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The map label for this gene is kmo [H]

Identifier: 146300954

GI number: 146300954

Start: 3825674

End: 3827125

Strand: Direct

Name: kmo [H]

Synonym: Fjoh_3209

Alternate gene names: 146300954

Gene position: 3825674-3827125 (Clockwise)

Preceding gene: 146300950

Following gene: 146300957

Centisome position: 62.75

GC content: 40.15

Gene sequence:

>1452_bases
GTGGAAAAAGCAGAAAACGAAAAAACAAGCTGGACTATTTGTAAAGAATGCCAAGGAAGTGGTAAAAAAAACCGCGGACT
CAGCAATAAAGCCCGTCGTGATTATCAAACAGCATTAGATTTATTTCAAAAAAATAACAATGAAGGCAAAGCTCCTGTCC
GCCCAAAAGCACACTTATACACCTGCACAAAATGCAACGGATCTGGTTTGGTTTCTTCACTAAATTTTCCTGAACCTGAC
AATAAAAACCTGCCTCATATTGCTATTATTGGTGCCGGTATTGGCGGTACGGCTCTAGCTGTGGCTTGTTTGCACAGAGG
AATTCCTTTTACACTTTTTGAACGTGATGCTGATTTCGAAGCCCGATCCCAAGGTTACGGACTTACTTTACAGCAGGCTA
GTAAGGCAATCGAAGGTTTAGGTATTTTTTCATTAGACGAAAAAGTTATTTCGACAAGACACTTGGTTCATACTACAGAA
GGAAAAGTTATTGGCGAATGGGGAATTCGAAAATGGCTGCAGTCTAATGCAAAAACAACTTCTAAACGCACCAATATGCA
TATCGCCAGGCAGTCTTTGCGTCTGGCTTTGCTTGAACAGCTTGGCGGACATGATAAAGTTCAATGGGGACATCAATTAA
TTGATTTTAACCAAAATGATAAAAATGTTGACCTCAATTTTCAGGTAAACGGCGAAACTAAAAGTTGTAAAGCAGATCTT
GTTGTTGGTGCTGATGGAATTCGCAGTTCTGTTCGAAAGTTGCTGATTGGCGATGAAACTACGCCTTTACGTTATTTGGA
CTGCATTGTAATATTAGGAATCTGTCCTTTGAGCACTCTTGAAAATCTAGAAAGCCCTTTGCTCGACGGTGCAACCGTGT
TTCAAACGGCAAACGGTAATGAACGCATCTACATTATGCCTTACAAATCAGATTCTATAATGTGGCAGCTTAGTTTTCCA
ATGTCTGAAAACGATGCAAAAATATTAAGTGCAAAAGGTCAAAAAGCACTCAAAGAAGAAGCCTGCCGCAGAACACAGTG
GCACGATCCTATTCCGCAGATTTTAATGGCAACCCAAGAAACCCAGATTTCAGGATATCCTGTTTATGACCGCGAATTGC
TGCAGTCAGATTTATTAAAAAATGCCGGTTCAGTAACTTTAATTGGCGATGCTGCTCACCCAATGAGTCCGTTTAAAGGA
CAAGGAGCCAATCAGGCATTATTAGATGCGCTGACATTAGCAAGAGGAATCGTAAAAGCATGCAGAAATTGTCAATGGAA
AGAAATTGGAATCAGGGAAAGTGTATTAACAGAATTTGAAGCTGAAATGATAGAACGCAGTGCCATAAAAGTAAAAGGCT
CTGCAGATGCAGCTCAGTTTTTACATTCTGAAATTGTACTCTATGAAGGCGACGAACCAAGAGGCCGCTGTTTAAAGAAA
AAAGAAATATAG

Upstream 100 bases:

>100_bases
AATTTTGAAGCCGTTTTGACAAGCCCATCTTTTGTCCTAAATTTGCACACCAGAAAACGCAGAAAAATTCACGTTTTAAA
GTCCGGTAAAATAAGAGAAA

Downstream 100 bases:

>100_bases
AAAACTCATTATACAACAAAGCCCATTCCTGTTTAGGTTTGGGCTTTTTTAGTCTTACAACTGAGGTATTTTTAAAGCTG
ATTCAAATAATTAATTATTA

Product: FAD-binding monooxygenase

Products: NA

Alternate protein names: PfKMO; Kynurenine 3-hydroxylase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MEKAENEKTSWTICKECQGSGKKNRGLSNKARRDYQTALDLFQKNNNEGKAPVRPKAHLYTCTKCNGSGLVSSLNFPEPD
NKNLPHIAIIGAGIGGTALAVACLHRGIPFTLFERDADFEARSQGYGLTLQQASKAIEGLGIFSLDEKVISTRHLVHTTE
GKVIGEWGIRKWLQSNAKTTSKRTNMHIARQSLRLALLEQLGGHDKVQWGHQLIDFNQNDKNVDLNFQVNGETKSCKADL
VVGADGIRSSVRKLLIGDETTPLRYLDCIVILGICPLSTLENLESPLLDGATVFQTANGNERIYIMPYKSDSIMWQLSFP
MSENDAKILSAKGQKALKEEACRRTQWHDPIPQILMATQETQISGYPVYDRELLQSDLLKNAGSVTLIGDAAHPMSPFKG
QGANQALLDALTLARGIVKACRNCQWKEIGIRESVLTEFEAEMIERSAIKVKGSADAAQFLHSEIVLYEGDEPRGRCLKK
KEI

Sequences:

>Translated_483_residues
MEKAENEKTSWTICKECQGSGKKNRGLSNKARRDYQTALDLFQKNNNEGKAPVRPKAHLYTCTKCNGSGLVSSLNFPEPD
NKNLPHIAIIGAGIGGTALAVACLHRGIPFTLFERDADFEARSQGYGLTLQQASKAIEGLGIFSLDEKVISTRHLVHTTE
GKVIGEWGIRKWLQSNAKTTSKRTNMHIARQSLRLALLEQLGGHDKVQWGHQLIDFNQNDKNVDLNFQVNGETKSCKADL
VVGADGIRSSVRKLLIGDETTPLRYLDCIVILGICPLSTLENLESPLLDGATVFQTANGNERIYIMPYKSDSIMWQLSFP
MSENDAKILSAKGQKALKEEACRRTQWHDPIPQILMATQETQISGYPVYDRELLQSDLLKNAGSVTLIGDAAHPMSPFKG
QGANQALLDALTLARGIVKACRNCQWKEIGIRESVLTEFEAEMIERSAIKVKGSADAAQFLHSEIVLYEGDEPRGRCLKK
KEI
>Mature_483_residues
MEKAENEKTSWTICKECQGSGKKNRGLSNKARRDYQTALDLFQKNNNEGKAPVRPKAHLYTCTKCNGSGLVSSLNFPEPD
NKNLPHIAIIGAGIGGTALAVACLHRGIPFTLFERDADFEARSQGYGLTLQQASKAIEGLGIFSLDEKVISTRHLVHTTE
GKVIGEWGIRKWLQSNAKTTSKRTNMHIARQSLRLALLEQLGGHDKVQWGHQLIDFNQNDKNVDLNFQVNGETKSCKADL
VVGADGIRSSVRKLLIGDETTPLRYLDCIVILGICPLSTLENLESPLLDGATVFQTANGNERIYIMPYKSDSIMWQLSFP
MSENDAKILSAKGQKALKEEACRRTQWHDPIPQILMATQETQISGYPVYDRELLQSDLLKNAGSVTLIGDAAHPMSPFKG
QGANQALLDALTLARGIVKACRNCQWKEIGIRESVLTEFEAEMIERSAIKVKGSADAAQFLHSEIVLYEGDEPRGRCLKK
KEI

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: =1.14.13.9 [H]

Molecular weight: Translated: 53448; Mature: 53448

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAENEKTSWTICKECQGSGKKNRGLSNKARRDYQTALDLFQKNNNEGKAPVRPKAHLY
CCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
TCTKCNGSGLVSSLNFPEPDNKNLPHIAIIGAGIGGTALAVACLHRGIPFTLFERDADFE
EEEECCCCCCEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCC
ARSQGYGLTLQQASKAIEGLGIFSLDEKVISTRHLVHTTEGKVIGEWGIRKWLQSNAKTT
HHCCCCCEEHHHHHHHHHCCCEEEHHHHHHHHHHEEEECCCCEEEHHHHHHHHHCCCCCH
SKRTNMHIARQSLRLALLEQLGGHDKVQWGHQLIDFNQNDKNVDLNFQVNGETKSCKADL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHCCCCCCCCCEEEEEEECCCCCCCCEEE
VVGADGIRSSVRKLLIGDETTPLRYLDCIVILGICPLSTLENLESPLLDGATVFQTANGN
EECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCC
ERIYIMPYKSDSIMWQLSFPMSENDAKILSAKGQKALKEEACRRTQWHDPIPQILMATQE
CEEEEEEECCCCEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHCCC
TQISGYPVYDRELLQSDLLKNAGSVTLIGDAAHPMSPFKGQGANQALLDALTLARGIVKA
CCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CRNCQWKEIGIRESVLTEFEAEMIERSAIKVKGSADAAQFLHSEIVLYEGDEPRGRCLKK
HHCCCCHHCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHEEEEEECCCCHHCCCCC
KEI
CCC
>Mature Secondary Structure
MEKAENEKTSWTICKECQGSGKKNRGLSNKARRDYQTALDLFQKNNNEGKAPVRPKAHLY
CCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
TCTKCNGSGLVSSLNFPEPDNKNLPHIAIIGAGIGGTALAVACLHRGIPFTLFERDADFE
EEEECCCCCCEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCC
ARSQGYGLTLQQASKAIEGLGIFSLDEKVISTRHLVHTTEGKVIGEWGIRKWLQSNAKTT
HHCCCCCEEHHHHHHHHHCCCEEEHHHHHHHHHHEEEECCCCEEEHHHHHHHHHCCCCCH
SKRTNMHIARQSLRLALLEQLGGHDKVQWGHQLIDFNQNDKNVDLNFQVNGETKSCKADL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHCCCCCCCCCEEEEEEECCCCCCCCEEE
VVGADGIRSSVRKLLIGDETTPLRYLDCIVILGICPLSTLENLESPLLDGATVFQTANGN
EECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCC
ERIYIMPYKSDSIMWQLSFPMSENDAKILSAKGQKALKEEACRRTQWHDPIPQILMATQE
CEEEEEEECCCCEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHCCC
TQISGYPVYDRELLQSDLLKNAGSVTLIGDAAHPMSPFKGQGANQALLDALTLARGIVKA
CCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CRNCQWKEIGIRESVLTEFEAEMIERSAIKVKGSADAAQFLHSEIVLYEGDEPRGRCLKK
HHCCCCHHCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHEEEEEECCCCHHCCCCC
KEI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA