAMWFH
EEEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHC
RPFRADEWLLYAQDSPSAQGGRGLTRGSIFKPDGTLVASVAQEGSIRERWA
CCCCCCCEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]