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The map label for this gene is ddc [H]

Identifier: 146300916

GI number: 146300916

Start: 3773929

End: 3775446

Strand: Direct

Name: ddc [H]

Synonym: Fjoh_3171

Alternate gene names: 146300916

Gene position: 3773929-3775446 (Clockwise)

Preceding gene: 146300915

Following gene: 146300917

Centisome position: 61.9

GC content: 36.76

Gene sequence:

>1518_bases
ATGCAAAACCTATTAGACAATGCCCCGGATGTCTTTGTTAAAAGCGCCGCTGACGATTTTTATCAGGATATTTTTCATGA
AAATTCCGGAACAGAATATGCCAATGCCATAGAATTAGTTCAAAAACGTGTAGCAGGTTTTCTTGAAAATACTAAAATCC
CGTTCAGCGGTATTAAACCTGACGAAATACGAAATAAAGTAGAAGCTGTAAACCTTGATCAGCCAGTTCAGGATTATGAA
ACCCTTTGGGACGAGATCGATGAAATTTATGTAAATCATGCCACTGCTTACCATTTACCAGAATATATAGCCCACTTAAA
CTGCCCTGTTGTAATTCCTGCTTTAGCAGCCGATGTATTGATTAGCGCTATTAACTCATCGCAAGACACGTATGACCAAA
GTGCAGGTGGAACATTCATTGAAAGAAAATTGATTGCCTGGACTGGCGAACAAATTGGATATAATGTAGATTGTGATGGT
ATTTTTACTGGCGGCGGATCACAAAGTAACCTTATGGGACTGCTATTGGCCAGAGATTATTTTGCTTTAAAATACCTCAA
CTGGAACATCAAATTAAATGGCTGTCCGCCGGATTCAAGTAAATTCAGAATTTTTGTTTCAGAGAAATCTCATTTCAGCA
ATCAAAAAAATGCTTCTATTCTAGGTCTTGGCGAGCAGTCTATTGTTCAGGTTGTAACAGACAGCCGTTACAGAATGGAC
GCTGAAAAATTAAAGCAGGCCATTCTTGAAGAAAAAGAAAAAGGCAACATTCCTATTGCTATTGTGGCTACAGCAGGAAC
AACAGATTTTGGGAACATCGATCCATTATCTGAAATTTCAGTTTTGGCAAAAGAACATGAATTATGGATGCATGTTGACG
CCGCTTATGGCTGCGGGTTATTGCTGACAGATACATACAAACATTTGTTAAACGGAATTGAACAAGCTGATTCTGTTACA
ATTGATTATCATAAATCTTTCTTTCAGCCTATTTGCAGCAGTGCTTTTATGGTGAGAAACAAACAGCATCTTCATATCAT
AAAACATCATGCTGATTATTTAAATCCAAAAGAACAGGATTACGATGAACTTCCGGCACAAATAAACAAATCTCTGGTAC
AAAGTACACGCCGTTTTGATGCTTTAAAACTATGGTGTACACTGCGTTATATGGGAAGAACTAAACTTGGACAGTATACA
GATACCATTATTGAAACGACCAAACAAACAGCTGAAATACTGGAAAACGACAAAGACTTTGAACTCTTAACAGATTCTGA
TTTAAGTGTTTTGGTTTTTAGATACAAACTAGACGGCTGGCCTGGAGACACTTGTAAAATGAACTTACACATCAAAAAGA
AAATGTTTTTTAACGGTGAAGTCTTAGTGGCAAGCACAAAAGTAAACGGCATTTTTTACCTCAAGTTTACCATTTTGAAT
CCATTAACAACAATCGCACACATCAATAATATCCTTTCAATTATAAAAAAACACGGAAATGACTACATCTTCTCCTAA

Upstream 100 bases:

>100_bases
GTTATTATCCAGAAGATCTTGAGCCATCCAGAAAAAAGCGAACCCCGATTTCTAACAAAGTAACTTATTTTAAATAACCT
CAATTCTAAAACTTATAATT

Downstream 100 bases:

>100_bases
AGAGATTGCTCAGGAAGCAGTCGATATTACGTTTACTATTTTACTTAACTGCTGTGTTCGCGAACTAGGCAACAGCAGTT
TTTATGAAGGGGTTCCTAAA

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MQNLLDNAPDVFVKSAADDFYQDIFHENSGTEYANAIELVQKRVAGFLENTKIPFSGIKPDEIRNKVEAVNLDQPVQDYE
TLWDEIDEIYVNHATAYHLPEYIAHLNCPVVIPALAADVLISAINSSQDTYDQSAGGTFIERKLIAWTGEQIGYNVDCDG
IFTGGGSQSNLMGLLLARDYFALKYLNWNIKLNGCPPDSSKFRIFVSEKSHFSNQKNASILGLGEQSIVQVVTDSRYRMD
AEKLKQAILEEKEKGNIPIAIVATAGTTDFGNIDPLSEISVLAKEHELWMHVDAAYGCGLLLTDTYKHLLNGIEQADSVT
IDYHKSFFQPICSSAFMVRNKQHLHIIKHHADYLNPKEQDYDELPAQINKSLVQSTRRFDALKLWCTLRYMGRTKLGQYT
DTIIETTKQTAEILENDKDFELLTDSDLSVLVFRYKLDGWPGDTCKMNLHIKKKMFFNGEVLVASTKVNGIFYLKFTILN
PLTTIAHINNILSIIKKHGNDYIFS

Sequences:

>Translated_505_residues
MQNLLDNAPDVFVKSAADDFYQDIFHENSGTEYANAIELVQKRVAGFLENTKIPFSGIKPDEIRNKVEAVNLDQPVQDYE
TLWDEIDEIYVNHATAYHLPEYIAHLNCPVVIPALAADVLISAINSSQDTYDQSAGGTFIERKLIAWTGEQIGYNVDCDG
IFTGGGSQSNLMGLLLARDYFALKYLNWNIKLNGCPPDSSKFRIFVSEKSHFSNQKNASILGLGEQSIVQVVTDSRYRMD
AEKLKQAILEEKEKGNIPIAIVATAGTTDFGNIDPLSEISVLAKEHELWMHVDAAYGCGLLLTDTYKHLLNGIEQADSVT
IDYHKSFFQPICSSAFMVRNKQHLHIIKHHADYLNPKEQDYDELPAQINKSLVQSTRRFDALKLWCTLRYMGRTKLGQYT
DTIIETTKQTAEILENDKDFELLTDSDLSVLVFRYKLDGWPGDTCKMNLHIKKKMFFNGEVLVASTKVNGIFYLKFTILN
PLTTIAHINNILSIIKKHGNDYIFS
>Mature_505_residues
MQNLLDNAPDVFVKSAADDFYQDIFHENSGTEYANAIELVQKRVAGFLENTKIPFSGIKPDEIRNKVEAVNLDQPVQDYE
TLWDEIDEIYVNHATAYHLPEYIAHLNCPVVIPALAADVLISAINSSQDTYDQSAGGTFIERKLIAWTGEQIGYNVDCDG
IFTGGGSQSNLMGLLLARDYFALKYLNWNIKLNGCPPDSSKFRIFVSEKSHFSNQKNASILGLGEQSIVQVVTDSRYRMD
AEKLKQAILEEKEKGNIPIAIVATAGTTDFGNIDPLSEISVLAKEHELWMHVDAAYGCGLLLTDTYKHLLNGIEQADSVT
IDYHKSFFQPICSSAFMVRNKQHLHIIKHHADYLNPKEQDYDELPAQINKSLVQSTRRFDALKLWCTLRYMGRTKLGQYT
DTIIETTKQTAEILENDKDFELLTDSDLSVLVFRYKLDGWPGDTCKMNLHIKKKMFFNGEVLVASTKVNGIFYLKFTILN
PLTTIAHINNILSIIKKHGNDYIFS

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=486, Percent_Identity=30.2469135802469, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI4503875, Length=486, Percent_Identity=30.2469135802469, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI197383062, Length=423, Percent_Identity=28.8416075650118, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI194294551, Length=408, Percent_Identity=30.3921568627451, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI58331246, Length=460, Percent_Identity=28.4782608695652, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI4503281, Length=474, Percent_Identity=24.4725738396624, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI132814448, Length=474, Percent_Identity=24.4725738396624, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI92110055, Length=446, Percent_Identity=24.2152466367713, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71993062, Length=331, Percent_Identity=27.7945619335347, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17555682, Length=331, Percent_Identity=27.7945619335347, Blast_Score=151, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71993058, Length=331, Percent_Identity=27.7945619335347, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17534817, Length=450, Percent_Identity=24.8888888888889, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17534819, Length=450, Percent_Identity=24.8888888888889, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI71981211, Length=481, Percent_Identity=24.1164241164241, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71981217, Length=490, Percent_Identity=23.6734693877551, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17551992, Length=513, Percent_Identity=21.6374269005848, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI133931025, Length=391, Percent_Identity=21.9948849104859, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21356415, Length=411, Percent_Identity=29.1970802919708, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI17136594, Length=330, Percent_Identity=32.4242424242424, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24657193, Length=379, Percent_Identity=29.023746701847, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24657185, Length=379, Percent_Identity=29.023746701847, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24657188, Length=379, Percent_Identity=29.023746701847, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24585139, Length=452, Percent_Identity=25.4424778761062, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI221476190, Length=454, Percent_Identity=25.5506607929515, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24585143, Length=454, Percent_Identity=25.5506607929515, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24652373, Length=458, Percent_Identity=24.0174672489083, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24585135, Length=472, Percent_Identity=23.0932203389831, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17136190, Length=463, Percent_Identity=22.0302375809935, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24586044, Length=488, Percent_Identity=24.1803278688525, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28573972, Length=428, Percent_Identity=23.8317757009346, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 57044; Mature: 57044

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNLLDNAPDVFVKSAADDFYQDIFHENSGTEYANAIELVQKRVAGFLENTKIPFSGIKP
CCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
DEIRNKVEAVNLDQPVQDYETLWDEIDEIYVNHATAYHLPEYIAHLNCPVVIPALAADVL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHHHHHHH
ISAINSSQDTYDQSAGGTFIERKLIAWTGEQIGYNVDCDGIFTGGGSQSNLMGLLLARDY
HHHHCCCCHHCCCCCCCHHHHHHHEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHH
FALKYLNWNIKLNGCPPDSSKFRIFVSEKSHFSNQKNASILGLGEQSIVQVVTDSRYRMD
EEEEEEEEEEEECCCCCCCCCEEEEEECCHHCCCCCCCEEEECCHHHHHHHHHCCCCCCC
AEKLKQAILEEKEKGNIPIAIVATAGTTDFGNIDPLSEISVLAKEHELWMHVDAAYGCGL
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHCCCE
LLTDTYKHLLNGIEQADSVTIDYHKSFFQPICSSAFMVRNKQHLHIIKHHADYLNPKEQD
EEHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHEEHHHHHCCCCCCC
YDELPAQINKSLVQSTRRFDALKLWCTLRYMGRTKLGQYTDTIIETTKQTAEILENDKDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
ELLTDSDLSVLVFRYKLDGWPGDTCKMNLHIKKKMFFNGEVLVASTKVNGIFYLKFTILN
EEEECCCCEEEEEEEEECCCCCCCEEEEEEEEEEEEECCEEEEEEEEECEEEEEEEEHHH
PLTTIAHINNILSIIKKHGNDYIFS
HHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQNLLDNAPDVFVKSAADDFYQDIFHENSGTEYANAIELVQKRVAGFLENTKIPFSGIKP
CCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
DEIRNKVEAVNLDQPVQDYETLWDEIDEIYVNHATAYHLPEYIAHLNCPVVIPALAADVL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHHHHHHH
ISAINSSQDTYDQSAGGTFIERKLIAWTGEQIGYNVDCDGIFTGGGSQSNLMGLLLARDY
HHHHCCCCHHCCCCCCCHHHHHHHEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHH
FALKYLNWNIKLNGCPPDSSKFRIFVSEKSHFSNQKNASILGLGEQSIVQVVTDSRYRMD
EEEEEEEEEEEECCCCCCCCCEEEEEECCHHCCCCCCCEEEECCHHHHHHHHHCCCCCCC
AEKLKQAILEEKEKGNIPIAIVATAGTTDFGNIDPLSEISVLAKEHELWMHVDAAYGCGL
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHCCCE
LLTDTYKHLLNGIEQADSVTIDYHKSFFQPICSSAFMVRNKQHLHIIKHHADYLNPKEQD
EEHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHEEHHHHHCCCCCCC
YDELPAQINKSLVQSTRRFDALKLWCTLRYMGRTKLGQYTDTIIETTKQTAEILENDKDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
ELLTDSDLSVLVFRYKLDGWPGDTCKMNLHIKKKMFFNGEVLVASTKVNGIFYLKFTILN
EEEECCCCEEEEEEEEECCCCCCCEEEEEEEEEEEEECCEEEEEEEEECEEEEEEEEHHH
PLTTIAHINNILSIIKKHGNDYIFS
HHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]